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Zheng H.,Tangshan Workers Hospital Group | Ma D.,Hebei United University | Li O.,Tangshan Workers Hospital Group | Li Y.,Tangshan Workers Hospital Group | And 3 more authors.
Chinese Journal of Clinical Oncology | Year: 2013

Objective: The present study aimed to investigate the relationship between cervical intraepithelial neoplasia (CIN) and human papilloma virus (HPV) infection during pregnancy using liquid-based cytology and HPV test. Methods: We prospectively studied the clinical data of 72 pregnant women with CIN who were hospitalized between January 2006 and January 2012 at Tangshan Gongren Hospital. All patients underwent liquid-based thin-layer cytology technique and/or HPV test. Results: Thirty two cases, which included 16 cases each of CIN I and II, displayed high-grade squamous intraepithelial lesion. The other 40 cases were CIN III characterized by low-grade squamous intraepithelial lesion based on biopsy pathology through colposcopy. A total of 48 (85.7%) HPV-positive cases were determined among 56 antenatal patients. Moreover, 32 of the 48 HPV-positive cases had either HPV16 infection alone or a mixture of different infection types. Conclusion: Results indicated that the CIN pregnant patients exhibited high frequency of HPV infections, and its HPV16 type is closely associated with the pathological development of high-grade lesions. Source

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