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Taizhou, China

Liu C.,Taizhou Medical College
Journal of Biomedicine and Biotechnology | Year: 2011

Cancer diagnosis is important, and the early diagnosis of cancers could predict a more successful treatment. The proteomic studies emerged to be useful in combined analyses of samples from patients and provide more accurate diagnosis when compared to the single-factor-based diagnosis. In recent years, cancer detection with surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS) is flourishing and brought significant progress in this area. This paper summarizes some recent results with this technique for cancer diagnosis. Copyright © 2011 Chibo Liu.

Xia X.-W.,Taizhou Medical College | Shen J.-M.,Taizhou Medical College
Chinese Journal of Cancer Prevention and Treatment | Year: 2010

OBJECTIVE: To sum up the domestic and abroad articles related to function magnetic resonance imaging of prostate cancer. METHODS: By PubMed and CNKI retrieval systems, the literature was searched from 1997-01 to 2010-02 with "prostate cancer, magnetic resonance imaging (MR), diffusion-weighted imaging (DWI), dynamic contrast-enhanced MR, magnetic resonance spectroscopy (MRS)" as the key words. The selection standards: 1) Histologic background of prostate cancer. 2) The development of diffusion-weighted imaging in prostate cancer. 3) The development of dynamic contrast-enhanced MR in prostate cancer. 4)The development of MRS in prostate cancer. According to the above standards, 28 papers were finally analyzed. RESULTS: Various functional magnetic resonance (MR) imaging techniques are used for evaluating prostate cancer including diffusion-weighted imaging, dynamic contrast-enhanced MR imaging, and MR spectroscopy. These techniques provide unique information that is helpful to differentiate prostate cancer from non-cancerous tissue and have been proven to improve the diagnostic performance of MR not only for cancer detection, but also for staging, post-treatment monitoring, and guiding prostate biopsies. This article will review the basic principles and clinical significance of functional MR imaging for evaluating prostate cancer. However, each functional MR imaging technique also has inherent challenges. CONCLUSIONS: It is important to study the application of the functional magnetic resonance imaging in prostate cancer. It can increase the accurate detection of prostate cancer.

Zhou K.,Taizhou Medical College | Jin H.,Taizhou Medical College | Luo Y.,Taizhou Medical College
International Journal of Surgical Pathology | Year: 2013

This study used immunohistochemical methods for detecting the expression of E-cadherin and β-catenin in pituitary adenoma. Specimens were collected from 91 cases. EnVision was used for immunohistochemical staining. The results were graded depending on the staining intensity and range. Associations between E-cadherin and β-catenin expression and tumor subtype, invasiveness, and postoperative recurrence were investigated. There was a significant downregulation of E-cadherin and β-catenin in growth hormone (GH)-type tumors when compared with prolactin-type tumors (uc = 2.693 and 2.109, respectively; P <.05). E-cadherin and β-catenin were downregulated in invasive pituitary adenomas (uc = 3.563 and 4.166, respectively; P <.05) and in clinically recurring pituitary adenomas (uc = 2.871 and 3.866, respectively; P <.05). There was no difference in the percentage of invasive prolactin and GH secreting tumors (28.57% and 22.86%, respectively; P >.05). The expression of E-cadherin and β-catenin in pituitary adenoma was significantly downregulated and related to subtype, invasiveness, and postoperative recurrence. © The Author(s) 2013.

Zhou K.Y.,Taizhou Medical College | Jin H.H.,Taizhou Medical College | Liu C.B.,Taizhou Medical College
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology | Year: 2013

Application of matrix assisted laser desorption ionization time of flight mass spectrometry enhancement (MALDI-TOF-MS) combined with WCX nanometer magnetic bead technique, screening of the serum biomarkers in pituitary adenoma, to establish a serum protein fingerprint classification decision tree. Analyse the serum samples of 40 cases of pituitary adenoma and 60 cases of healthy adult and find the different protein peaks, then to establish the diagnosis model and the classification decision tree of pituitary adenomas. A total of 42 differences in protein peaks were identified in the experimental and control group (P < 0.01). The diagnosis model of pituitary adenomas was established by three protein peaks (3382.0, 4601.9, 9191.2). The model could screen the pituitary adenoma out of the normal population. The sensitivity was 90.00% and the specificity was 88.30%. By the double blind experimental validation, the model could diagnose the pituitary adenoma and the sensitivity was 88%, the specificity was 83.30%. Significantly different protein peaks can be screened out between pituitary adenoma cases and healthy controls using MALDI-TOF-MS combined with WCX technique, and these protein peaks may be used as a pituitary adenoma detection, follow-up indicator.

Zhou K.,Taizhou Medical College | Jin H.,Taizhou Medical College | Zhou T.,Taizhou Medical College | Luo Y.,Taizhou Medical College
Medical Oncology | Year: 2013

The aim of this study is to investigate BAG-1 expression in human meningiomas and to assess its association with pathological and clinical characteristics. BAG-1 expression was analyzed in 158 specimens of meningiomas using immunohistochemical staining, and the results were graded according to the positivity ratio and the staining intensity. We examined the correlations between BAG-1 expression and the 2007 WHO pathological classification, peritumoral edema and postoperative recurrence. There were no significant differences in BAG-1 expression among meningioma subtypes within the same histopathologic grade, as well as between grades II and III. BAG-1 expression in grade I was much higher than in grade II (P < 0.05) or III (P < 0.01). BAG-1 expression was gradually decreased with increasing WHO pathologic classification (χ 2 = 141.49, P < 0.01), as well as with the increase in peritumoral edema (χ 2 = 43.93, P < 0.01) and postoperative recurrence (χ 2 = 55.13, P < 0.01). BAG-1 expression in meningioma depends upon WHO pathologic classification and is decreased in higher tumor classification. It is associated with heavier peritumoral edema and more postoperative recurrences. © 2013 Springer Science+Business Media New York.

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