Lee A.Y.-L.,National Health Research Institute |
Fan C.-C.,Mackay Memorial Hospital Taipei |
Fan C.-C.,Yuanpei University |
Chen Y.-A.,Yuanpei University |
And 4 more authors.
Integrative Cancer Therapies | Year: 2015
Hypotheses. Epithelial-mesenchymal transition (EMT) and invasion play a critical role in cancer progression and metastasis. We have shown that low E-cadherin and high Twist expression are significantly correlated with prognostic survival prediction in oral squamous cell carcinoma (OSCC). This study aimed to determine the anti-invasive effect of curcumin on the expression of matrix metalloproteinases (MMPs) and of EMT regulators in OSCC. Methods. SCC-25 cells were treated with curcumin, and cell proliferation, invasion, and expression of MMPs and EMT regulators were assessed for cell viability by trypan blue exclusion, for invasion by Matrigel invasion chamber, and for EMT regulators and MMP changes in the levels of proteins by immunoblotting. Results. Our data showed that curcumin treatment not only decreased the expression of MMP-2 and MMP-9 to inhibit invasiveness in oral cancer but also modulated the expression of EMT markers, such as Snail, Twist, and E-cadherin, and induced p53 expression that is crucial to EMT repression. Conclusion. Curcumin has the potential to become an adjunctive regimen for the prevention of cancer progression and metastasis in oral cancer. © SAGE Publications.
Huang L.-C.,Mackay Memorial Hospital |
Chang J.-H.,Mackay Memorial Hospital Taipei |
Wang N.-L.,Mackay Memorial Hospital Taipei
Pediatrics and Neonatology | Year: 2012
Congenital central hypoventilation syndrome (CCHS) is a rare condition. The main characteristic is respiratory insufficiency during sleep. Patients who have CCHS need varying degrees of ventilation support during sleep, or even all day long, according to its severity. We report a term baby with repeated extubation failure, CCHS and Hirschsprung's disease diagnosed at 1 month of age. This patient was discharged at 5 months old with a home ventilator and reached normal developmental milestones. © 2012, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.