Takiron Co.

Kōbe-shi, Japan

Takiron Co.

Kōbe-shi, Japan
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Tanaka K.,Kyoto University | Takemoto M.,Kyoto University | Fujibayashi S.,Kyoto University | Neo M.,Kyoto University | And 2 more authors.
Spine | Year: 2011

Study Design. Experimental animal study. Objective. To investigate the osteogenic properties of a particulate uncalcined, unsintered hydroxyapatite/polydllactide (u-HA/PdlLA) composite scaffold loaded with bone marrow aspirate (BMA). Summary Of Background Data. Because of the high morbidity associated with bone graft harvesting, current research in spine surgery has largely focused on bone graft alternatives involving a combination of scaffolds and osteogenic substances. BMA is obtained by a simple and relatively noninvasive method and can easily be clinically applied as an osteogenic material. However, few studies have reported successful posterolateral spinal fusion (PLF) with BMA-loaded synthetic materials. Methods. Porous u-HA/PdlLA composites loaded with BMA were used as bone graft substitutes. In experiment 1, porous u-HA/PdlLA cylinders containing or lacking BMA were implanted in rabbit muscles. They were retrieved 4, 8, and 12 weeks after implantation, and ectopic bone formation was histologically evaluated. In experiment 2, 48 rabbits underwent PLF with 1 of 4 bone grafts: autogenous bone (group 1); single-strip u-HA/PdlLA alone (group 2); morselized u-HA/PdlLA + BMA (group 3); or single-strip u-HA/PdlLA + BMA (group 4). After 12 weeks, fusion was assessed by manual palpation, microcomputed tomography, mechanical tests, and histologic examination. Results. In experiment 1, ectopic bone formation was observed in BMA-loaded u-HA/PdlLA, and the new bone area increased until 12 weeks after implantation. In experiment 2, the fusion rates in groups 1, 2, 3, and 4 were 58.3%, 16.7%, 66.7%, and 91.7%, respectively, as determined by manual palpation, and 66.7%, 16.7%, 75.0%, and 91.7%, respectively, as determined by microcomputed tomography. The mechanical strength was significantly greater in group 4 than in the other groups (P < 0.05). Conclusion. Conclusion. Our results indicate that BMA-loaded porous μ-HA/PdlLA is an effective alternative to autogenous bone grafts. The structure and composition of porous u-HA/PdlLA render it an effective scaffold for BMA. Copyright © 2011 Lippincott Williams &Wilkins.


Patent
Takiron Co. | Date: 2010-09-15

An object of the present invention is to provide a biomaterial for an artificial cartilage that eliminates the risk of possible adverse effects due to scattering of fragments of the biodegradable and bioabsorbable polymers and is joined further solidly to vertebral bodies and the like with increased adhesiveness. The biomaterial for an artificial cartilage according to the present invention includes: an organized structure comprising organic fibers arranged in one of a multiaxial three-dimensional woven or knitted structure having three or more axes and a combined structure of the woven structure and the knitted structure; and a biodegradable and bioabsorbable pin provided inside the organized structure, two ends of the pin becoming projected from upper and lower surfaces of the organized structure upon compression on the organized structure from above and below, each of the upper and lower surfaces or either one of the surfaces of the organized structure having a superficial portion of a soft layer that is softer than the other portion of the organized structure, part or all of the organic fibers of the superficial portion being coated with a biodegradable and bioabsorbable polymer complex containing bioactive bioceramic powder. Adhesiveness with vertebral bodies and the like is increased by making the superficial portion(s) of the organized structure as a soft layer, the scattering of the polymers is prevented by coating the organic fibers of the superficial portion with the above complex, and the solid joint to vertebral bodies and the like is achieved.


