Chang H.-H.,Tajen University |
Chou H.-W.,National Central University
Behaviour and Information Technology | Year: 2011
The use of enterprise resource planning (ERP) systems has grown enormously since 1990, but the failure to completely learn how to use them continues to produce disappointing results. Today's rapidly changing business environment and the integrative applications of ERP systems force users to continuously learn new skills after ERP implementation. This study explores the effects of post-implementation learning on ERP usage and ERP impact and identifies the factors that can impact post-implementation learning, such as social capital and post-training self-efficacy. This study employs a survey method to examine the perceptions of ERP users. The theoretical model is tested by using structural equation modelling on a dataset of 812 users. This study finds that post-implementation learning has a significant positive effect on ERP usage and ERP impact, and that social capital and post-training self-efficacy are important antecedent factors of post-implementation learning. Post-training self-efficacy also significantly affects ERP usage and ERP impact. The implications for research, practice and future research directions are discussed.
Chakraborty C.,Galgotias University |
Doss C.G.P.,Vellore Institute of Technology |
Bandyopadhyay S.,Indian Statistical Institute |
Agoramoorthy G.,Tajen University
Wiley Interdisciplinary Reviews: RNA | Year: 2014
The prevalence of type-2 diabetes (T2D) is increasing significantly throughout the globe since the last decade. This heterogeneous and multifactorial disease, also known as insulin resistance, is caused by the disruption of the insulin signaling pathway. In this review, we discuss the existence of various miRNAs involved in regulating the main protein cascades in the insulin signaling pathway that affect insulin resistance. The influence of miRNAs (miR-7, miR-124a, miR-9, miR-96, miR-15a/b, miR-34a, miR-195, miR-376, miR-103, miR-107, and miR-146) in insulin secretion and beta (β) cell development has been well discussed. Here, we highlight the role of miRNAs in different significant protein cascades within the insulin signaling pathway such as miR-320, miR-383, miR-181b with IGF-1, and its receptor (IGF1R); miR-128a, miR-96, miR-126 with insulin receptor substrate (IRS) proteins; miR-29, miR-384-5p, miR-1 with phosphatidylinositol 3-kinase (PI3K); miR-143, miR-145, miR-29, miR-383, miR-33a/b miR-21 with AKT/protein kinase B (PKB) and miR-133a/b, miR-223, miR-143 with glucose transporter 4 (GLUT4). Insulin resistance, obesity, and hyperlipidemia (high lipid levels in the blood) have a strong connection with T2D and several miRNAs influence these clinical outcomes such as miR-143, miR-103, and miR-107, miR-29a, and miR-27b. We also corroborate from previous evidence how these interactions are related to insulin resistance and T2D. The insights highlighted in this review will provide a better understanding on the impact of miRNA in the insulin signaling pathway and insulin resistance-associated diagnostics and therapeutics for T2D. © 2014 John Wiley & Sons, Ltd.
Huang H.-H.,National Cheng Kung University |
Huang H.-H.,Tajen University |
Kuo Y.-H.,National Cheng Kung University
IEEE Transactions on Fuzzy Systems | Year: 2010
As cross-lingual information retrieval is attracting increasing attention, tools that measure cross-lingual semantic similarity between documents are becoming desirable. In this paper, two aspects of cross-lingual semantic document similarity measures are investigated: One is document representation, and the other is the formulation of similarity measures. Fuzzy set and rough set theories are applied to capture the inherently fuzzy relationships among concepts expressed by natural languages. Our approach first develops a language-independent sense-level document representation based on the fuzzy set model to reduce the barrier between different languages and further explores the fuzzyrough hybrid approach to obtain a more robust macrosense-level document representation through the partitioning of the integrated sense association network of the document collection into macrosenses. Then, Tverskys notion of similarity and the F1 measure on information retrieval are adopted to formulate, respectively, two document similarity measures with fuzzy set operations on the two proposed document representations. The effectiveness of our approach is demonstrated by its success rate in identifying the English translations to their corresponding Chinese documents in a collection of ChineseEnglish parallel documents. Moreover, the proposed approach can be easily extended to process documents in other languages. It is believed that the proposed representations, along with the similarity measures, will enable more effective text mining processes. © 2006 IEEE.
