Tangshan, China
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Song H.-M.,Tangshan Second Hospital | Ma J.-H.,Tangshan Second Hospital | Chen H.,Hebei United University
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Hip replacement surgery is a common surgery in elderly patients. Regulatory effect of dexmedetomidin on inflammatory response in the aged patients after hip replacement attracted more and more attention. OBJECTIVE: To observe the effects of dexmedetomidin on inflammatory response in aged patients undergoing hip replacement, and to provide theoretical reference for inflammatory sedation. METHODS: 100 elderly patients aged from 60 to 75 years with hip replacement surgery were randomly divided into control group and observation group (n=50). The control group intravenously received midazolam injection. The observation group received dexmedetomidin injection. Changes in inflammatory markers, such as C-reactive protein, tumor necrosis factor-α and leukocyte count and Ramsay sedation score changes were compared and observed between the two groups before replacement (T0), 24 hours (T1) and 48 hours (T2) after replacement. RESULTS AND CONCLUSION: Leukocyte level presented an increased trend in both groups at T1. C-reactive protein and tumor necrosis factor-α levels decreased, and no significant difference was detected between the two groups (P > 0.05). At T2, leukocyte levels were significantly increased in the observation group (P < 0.05), and leukocyte levels were gradually returned to T0 level in the control group. C-reactive protein and tumor necrosis factor-α levels were lower at T2 than at T1 in both groups (P < 0.05). However, the decreased degree was bigger in the observation group than in the control group. Ramsay sedation score was significantly higher in the observation group than in the control group at T1 and T2 (P < 0.01). These findings indicate that dexmedetomidine for sedation after hip replacement can lessen inflammatory response and contribute to the recovery of hip function. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Song H.-M.,Tangshan Second Hospital | Du N.,Tangshan Second Hospital
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

OBJECTIVE: To explore isobaric spinal anesthesia in combination with lumbar plexus anesthesia in application of elderly hip joint surgery. METHODS: With lumbar anesthesia, hip replacement as Chinese key words, articles published between January 2000 and March 2010 were searched. Articles related with lumbar anesthesia, hip replacement were included. Repetitive studies were excluded. Finally, 11 articles were discussed, and 50 patients selectively undergoing hip replacement were selected as clinical validation. Using isobaric spinal anesthesia in combination with lumbar plexus anesthesia, the patients were maintained in lateral position. Hemodynamics and heart rate changes before, and 5, 15, 30 minutes after anesthesia were observed. Bilateral algesia blocking plane, temperature sense and touch sensation, Bromage motor blocking score, adverse effects, effective analgesia time and effective blocking time of affected limbs were investigated. RESULTS: Currently used anesthesia methods for the elderly hip replacement include ropivacaine lateral combined spinal epidural anesthesia, levobupivacaine in combination with sufentanil combined spinal epidural anesthesia, continuous epidural anesthesia in combination with low-dose bupivacaine lumbar anesthesia. Studies have shown that combined anesthesia displays better than medication alone. Clinical results show that hemodynamics and heart rate remained unchanged following isobaric spinal anesthesia in combination with lumbar plexus anesthesia. Algesia blocking plane, temperature sense and touch sensation, Bromage motor blocking score of lesioned side displayed significant differences compared with normal side (P < 0.01). In addition, 1 case developed vomiting and 6 hypotension. The effective analgesia time and effective blocking time of affected limbs were (5.5±2.2) hours and (2.5±0.5) hours were investigated. CONCLUSION: Isobaric spinal anesthesia in combination with lumbar plexus anesthesia is safe and reliable in elderly hip replacement with little physiological interference.


