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Shang J.-W.,Chinese Peoples Liberation Army | Shang J.-W.,Taiyuan City Center Hospital | Ma X.,Chinese Peoples Liberation Army | Zhang X.,Chinese Peoples Liberation Army | And 2 more authors.
Chinese Medical Journal | Year: 2013

Background Partial nephrectomy is currently the standard treatment for clinical T1 renal neoplasms, as it can provide oncologic outcomes equivalent to radical nephrectomy. The aim was to evaluate the efficacy of self-retaining suture (SRS) in renorrhaphy technique in retroperitoneal laparoscopic partial nephrectomy (LPN) for a single renal mass of moderate or high complexity by assessing peri-operative outcomes. Methods A retrospective analysis was done of 64 patients between 2010 and 2012 for complex renal mass (RENAL score ≥7) in whom retroperitoneal LPN was performed with two layers using continuous knotless barbed suture (Quill PDO SRS group; n=34) and absorbable vicryl (non-SRS group; n=30), respectively. Cases were matched for RENAL score. All the surgical procedures were performed by the same surgeon with experience of more than 500 cases of LPN. Comparisons were made in patients and preoperative outcomes and peri-operative complications between SRS group and non-SRS group. Results Mean warm ischemia time (WIT) in SRS group was less than non-SRS group (18.0 vs. 24.8 minutes, P=0.021). Renorrhaphy suture cost in SRS group was lower than non-SRS group ($269.6 vs. $335.8, P=0.001). There were no significant differences between the two groups for postoperative changes in creatinine and estimated glomerular filtration rate and the rate of peri-operative complications. Conclusion SRS was safe for complex renal tumor with two layers, continuous and unknot suture, during LPN and would reduce the WIT and renorrhaphy suture cost significantly. Source

Liu J.,Taiyuan City Center Hospital | Zhang B.,Taiyuan City Center Hospital
Nano Biomedicine and Engineering | Year: 2010

The Electrochemical behaviors of Daunorubicin hydrochloride, and the interactions between Daunorubicin hydrochloride and BSA, were studied in this paper, with Linear sweep voltammetry and Cyclic voltammety methods. The results showed that, there was a reductive peak at E=-0.66V in the Linear sweep voltammetry of Daunorubicin hydrochloride, on condition of 0.1 mol·L -1Na 2SO 4, pH 8.5B-R buffer solution. After BSA was introduced, the system peak current reduced. There was a maximal system peak current Δip", when the concentration of Daunorubicin hydrochloride was 5.0×10 -5 molL -1. At the range of 5.0×10 -8 molL-1 -1.0×10 -1 molL -1 of the concentration of BSA, it existed a good linear relation between the reduced valve of the peak current of Daunorubicin hydrochloride and the concentration of BSA. This method can be used in the detection of the concentration of BSA. © 2010 J. Liu et al. Source

Hao H.-H.,Shanxi Medical University | Wang L.,Shanxi Medical University | Guo Z.-J.,Taiyuan City Center Hospital | Bai L.,Taiyuan City Center Hospital | And 6 more authors.
Neuroscience Bulletin | Year: 2013

Secondary damage is a critical determinant of the functional outcome in patients with spinal cord injury (SCI), and involves multiple mechanisms of which the most important is the loss of nerve cells mediated by multiple factors. Autophagy can result in cell death, and plays a key role in the development of SCI. It has been recognized that valproic acid (VPA) is neuroprotective in certain experimental animal models, however, the levels of autophagic changes in the process of neuroprotection by VPA treatment following SCI are still unknown. In the present study, we determined the extent of autophagy after VPA treatment in a rat model of SCI. We found that both the mRNA and protein levels of Beclin-1 and LC3 were significantly increased at 1, 2, and 6 h after SCI and peaked at 2 h; however, Western blot showed that autophagy was markedly decreased by VPA treatment at 2 h post-injury. Besides, post-SCI treatment with VPA improved the Basso-Beattie-Bresnahan scale, increased the number of ventral horn motoneurons, and reduced myelin sheath damage compared with vehicle-treated animals at 42 days after SCI. Together, our results demonstrated the characteristics of autophagy expression following SCI, and found that VPA reduced autophagy and enhanced motor function. © 2013 Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg. Source