Tzeng T.-F.,Pao Chien Hospital |
Liu I.-M.,Tajen University
Phytomedicine | Year: 2013
6-Gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) is one of the pungent constituents of Zingiber zerumbet (L) Smith (Zingiberaceae family). In this study, we investigated the effects of 6-gingerol on the inhibition of adipogenesis in 3T3-L1 cells. After treatment with 6-gingerol in differentiation medium for 4 or 8 days, the 3T3-L1 cells were lysed for experimental analysis. Cells were stained with Oil-Red-O to detect oil droplets in adipocytes. The 3T3-L1 cells were lysed and measured for triglyceride contents. The protein expression of adipogenesis-related transcription factor was evaluated by Western blot analysis. 6-Gingerol suppressed oil droplet accumulation and reduced the droplet size in a concentration (5-15 μg/ml)- and time-dependent manner. Treatment of 3T3-L1 cells with 6-gingerol reduced the protein levels of peroxisome proliferator-activated receptor (PPAR)γ and CCAAT/enhancer-binding protein (C/EBP)α. Additionally, the protein levels of fatty acid synthase (FAS) and adipocyte-specific fatty acid binding protein (aP2) decreased upon treatment with 6-gingerol. Meanwhile, 6-gingerol diminished the insulin-stimulated serine phosphorylation of Akt (Ser473) and GSK3β (Ser9). These results suggest that 6-gingerol effectively suppresses adipogenesis and that it exerts its role mainly through the significant down-regulation of PPARγ and C/EBPα and subsequently inhibits FAS and aP2 expression. 6-Gingerol also inhibited differentiation in 3T3-L1 cells by attenuating the Akt/GSK3β pathway. Our findings provide important insights into the mechanisms underlying the anti-adipogenic activity of 6-gingerol. © 2013 Elsevier GmbH. All rights reserved.
Doss C G.P.,Vellore Institute of Technology |
Agoramoorthy G.,Tajen University |
Chakraborty C.,Galgotias University
Frontiers in Bioscience - Landmark | Year: 2014
Tumor necrosis factor, a regulatory cytokine, is extremely important signaling protein in the immune system. Among TNF family, TNF-α, TNF-beta; are most the significant family members. Receptor of TNF namely TNFR1 and TNFR2 stimulates two different signaling pathways. TNFR1 signaling induces apoptosis pathway. Conversely, TNFR2 signaling triggers cell survival pathways. In this paper, we discuss about the TNF family with special reference to TNF-α/ TNF-beta;, different hypothesis related to autoimmunity and role of TNF, structure of TNF-α/ TNF-beta;, distribution and normal activity in human body of TNF, receptors and signaling pathway for drug targeting. Finally, we also discuss about the therapy for autoimmune diseases and immune-mediated inflammatory diseases (IMIDs) using small molecules or therapeutic proteins.
Tzeng T.-F.,Tajen University |
Liou S.-S.,Tajen University |
Chang C.J.,Tajen University |
Liu I.-M.,Tajen University
Nutrition and Metabolism | Year: 2013
Background: Zerumbone is one of the pungent constituents of Zingiber zerumbet (L) Smith (Zingiberaceae family). The aim of the present study was to examine the effects of zerumbone in rats with streptozotocin-induced diabetic nephropathy (DN). Methods. Diabetic rats were treated orally with zerumbone (20 or 40 mg/kg/day) for 8 weeks. Changes in renal function-related parameters in plasma and urine were analyzed at the end of the study. Kidneys were isolated for pathology histology, immunohistochemistry, and Western blot analyses. Results: Diabetic rats exhibited renal dysfunction, as evidenced by reduced creatinine clearance, increased blood glucose, blood urea nitrogen and proteinuria, along with marked elevation in the ratio of kidney weight to body weight, that were reversed by zerumbone. Zerumbone treatment was found to markedly improve histological architecture in the diabetic kidney. Hyperglycemia induced p38 mitogen-activated protein kinase activation, leading to increased infiltration of macrophages and increased levels of interleukin (IL)-1, IL-6 and tumor necrosis factor-α. All of the above abnormalities were reversed by zerumbone treatment, which also decreased the expression of intercellular adhesion molecule-1, monocyte chemoattractant protein-1, transforming growth factor-β1 and fibronectin in the diabetic kidneys. Conclusions: The beneficial effect of zerumbone in rats with DN is at least in part through antihyperglycemia which was accompanied by inhibition of macrophage infiltration via reducing p38 mediated inflammatory response. ©2013 Tzeng et al.;licensee BioMed Central Ltd.