Patent
Takiron Engineering Co. and Takiron Co. | Date: 2015-09-02

To provide a pipe inner-layer structure that allows inner surface materials to be accurately disposed, includes inner surface materials, simplifies installation work by saving labor in assembling component members, and has durability over a long period of time even after the completion of work, the pipe inner-layer structure of a pipe includes: fixed members 2 that are installed along an inner peripheral surface of a pre-installed pipe 1 at intervals in the pipe-axial direction of the pre-installed pipe 1; connection members 3 that are disposed on the fixed members 2 and include first fitting portions 31 to which an inner surface material 4 is fitted and second fitting portions 32 for installation to the fixed member 2; and the inner surface material 4 in the shape of a band, which is fitted to the first fitting portions 31 of the connection members 3 and is provided across fixed members 2 adjacent to each other in the pipe-axial direction. The connection members 3 are adapted so as to be divided and disposed on the fixed members 2 through the second fitting portions 32 included in the respective connection members 3.


Patent
Takiron Co. | Date: 2012-01-13

The present invention provides an implant material comprising an organic-inorganic complex porous article and a production method thereof. The organic-inorganic complex porous article is a biodegradable and bioabsorbable bioactive porous article in which a bioactive bioceramics powder is uniformly dispersed in a biodegradable and bioabsorbable polymer, wherein it has continuous pores and the bioceramics powder is partly exposed to the pore inner surface or the pore inner surface and the porous article surface.


Patent
Takiron Co. and Kobe University | Date: 2014-11-20

A drill guide has a main body in which a drill insertion hole is formed and plural projection portions to be inserted into plural bone tunnels. The plural projection portions project forward from the main body parallel with the center line of the drill insertion hole, a virtual drill insertion hole which extends from the drill insertion hole of the main body is formed between the plural projection portions parallel with their center lines by cutting out confronting portions of the plural projection portions, and the length of at least one of the drill insertion hole and the virtual drill insertion hole is 5 mm or more. The drill guide can guide a drill so as to be correctly between plural bone tunnels bored through a living body bone without causing axis deviation so that a link bone tunnel for connecting the plural bone tunnels can be formed between them in the same direction as their direction.


Provided is a slide jig for connecting face materials, in which the face materials can be easily connected together while fitting claws are reliably fit together. The slide jig is used in order to connect belt-like face materials 1 that are arranged side by side in a width direction by respectively fitting face material fitting claws 12, which are respectively formed in grooves 11 that are respectively formed at end portions of the face materials 1 in the width direction, to face material connecting member fitting claws 22 which are oppositely formed in protrusions 21 which are formed in a face material connecting member 2 arranged across the end portions of both the face materials 1 in the width direction. A support portion 31 that is inserted into the groove 11 of the face material 1, a protrusion guide portion 32 that is inserted between the protrusions 21 which are formed in the face material connecting member 2, and a pressing portion 33 that presses a surface of the face material connecting member 2 are integrated with a joint portion 34. The support portion 31 is provided so as to be positioned in a front of a jig 3A in a slide direction, and the protrusion guide portion 32 and the pressing portion 33 are provided so as to be positioned in the rear of the jig 3A in the slide direction.


Patent
Takiron Co. and Kobe University | Date: 2014-11-20

A guide pin piercing jig includes a cylinder unit and a frame having a positioning projection at a tip thereof, in which the cylinder unit has plural parallel guide pin insertion cylinders and tentative fixing unit and is attached to the frame slidably so as to be directed to the tip of the frame. It becomes possible to pierce living body bone with plural guide pins for hollow drills to a proper portion of a living body bone in a proper direction with parallel arrangement to form a bone tunnel that has a rectangular or elliptical opening and is suitable for tendon transplantation.


Patent
Takiron Co. and Kobe University | Date: 2014-11-20

A guide pin piercing jig includes a curved frame, a front cylinder unit provided at a front end of the frame, and a rear cylinder unit provided at a rear end of the frame, in which the front cylinder unit has a positioning projection and a boring aiming portion at a tip thereof, the rear cylinder unit has a plurality of parallel guide pin insertion cylinders into which to insert the guide pins and a tentative fixing unit provided at a tip of the rear cylinder unit, and the rear cylinder unit is provided at a rear end of the frame slidably so as be directed to a tip of the front cylinder unit. It becomes possible to aim at a proper portion of a living body bone through which to bore a bone tunnel and to pierce the living body bone with guide pins for hollow drills from behind the living body bone to the proper aiming portion in a proper direction.