Ren L.-T.,Taiyuan City Center Hospital | Wei C.-G.,Shanxi Medical University | Niu J.-P.,Taiyuan City Center Hospital | Lin S.-Z.,Taiyuan City Center Hospital
Chinese Journal of Tissue Engineering Research | Year: 2013

Background: The distortion capability of cells can reflect the changes of cell structure and function. To date, the studies on the cell mechanics of nucleus pulposus are rare. Objective: To analyze the distortion capability of normal and degenerative nucleus pulposus in vitro. Methods: The normal and degenerative nucleus pulposus cells were respectively obtained from discarded nucleus pulposus tissue of 3 scoliosis patients and 3 intervertebral disc hernitaion patients. Pancreatin and collagenase type II were used to isolate the nucleus pulposus tissue and performed with primary culture. The micropipette aspiration test was used to measure the length of nucleus pulposus cells aspirated into micropipette at 4 seconds under suitable negative pressure, and the statistical analysis was performed. Results and Conclusion: The negative pressure of the normal and degenerative nucleus pulposus cells were (411.31±27.93) Pa and (434.24±46.26) Pa respectively, and the difference was significant (P < 0.05). Within 4 seconds, the lengths of the normal and degenerative nucleus pulposus cells aspirated into micropipette were (2.20±0.92) μm and (2.48±0.71) μm, their differences were not significant (P > 0.05). With the certain time and the same length of the normal and degenerative nucleus pulposus cells aspirated into micropipette, the degenerative nucleus pulposus cells needed greater negative pressure than normal nucleus pulposus cells. It indicates that the distortion capability of degenerative nucleus pulposus cells is worse than that of normal nucleus pulposus cells. Source

Chen C.,Taiyuan City Center Hospital | Zhang J.,Taiyuan City Center Hospital | Wang H.,Taiyuan City Center Hospital | Wang X.,Armed Police Hospital of Shanxi Province | And 2 more authors.
Journal of the National Medical Association | Year: 2012

Background: Recurrent stroke is one of severe outcomes of transient ischemic attack (TIA) and minor ischemic stroke (MIS), which are collectively termed as nondisabling stroke. However, the association between multiple risk factors and nondisabling stroke has not been fully studied. Here, we aimed to identify predicative risk factors in TIA and MIS in order to prevent recurrent nondisabling stroke. Methods: We used logistic regression methods to analysis risk factors in 620 patients with TIA or MIS between August 2006 and January 2009 and followed up to 90 days. We selected 20 factors, including age, gender, body mass index (BMI), smoking and alcohol history, blood pressure, limb weakness, speech impairment, diabetes, ischemic brain lesions, previous history of stroke (>24 hours), coronary atherosclerotic heart disease, cardiac function insufficiency, duration of symptoms of at least 1 hour, blood lipids, lysophosphatidic acid, C-reactive protein, atrial fibrillation, and carotid artery plaque in ultrasound examination. Results: We found that limb weakness, history of cerebrovascular events, and carotid artery plaque in ultrasound examination were risk factors of recurrent stroke within 14 days, whereas the factors for the recurrence within 90 days were duration of symptoms of at least 1 hour, speech impairment, limb weakness, BMI of at least 25 kg/m2, history of cerebrovascular events, and carotid artery plaque in ultrasound examination. Conclusion: Six risk factors are associated with recurrent nondisabling stroke, including symptom duration of at least 1 hour, speech impairment, limb weakness, BMI of at least 25 kg/m2, history of cerebrovascular events, and carotid artery plaque in ultrasound examination. Thus, identification and prevention of these risk factors may reduce recurrent stroke. Source

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