Fang B.,General Hospital of Taiyuan Iron and Steel Group Co. |
Wu Z.-F.,Shanxi Medical University
Chinese Journal of Medical Imaging Technology | Year: 2011
Objective: To analyze the changes in apical segmental bronchus thickness of the right upper lobe in patients with different grades of chronic obstructive pulmonary disease (COPD), and to assess the relationship between airway wall thickness and lung function test (PFT). Methods: Both 64-slice spiral CT scans and PFT were performed on 60 patients with COPD in stage 1-4 (COPD group) and 15 normal healthy adults (control group). On the perpendicular airway images of apical segmental bronchus of the right upper lobe, airway wall thickness was measured, then the airway wall thickness to airway diameter ratio (TDR) and the percentage of airway area to total airway cross sectional area (WA%) were calculated. Changes were analyzed between every index. Relationship between the measurements and PFT was observed. Results: TDR and WA% of COPD group were significantly higher than those of healthy subjects group (all P<0.05), and went worse gradually following the grading of COPD. TDR and WA% negatively correlated with ratio of measurement to prediction of forced expiratory volume at the first second (FEV1% [r=-0.86, -0.86]), forced expiratory flow during middle half of FVC (FEF25%-75% [r=-0.89, -0.88]), ratio of the first second forced vital capality (FEV1/FVC% [r=-0.90, -0.87]) and diffusing capacity of the lung for carbon monoxide (DL CO [r=-0.74, -0.75]), positively correlated with ratio of residual volume to total lung capacity (RV/TLC[r=0.77, 0.76, all P<0.05]). Conclusion: There are marked correlation in both TDR and WA% on apical segmental bronchus of the right upper lobe and the parameters of PFT in patients with different grades of COPD. The measurement and calculation of airway wall thickness is helpful to the accurate and direct evaluation on the reconstruction of airway, as well as the relationship between airway dimension and airflow limitation.