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Parthiban J.,Tagore Dental college and Hospital | Srinivasan I.,Mr Ambedkar Dental College And Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Over the past two decades, there has been an explosion of interest in Autism Disorder (AD). Knowledge and awareness on the condition has grown exponentially at all levels among the general public, parents, health professionals, the research community and more recently, at parliamentary level. The world has begun to recognize the scope of this problem and act internationally and locally to improve the lives of the growing number of individuals and families affected by this devastating disorder. This article reviews the dental literature since 1969 and it summarizes characteristics of patients with AD, oral health status and dental management of patients with AD.


Jeelani S.,Indira Gandhi Institute of Dental science | Jagat Reddy R.C.,Chettinad Dental College and Research Institute | Maheswaran T.,Vivekanandha Dental College for Women | Asokan G.S.,Tagore Dental College and Hospital | Anand B.,Ragas Dental College and Hospital
Journal of Pharmacy and Bioallied Sciences | Year: 2014

Emerging as a targeted, safe, and efficient pharmacotherapy is the approach of theranostics, which focuses on patient-centered care. It is a combination of diagnosis and therapeutics. It provides a transition from conventional medicine to personalized medicine. It deals with the custom made treatment plan based on uniqueness of every individual thus resulting in right drug for the right patient at the right time. Genetics plays a significant role in theranostics. Theranostics provides a cost-effective specific successful treatment protocol. Pharmacogenetics, proteomics and biomarker profiling forms the backbone of theranostics. The role of theranostics is interestingly appreciated at multi levels with special consideration in oncology wherein nano formulations in the form of liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles, quantum dots and carbon nanotubes play a very important role. Thus, theranostics is a holistic transition from trial and error medicine to predictive, preventive and personalized medicine leading to improved quality care of pharmacotherapy.


Jimson S.,Bharath University | Prakash C.,Tagore Dental College and Hospital | Balachandran C.,Madras Veterinary College | Raman M.,Madras Veterinary College
Indian Journal of Dental Research | Year: 2013

Oral myiasis is a rare disease caused by larvae of dipteran flies. Houseflies are strongly suspected of transmitting at least 65 diseases to humans, including typhoid fever, dysentery and cholera. Flies regurgitate and excrete wherever they come to rest and thereby mechanically are the root cause for disease organisms. A case of oral myiasis caused by Chrysomya bezziana in the maxillary anterior region in a 40-year-old patient is presented. Manual removal of maggots, and surgical debridement of wound was done followed by broad-spectrum anti-parasitic medications. A note on the identification of the larva and histopathology of the tissue is also highlighted here.


Asokan G.S.,Tagore Dental College and Hospital | Jeelani S.,Indira Gandhi Institute of Dental Science | Gnanasundaram N.,Saveetha Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2014

Purpose of the Study: The present study was conducted to evaluate epigenetic alteration of five tumour suppressor genes in the oral precancer and cancer patients.Materials and Methods: The study was carried out in three groups namely control group of five people (normal healthy individuals), 10 oral leukoplakia patients and 10 oral squamous cell carcinoma patients. Incisional biopsy was done and part of the tissue sent for histological examination and part of tissue sent for hypermethylation study of p16, p15, hMLH, MGMT, E-cadherin tumour suppressor genes. Methylation specific polymerase chain reaction was carried out for detecting methylation in promoter regions of tumour suppressor genes. The resultant PCR products were run in a 2.5% Agarose gel and the promoter hypermethylation status of the five tumour suppressor genes were analysed.Results: In oral Leukoplakia patients, 60% of methylation in the case of p16 gene, 30% of methylation in the case of MGMT gene and 60% of methylation in the case of E-cadherin gene. In oral Squamous cell carcinoma patients, 60% of methylation in the case of p16 gene, 40% of methylation in the case of MGMT, 60% of methylation in the case of E-cadherin gene, 20% in case of p15,10% in case of hMLH gene.Conclusion: Our results suggest that epigenetic mechanisms of inactivation of tumour suppressor genes, such as aberrant methylation of p16 and E-cadherin genes occur early in head and neck tumourigenesis and might play a role in the progression of these lesions. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved.


