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Omaha, NE, United States

Zabramski J.M.,Barrow Neurological Institute | Preul M.C.,Barrow Neurological Institute | Debbins J.,Barrow Neurological Institute | McCusker D.J.,Technical Support Inc.
Surgical Neurology International | Year: 2012

Background: Exposure of externally programmable shunt-valves (EPS-valves) to magnetic resonance imaging (MRI) may lead to unexpected changes in shunt settings, or affect the ability to reprogram the valve. We undertook this study to examine the effect of exposure to a 3T MRI on a group of widely used EPS-valves. Methods: Evaluations were performed on first generation EPS-valves (those without a locking mechanism to prevent changes in shunt settings by external magnets other than the programmer) and second generation EPS-valves (those with a locking mechanisms). Fifteen new shunt-valves were divided into five groups of three identical valves each, and then exposed to a series of six simulated MRI scans. After each of the exposures, the valves were evaluated to determine if the valve settings had changed, and whether the valves could be reprogrammed. The study produced 18 evaluations for each line of shunt-valves. Results: Exposure of the first generation EPS-valves to a 3T magnetic field resulted in frequent changes in the valve settings; however, all valves retained their ability to be reprogrammed. Repeated exposure of the second generation EPS-valves has no effect on shunt valve settings, and all valves retained their ability to be interrogated and reprogrammed. Conclusions: Second generation EPS-valves with locking mechanisms can be safely exposed to repeated 3T MRI systems, without evidence that shunt settings will change. The exposure of the first generation EPS-valves to 3T MRI results in frequent changes in shunt settings that necessitate re-evaluation soon after MRI to avoid complications. Copyright © 2012 Zabramski JM. Source

Mafra F.A.,Federal University of ABC | Christofolini D.M.,Federal University of ABC | Cavalcanti V.,Federal University of ABC | Vilarino F.L.,Federal University of ABC | And 4 more authors.
Archives of Medical Research | Year: 2014

Background and Aims: Considering the complex cellular and molecular mechanisms involved in endometriosis formation and progression and the similarities concerning the association of endometriosis with tumorigenesis and metastasis, we hypothesized a possible relationship between telomerase and the development/progression of endometriosis. The present study aimed to evaluate the expression of telomerase in the endometrium and peritoneal endometriotic lesions from women with endometriosis and controls. Methods: A case-control study was performed comprising 25 infertile women with endometriosis and 44 fertile women without endometriosis as controls. Samples of endometrium and endometriotic peritoneal lesions of the same patient were harvested in the late luteal phase of the cycle. The expression of hTERT and GAPDH genes was measured by mRNA using qRT-PCR based on TaqMan methodology. Student t test was used to compare the values between the groups; p >0.05 was accepted as statistically significant. Results: The mean expression of hTERT in the endometriosis group was significantly high when compared to the control group (1.24 ± 4.67 vs. 0.31 ± 1.10, p= 0.026). When the expression of hTERT was compared in relation to disease stage, the group of moderate/severe endometriosis showed increased expression in relation to control group (2.59 ± 7.35 vs. 0.31 ± 1.10, p= 0.026). Regarding endometriotic peritoneal lesions, only one 1/25 expressed hTERT mRNA. This patient had deep endometriosis. Conclusions: There was an association between the expression of telomerase (hTERT mRNA) and the genesis and progression of endometriosis. © 2014 IMSS. Source

Horikoshi S.,University of Tokyo | Matsumoto N.,University of Tokyo | Omata Y.,Technical Support Inc. | Kato T.,University of Tokyo
Journal of Applied Physics | Year: 2014

Metal nanoparticles (NPs) exhibit localized surface plasmon resonance (LSPR) and thus have potential for use in a wide range of applications. A facile technique for the preparation of NP films using an electron-cyclotron-resonance plasma sputtering method without a dewetting process is described. Field emission scanning electron microscopy (FE-SEM) observations revealed that the Au NPs grew independently as island-like particles during the first stage of sputtering and then coalesced with one another as sputtering time increased to ultimately form a continuous film. A plasmon absorption peak was observed via optical measurement of absorption efficiency. The LSPR peak shifted toward longer wavelengths (red shift) with an increase in sputtering time. The cause of this plasmon peak shift was theoretically investigated using the finite-difference time-domain calculation method. A realistic statistical distribution of the particle shapes based on FE-SEM observations was applied for the analysis, which has not been previously reported. It was determined that the change in the shape of the NPs from spheroidal to oval or slender due to coalescence with neighbouring NPs caused the LSPR peak shift. These results may enable the design of LSPR devices by controlling the characteristics of the nanoparticles, such as their size, shape, number density, and coverage. © 2014 AIP Publishing LLC. Source

Agency: Department of Defense | Branch: Air Force | Program: STTR | Phase: Phase I | Award Amount: 99.91K | Year: 2010

Our proposal is to develop SCADA Hawk: an integrated anti-tamper technology that uses a hardware-software combined methodology for the observational monitoring of existing systems with selective reaction capabilities. By enabling detailed monitoring capabilities our goal is to isolate anomalies in system behavior and take preventive measures. While profiling of normal behavior on traditional IT systems might be infeasible, the repetitive and predictable nature of SCADA system operation lends itself nicely to the technique. The monitoring will eventually be accomplished by the creation of various “instrumentation modules” whose job is to examine such items as network traffic, commands being delivered by the SCADA system, and so forth. We plan on utilizing two kinds of modular constructs: 1. Software Instrumentation, named (COLLECTORs) that actively collects and reports any transitions in the operational states of the SCADA system and prevents tampering by blocking unauthorized or unexpected instruction sequences. 2. Firmware-based Behavior Monitoring modules, named (AGENTs) that continuously verifies in real-time that the operational states collected by the COLLECTOR match the expected operational profile for the monitored software application. Anomalies are reported to a central station as well as preventive steps (if known) are conveyed back to the COLLECTOR to engage in tamper-prevention steps.

Aeromantenimiento S.A., Aveos Fleet Performance Inc. and Technical Support Inc. | Date: 2010-12-14

Printed training materials relating to aircraft maintenance, repair and overhaul. Aircraft safety and maintenance training; training for maintenance, repair and overhaul of aircraft, airframes, engines and engine parts and components.

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