Tagore Medical College and Hospital

Chennai, India

Tagore Medical College and Hospital

Chennai, India

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Rajeswary H.,Dr. M.G.R. Educational and Research Institute | Samudram P.,Tagore Medical College and Hospital | Geetha A.,Bharathi Womens College
Indian Journal of Experimental Biology | Year: 2011

A comparison of analysis in evaluating the hepatoprotective action of ethanolic extract of M. azedarach (MAE) and P. longum (PLE) with their combination biherbal extract (BHE) against carbon tetrachloride (CCl 4) induced hepatic damage is reported in albino rats. There was a marked elevation of serum marker enzyme levels in CCl 4 treated rats, which were restored towards normalization in the drug (MAE and/or PLE:50 mg/kg body weight po, once daily for 14 days) treated animals. The biochemical parameters like total protein, total bilirubin, total cholesterol, triglycerides, and urea were also restored towards normal levels. The combined BHE showed more significant reduction of the enzymes than MAE or PLE against CCl 4 induced hepatotoxicity. The results strongly indicate that BHE has more potent hepatoprotective action than MAE or PLE individually against CCl 4 induced hepatic damage in rats. Among these extracts, BHE showed similar hepatoprotective action to silymarin, which was the positive control in this study.


Paul S.,Tagore Medical College and Hospital
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2015

Background: Chitosan (deacetylated chitin) and its derivatives, which are known to possess pharmaceutical and biomedical properties, have gained considerable attention in the biomedical field. The nontoxic, biocompatible, and biodegradable nature of chitosan makes it possible to use it for therapeutic purpose. It exhibits antibacterial effect on both Gram-positive and Gram-negative cell wall types of bacteria and so-called “antimicrobial polysaccharide.” Aims and Objective: To study the antibacterial activities of native chitosan and its derivatives against three Gram-negative bacteria (Escherichia coli, Klebsiella spp., and Proteus spp.). Materials and Methods: Bactericidal activity of native chitosan, chitosan hydrolysates obtained by hydrogen peroxide (H2O2) and lysozyme degradation, chitosan–zinc (Zn) complex, and glucosamine hydrochloride was tested against ATCC strains of E. coli, Klebsiella spp., and Proteus spp. and clinical isolates of E. coli, Klebsiella spp., and Proteus spp. procured from a clinical diagnostic laboratory. Statistical analysis was done using SPSS software, version 20. Results: Both chitosan and its derivatives markedly inhibited the growth of most bacteria tested; however, the effects differed with regard to the type of the bacterium. The minimum inhibitory concentration for E. coli ATCC strain was 50 µg and its bactericidal activity was dose dependent. Chitosan hydrolysates also exhibited an inhibitory effect, although differences were seen among strains. Degrades from H2O2 had higher activity than native chitosan. Lysozyme-degraded chitosan had less activity compared to hydrolysates obtained from H2O2 hydrolysis. Chitosan–Zn complex also showed wide spectrum of antimicrobial activities against all the microorganisms tested and the effects were found to increase with increasing chelate ratios. No antibacterial effect was observed in the case of monomer glucosamine hydrochloride, showing that only oligomers have bactericidal effect. Conclusion: The antibacterial potential of chitosan and its derivatives is considerable and its prospect to be developed as a chemotherapeutic agent is high. © 2015, Mrs Deepika Charan. All rights reserved.


Srinivasulu,Tagore Medical College and Hospital | Khaja S.,Mamata Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2014

Burns are one of the most devastating injury encountered in Medicine. Though common both in developed and developing countries, burns are major problem in developing country like India. No age bar to sustain injuries with burns. Many factors such as social, economical, cultural and psychological influence cause of death. A prospective study of the admitted patients, showed the most commonest substance causing burn being Kerosene. Females were affected mostly housewives(27%), while males mostly were electrocuted. Most deaths were accidental in nature(81.8%). © 2014, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.


Ashokkumar T.,Tagore Medical College and Hospital | Chacko T.V.,PSG FAIMER South Asia Regional Institute | Munuswamy S.,Indian Institute of Public Health
International Journal of Tropical Medicine | Year: 2012

In the era of population ageing, accurate assessments of need for disability assistance are essential for effective planning of support services for the elderly: to assess the physical disabilities in Activities of Daily Living (ADL) among the elderly; to identify the unmet needs in physical disabilities among them and to identify the predictors of unmet needs in physical disabilities of elderly so that they can act as surrogate markers to identify those in need of the services. A cross sectional study and 305 elderly aged 60 years and above were selected from seven villages that were planned to be covered by PSG Geriatric Day Care Centre. Of the 305 elderly studied, 53.1% were disabled and 32.8% elders have unmet needs for their disability. The predictors of unmet needs are living alone elderly, aged >70 years, single (other than married), financially fully dependent elderly, those elderly had more number (level) of disability and elderly having more morbidity. © Medwell Journals, 2012.


