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Veerakumar R.,Priyadarshini Dental College and Hospital | Pari M.A.,Priyadarshini Dental College and Hospital | Prabhu M.N.,Tagore Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2011

The phenomenon of tooth fusion arises through union of two normally separated tooth germs, and depending upon the stage of development of the teeth at the time of union, it may be either complete or incomplete. On some occasions, two independent pulp chambers and root canals can be seen. Fusion occurs infrequently but could cause esthetic, spacing and a periodontal problem. The purpose of this article was to present a clinical case where fusion is present. The present article highlights the presence of a primary double tooth and also the fusion of permanent successors in the maxillary anterior region. These cases necessitate careful examination and treatment planning as they may be associated with anomalies in the succeeding permanent dentition. Source

Jimson S.,Bharath University | Prakash C.,Tagore Dental College and Hospital | Balachandran C.,Madras Veterinary College | Raman M.,Madras Veterinary College
Indian Journal of Dental Research | Year: 2013

Oral myiasis is a rare disease caused by larvae of dipteran flies. Houseflies are strongly suspected of transmitting at least 65 diseases to humans, including typhoid fever, dysentery and cholera. Flies regurgitate and excrete wherever they come to rest and thereby mechanically are the root cause for disease organisms. A case of oral myiasis caused by Chrysomya bezziana in the maxillary anterior region in a 40-year-old patient is presented. Manual removal of maggots, and surgical debridement of wound was done followed by broad-spectrum anti-parasitic medications. A note on the identification of the larva and histopathology of the tissue is also highlighted here. Source

Asokan G.S.,Tagore Dental College and Hospital | Jeelani S.,Indira Gandhi Institute of Dental science | Gnanasundaram N.,Saveetha Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Purpose of the Study: The present study was conducted to evaluate epigenetic alteration of five tumour suppressor genes in the oral precancer and cancer patients.Materials and Methods: The study was carried out in three groups namely control group of five people (normal healthy individuals), 10 oral leukoplakia patients and 10 oral squamous cell carcinoma patients. Incisional biopsy was done and part of the tissue sent for histological examination and part of tissue sent for hypermethylation study of p16, p15, hMLH, MGMT, E-cadherin tumour suppressor genes. Methylation specific polymerase chain reaction was carried out for detecting methylation in promoter regions of tumour suppressor genes. The resultant PCR products were run in a 2.5% Agarose gel and the promoter hypermethylation status of the five tumour suppressor genes were analysed.Results: In oral Leukoplakia patients, 60% of methylation in the case of p16 gene, 30% of methylation in the case of MGMT gene and 60% of methylation in the case of E-cadherin gene. In oral Squamous cell carcinoma patients, 60% of methylation in the case of p16 gene, 40% of methylation in the case of MGMT, 60% of methylation in the case of E-cadherin gene, 20% in case of p15,10% in case of hMLH gene.Conclusion: Our results suggest that epigenetic mechanisms of inactivation of tumour suppressor genes, such as aberrant methylation of p16 and E-cadherin genes occur early in head and neck tumourigenesis and might play a role in the progression of these lesions. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source

Parthiban J.,Tagore Dental College and Hospital | Srinivasan I.,Mr Ambedkar Dental College And Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Over the past two decades, there has been an explosion of interest in Autism Disorder (AD). Knowledge and awareness on the condition has grown exponentially at all levels among the general public, parents, health professionals, the research community and more recently, at parliamentary level. The world has begun to recognize the scope of this problem and act internationally and locally to improve the lives of the growing number of individuals and families affected by this devastating disorder. This article reviews the dental literature since 1969 and it summarizes characteristics of patients with AD, oral health status and dental management of patients with AD. Source

Jayachandran S.,Government of Tamilnadu | Balaji N.,Tagore Dental College and Hospital
Indian Journal of Palliative Care | Year: 2012

Background: Radiation mucositis is an early effect of head and neck radiotherapy. Mucositis can cause ulcers, and patients may experience pain and dysphagia which need proper management. This study was conducted in 60 patients with oral malignancy. Aim : To evaluate the effect of natural honey and 0.15% benzydamine hydrochloride on onset and severity of radiation mucositis and to compare it with control. Materials and Methods : This study was conducted in the Department of Oral Medicine and Radiology, Tamilnadu Government Dental College and Hospital, Chennai, from April to December 2010. The sample size comprised of 60 patients, of both genders, diagnosed with oral malignancy clinically and histopathologically and planned for radiotherapy. The patients were assigned into three groups by random sampling. Each group consisted of 20 patients. Group 1 patients were instructed for topical application of natural honey, groups 2 and 3 were instructed for topical application of 0.15% benzydamine hydrochloride and 0.9% normal saline respectively. The onset of mucositis and the severity of mucositis were graded during the course of the radiotherapy and two weeks after radiotherapy, with WHO mucositis grading in all the three groups and statistically analysed with SPSS version 11 software. Results: A significant reduction in mucositis in honey-received patients compared with 0.15% benzydamine hydrochloride, 0.9% normal saline applied patients occurred. The differences between the groups were statistically significant (P < 0.001). Conclusion: Pure natural honey can be an effective agent in managing radiation induced oral mucositis. Honey could be a simple, potent and inexpensive agent, which is easily available, and it can be a better therapeutic agent in managing radiation mucositis in developing countries like India for the management of this morbidity. Source

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