Tabriz University of Medical Sciences
Tabriz, Iran

Tabriz University of Medical science is public medical science university located in Tabriz, East Azarbaijan Province, Iran. It is ranked as one of Iran's top medical schools, with more than 5000 students.The University consists of seven faculties: Medicine, Pharmacy, Dentistry, Paramedical science, Health & Nutrition, Rehabilitation, and Nursing & Midwifery. The school offers professional degrees in Medicine , Dentistry , Pharmacy ; Bachelor's, Master's, and Doctor of Philosophy in various other medically related subjects. The school also offers technical courses in pursuit of Associate's degrees and certification in medically related fields.In addition, TUMS operates over 10 teaching hospitals and is a major medical care provider in East Azarbaijan Province and the surrounding provinces. Wikipedia.

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Meshkini A.,Tabriz University of Medical Sciences
Spine | Year: 2017

STUDY DESIGN.: Case report OBJECTIVE.: To report a case of foreign body mimicking spinal tumor Background: Textiloma, SUMMARY OF BACKGROUND DATA.: Gossypiboma or more broadly Retained Foreign Object (RFO) is a surgical complication resulting from foreign materials such as cotton or gauze pads, surgical sponge, accidentally left inside a patientʼs body. Such foreign materials cause foreign body reaction in the surrounding tissue. METHODS.: A retrospective case report was performed. Informed consent obtained from patient RESULTS.: We describe a case of textiloma in which the patient presented with low- back- pain and radiculopathy 12 years after L5\S1 discectomy. Imaging revealed a round mass lesion in the sacral space. CONCLUSION.: At the end of surgery, the operative site should be flushed with saline and carefully examined for any foreign materials.Level of Evidence: 4 Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

Rahimpour Y.,Tabriz University of Medical Sciences | Hamishehkar H.,Tabriz University of Medical Sciences
Expert Opinion on Drug Delivery | Year: 2012

Introduction: Cosmeceuticals are cosmetic products with biologically active ingredients purporting to have medical or drug-like benefits. Some cosmeceuticals can act effectively when reaching their target sites in the deeper layers of the skin. However, the barrier nature of skin causes significant difficulties for compounds to be delivered through. Therefore, scientists are investigating various strategies to overcome these barrier properties. Liposomes have been claimed to improve the topical delivery of compounds. Areas covered: This paper offers a brief overview of current approaches in the research and development of liposomal formulations to improve the performance of cosmeceuticals, from recent literature. This review deals with the potential of liposomes as a skin delivery system for cosmeceuticals, with a focus on the clinical application of liposomes. Expert opinion: Liposomes are well-known vesicular cosmetic delivery systems. The topical application of liposomes offers a wide range of advantages including increased moisturization, restoring action, biodegradability, biocompatibility and extended and slow dermal release. Their similar structure to biological membranes allows penetration into the epidermal barrier, compared with other delivery systems. The incorporation of cosmeceuticals using suitable delivery systems is important in the management of cosmetic disorders. © 2012 Informa UK, Ltd.

Maghsoodi M.,Tabriz University of Medical Sciences
Advanced Pharmaceutical Bulletin | Year: 2015

Crystallization is often used for manufacturing drug substances. Advances of crystallization have achieved control over drug identity and purity, but control over the physical form remains poor. This review discusses the influence of solvents used in crystallization process on crystal habit and agglomeration of crystals with potential implication for dissolution. According to literature it has been known that habit modification of crystals by use of proper solvents may enhance the dissolution properties by changing the size, number and the nature of crystal faces exposed to the dissolution medium. Also, the faster dissolution rate of drug from the agglomerates of crystals compared with the single crystals may be related to porous structure of the agglomerates and consequently their better wettability. It is concluded from this review that in-depth understanding of role of the solvents in crystallization process can be applied to engineering of crystal habit or crystal agglomeration, and predictably dissolution improvement in poorly soluble drugs. © 2015 The Authors.