Srirangaramasamy J.,Tagore Medical College and Hospital | Srirangaramasamy J.,Second Street | Kathirvelu S.,Hopkins ENT
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2016

Sarcoidosis is a multi systemic granulomatous disorder involving all the organs of the body. Heerfordt’s syndrome is an acute and rare presentation of sarcoidosis. It presents with fever, uveitis and bilateral parotid swelling with unilateral or bilateral facial palsy. It is seen in 0.3 % of cases of sarcoidosis. Typical presentation of Heerfordt’s syndrome is rare. Facial palsy is seen in 25–50 % of Heerfordt’s syndrome. Bilateral facial palsy is very rare contributing to only 0.3–2 % of all cases of facial nerve palsies. The diagnosis is very difficult as the facial features are less obvious compared to unilateral palsy. In this case report, we have presented a rare case of Heerfordt’s syndrome with bilateral facial palsy which was misdiagnosed as mumps. This case highlights the importance of including Heerfordt’s syndrome in evaluating the causes of facial palsy. Bilateral facial palsy unlike unilateral is less obvious. Hence a detailed history, thorough clinical examination and relevant investigations will aid in arriving at diagnosis and better management of the patient. © 2016 Association of Otolaryngologists of India


Emprm V.,ESI Post Graduate Institute of Medical science and Research PGIMSR | Rajanandh M.G.,Sri Ramachandra University | Nageswari A.D.,Tagore Medical College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Chronic airway inflammation and remodelling are fundamental features of asthma. The molecular phenotypes in asthma are Th2 high and Th2 low. Serum periostin is a biomarker which aid in understanding Th2 high eosinophilic asthma. Aim: The present study aimed to identify whether or not serum periostin is a systemic biomarker for eosinophilic airway inflammation in asthmatics. Materials and Methods: The study was designed as a prospective, case control study. Patients who presented with consistent symptoms of asthma and confirmed by spirometry with reversibility were the cases. The controls were healthy subjects who had no history of lung disease with normal lung function. The sputum and blood samples were collected from both the groups. Sputum eosinophils, Absolute Eosinophil Counts (AEC) and serum periostin levels were compared between the groups. Results: The study comprised of 101 participants in which 30 were controls and 71 were cases. In the study group, mean post FEV1 was 64.45. There was a positive correlation of sputum eosinophils with severity of obstruction. The ROC curve analysis showed the cut-off value of 24.556 for serum periostin with the p-value of <0.001. As the severity of obstruction increased, the serum periostin levels were also found to be increased. Serum periostin had a sensitivity and specificity of 97.18% and 86.67% with a diagnostic accuracy of 94.06%. Conclusion: Serum periostin appears to be a more sensitive tool for detection of airflow limitation in asthmatic patients with a Th2 high eosinophilic phenotype when compared to AEC and sputum eosinophils. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.


Ramesh V.,Bharath University | Hari R.,Dr. M.G.R. Educational and Research Institute | Pandian S.,Tagore Medical College and Hospital | Arumugam G.,Bharathi Womens College
Journal of Complementary and Integrative Medicine | Year: 2011

The in-vitro free radical scavenging efficacy of the combined ethanolic Biherbal extract (BHE) from equal quantities of the leaves of Eclipta alba and seeds of Piper longum was investigated. This was compared with its individual preparation of ethanolic extract of Eclipta alba (EAE) and ethanolic extract of Piper longum (PLE). The 1, 1, diphenyl-2-picrylhydrazyl (DPPH), super oxide, nitric oxide, hydroxyl radical scavenging activity and reducing power from BHE, EAE, and PLE were investigated employing various established in vitro systems. Total phenolic and flavonoid content were also determined. The results revealed that BHE has notable activity in quenching of DPPH, super oxide, nitric oxide, and hydroxyl radicals when compared to its individual preparation of EAE and PLE. The BHE at 1000 μg/ml showed maximum scavenging of DPPH (88.75%) super oxide (84.78%) nitric oxide (89.02%) and hydroxyl (82.82%) against the scavenging of EAE and PLE which showed DPPH (81.77%,83.54%) super oxide (79.88 ± 1.84, 80.88 ± 1.44%) nitric-oxide (76.14 ± 1.80, 77.2 ± 1.18%) and hydroxyl (79.86%, 74.64%) radicals respectively at the same concentration. A linear correlation between BHE and reducing power was also observed. The quantitative estimation of the extract revealed the considerable amount of phenols and flavonoids. The results of this study strongly indicate that the BHE has more potent antioxidant potential action than its individual preparation EAE or PLE. © 2011 De Gruyter. All rights reserved.


