Bojat V.,tchenov Moscow Medical University |
Baranov D.S.,tchenov Moscow Medical University |
Oganesyan E.A.,tchenov Moscow Medical University |
Hamdy Y.M.,tchenov Moscow Medical University |
And 2 more authors.
Bulletin of Experimental Biology and Medicine | Year: 2011
Paclitaxel dosage form on nanoparticles of 200-300 nm based on lactic and glycolic acid copolymer was obtained by the co-precipitation method. The possibility of controlled release of paclitaxel at pH 7.4 for 24 h was studied in vitro. Studies on Jurkat/WT human T-lymphoblastic leukemia cells showed that incorporation of paclitaxel in the nanoparticles led to a 4-fold increase of its cytotoxicity (6.8∈×∈10 -6 M) in comparison with paclitaxel solution. The efficiency of compositions containing polysorbate-80 was comparable to that of non-modified nanoparticles containing paclitaxel. © 2011 Springer Science+Business Media, Inc. Source