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John J.,Td Medical College Alleppey | Mathangi D.C.,Chettinad Hospital and Research Institute | Dilara K.,Sri Ramachandra University | Subhashini A.S.,Sri Ramachandra University | Vijayraghavan J.,Sri Ramachandra University
Biomedicine | Year: 2011

Background and Objectives: Pregnancy is a physiological state accompanied by a high energy demand and an increased oxygen requirement. Augmented levels of oxidative stress would be expected because of the increased intake and utilization of oxygen. The present study was undertaken to elucidate the degree of oxidative stress in various trimesters of pregnancy. Methods: Twenty healthy pregnant women and age matched, 20 healthy non pregnant women were selected as subjects for this longitudinal study. Plasma MDA concentration was estimated as thiobarbituric acid reacting substances (TBARS). Results: A significant increase (p< 0.05) in plasma MDA concentration in pregnant women was seen when compared with non-pregnant women. Plasma malondialdehyde concentration was noted at increase with the trimester and maternal age. Interpretation and Conclusion: Pregnancy results in oxidative stress and it is increased with the trimester and maternal age. Source

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