Jaymand M.,Tabriz University of Medical Sciences
Polymer Chemistry | Year: 2014

It is an unquestionable fact that syndiotactic polystyrene (sPS) has stimulated great interest on the basis of its importance in basic scientific research and potential industrial applications. It is regarded as a new low-cost engineering polymer with various desirable properties, such as a high melting temperature (270 °C), fast crystallization rate, low dielectric constant, excellent mechanical properties, low permeability to gases, outstanding dimensional stability, excellent processing characteristics at a very low melt viscosity, and good chemical resistance. However, some drawbacks of sPS restrict its practical use: its brittleness, a disadvantage in applications where mechanical properties are important; the absence of polar groups for adhesion to substrates and compatibility with polar polymers; and the need to process sPS at high temperatures due to its high melting points. Thus, modification of sPS is necessary to expand its applications, and has been the subject of much investigation. This review provides a snapshot of recent progress in the chemical modification of syndiotactic polystyrene, including in situ functionalization of sPS (syndiospecific copolymerization of styrene with a second monomer and catalytic chain transfer to a chain transfer agent), post-functionalization of sPS (introduction of polar groups into sPS, graft or block copolymerization onto sPS, and hydrogenation of sPS or its copolymers) and monomer modification. © 2014 the Partner Organisations.

Danesh-Bahreini M.A.,Tabriz University of Medical Sciences
International journal of nanomedicine | Year: 2011

Leishmaniasis is a protozoan disease, affecting 12 million people in different regions of the world with a wide spectrum of diseases. Although several chemotherapeutic agents have been used for treating the disease, long-term therapy, limited efficacy and the development of drug-resistant parasites remain the major limitations. To develop a new nanovaccine for leishmaniasis, recombinant Leishmania superoxide dismutase (SODB1) was loaded onto chitosan nanoparticles by the ionotropic gelation method. Size and loading efficiency of the nanoparticles were evaluated and optimized, and an immunization study was undertaken on BALB/c mice. The mice received phosphate buffer saline (PBS), superoxide dismutase B1 (SODB1) in PBS and nanoparticles via subcutaneous injection. Soluble Leishmania Antigens (SLA) and complete Freund's adjuvant (CFA) were also injected subcutaneously three times every three weeks (some groups received only a single dose). Three weeks after the last injection, blood samples were collected and assessed with ELISA to detect IgG2a and IgG1. Immunological analysis showed that in single and triple doses of SODB1 nanoparticles, IgG2a and IgG2a/IgG1 were significantly higher than the other groups (P<0.05). The results revealed that formulations of SODB1 in biodegradable and stable chitosan nanoparticles can increase the immunogenicity toward cell-mediated immunity (T(H)1 cells producing IgG2a in mice) that is effective in Leishmania eradication and could be presented as a single dose nanovaccine for leishmaniasis.

Jaymand M.,Tabriz University of Medical Sciences
RSC Advances | Year: 2014

In recent decades, there has been growing interest in the development of organic-inorganic hybrid materials in order to obtain new kinds of materials with synergetic or complementary behavior for various practical and technological applications. Among the numerous kinds of these materials the conductive polymers/zeolite (nano-)composites represent a new class of materials system due to their novel physicochemical properties and potential for various practical and technological applications such as sensors, cathodes of the cells, anticorrosive, membranes, and selective removal of heavy metal ions from sea water and industrial waste water. However, these materials were under-exploited and there were only a few studies conducted for the preparation and application of conductive polymer/zeolite hybrids. This review provides a snapshot of recent progress in the synthesis, materials properties, and applications of conductive polymers/zeolite (nano-)composites reported until March 2014. This journal is © the Partner Organisations 2014.

Jaymand M.,Tabriz University of Medical Sciences
Progress in Polymer Science | Year: 2013

Polyaniline (PANI) has been the subject of considerable recent interest because of their unique electrical behavior, good environmental stability in doped and neutral states, ease of synthesis and wide applications in different fields. However, the main drawback of PANI is lack of solubility, which explains its limited processability due to a rigid backbone. Various procedures have been adapted to improve its processability. The major part of this review is a discussion of some of the methods employed for chemical modification of PANI, including doping via Acid-Base chemistry, sulfonation of PANI or copolymerization of aniline with sulfonated aniline derivatives, synthesis of PANI composites with processable polymers, copolymerization of aniline with substituted corresponding monomers, incorporation of polymeric chains or long and flexible alkyl chains in the PANI backbone, and enzymatic polymerization of aniline during the last decade. © 2013 Elsevier Ltd. All rights reserved.

