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Ganesh P.R.,Tamil Nadu Government Dental College | Karthikeyan R.,Tamil Nadu Government Dental College | Muthukumaraswamy A.,Tamil Nadu Government Dental College | Anand J.,Tamil Nadu Government Dental College
Oral Health and Preventive Dentistry | Year: 2017

Periodontitis, the chronic inflammatory disease of the supporting tissues of the teeth, has now been implicated in a variety of disparate systemic infections of various organs such as the lungs, heart, kidneys and brain. This review examines various associations involving chronic inflammatory processes arising from the periodontium and Alzheimer's disease, a progressive dementia of the brain with an as yet unknown origin. Causal pathways are also reviewed, e.g. the direct invasion of oral pathogens such as T. socranski and T. denticola from the periodontium across the blood-brain barrier, as well as common susceptibilities between the two tissues in terms of systemic dissemination from oral infections. Finally, potential anti-inflammatory therapies targeted at both the periodontium and brain are discussed, as periodontal infections are one of the treatable, preventable aetiopathologies involved in Alzheimer's disease. © Quintessenz. All right reserved.


PubMed | Institute of Dental Education and Advanced Studies and Tamil Nadu Government Dental College
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2015

Full mouth rehabilitation includes a promising treatment planning and execution thus fulfilling esthetic, occlusal, and functional parameters maintaining the harmony of the stomatognathic system. Crown lengthening procedures have become an integral component of the esthetic armamentarium and are utilized with increasing frequency to enhance the appearance of restorations placed in the esthetic zone. Crown lengthening plays a role to create healthy relationship of the gingiva and bone levels so as to gain access to more of the tooth which can be restored, if it is badly worn, decayed or fractured, below the gum line. This paper highlights the full mouth crown lengthening procedure performed on a patient with amelogenesis imperfecta.


PubMed | National Central University, Bharathiar University, University Putra Malaysia, Tamil Nadu Government Dental College and 3 more.
Type: Journal Article | Journal: Laboratory investigation; a journal of technical methods and pathology | Year: 2015

The ultimate goal of dental stem cell research is to construct a bioengineered tooth. Tooth formation occurs based on the well-organized reciprocal interaction of epithelial and mesenchymal cells. The dental mesenchymal stem cells are the best explored, but because the human odontogenic epithelium is lost after the completion of enamel formation, studies on these cells are scarce. The successful creation of a bioengineered tooth is achievable only when the odontogenic epithelium is reconstructed to produce a replica of natural enamel. This article discusses the untapped sources of odontogenic epithelial stem cells in humans, such as those present in the active dental lamina in postnatal life, in remnants of dental lamina (the gubernaculum cord), in the epithelial cell rests of Malassez, and in reduced enamel epithelium. The possible uses of these stem cells in regenerative medicine, not just for enamel formation, are discussed.


PubMed | Tamil Nadu Government Dental College and Meenakshi Ammal Dental College and Hospital
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

Several commercially available luting agents are used to cement the dental restorations such as intra-coronal, extra-coronal, and fixed partial dentures. Tensile bond strength (TBS) and accurate marginal fit are the essential factors to determine the good clinical results in fixed prosthesis. The retentivity of the luting cements is assessed by their adhesive capacity over the tooth surface and metal surface. Generally, the adhesive ability has been evaluated with The study is divided into four groups with 10 samples for each of the luting cement taken up for testing TBS and four groups with 5 samples for each luting agent chosen for assessing marginal fit. The results were tabulated and statistically analyzed.In this The TBS value of zinc phosphate cement and glass ionomer cement were found to be almost same. The chemical adhesiveness of the glass ionomer with calcium ions of enamel and dentin may be the attributed reason (ionic bonding). In this study, the polycarboxylate is the one that showed low TBS, and it may be attributed to the weakness of the cement due to reduced film thickness, though this cement has a chemical bonding nature. The observation of results of marginal fit in this study is the increased gap found in zinc phosphate cement followed by resin cement, zinc polycarboxylate, and glass ionomer cement. It is agreeable to estimate the marginal fit of the restoration, which could be affected by the film thickness of the luting cement along with other factors.