Veerakumar R.,Priyadarshini Dental College and Hospital | Pari M.A.,Priyadarshini Dental College and Hospital | Prabhu M.N.,Tagore Dental College and Hospital
Journal of Clinical and Diagnostic Research | Year: 2011

The phenomenon of tooth fusion arises through union of two normally separated tooth germs, and depending upon the stage of development of the teeth at the time of union, it may be either complete or incomplete. On some occasions, two independent pulp chambers and root canals can be seen. Fusion occurs infrequently but could cause esthetic, spacing and a periodontal problem. The purpose of this article was to present a clinical case where fusion is present. The present article highlights the presence of a primary double tooth and also the fusion of permanent successors in the maxillary anterior region. These cases necessitate careful examination and treatment planning as they may be associated with anomalies in the succeeding permanent dentition.


Prabhakar J.,Tagore Dental College and Hospital | Priya M.S.,Tagore Dental College and Hospital | Jones Tarcius Doss L.,Anna University | Sukumaran V.G.,Sree Balaji Dental College and Hospital
International Journal of Morphology | Year: 2013

The aim of this study was to radiographically investigate the curve existing in slightly curved mesiobuccal canal of mandibular first molar by applying Piecewise straight line approximation. Extracted human mandibular molars were radiographed and one hundred radiographs were selected whose mesiobuccal canal showed slight curvature (10-20°) according to Schneider's method. The curves were traced and analyzed using Piecewise straight line method. Each curve was considered as a unit consisting of six different pieces of straight lines joining at seven specific points and the angle of curvature at these points was determined using the slope formula. All curves analyzed in this study had varying degrees of curvatures at different points on the curve. Maximum curvature (0.40°) was recorded at the middle third of the root canal. Within the limitation of the study, significant curvature occurs through out the curve existing in the mesiobuccal canal of mandibular first molar and the middle third of the curve showing greater degree of curvature. There is a possibility of greater curvature occurring in the coronal third of the curve. Though three dimensional studies would be more appropriate, Piecewise straight line approximation may be a better method than existing methods to simulate canal geometry.


Jayachandran S.,Government of Tamilnadu | Balaji N.,Tagore Dental College and Hospital
Indian Journal of Palliative Care | Year: 2012

Background: Radiation mucositis is an early effect of head and neck radiotherapy. Mucositis can cause ulcers, and patients may experience pain and dysphagia which need proper management. This study was conducted in 60 patients with oral malignancy. Aim : To evaluate the effect of natural honey and 0.15% benzydamine hydrochloride on onset and severity of radiation mucositis and to compare it with control. Materials and Methods : This study was conducted in the Department of Oral Medicine and Radiology, Tamilnadu Government Dental College and Hospital, Chennai, from April to December 2010. The sample size comprised of 60 patients, of both genders, diagnosed with oral malignancy clinically and histopathologically and planned for radiotherapy. The patients were assigned into three groups by random sampling. Each group consisted of 20 patients. Group 1 patients were instructed for topical application of natural honey, groups 2 and 3 were instructed for topical application of 0.15% benzydamine hydrochloride and 0.9% normal saline respectively. The onset of mucositis and the severity of mucositis were graded during the course of the radiotherapy and two weeks after radiotherapy, with WHO mucositis grading in all the three groups and statistically analysed with SPSS version 11 software. Results: A significant reduction in mucositis in honey-received patients compared with 0.15% benzydamine hydrochloride, 0.9% normal saline applied patients occurred. The differences between the groups were statistically significant (P < 0.001). Conclusion: Pure natural honey can be an effective agent in managing radiation induced oral mucositis. Honey could be a simple, potent and inexpensive agent, which is easily available, and it can be a better therapeutic agent in managing radiation mucositis in developing countries like India for the management of this morbidity.