Hazarika N.,Tagore Medical College and Hospital | Rajaprabha R.,Tagore Medical College and Hospital
Indian Journal of Dermatology | Year: 2016

Background and Aims: Acne vulgaris affects about 85% of adolescents, often extending into adulthood. Psychosocial impact of acne on health-related quality of life (QoL) has been identified, but it remains under-evaluated, especially in Indian patients. This study was aimed to assess the impact of acne and its sequelae on the QoL. Materials and Methods: This was a hospital-based, prospective, cross-sectional study done between June and November 2014 on 114 consenting patients above 15 years of age with acne vulgaris. Acne vulgaris and its sequelae were graded, and QoL was assessed by using Dermatology Life Quality Index (DLQI) questionnaire. Results: Most cases (64%) were between 15 and 20 years. Females (57%) outnumbered males. Facial lesions (61.4%) and grade II acne were most common. Mean DLQI score was 7.22. DLQI scores were statistically influenced by the age of the patient, duration and grade of acne, acne scar, and postacne hyperpigmentation. Conclusion: This study showed significant impairment of QoL in acne patients. Assurance and counseling along with early treatment of acne vulgaris are important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment.


Hazarika N.,Tagore Medical College and Hospital | Archana M.,Tagore Medical College and Hospital
Indian Journal of Dermatology | Year: 2016

Background: Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period. Aims: To assess the impact of acne on the various psychosocial domains of daily life. Materials and Methods: This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January to March 2015. A total of 100 consecutive, newly diagnosed patients of acne vulgaris, aged 15 years and above were included in this study. The relationship between acne vulgaris and its sequelae was analyzed with ten different domains of daily life by using dermatology life quality index (DLQI) questionnaire. Results: Females (56%), 15-20 year olds (61%), facial lesions (60%), and Grade II acne (70%) were most common. Acne scars were noted in 75% patients, whereas 79% cases had post-acne hyperpigmentation. Thirty-seven percent patients had DLQI scores of (6-10) interpreted as moderate effect on patient's life. Statistically significant correlation (P < 0.05) found were as follows: Physical symptoms with grade of acne; embarrassment with site and grade of acne; daily activities with grade of acne and post-acne pigmentation; choice of clothes with site of acne; social activities with gender, site and grade of acne; effect on work/study with grade of acne; interpersonal problems with site and post-acne pigmentation; sexual difficulties with grade of acne. Limitation: It was a hospital-based study with small sample size. Conclusion: Significant impact of acne and its sequelae was noted on emotions, daily activities, social activities, study/work, and interpersonal relationships. Assurance and counseling along with early treatment of acne vulgaris is important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment. © 2016 Indian Journal of Dermatology | Published by Wolters Kluwer - Medknow.


PubMed | Tagore Medical College and Hospital
Type: Journal Article | Journal: Indian journal of dermatology | Year: 2016

Acne vulgaris causes erythematous papulopustular lesions in active stage and often leave behind residual scarring and pigmentation. Its onset in adolescence may add to the emotional and psychological challenges experienced during this period.To assess the impact of acne on the various psychosocial domains of daily life.This was a prospective, cross-sectional study done in the dermatology out-patient department of a tertiary care hospital from January to March 2015. A total of 100 consecutive, newly diagnosed patients of acne vulgaris, aged 15 years and above were included in this study. The relationship between acne vulgaris and its sequelae was analyzed with ten different domains of daily life by using dermatology life quality index (DLQI) questionnaire.Females (56%), 15-20 year olds (61%), facial lesions (60%), and Grade II acne (70%) were most common. Acne scars were noted in 75% patients, whereas 79% cases had post-acne hyperpigmentation. Thirty-seven percent patients had DLQI scores of (6-10) interpreted as moderate effect on patients life. Statistically significant correlation (P < 0.05) found were as follows: Physical symptoms with grade of acne; embarrassment with site and grade of acne; daily activities with grade of acne and post-acne pigmentation; choice of clothes with site of acne; social activities with gender, site and grade of acne; effect on work/study with grade of acne; interpersonal problems with site and post-acne pigmentation; sexual difficulties with grade of acne.It was a hospital-based study with small sample size.Significant impact of acne and its sequelae was noted on emotions, daily activities, social activities, study/work, and interpersonal relationships. Assurance and counseling along with early treatment of acne vulgaris is important to reduce disease-related psychosocial sequelae and increase the efficacy of treatment.

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