Xu W.,Tangshan Second Hospital | Li Y.-M.,Tangshan Second Hospital | Gu S.-S.,Tangshan Second Hospital
Journal of Clinical Rehabilitative Tissue Engineering Research | Year: 2010

OBJECTIVE: To introduce application and advances of pedicle screw internal fixation in treating thoracolumbar fracture. METHODS: A computer-based online search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm) was performed for related articles with key words "vertebral pedicle screw, thoracolumbar fracture, internal fixation" in English and Chinese. Articles related to anatomic basis, biomechanical analysis, clinical application and advantages and disadvantages, published in authoritative journals recently in the same filed were included. A total of 31 articles were finally included. RESULTS: Transpedicular internal fixators can effectively restore vertebral height and physiological curve to recover and fix the displaced bone block to original position to decompress the neural tube. Pedicle screw fixation can provide strong fixation, correct deformity, maintain spinal three-dimensional position, and provide good biomechanical stability. Recently, the combination of various techniques and development of minimal invasive technique increase posterior approaches for thoracolumbar fracture, which are all on the basis of pedicle screw fixation. CONCLUSION: Pedicle screw fixation is an effective technique for thoracolumbar internal fixation and can be used for various thoracolumbar instabilities, in particular the thoracolumbar fractures.


Yang S.,Tangshan Second Hospital | Guo Q.,Johns Hopkins University | Guo Q.,Wilmer Eye Institute | Shores L.S.,Johns Hopkins University | And 8 more authors.
Journal of Biomedical Materials Research - Part A | Year: 2015

Replacement of autogenous or allograft bones by artificial graft materials represents a growing area of interest in current bone repair strategies. Bioactive ceramics in particulate form, such as Bioglass® (BG) 45S5, stimulate bone mineralization comparable to autologous bone grafts, but have potential issues of particle migration and inflammation. The aim of this study was to employ a chondroitin sulfate- (CS-) based bioadhesive to improve integration of the bioglass (NovaBone® Putty) to prevent particle migration and promote bone regeneration. This BG-CS composite can encapsulate bone marrow (BM) to form a mechanically stable construct, BG-CS-BM. Rheological characterization confirmed the formation of CS-BM hydrogel by reacting the CS-based bioadhesive with the BM. Compared to the bioglass, the BG-CS-BM composite demonstrated a superior capacity to maintain construct integrity under both aqueous and turbulent environments in vitro. After implantation for 4 weeks in a critical-size distal femoral bone defect in a rabbit model, there was significantly greater bone growth in BG-CS-BM as compared to bioglass-only and the empty control. Unlike BG-CS-BM, BG-CS recruited BM in situ from the bone defect. BG-CS demonstrated a similar effect in bone formation but at a comparatively slower rate than BG-CS-BM over 6-weeks' implantation. © 2014 Wiley Periodicals, Inc.


Yang S.,Tangshan Second Hospital
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2011

To give a preliminary experimental evidence and to prove chitosan and allogeneic morselized bone as potential bone substitutions in repairing rabbit radius segmental defect. Chitosan and allogeneic morselized bone were mixed with various ratios (1:5, 1:10, 1:25, 1:50, and 1:100). After preparation, the physical and chemical properties of the composites were preliminary detected; the composites at the ratios of 1:50 and 1:25 had good physical and chemical properties and were used for the animal experiment. The radius segmental defects of 15 mm in length were made in 50 adult New Zealand white rabbits (weighing 2.5-3.0 kg), then the animals were divided into 2 groups. In groups A and B, chitosan/allogeneic morselized bone composites were implanted at the ratio of 1:50 and 1:25, respectively. After 1, 2, 4, 8, and 12 weeks of operation, the gross, histological, immunohistochemical observations were performed. Before the rabbits were sacrificed, X-ray films were taken; the serum calcium and alkaline phosphatase (ALP) concentration were measured; and the biomechanical measurement was carried out at 12 weeks. The results of gross observation were essentially consistent with those of the X-ray films. The histological observation showed that the bone formation was earlier in group A than in group B; the amount of new bone formation in group A was more than that in group B; and the bone forming area in group A was bigger than that in group B (P < 0.05) at 4 and 8 weeks after operation. The immunohistochemical staining showed that vascular endothelial growth factor and insulin-like growth factor receptor II proteins expressed in the cytoplasm of 2 groups after 4 and 8 weeks, and the expression in group A was higher than that in group B (P < 0.05). There was no significant difference in the serum calcium concentration between 2 groups at each time point (P > 0.05). After 4 and 8 weeks, the ALP concentration in group A was significantly higher than that in group B (P < 0.05). After 12 weeks, the radius maximum bending loads of groups A and B were (299.75 +/- 27.69) N and (278.54 +/- 17.09) N, respectively, showing significant difference (t=4.045, P=0.002). The composite of chitosan and allogeneic morselized bone has good osteogenic activity and can be used as a bone tissue engineering scaffold, and the optimum ratio of chitosan to allogeneic morselized bone was 1:50.


