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Hou H.,Taishan Medical University | Wang C.,Taishan Medical University | Sun F.,Taishan Hospital | Zhao L.,Taishan Medical University | And 2 more authors.
Inflammation Research | Year: 2015

Background: Interleukin-6 (IL-6) is an important mediator of atherosclerotic disease and is also associated with coronary artery disease (CAD). The growing evidences suggest that polymorphisms in the IL-6 promoter region influence the progression of CAD. This study was performed to update the systematic results of association of IL-6 gene polymorphisms with CAD. Methods: PubMed, Embase, and China Biology Medicine were searched systematically for English and Chinese articles published up to October 31, 2014. Data were extracted using standardized forms. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. Subgroup analyses were made on ethnicity. Results: A total of 42 studies including 15,145 cases and 21,496 controls were combined in this meta-analysis. IL-6 gene −174G/C polymorphism was associated with an increased risk of CAD (for C allele versus G allele: OR = 1.11, 95 % CI 1.02–1.20; for C/C versus G/G: OR = 1.21, 95 % CI 1.03–1.42; for C/C + C/G versus G/G: OR = 1.14, 95 % CI 1.03–1.27). In the subgroup analyses based on ethnicity, a significant association was found between −174 G/C polymorphism and CAD in Caucasians (for C allele versus G allele: OR = 1.12, 95 % CI 1.03–1.22; for C/C versus G/G: OR = 1.21, 95 % CI 1.02–1.42; for C/C + C/G versus G/G: OR = 1.16, 95 % CI 1.05–1.29). In order to reduce heterogeneity, we removed the outlier studies by a Galbraith plot analysis. As a result, the pooled ORs demonstrated no association of −174G/C polymorphism and CAD (C allele versus G allele: OR = 1.02, 95 % CI 0.97–1.06, p = 0.48; C/C versus G/G: OR = 0.1.03, 95 % CI 0.94–1.13, p = 0.48; C/G + C/C versus G/G: OR = 1.03, 95 % CI 0.96–1.09, p = 0.41; C/C versus C/G + G/G: OR = 1.02, 95 % CI 0.94–1.10, p = 0.70, respectively). The polymorphism of −572 G/C was not associated with CAD significantly (for C allele versus G allele: OR = 0.86, 95 % CI 0.74–1.01; C/C versus G/G: OR = 0.99, 95 % CI 0.43–2.27; C/G + C/C versus G/G: OR = 0.96, 95 % CI 0.80–1.15, respectively). In addition, subgroup analyses showed an association between −572 G/C polymorphism and CAD risk among Chinese (C allele versus G allele: OR = 0.64, 95 % CI 0.48–0.85; C/C versus G/G: OR = 0.38, 95 % CI 0.18–0.81; C/G + C/C versus G/G: OR = 0.47, 95 % CI 0.22–1.00; C/C versus C/G + G/G: OR = 0.58, 95 % CI 0.42–0.81). Conclusion: The C allele of −174G/C polymorphism may associate with increased sensibility to CAD among Caucasians in overall analysis. Nevertheless, the effect is interfered by heterogeneity across the included studies. The C allele of −572G/C polymorphism may decrease the risk of CAD in Chinese. © 2015, Springer Basel. Source


Qu B.,Taishan Hospital | Qu T.,Guangdong Medical College
Cardiovascular Ultrasound | Year: 2015

Atherosclerosis causes significant morbidity and mortality. Carotid intima-media thickness (CIMT) predicts future cardiovascular and ischaemic stroke incidence. CIMT, a measure of atherosclerotic disease, can be reliably determined in vivo by carotid ultrasound. In this review, we determined that CIMT is associated with traditional cardiovascular risk factors such as age, sex, race, smoking, alcohol consumption, habitual endurance exercise, blood pressure, dyslipidemia, dietary patterns, risk-lowering drug therapy, glycemia, hyperuricemia, obesity-related anthropometric parameters, obesity and obesity-related diseases. We also found that CIMT is associated with novel risk factors, including heredity, certain genotypic indices, anthropometric cardiovascular parameters, rheumatoid arthritis, immunological diseases, inflammatory cytokines, lipid peroxidation, anthropometric hemocyte parameters, infectious diseases, vitamin D, matrix metalloproteinases, and other novel factors and diseases. However, the conclusions are inconsonant; the underlying causes of these associations remain to be further explored. © 2015 Qu and Qu. Source