PubMed | Tagore Dental College and Hospital, Rajas Dental College and Hospital, Madha Dental College and Hospital and Rajah Muthiah Dental College and Hospital
Type: Review | Journal: Journal of pharmacy & bioallied sciences | Year: 2016

A review in affected persons attitude in abstract care of edentulous patients has to be a priority in elderly individuals. The development of complete dentures (CDs) has been the selection of remedy retaining in mind the socioeconomic popularity, age, and nutritional elements. However, most of the patients complain of loss of retention in mandibular implant-supported overdentures (ODs), which compensated the downside of the loss of retention in complete dentures (CDs). Moreover, implant supported over dentures (ISOVDs) supplied accurate exceptional of lifestyles, esthetics, progressed nutritional deficiencies, and provided good patient satisfaction. The place of dental implants and desire of retentive attachments for implant supported mandibular over dentures (ISOVD) are selected on clinician preference and professional opinion. This text offers a fundamental statistics regarding implant placement, mode of treatment to be selected, and patient care. Two implants provide extraordinary long-term achievement and survival with improved oral capabilities. Single midline implant OD is costly, powerful, and may be a promising alternative. In maxilla, 4-6 implants splinted with bar have located to give true results.


PubMed | Tagore Dental College and Hospital, Dr Sudha And Nageswara Rao Siddartha Institute Of Dental Science and Rajas Dental College and Hospital
Type: Journal Article | Journal: Journal of pharmacy & bioallied sciences | Year: 2015

Since the introduction of lasers in dentistry in the mid-1990s, research in laser supported dental therapies is progressing at a rapid pace. Orthodontics is no exception. In orthodontics, lasers have many diagnostic, therapeutic, and biomodulating applications. To update the various applications of lasers in orthodontics. Lasers work by delivering energy in the form of light. Laser, striking the biological tissues can either get reflected, absorbed or scattered depending on several factors. Depending on the fate of the emitted laser, it can be applied for different diagnostic, therapeutic and surgical procedures. The knowledge and understanding of different types of lasers and its specific applications is a prerequisite before it can be applied beneficially. In Orthodontics, the versatility of laser has expanded into bonding, curing, debonding, imaging, growth modification, pain reduction, etc. Definitely laser has extended its tentacles from diagnosis to treatment in orthodontics.


PubMed | Tagore Dental College and Hospital, Thai Moogambigai Dental College and Hospital and Prince Abdulaziz Bin Musaad Hospital
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016

The occlusal surfaces of the teeth usually have pits and fissures which provide a good environment for demineralization with minimal salivary access and make them caries prone. The success of pit and fissure sealing materials is highly dependent on the marginal sealing ability of the fissures.The present study was carried out to evaluate and compare the marginal sealing ability of two commercially available pit and fissure sealants.A total of 50 human premolar teeth were used in this invitro study. Group 1 included 25 teeth for application of Clinpro sealant and Group 2 included twenty 25 for application of Helioseal F sealant. Samples were stored in artificial saliva for 72 hours before thermocycling. The samples were immersed in 2% methylene blue solution for 24 hours. The sectioned samples were examined under an Optical Stereomicroscope and compared in terms of the extent of microleakage based on the amount of dye penetration between the sealant and tooth substance interface. The dye penetration scores in both the groups was statistically analysed using Chi square test and Mann Whitney Test. A p-value of less than 0.05 was considered to be statistically significant.It was seen that in Group 1, 12 samples (48%) had no dye penetration (Grade 0) while in Group 2, 6 samples (24%) demonstrated Grade 0 penetration. Group 2 had the most extensive dye penetration (Grade 3) in 8 of 25 samples (32%) (p=0.014).On comparison of the microleakage scores of the groups, a statistically significant difference was found between the two groups; indicating a much better performance of Clinpro as compared to Helioseal F.

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