Badalzadeh R.,Tabriz University of Medical Sciences
Journal of cardiovascular pharmacology and therapeutics | Year: 2012

The interaction of diabetes with cardioprotection by postconditioning in ischemia/reperfusion injury remains unclear. The aim of this study was to investigate the concomitant effects of ischemic postconditioning (IPostC) and cyclosporine-A (CsA) on nitric oxide (NO) content and parameters of cardiac function of the diabetic myocardium injured by ischemia/reperfusion. Diabetes was induced by single injection of streptozotocin (50 mg/kg; intraperitoneally [ip]) in Wistar rats (250-320 g) and the diabetic period was 8 weeks. The hearts (n = 96) were removed quickly, mounted on Langendorff apparatus, and then subjected to 30-minute regional ischemia followed by 45-minute reperfusion. Ischemic postconditioning was induced by 3 cycles of 30-second reperfusion/ischemia at the onset of reperfusion. Myocardial function was measured throughout the experiment, and infarct size (IS) was identified by triphenyltetrazolium chloride (TTC) staining. Total amounts of NO metabolites were determined using Griess method and enzyme-linked immunosorbent assay (ELISA) reader. Administration of either IPostC or CsA alone in nondiabetic animals significantly improved myocardial function and reduced the ISs (28% ± 1.9% or 23% ± 2.0% vs 41% ± 2.9% of the risk zone [RZ], respectively; P < .01), but they had no effect on diabetic hearts (35% ± 1.8% or 32% ± 2.1% vs 39% ± 3.1%, respectively). In addition, myocardial NO level was significantly increased by IPostC only in nondiabetic animals (P < .01). However, after administration of CsA (5 minutes before and 10 minutes after the onset of reperfusion) in postconditioned animals, the cardioprotective and NO-enhancing effects of IPostC were restored in diabetic rats (IS: 21% ± 1.1% vs 39% ± 3.1%), similar to those in nondiabetic controls (19% ± 1.3% vs 41% ± 2.9%; P < .01). The present study indicated that IPostC or CsA failed to affect NO levels and failed to protect the diabetic myocardium against ischemia/reperfusion injury. Moreover, concomitant administration of CsA and IPostC at reperfusion can increase NO content and protect the diabetic myocardium.

Dolatabadi J.E.N.,Tabriz University of Medical Sciences
International Journal of Biological Macromolecules | Year: 2011

Flavonoids occupy an important position in chemistry and pharmacology. Various flavonoids, particularly quercetin have potential to form molecular complexes with nucleic acid structure and have attracted recent attention for their prospective clinical and pharmacological utility. This review highlights the properties of quercetin and its different metal complexes as well as their interactions with DNA reported by several research groups. Various analytical techniques were employed including absorbance, fluorescence and circular dichroism spectroscopies, viscosity and voltammetry to provide more details about binding mechanism of these materials with DNA. © 2010 Elsevier B.V.

Tabrizi A.B.,Tabriz University of Medical Sciences
Journal of Hazardous Materials | Year: 2010

A novel, simple and efficient method for the iron (Fe) speciation and determination in different water samples was developed using dispersive liquid-liquid microextraction (DLLME) technique followed by spectrophotometric analysis. The procedure is based on complexation of Fe(II) with O-phenanthroline (O-Phen), the subsequent ion-association formation with picrate anion, then extraction of the complex using DLLME technique. Some important parameters such as the type and volume of extraction and dispersive solvents as well as the extraction time were investigated and optimized in detail. Under the optimum conditions, the calibration graphs were linear over the range of 0.025-1.0μgmL-1 with limit of detection of 7.5μgL-1. Relative standard deviation for five replicate determinations of Fe at 0.2μgmL-1 concentration level was calculated to be 1.2%. Average recoveries for spiked samples were determined to be between 90% and 108%. The method was applied to water samples and parenteral solutions and the amounts of Fe found in these samples using the proposed method were similar with those obtained by a standard method. © 2010 Elsevier B.V.

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