Selvam N.,Tamil Nadu Government Dental College | Sadaksharam J.,Tamil Nadu Government Dental College | Singaravelu G.,Anna University | Ramu R.,Anna University
Journal of Cancer Research and Therapeutics | Year: 2015

Aim of the Study: Oral leukoplakia (OL) is the most common potentially malignant disorder that may transform into oral carcinoma. By treating leukoplakia in its incipient stage, the risk of occurrence of oral carcinoma can be prevented. In this aspect, photodynamic therapy (PDT) can serve as a useful treatment modality. The aim of the study is to treat patients with OL using PDT in which 5-aminolevulinic acid (ALA) is used as a photosensitizer. Materials and Methods: Five patients with OL were included in the study. They were treated with 10% ALA mediated PDT (light source: Xenon lamp, power: 0.1 W, wavelength: 630 ± 5 nm, total dose: 100 J/cm 2 per session) for 6-8 sessions. Follow-up was done for a period of 1 year. Results: One month (4 weeks) after ALA-PDT, the response was evaluated based on clinical examination. It was as follows: Complete response: Two patients; partial response: Two patients; and no response: One patient. There was no recurrence in any of the cases. Conclusion: There was satisfactory reduction in the size of the OL lesion without any side-effects. Thus, ALA mediated PDT seems to be a promising alternative for the treatment of OL.


Chandra S.J.,Tamil Nadu Government Dental College
Journal International Medical Sciences Academy | Year: 2010

We are reporting cases of submandibular modalities of conventional radiography ultrasonogram (USG), Computed Tomography (C.T. scan) subsequent treatment approach.


Jayanthi R.,Stanley Medical College | Nasser K.S.G.A.,Tamil Nadu Government Dental College | Monica K.,Stanley Medical College
Journal of Association of Physicians of India | Year: 2016

Lidocaine Hydrochloride is an amide ester, which is widely used local anesthetic agent that is well tolerated but what is less known is the occurrence of systemic toxicity which manifests in the central nervous and cardiovascular systems. We report here 3 cases of Lidocaine associated Seizures. © 2016, Journal of Association of Physicians of India. All Rights reserved.


Gunasekar C.,ESIC Hospital | Nasser K.S.G.A.,Tamil Nadu Government Dental College | Sabarigirinathan C.,Tamil Nadu Government Dental College | Kumar K.R.,Tamil Nadu Government Dental College
Indian Journal of Dental Research | Year: 2013

Restoration of near normal functions in patients who have been treated with hemimaxillectomy is generally difficult, in view of the restriction in mouth opening following healing of large surgical wound. Further, the extent and nature of the surgical defect differ from patient to patient. Thus, design of an obturator needs to be patient oriented. In this report, we describe a novel snap-on attachment with O-ring in a conventional two piece hollow bulb obturator for a 70-year-old male treated for carcinoma of the left maxilla and sinus.


PubMed | Tamil Nadu Government Dental College
Type: Journal Article | Journal: Nigerian journal of clinical practice | Year: 2012

Various routes have been reported with respect to the transmission of human immunodeficiency virus (HIV) from one individual to another. But it is not clear whether they alter the clinical expression of the disease. This study was conducted to know whether there exists any difference in the occurrence of periodontal lesions among untreated HIV subjects who acquired the disease either through intravenous drug abuse or sexual contact and to correlate those lesions with immune suppression as indicated by CD 4 T lymphocyte counts.In this cross-sectional study 213 HIV-positive subjects who had not started on Highly Active Anti Retroviral Therapy (HAART) were selected and divided into two groups intravenous drug users (IVDU) and non-IVDU (NIVDU). CD 4 T lymphocyte counts were evaluated and clinical examination was done to detect the presence of pathologic periodontal lesions.Mean probing depth (PD) and clinical attachment level (CAL) are significantly higher in drug users than nondrug users. When periodontal lesions are compared with CD 4 cell counts, it is found that significant inverse relation exists between linear gingival erythema, necrotizing ulcerative periodontitis, and CD 4 counts, but only in nondrug users.An inverse correlation between linear gingival erythema, necrotizing ulcerative periodontitis, and CD 4 counts in NIVDU indicating their reliability as a marker for immune suppression. Periodontitis is more prevalent among drug users indicating some difference in disease expression among the groups.


PubMed | Tamil Nadu Government Dental College and Stanley Medical College
Type: Case Reports | Journal: The Journal of the Association of Physicians of India | Year: 2016

Lidocaine Hydrochloride is an amide ester, which is widely used local anesthetic agent that is well tolerated but what is less known is the occurrence of systemic toxicity which manifests in the central nervous and cardiovascular systems. We report here 3 cases of Lidocaine associated Seizures.

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