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Neyagawa, Japan

Hu X.,University of Tsukuba | Cheng D.,Taisei Kogyo Co. | Wang L.,Natural Product Industry of Tsukuba Co. | Li S.,University of Tsukuba | And 4 more authors.
Pakistan journal of pharmaceutical sciences | Year: 2015

This study aimed to evaluate the anti-hyperglycemic effect of ethanol extract from Actinidia kolomikta (Maxim. etRur.) Maxim. root (AKE).An in vitro evaluation was performed by using rat intestinal α-glucosidase (maltase and sucrase), the key enzymes linked with type 2 diabetes. And an in vivo evaluation was also performed by loading maltose, sucrose, glucose to normal rats. As a result, AKE showed concentration-dependent inhibition effects on rat intestinal maltase and rat intestinal sucrase with IC(50) values of 1.83 and 1.03mg/mL, respectively. In normal rats, after loaded with maltose, sucrose and glucose, administration of AKE significantly reduced postprandial hyperglycemia, which is similar to acarbose used as an anti-diabetic drug. High contents of total phenolics (80.49 ± 0.05mg GAE/g extract) and total flavonoids (430.69 ± 0.91mg RE/g extract) were detected in AKE. In conclusion, AKE possessed anti-hyperglycemic effects and the possible mechanisms were associated with its inhibition on α-glucosidase and the improvement on insulin release and/or insulin sensitivity as well. The anti-hyperglycemic activity possessed by AKE maybe attributable to its high contents of phenolic and flavonoid compounds.

Tange M.,Taisei Kogyo Co. | Manonukul A.,National Metal and Materials Technology Center | Srikudvien P.,National Metal and Materials Technology Center
Materials Science and Engineering A | Year: 2015

Several organic components are involved in the fabrication of titanium foam using the replica impregnation method, for example polyurethane (PU) foam is used as sacrificial template and PVA as a thickening agent in titanium slurry. Such organic ingredients if not properly selected and subsequently efficiently removed during debinding can be detrimental to the mechanical properties of the titanium foam produced. In this study, polyester- and polyether-based PU foams, as well as degraded polyester-based PU foam, have been used to study the effects of template material on titanium foam quality. In addition, the effects of three different weight percentages of PVA in slurry formulation on coating uniformity have been investigated. The results showed that new (non-degraded) polyester-based PU foam is suitable as the template material for titanium foam production providing foam with a low level of contamination and acceptable compressibility behaviour. Although increasing PVA content increased the viscosity of titanium slurry and improved the coating coverage ability of slurry on the PU foam template, too high PVA content tended to cause pore blockage. The optimum PVA content was found to be 1.5. wt%. © 2015 Elsevier B.V.

Manonukul A.,National Metal and Materials Technology Center | Srikudvien P.,National Metal and Materials Technology Center | Tange M.,Taisei Kogyo Co.
Materials Science and Engineering A | Year: 2016

The most common sacrificial material for producing metal foam using the replica impregnation method is polyurethane foam (PU) since it is readily available with different cell sizes. This work studied the microstructure and mechanical properties of commercially pure titanium with varied cell sizes. Titanium foams were fabricated using PU foam with four different cell sizes as templates. The results show that as the number of pores per inch (ppi) increased, the apparent density increased, i.e. the cell size decreased, the porosity decreased and the load bearing capacity increased nonlinearly. This work agreed with the scaling law of Gibson and Ashby for determination of the limit stress. However, the Gibson and Ashby model significantly over-predicted the value for quasi-elastic modulus. © 2015 Elsevier B.V.

Hu X.,University of Tsukuba | Cheng D.,Taisei Kogyo Co. | Zhang Z.,University of Tsukuba
Pharmaceutical Biology | Year: 2016

Context The root of Helicteres angustifolia L. (Sterculiaceae) has been used as folk herbal drug to treat cancer, bacterial infections, inflammatory, and flu in China. However, there is no report on its antidiabetic activity. Objective This study evaluates the antidiabetic activity of ethanol extract from H. angustifolia root. Materials and methods The promoting effect of H. angustifolia root ethanol extract (25, 50, and 100 μg/mL) on glucose uptake was evaluated using HepG2 cell, differentiated C2C12 myotubes, and differentiated 3T3-L1 adipocytes. The antidiabetic activity of the extract was assessed in vivo using STZ-induced diabetic rats by orally administration of the extract (200 and 400 mg/kg b.w.) once per day for 28 d. Blood glucose, TG, TC, TP, HDL-C, UA, BUN, AST, ALT, insulin, and HOMA-IR were analyzed. Results The results showed that the extract increased glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes with an IC50 value of 79.95 and 135.96 μg/mL, respectively. And about 12%, 19%, and 10% (p < 0.05) in HepG2 cells when compared with the control at the concentration of 25, 50, and 100 μg/mL, respectively. After 28 days’ treatment with the extract, significant reduction was observed in blood glucose, HOMA-IR, TC, TG, UA, BUN, AST, and ALT levels, while the levels of TP and HDL cholesterol increased. Discussion and conclusion These results suggest that H. angustifolia root ethanol extract possess potent antidiabetic activity, which is the first report on antidiabetic activity of this plant. © 2016 Taylor & Francis

A thermal formation sintering compound containing a binder, a sinterable powder material and a pore formation material, for formation into a predetermined shape in a thermal formation step, removal of the binder in a degreasing step, and sintering of the powder material in a sintering step is provided. The binder contains a low-temperature draining component which melts in the thermal formation step, begins draining at a temperature lower than a draining temperature of the pore formation material, and drains at a temperature lower than a temperature at which the pore formation material drains; and a high-temperature draining component which melts in the thermal formation step, begins draining after the pore formation material begins draining, and drains at a temperature higher than does the pore formation material.

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