Qu B.-G.,Taishan Hospital | Bi W.,Surgery of Gastroenterology | Jia Y.-G.,Taishan Hospital | Jia Y.-G.,Taishan College | And 12 more authors.
Cell Stress and Chaperones | Year: 2016

The association between alcoholic liver disease (ALD) and the inflammatory response remains controversial. The aim of this study was to explore this association between ALD and inflammation. We enrolled 214 male participants, who were divided into three age-matched groups: ALD (n = 135), chronic alcohol ingestion without ALD (non-ALD; n = 42), and control (n = 37). The BMI was significantly higher in the ALD group than in the non-ALD and control groups (all P = 0.000). Further, the constituent ratio of the liver inflammatory level was significantly higher in the ALD group than in the non-ALD and control groups (P = 0.002 and P = 0.000, respectively). In addition, the median serum ALT, AST, and GGT levels were significantly higher in the ALD group than in the control group (P = 0.023, P = 0.008, and P = 0.000, respectively); these levels were also significantly higher in the ALD group than in the non-ALD group (P = 0.013, P = 0.010, and P = 0.000, respectively). The median serum CRP level was significantly higher in the ALD group than in the non-ALD and control groups (P = 0.006 and P = 0.000, respectively). Further, the median serum TNF-α level was significantly lower in the ALD group than in the non-ALD and control groups (P = 0.004 and P = 0.000, respectively). The median serum sOX40L and HSP70 levels were significantly lower in the ALD group than in the control group (P = 0.008 and P = 0.018, respectively). In addition, the ALT, AST, and GGT levels were positively correlated with the CRP level (r = 0.211, P = 0.002; r = 0.220, P = 0.001 and r = 0.295, P = 0.000, respectively), and the GGT level was negatively correlated with the TNF-α (r = −0.225, P = 0.001), sOX40L (r = −0.165, P = 0.016), and HSP70 levels (r = −0.178, P = 0.009). Further, the Cr level was negatively correlated with the IL-10 level (r = −0.166, P = 0.015). Logistic regression analysis verified that the BMI (OR = 1.637, 95%CI: 1.374–1.951, P = 0.000) and GGT level were significantly higher (OR = 1.039, 95%CI: 1.020–1.059, P = 0.000) and that the TNF-α (OR = 0.998, 95%CI: 0.996–1.000, P = 0.030) and HSP70 levels were significantly lower (OR = 1.017, 95%CI: 1.003–1.031, P = 0.029) in the ALD group than in the non-ALD group. Further, the moderate-to-severe ALD patients had a significantly higher serum CRP level (Or = 1.349, 95%CI: 1.066–1.702, P = 0.013) and significantly lower HSP60 (OR = 0.965, 95%CI: 0.938–0.993, P = 0.014) and HSP70 levels (OR = 0.978, 95%CI: 0.962–0.995, P = 0.010) than the mild ALD patients. These results suggest that ALD patients may present with obesity, liver damage, and an imbalanced inflammatory immune response, mainly manifesting as decreased levels of immune inflammatory cytokines. In addition, they suggest that certain liver and kidney function parameters and ALD severity are either positively or negatively correlated with certain inflammatory cytokines. Hence, ALD patients may be at increased risks of obesity- and inflammation-related diseases. Accordingly, to control the inflammatory response, preventative measures for patients with this disease should include weight control and protection of liver and kidney function. © 2016 Cell Stress Society International Source


Qu B.,Taishan Hospital | Su J.,Taishan Hospital | Wang Z.,Taishan Hospital | Wang Y.,Taishan Hospital | And 9 more authors.
PLoS ONE | Year: 2015

