Caetano-Anolles K.,University of Illinois at Urbana - Champaign |
Mishra S.,University of Illinois at Urbana - Champaign |
Mishra S.,Tech Forum |
Mishra S.,National Institute of Technology Tiruchirappalli |
Rodriguez-Zas S.L.,University of Illinois at Urbana - Champaign
PLoS ONE | Year: 2015
Levels of myostatin expression and physical activity have both been associated with transcriptome dysregulation and skeletal muscle hypertrophy. The transcriptome of triceps brachii muscles from male C57/BL6 mice corresponding to two genotypes (wild-type and myostatin-reduced) under two conditions (high and low physical activity) was characterized using RNA-Seq. Synergistic and antagonistic interaction and ortholog modes of action of myostatin genotype and activity level on genes and gene pathways in this skeletal muscle were uncovered; 1,836, 238, and 399 genes exhibited significant (FDR-adjusted P-value < 0.005) activity-by-genotype interaction, genotype and activity effects, respectively. The most common differentially expressed profiles were (i) inactive myostatin-reduced relative to active and inactive wild-type, (ii) inactive myostatin-reduced and active wild-type, and (iii) inactive myostatin-reduced and inactive wild-type. Several remarkable genes and gene pathways were identified. The expression profile of nascent polypeptide-associated complex alpha subunit (Naca) supports a synergistic interaction between activity level and myostatin genotype, while Gremlin 2 (Grem2) displayed an antagonistic interaction. Comparison between activity levels revealed expression changes in genes encoding for structural proteins important for muscle function (including troponin, tropomyosin and myoglobin) and for fatty acid metabolism (some linked to diabetes and obesity, DNA-repair, stem cell renewal, and various forms of cancer). Conversely, comparison between genotype groups revealed changes in genes associated with G1-to-S-phase transition of the cell cycle of myoblasts and the expression of Grem2 proteins that modulate the cleavage of the myostatin propeptide. A number of myostatin-feedback regulated gene products that are primarily regulatory were uncovered, including microRNA impacting central functions and Piezo proteins that make cationic current-controlling mechanosensitive ion channels. These important findings extend hypotheses of myostatin and physical activity master regulation of genes and gene pathways, impacting medical practices and therapies associated with muscle atrophy in humans and companion animal species and genome-enabled selection practices applied to food-production animal species. © 2015 Caetano-Anollés et al.
Mehos G.,Jenike and Johanson Inc. |
Mehos G.,Tech Forum
Chemical Engineering Progress | Year: 2011
The article describes the solids-flow property tests that should be performed and explains how to design an effective dust collector based on these properties. As dust-laden gas enters the baghouse and passes through the filter bags, particulates collect on the bags' fabric. Overtime, the buildup of dust causes the pressure drop across the fabric to rise, and the filter media must therefore be periodically cleaned, either by shaking or by applying a reverse-flow high-pressure pulse of air. The collector's outlet must therefore be equipped with an airlock to seal the hopper against the suction vacuum. A rotary valve is most commonly used for this because of its relatively low cost and simplicity. For dust collection hoppers with elongated outlets, sealing is accomplished by locating the airlock at the screw feeder discharge. The rotary valve or double flap valve must operate at a rate faster than the instantaneous rate of the screw feeder.
News Article | January 25, 2013
Chahine J.A.,Tech Forum |
Ha M.N.,Tech Forum |
Hem V.,Lectrus Corporation |
Tzouanas V.,University of Houston-Downtown
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2014
Because of the rising energy prices, green-house effects, and environmental concerns, there has been a lot of emphasis on using alternative, renewable energy sources. This paper is concerned with the use of solar energy to meet the energy needs of a scaled model house. Photovoltaic (PV) panels are used to collect solar energy and convert it to electrical energy. In this experimental study, the design of a photovoltaic system is presented for a small model house along with its associated instrumentation, real time data acquisition and automation using NI® LabVIEW. The study clearly shows that energy requirements can be met using renewable energy sources and that the goal of a zero energy house is attainable in many locations. This work was performed in partial fulfillment of the requirements of the Senior Capstone Project course in controls and instrumentation of the Engineering Technology department at the University of Houston - Downtown and then was continued as research project as part of continuing education. Student experiences are summarized and the need for teamwork and effective project management methods is emphasized. © American Society for Engineering Education, 2014.
Agency: Cordis | Branch: FP7 | Program: CSA-CA | Phase: REGIONS-2012-2013-1 | Award Amount: 2.07M | Year: 2012
The global maritime market is on a strong growth trajectory, and this project aims to harness that growth to create economic and employment benefits for Europe. On the one hand, growth is driven by commercial megatrends such as demand for marine/offshore renewable energy, fish products and emerging potential for blue biotech products; on the other hand, there is high demand for efficient use and management of the ocean resource, as described in the EU Integrated Maritime Strategy. Increasing Europes innovation capacity in maritime resource efficiency will underpin successful exploitation of these growth opportunities. Traditionally, the maritime industries have been slow to explore how demands for resource efficiency would impact on them. Fish stock depletion and rising fuel costs have, of course, risen quickly up the political and commercial agendas, and shipping companies as well as builders and engine manufacturers have invested in improving fuel efficiency. However, the wider needs for maritime resource efficiency are posing challenges which in many cases lack viable solutions. Emerging marine activities (for example in exploiting marine renewable energy) are presenting new opportunities for innovation, but are also highlighting areas where further improvements in resource efficiency need to be achieved. European member states contain a number of Regional Research Driven Clusters (RRDCs) which are active in the fields of maritime development and marine & coastal resource management. This project will add significant value to this existing cluster infrastructure, via three main approaches that will support their long-term development and sustainability: Facilitating interaction and knowledge exchange between RRDCs each focused on its world-class strengths (Smart Specialisation); Raising the effectiveness of RRDCs by strengthening shared approaches to innovation support Using RRDC activities to stimulate involvement of supply chain companies