Patent
Takiron Co. | Date: 2015-08-27

A ligament fixture to be inserted and fixed into a fitting hole formed in an in-vivo bone is provided, and includes an in-vivo degradable and absorbable material which is a polymer-bioceramic composite material. The ligament fixture has at least one pair of opposed surfaces which are inclined faces gradually getting closer to each other toward to a front-end side of the ligament fixture and which form a wedge shape having a resistance imparting parts on each of the inclined faces. The ligament fixture includes a front-end part having a cross-sectional profile smaller than a cross-sectional profile of the fitting hole, and a main body part continuing from the front-end part, the main body part including a section having a cross-sectional profile larger than the cross-sectional profile of the fitting hole.


Shikinami Y.,Shikinami Yasuo Institute | Kawabe Y.,Takiron Co. | Yasukawa K.,Takiron Co. | Tsuta K.,Takiron Co. | And 2 more authors.
Spine Journal | Year: 2010

Background context: In the quest for clinically functional artificial intervertebral discs (AIDs), multidisciplinary technologies have been employed. Existing solid mobile AIDs essentially consist of the superposition of solid plates and core materials; however, it is thought that an ideal surgical AID technology has not yet been developed. To overcome the limitation of these existing AIDs, we developed a unique flexible AID disc system on the basis of our original biomimetic concept. The AID is composed of a cubic three-dimensional fabric (3DF) with a triaxial fiber alignment, which offers biomimetic long-term dynamic mechanical behavior along with durability. Purpose: This article substantiates the potential clinical use of the 3DF disc system that quite differs from existing ones. Study design: We designed the lumbar and cervical 3DF discs that improved the structural weaknesses caused by the collagenous fiber alignment of biological intervertebral disc. Bioresorbable hydroxyapatite particles were deposited on the surface layer of the 3DF disc to promote new bony ingrowth and to ensure secure binding at the interface of the contacting vertebral bodies. A stand-alone system was devised for surgical reliability in terms of both positioning and fixation, allowing tight press fitting with the vertebral bodies. Bioactive and bioresorbable pins were penetrated through the 3DF disc body and projected from the surface to allow ideal insertion and fixation to the disc space, preserving the precise position during dynamical movement. In vitro endurance of the 3DF disc was examined under long-term alternating stresses, and the in vivo animal tests were conducted in the intervertebral lumbar discs at L5-L6 excised from baboons and replaced with the lumbar 3DF disc. Methods: The static mechanical endurance was assessed through a creep test. In vitro endurance of the 3DF disc under repetitive stresses including axial compressing, flexion-extension, torsional twisting, and lateral bending were applied to the 3DF disc for a long-term for up to 105 million stresses, which is roughly equivalent to exposure of natural biological movement for more than 50 years. In the animal test, eight baboons were euthanized 6 months postoperatively. To their extracted spines, six pure moments (flexion and extension, left and right lateral bending, and left and right torsion) were applied vertically to the superior end of the specimen and then values of range of motions (ROMs) were calculated. Histological analyses were conducted on 12 reticuloendothelial and systemic tissues. Results: The 3DF disc retained its biomimetic "J-shaped" stress-strain behavior without generating wear debris for up to 105 million stresses. A 130-N loading for the creep test decreased the height of 0.3 mm during 80 to 1,000 hours. In the biomechanical test, ROM values of axial rotation and flexion-extension showed no significant difference from the intact excluding that of lateral bending because the location of each pin to stand alone certainly controlled the bending behavior only. The histological analysis indicated no significant pathologic changes induced by the 3DF disc. Conclusions: The 3DF disc system is clinically suitable for human disc replacement arthroplasty based on the findings of long-term durability with dynamic motion in vitro and effective animal tests in vivo. This system surely overcomes the limitations of existing solid AIDs, and the clinical potential of the biomimetic 3DF discs has been verified. This new biomaterial technology delivers most of the functions and characteristics required by a clinically available AID if applied correctly by surgeons. © 2010 Elsevier Inc. All rights reserved.

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