Wang Z.,Tajen University
MATEC Web of Conferences | Year: 2016
Tourism industry is closely linked with the natural environment but with a highly indivisibility of symbiotic relationship. Green tourism and green tourism hotel are not only the spindle stage of development industry. The environmental protection is also an environmental conservation and sustainable development of substantive liability demonstration. The study is also belong to the substance RDF itself, so we can call "clean energy". The raw materials came from agricultural waste through proper blending ratio and control technology, after PP14 adhesive extruded through the fluidized bed pyrolysis cracking process to burn stability. The recovery can also be used as fuel volatile process of drying and gasification. However, in the actual economic cost of the test running the hotel industry can reduce the cost per MJ USD $ 0.0082, more economical than coal expenses 23.17% of the fuel. Therefore, green hotel through biomass fuels RDF as clean fuels can further reduce carbon emissions to reach the green hotel of expectations. © The Authors, published by EDP Sciences, 2016.
Chakraborty C.,Iilm Academy Of Higher Learning Greater Noida |
Agoramoorthy G.,Tajen University
Biotechnology Advances | Year: 2010
India's biotechnology industry has been growing towards new heights in conjunction with the recent economic outburst. The country has the potential to revolutionize biopharmaceutical and healthcare sectors. In this review, we have highlighted the achievements of India's biotechnology industry, especially biopharmaceutical and healthcare sectors that include therapeutics, diagnostics, stem cell research, human healthcare related bioinformatics and animal health care. We have also described regulatory mechanisms involved in India's health care biotech including manpower development. © 2009 Elsevier Inc. All rights reserved.
Chinnasamy P.,International Water Management Institute |
Agoramoorthy G.,Tajen University
Water Resources Management | Year: 2015
Groundwater irrigation is the most predominant method used across India. The south Indian state of Tamil Nadu is one of the largest producers of agricultural products, and is largely dependent on groundwater for irrigation. The impact of increased irrigation due to intensification of agricultural activities on groundwater levels has not been well researched, both spatially and temporally. Hence this study has used remote sensing data from NASA’s Gravity Recovery and Climate Experiment and the Global Land Data Assimilation Systems to assess the total change in groundwater storage across the state of Tamil Nadu over a period of 11 years, from 2002 to 2012. The results show groundwater depletion at the rate of 21.4 km3 yr−1, which is 8% more than the annual recharge rate (19.81 km3 yr−1) owing to the total rainfall of 1016 mm yr1. Maximum depletion was observed in 2008, while the least depletion was observed in 2002 with rates of 41.15 and 0.32 cm yr−1, respectively. Districts such as Dharmapuri, Vellore and Thiruvannamali encountered intense groundwater depletion. Observed spatiotemporal groundwater storage will benefit India’s water resource managers and policymakers for the future management of groundwater resources to enhance food and water security. © 2015, Springer Science+Business Media Dordrecht.
Chakraborty C.,Vellore Institute of Technology |
Agoramoorthy G.,Tajen University |
Hsu M.J.,National Sun Yat - sen University
PLoS ONE | Year: 2011
Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algorithm analysis and mathematical models. © 2011 Chakraborty et al.