Li C.J.,Tangshan Second Hospital | Wang B.C.,Tangshan Second Hospital | Liu D.Q.,Tangshan Second Hospital
Genetics and Molecular Research | Year: 2014

The purpose of this study was to summarize the clinical application and results of the double-loop locking cross-stitch suture and suspension fixation method for medial collateral ligament origin reconstruction. Thirty-six patients (21 males, 15 females) with an average age of 40 years (range = 17-58 years), who underwent treatment for acute fracture of the medial collateral ligament at our hospital from February 2008 to May 2009, were included in this study. All patients presented unilateral injuries (17 right-sided, 19 left-sided) and underwent repair with the double-loop locking cross-stitch suture and suspension fixation method. All incisions in this group of patients healed by first intention. Thirty-two patients were followed up for 6-20 months (average = 12 months). There were no reports of wound infection, ligament re-fracture or other complications in the follow-up period. Based on the Lysholm knee-scoring scale, the patients received a 100% excellent and good rating (20 patients - excellent score, 12 patients - good score) postoperatively. The advantages of the doubleloop locking cross-stitch suture and suspension fixation method are a smaller incision, reliable fixation, and early restoration of knee joint stability. It is, therefore, an effective and low-risk method for the reconstruction of medial collateral ligament origin. © FUNPEC-RP.


PubMed | Tangshan Second Hospital
Type: Comparative Study | Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2011

To give a preliminary experimental evidence and to prove chitosan and allogeneic morselized bone as potential bone substitutions in repairing rabbit radius segmental defect.Chitosan and allogeneic morselized bone were mixed with various ratios (1:5, 1:10, 1:25, 1:50, and 1:100). After preparation, the physical and chemical properties of the composites were preliminary detected; the composites at the ratios of 1:50 and 1:25 had good physical and chemical properties and were used for the animal experiment. The radius segmental defects of 15 mm in length were made in 50 adult New Zealand white rabbits (weighing 2.5-3.0 kg), then the animals were divided into 2 groups. In groups A and B, chitosan/allogeneic morselized bone composites were implanted at the ratio of 1:50 and 1:25, respectively. After 1, 2, 4, 8, and 12 weeks of operation, the gross, histological, immunohistochemical observations were performed. Before the rabbits were sacrificed, X-ray films were taken; the serum calcium and alkaline phosphatase (ALP) concentration were measured; and the biomechanical measurement was carried out at 12 weeks.The results of gross observation were essentially consistent with those of the X-ray films. The histological observation showed that the bone formation was earlier in group A than in group B; the amount of new bone formation in group A was more than that in group B; and the bone forming area in group A was bigger than that in group B (P < 0.05) at 4 and 8 weeks after operation. The immunohistochemical staining showed that vascular endothelial growth factor and insulin-like growth factor receptor II proteins expressed in the cytoplasm of 2 groups after 4 and 8 weeks, and the expression in group A was higher than that in group B (P < 0.05). There was no significant difference in the serum calcium concentration between 2 groups at each time point (P > 0.05). After 4 and 8 weeks, the ALP concentration in group A was significantly higher than that in group B (P < 0.05). After 12 weeks, the radius maximum bending loads of groups A and B were (299.75 +/- 27.69) N and (278.54 +/- 17.09) N, respectively, showing significant difference (t=4.045, P=0.002).The composite of chitosan and allogeneic morselized bone has good osteogenic activity and can be used as a bone tissue engineering scaffold, and the optimum ratio of chitosan to allogeneic morselized bone was 1:50.

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