Taxus Research Laboratory

Hajdúnánás, Hungary

Taxus Research Laboratory

Hajdúnánás, Hungary
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Csende F.,Taxus Research Laboratory | Miklos F.,University of Szeged | Porkolab A.,Taxus Research Laboratory
Current Organic Chemistry | Year: 2010

Certain cycloalkane-anellated heterocycles undergo rearrangement under basic or acidic conditions via ring-contraction, ringexpansion or ring-opening pathways to afford new or unusual compounds. The reactivities and properties of cycloalkane-fused heterocycles differ significantly from those of heteroaromatic ring systems. Possible mechanisms are also discussed. © 2010 Bentham Science Publishers Ltd.


Csende F.,Taxus Research Laboratory | Miklos F.,University of Szeged | Stajer G.,University of Szeged
Current Organic Chemistry | Year: 2012

The present work contains a comprehensive overview of methods published in the period 2005-2011 for the preparation of polyheterocycles containing isoindole-fused ring(s). New synthetic routes are described for the construction of heterocycle-condensed isoindole derivatives with regard to the ring positions and types of these annelated ring systems. © 2012 Bentham Science Publishers.


Csende F.,Taxus Research Laboratory | Miklos F.,University of Szeged | Porkolab A.,Taxus Research Laboratory
Arkivoc | Year: 2013

Searching new targets for anti-inflammatory drug design, agents with the isoindole skeleton were focused on the basis of preliminary studies of NSAIDs as COX-1 and/or COX-2 enzyme inhibitors. Thus several novel N-substituted isoindoline derivatives as possible biologically active compounds were prepared as analogues of Indoprofen (1) starting from cis-2-[(4-methylphenyl)carbonyl] cyclohexanecarboxylic acid (3) by treatment with primary arylamines. © ARKAT-USA, Inc.


Csende F.,Taxus Research Laboratory
Mini-Reviews in Organic Chemistry | Year: 2015

Alkyl nitrites are inexpensive, mild, relatively stable and easy-to-handle alkyl esters of nitrous acid, that can be prepared simply and used in various synthetic reactions. Alkyl nitrites were discovered in the 19th century and were initially used as medical vasodilators. After several years it was observed, that alkyl nitrites are useful chemical reagents, especially as efficient NO source, consequently these were used for diazotization and as nitrating agent or oxidant. In this review several important and novel applications of alkyl nitrites in organic transformations are reported. © 2015 Bentham Science Publishers.

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