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Patent
Taiwan Biomaterial Co. | Date: 2014-10-02

A syringe includes a sleeve and a pressure vessel with high pressure fluid therein. The sleeve further comprises a sleeve piston. As the high pressure vessel contacts the sleeve piston, and a bump on the sleeve piston destroys the airtight status of the high pressure vessel. While the seal of the high pressure vessel is removed, the compressed fluid flows into the sleeve through the opening of the high pressure vessel and the hole of the sleeve piston. When the closed end of the sleeve moves closer to the closed end of the sleeve piston, the fluid in the sleeve is pressed and flows out of the sleeve through the sleeve hole of the sleeve.


Patent
TAIWAN BIOMATERIAL Co. | Date: 2015-03-09

Embodiments of the disclosure may include a pressure sensitive hydrogel composition. The composition may include a liquid solvent, a polymer, and an acid gas. The composition may be capable of having a fluid phase in which the acid gas is dissolved in the solvent and the polymer is dissolved in the solvent, and the composition may be capable of having a gel phase in which the acid gas is not dissolved in the liquid solvent and the polymer is precipitated out of the solvent. The composition may also include a chemical compound or a pharmaceutical agent that can be released after the composition is delivered to a target tissue region.


Liao C.-J.,Taiwan Biomaterial Company Ltd | Wang W.-H.,Taiwan Biomaterial Company Ltd | Liang H.-C.,Taiwan Biomaterial Company Ltd | Su Y.-C.,Taiwan Biomaterial Company Ltd | And 7 more authors.
Biomedical Engineering - Applications, Basis and Communications | Year: 2014

This study developed an innovative foamy collagen dural substitute. The foamy collagen was prepared by mixing collagen hydrogel and high-pressure oxygen in a stainless steel bottle as a container. A foamy collagen with 101 ± 43 μm in pore size and 50.5 ± 5.1% in porosity formed after release from the container. In the results of the in vitro degradation experiment, foamy collagen degraded slower than the commercially available DuraGen treated with 5 units/mL of collagenase solution. DuraGen degraded completely within three hours and foamy collagen had 39.2% (mean) of its original mass remaining 24 h after immersing in collagenase solution. The oxygen bubble structure was immobilized by the collagen fibrillogenesis and remained intact 3 and 7 days after subcutaneous implantation of the foamy collagen in rats, without any escape or merge of the oxygen bubbles. Fibrous tissue proliferated along the porous structure from the edge of the foamy collagen according to the histology analysis of subcutaneous implantation experiment in rats. The results of in vivo rabbit duraplasty experiment showed that the regenerated dura in foamy collagen group was thicker than that in DuraGen group, and was comparable to the native dura mater, without causing any adverse effects, such as intracranial pressure increase or cerebrospinal fluid leakage. © 2014 National Taiwan University. Source


Liao C.-J.,Taiwan Biomaterial Company Ltd | Wang W.-H.,Taiwan Biomaterial Company Ltd | Liang H.-C.,Taiwan Biomaterial Company Ltd | Su Y.-C.,Taiwan Biomaterial Company Ltd | And 6 more authors.
Biomedical Engineering - Applications, Basis and Communications | Year: 2014

This study developed an innovative foamy collagen dural substitute. The foamy collagen was prepared by mixing collagen hydrogel and high-pressure oxygen in a stainless steel bottle as a container. A foamy collagen with 101±43 μm in pore size and 50.5±5.1% in porosity formed after release from the container. In the results of the in vitro degradation experiment, foamy collagen degraded slower than the commercially available DuraGen treated with 5 units/mL of collagenase solution. DuraGen degraded completely within three hours and foamy collagen had 39.2% (mean) of its original mass remaining 24 h after immersing in collagenase solution. The oxygen bubble structure was immobilized by the collagen fibrillogenesis and remained intact 3 and 7 days after subcutaneous implantation of the foamy collagen in rats, without any escape or merge of the oxygen bubbles. Fibrous tissue proliferated along the porous structure from the edge of the foamy collagen according to the histology analysis of subcutaneous implantation experiment in rats. The results of in vivo rabbit duraplasty experiment showed that the regenerated dura in foamy collagen group was thicker than that in DuraGen group, and was comparable to the native dura mater, without causing any adverse effects, such as intracranial pressure increase or cerebrospinal fluid leakage. © 2014 National Taiwan University. Source

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