Different amounts of ingested alcohol can have distinct effects on the human body. However, there is limited research on chronic alcohol consumption with Helicobacter pylori infection. We sought to investigate the relationship between the cytokine profile, oxidative balance and H. pylori infection in subjects with chronic alcohol consumption. A total of 142 subjects were divided into three groups: 59 subjects with chronic alcohol ingestion and H. pylori infection (group A); 53 subjects with chronic alcohol ingestion without H. pylori infection (group B); and 30 control subjects (group C). The serum levels of CagA, interleukin (IL)-10, E-selectin, TNF-α, malondialdehyde (MDA) and superoxide dismutase (SOD) activity were measured by enzyme-linked immunosorbent assay (ELISA). We found that the ages and serum H. pylori CagA levels among the three groups, as well as both the mean drinking age and the mean daily alcohol consumption between groups A and B, were matched and comparable. Comparing the BMIs among the three groups, the BMI differences were found to be statistically significant (F=3.921, P<0.05).Compared with group C, the BMIs in groups A and B were significantly higher (P<0.001 and P<0.01, respectively); however, the BMI differences between group A and group B were not statistically significant (P>0.05). Additionally, no differences in the serum CagA levels were found in comparisons among the groups (all P>0.05). The serum IL-10 and E-selectin levels in group A were significantly lower than those in group B (serum IL-10: P<0.05; E-selectin: P<0.05). The serum IL-10 in group A was significantly higher than that in group C (P<0.01); the serum E-selectin levels in group A did not significantly differ compared with those in group C(P>0.05). Furthermore, the serum IL-10 and E-selectin levels in group B were significantly higher than those in group C (serum IL-10: P<0.001; E-selectin: P<0.05); however, the serum TNF-α levels did not differ among groups (all P>0.05). Although the serum levels of MDA and SOD in groups A and B were slightly lower than those in group C, there were no significant differences among groups (all P>0.05). In conclusion, we believe that H. pylori infection might cause a significant inhibition of certain cytokine profiles in subjects with chronic alcohol ingestion. Moreover, chronically ingested alcohol may exert an adjusted inflammatory effect, but there was no association between H. pylori infection, chronic alcohol consumption and oxidative balance. © 2015 Qu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source


Qu B.-G.,Taishan Hospital | Qu B.-G.,Taishan Medical College | Wang H.,Taishan Hospital | Wang H.,Taishan Medical College | And 16 more authors.
Medicine (United States) | Year: 2015

The relationships among inflammation, oxidative balance, and the severity of alcoholic fatty liver disease (AFLD) remain unknown. The aim of this study is to explore the relationships among tumor necrosis factor alpha (TNF-), heat shock protein 70 (HSP70), malondialdehyde (MDA), superoxide dismutase (SOD), and the severity of AFLD. From January 2012 to December 2013, 162 participants were enrolled in this study and divided into 4 groups: 44 cases of mild AFLD (group A), 55 cases of moderate-to-severe AFLD (group B), 44 cases of alcohol consumption without AFLD (groupC), and 20 cases of no alcohol consumption without AFLD (group D). A cross-sectional study was conducted by detecting the serum levels of TNF-, HSP70, MDA, and SOD by enzyme-linked immunosorbent assay. The median serum levels of TNF- and HSP70 among the 4 groups were statistically significant (P=0.000 and 0.001, respectively). The median serum levels of TNF- in groups A and B were significantly lower than in group C (P=0.002 and 0.000, respectively), and the median serum level of TNF- in group B was significantly lower than in group D (P=0.023). In addition, the median serum level of HSP70 in group B was significantly lower than in groups A and C (P=0.002 and 0.000, respectively), and the median serum level of HSP70 in group C was significantly higher than in group D (P=0.044). However, the median serum level of MDA in group B was significantly lower than only group C (P=0.008). Chronic alcohol ingestion without AFLD may result in a significant increase in the circulation of certain inflammatory markers; the severity of AFLD is associated with circulating inflammatory markers, and moderate-to-severe AFLD may result in a more significant reduction of these markers. However, moderate-to-severe AFLD may also result in a significant downregulation of oxidative stress products. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

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