Tanaka K.,Kyoto University |
Takemoto M.,Kyoto University |
Fujibayashi S.,Kyoto University |
Neo M.,Kyoto University |
And 2 more authors.
Study Design. Experimental animal study. Objective. To investigate the osteogenic properties of a particulate uncalcined, unsintered hydroxyapatite/polydllactide (u-HA/PdlLA) composite scaffold loaded with bone marrow aspirate (BMA). Summary Of Background Data. Because of the high morbidity associated with bone graft harvesting, current research in spine surgery has largely focused on bone graft alternatives involving a combination of scaffolds and osteogenic substances. BMA is obtained by a simple and relatively noninvasive method and can easily be clinically applied as an osteogenic material. However, few studies have reported successful posterolateral spinal fusion (PLF) with BMA-loaded synthetic materials. Methods. Porous u-HA/PdlLA composites loaded with BMA were used as bone graft substitutes. In experiment 1, porous u-HA/PdlLA cylinders containing or lacking BMA were implanted in rabbit muscles. They were retrieved 4, 8, and 12 weeks after implantation, and ectopic bone formation was histologically evaluated. In experiment 2, 48 rabbits underwent PLF with 1 of 4 bone grafts: autogenous bone (group 1); single-strip u-HA/PdlLA alone (group 2); morselized u-HA/PdlLA + BMA (group 3); or single-strip u-HA/PdlLA + BMA (group 4). After 12 weeks, fusion was assessed by manual palpation, microcomputed tomography, mechanical tests, and histologic examination. Results. In experiment 1, ectopic bone formation was observed in BMA-loaded u-HA/PdlLA, and the new bone area increased until 12 weeks after implantation. In experiment 2, the fusion rates in groups 1, 2, 3, and 4 were 58.3%, 16.7%, 66.7%, and 91.7%, respectively, as determined by manual palpation, and 66.7%, 16.7%, 75.0%, and 91.7%, respectively, as determined by microcomputed tomography. The mechanical strength was significantly greater in group 4 than in the other groups (P < 0.05). Conclusion. Conclusion. Our results indicate that BMA-loaded porous μ-HA/PdlLA is an effective alternative to autogenous bone grafts. The structure and composition of porous u-HA/PdlLA render it an effective scaffold for BMA. Copyright © 2011 Lippincott Williams &Wilkins. Source
Takiron Co. | Date: 2009-04-21
Adhesive materials for the building industry; Adhesives, other than for stationery or household purposes. Synthetic plastic as semi-finished products in form of plates, rods, profiles, hoses, tubes, blocks. Building materials, namely, wall boards; non-metal roofing panels; Wall panels not of metal.
Takiron Co. | Date: 2012-01-13
The present invention provides an implant material comprising an organic-inorganic complex porous article and a production method thereof. The organic-inorganic complex porous article is a biodegradable and bioabsorbable bioactive porous article in which a bioactive bioceramics powder is uniformly dispersed in a biodegradable and bioabsorbable polymer, wherein it has continuous pores and the bioceramics powder is partly exposed to the pore inner surface or the pore inner surface and the porous article surface.
Takiron Co. | Date: 2015-08-27
A ligament fixture to be inserted and fixed into a fitting hole formed in an in-vivo bone is provided, and includes an in-vivo degradable and absorbable material which is a polymer-bioceramic composite material. The ligament fixture has at least one pair of opposed surfaces which are inclined faces gradually getting closer to each other toward to a front-end side of the ligament fixture and which form a wedge shape having a resistance imparting parts on each of the inclined faces. The ligament fixture includes a front-end part having a cross-sectional profile smaller than a cross-sectional profile of the fitting hole, and a main body part continuing from the front-end part, the main body part including a section having a cross-sectional profile larger than the cross-sectional profile of the fitting hole.
Takiron Co. and Kobe University | Date: 2014-11-20
A guide pin piercing jig includes a cylinder unit and a frame having a positioning projection at a tip thereof, in which the cylinder unit has plural parallel guide pin insertion cylinders and tentative fixing unit and is attached to the frame slidably so as to be directed to the tip of the frame. It becomes possible to pierce living body bone with plural guide pins for hollow drills to a proper portion of a living body bone in a proper direction with parallel arrangement to form a bone tunnel that has a rectangular or elliptical opening and is suitable for tendon transplantation.