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Sreenivasa S.,Tumkur University | Mohan N.R.,Tumkur University | Madhu Chakrapani Rao T.,Tadimety Aromatics Pvt Ltd | Suchetan P.A.,Tumkur University | And 2 more authors.
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

In the title salt, C11H17N2O2S+·CF3COO-, the cation is protonated at the secondary piperazine N atom. The dihedral angle between the benzene ring and the piperazine mean plane is 85.54 (10)°. In the crystal, cations and anions are connected by two types of strong N - H...O hydrogen bonds into chains extending along [101]. The chains are further assembled into (10-1) layers via stacking interactions between benzene rings of the cations [centroid-centroid distance = 3.7319 (13) Å] and a C - H...O interaction involving a piperazine C - H group and a sulfonyl O atom. Another C - H...O interaction between the piperazine ring and the sulfonyl group connects the ions into a three-dimensional network. Source


Suchetan P.A.,Tumkur University | Sreenivasa S.,Tumkur University | Palakshamurthy B.S.,Tumkur University | Madhu Chakrapani Rao T.,Tadimety Aromatics Pvt Ltd | Vijithkumar,Indian Institute of Science
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

The title molecule, C6H7N3O, is almost planar (r.m.s. deviation = 0.0068 Å) and adopts an E conformation about the C=N double bond. In the crystal, molecules are linked by pairs of strong N - H...N hydrogen bonds, forming inversion dimers with R 2 2(10) motifs. The dimers are further linked into C(3) chains through O - H...N hydrogen bonds. Source


Mohan N.R.,Tumkur University | Sreenivasa S.,Tumkur University | Manojkumar K.E.,Tumkur University | Rao T.M.C.,Tadimety Aromatics Pvt Ltd | Suchetan P.A.,Tumkur University
Journal of the Brazilian Chemical Society | Year: 2014

A strategic synthesis of novel methylpyrimidine sulfonyl piperazines involving Suzuki coupling was designed and pharmacological activities of the compounds were evaluated. Reactions were carried out under conventional method and show good functional group transformations and high yields. Structures of the newly synthesized compounds were established by infrared spectroscopy (IR), 1H and 13C nuclear magnetic resonance (NMR) and liquid chromatography-mass spectrometry (LC-MS) and elemental analysis. The compounds were tested for in vitro antibacterial activity against Escherichia coli and Staphylococcus aureus bacterial strains, anthelmintic activity using Pheretima posthuma and anti-inflammatory activity involving carrageenan induced rat paw edema model. Some compounds were proven to be potent pharmacophores. © 2014 Sociedade Brasileira de Química. Source


Manojkumar K.E.,Tumkur University | Sreenivasa S.,Tumkur University | Shivaraja G.,Tumkur University | Rao T.M.C.,Tadimety Aromatics Pvt Ltd
MolBank | Year: 2013

N-(2-Chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide (3) was synthesized byreacting 4,4,4-trifluorobutanoic acid (1) with 2-amino-4-chlorobenzonitrile (2) in the presence of triethylamine and propylphosphonic anhydride in ethyl acetate. Characterization of the compound was done by IR, 1H-NMR, 13C-NMR, LC-MS and CHN analysis. © 2013 by the authors; licensee MDPI, Basel, Switzerland. Source


Palakshamurthy B.S.,Tumkur University | Suchetan P.A.,Tumkur University | Sreenivasa S.,Tumkur University | Lokanath N.K.,University of Mysore | Madhu Chakrapani Rao T.,Tadimety Aromatics Pvt Ltd
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the title compound, C14H21NO, the conformation across the N - C(O) bond is syn-periplanar, the C - N - C - C torsion being -5.9(5)°. The atoms of the ethyl group attached to the N atom are disordered over two sets of sites with occupancy ratios of 0.65(2):0.35(2) (CH2) and 0.689(14):0.311(14) (CH3)are linked by very weak C - HO interactions forming C(8) chains along [001]. C - Hπ interactions link the molecules along the c-axis direction. © Palakshamurthy et al. 2014. Source

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