Li C.-F.,Taihe Hospital of Shiyan |
Yao Y.,Taihe Hospital of Shiyan
Chinese Journal of Tissue Engineering Research | Year: 2015
Background: Studies have shown that under certain conditions, mesenchymal stem cells can be induced to differentiate into hepatocytes and promote local angiogenesis to generate new capillary network and build rich collateral circulation for the purpose of improvement and treatment of liver cirrhosis. Objective: To review the latest advances in mesenchymal stem cell transplantation for the treatment of liver cirrhosis. Methods: PubMed, CNKI, Wanfang and VIP databases were searched using keywords of “marrow stem cells, hepatic cirrhosis” in the title and abstracts for articles addressing mesenchymal stem cell transplantation for liver cirrhosis published from January 2000 to December 2014. Finally, 53 articles were reviewed. Results And Conclusion: Mesenchymal stem cells have self-replication and multi-directional differentiation potential, and also possess paracrine and immune functions, which are ideal seed cells used for cell replacement therapy. At present, the techniques for isolation, culture, identification and in vitro amplification of mesenchymal stem cells have been quite mature, and animal studies have confirmed that umbilical cord mesenchymal stem cells is safe and effective to treat decompensated cirrhosis, which can fundamentally treat target organ damage and improve liver function, but there are still many clinical issues to be resolved.
Shi Y.,Huazhong University of Science and Technology |
Shi Y.,Shanghai Genome Pilot Institutes for Genomics and Human Health |
Shi Y.,Changning Mental Health Center |
Li L.,Guangxi Province Tumor Hospital |
And 86 more authors.
Nature Genetics | Year: 2013
To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set on the basis of principal component analysis; the follow-up stages included two independent sample sets (1,824 cases and 3,808 controls for follow-up 1 and 2,343 cases and 3,388 controls for follow-up 2). We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, Pcombined, stringently matched = 9.69 × 10-9, per-allele odds ratio (OR)stringently matched = 1.26) and 17q12 (rs8067378, Pcombined, stringently matched = 2.00 × 10-8, per-allele ORstringently matched = 1.18). We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched = 4.52 × 10-27, per-allele ORstringently matched = 0.75). Our findings provide new insights into the genetic etiology of cervical cancer. © 2013 Nature America, Inc. All rights reserved.