Tabriz University of Medical science is public medical science university located in Tabriz, East Azarbaijan Province, Iran. It is ranked as one of Iran's top medical schools, with more than 5000 students.The University consists of seven faculties: Medicine, Pharmacy, Dentistry, Paramedical science, Health & Nutrition, Rehabilitation, and Nursing & Midwifery. The school offers professional degrees in Medicine , Dentistry , Pharmacy ; Bachelor's, Master's, and Doctor of Philosophy in various other medically related subjects. The school also offers technical courses in pursuit of Associate's degrees and certification in medically related fields.In addition, TUMS operates over 10 teaching hospitals and is a major medical care provider in East Azarbaijan Province and the surrounding provinces. Wikipedia.
Danesh-Bahreini M.A.,Tabriz University of Medical Sciences
International journal of nanomedicine | Year: 2011
Leishmaniasis is a protozoan disease, affecting 12 million people in different regions of the world with a wide spectrum of diseases. Although several chemotherapeutic agents have been used for treating the disease, long-term therapy, limited efficacy and the development of drug-resistant parasites remain the major limitations. To develop a new nanovaccine for leishmaniasis, recombinant Leishmania superoxide dismutase (SODB1) was loaded onto chitosan nanoparticles by the ionotropic gelation method. Size and loading efficiency of the nanoparticles were evaluated and optimized, and an immunization study was undertaken on BALB/c mice. The mice received phosphate buffer saline (PBS), superoxide dismutase B1 (SODB1) in PBS and nanoparticles via subcutaneous injection. Soluble Leishmania Antigens (SLA) and complete Freund's adjuvant (CFA) were also injected subcutaneously three times every three weeks (some groups received only a single dose). Three weeks after the last injection, blood samples were collected and assessed with ELISA to detect IgG2a and IgG1. Immunological analysis showed that in single and triple doses of SODB1 nanoparticles, IgG2a and IgG2a/IgG1 were significantly higher than the other groups (P<0.05). The results revealed that formulations of SODB1 in biodegradable and stable chitosan nanoparticles can increase the immunogenicity toward cell-mediated immunity (T(H)1 cells producing IgG2a in mice) that is effective in Leishmania eradication and could be presented as a single dose nanovaccine for leishmaniasis.
SalmanOgli A.,Tabriz University of Medical Sciences
Cancer Nanotechnology | Year: 2011
In this article, the syntheses and optical properties of core/shell quantum dot (CdSe/ZnS) and their applications are reviewed. Nevertheless, the main focus is to provide an overview on biological applications of quantum dots that contain imaging, targeting, and sensing. We discuss the different synthetic methods, optical properties (photoluminescence intensity, absorption, and fluorescence spectra), and their dependence on shape, size, and inner structure of quantum dots. Also, the different mechanisms of quantum dots bio-targeting (passive and active mechanisms) are discussed. The impact of quantum dots in bioimaging is reviewed regarding its photoluminescence intensity, absorption and emission spectrum, and photo-stability on high-quality and sensitivity imaging. Further, the difference between near infrared and visible emission quantum dots in deep tissue imaging will be reviewed and some of done works are considered and compared with each other. And finally, the biosensing potential/application of quantum dots in medical diagnosis is going to be highlighted. © 2011 Springer-Verlag.
Jaymand M.,Tabriz University of Medical Sciences
Polymer Chemistry | Year: 2014
It is an unquestionable fact that syndiotactic polystyrene (sPS) has stimulated great interest on the basis of its importance in basic scientific research and potential industrial applications. It is regarded as a new low-cost engineering polymer with various desirable properties, such as a high melting temperature (270 °C), fast crystallization rate, low dielectric constant, excellent mechanical properties, low permeability to gases, outstanding dimensional stability, excellent processing characteristics at a very low melt viscosity, and good chemical resistance. However, some drawbacks of sPS restrict its practical use: its brittleness, a disadvantage in applications where mechanical properties are important; the absence of polar groups for adhesion to substrates and compatibility with polar polymers; and the need to process sPS at high temperatures due to its high melting points. Thus, modification of sPS is necessary to expand its applications, and has been the subject of much investigation. This review provides a snapshot of recent progress in the chemical modification of syndiotactic polystyrene, including in situ functionalization of sPS (syndiospecific copolymerization of styrene with a second monomer and catalytic chain transfer to a chain transfer agent), post-functionalization of sPS (introduction of polar groups into sPS, graft or block copolymerization onto sPS, and hydrogenation of sPS or its copolymers) and monomer modification. © 2014 the Partner Organisations.
Jaymand M.,Tabriz University of Medical Sciences
RSC Advances | Year: 2014
In recent decades, there has been growing interest in the development of organic-inorganic hybrid materials in order to obtain new kinds of materials with synergetic or complementary behavior for various practical and technological applications. Among the numerous kinds of these materials the conductive polymers/zeolite (nano-)composites represent a new class of materials system due to their novel physicochemical properties and potential for various practical and technological applications such as sensors, cathodes of the cells, anticorrosive, membranes, and selective removal of heavy metal ions from sea water and industrial waste water. However, these materials were under-exploited and there were only a few studies conducted for the preparation and application of conductive polymer/zeolite hybrids. This review provides a snapshot of recent progress in the synthesis, materials properties, and applications of conductive polymers/zeolite (nano-)composites reported until March 2014. This journal is © the Partner Organisations 2014.
Ahangarzadeh Rezaee M.,Tabriz University of Medical Sciences
Japanese journal of infectious diseases | Year: 2012
We investigated the prevalence of multidrug resistance, production of extended-spectrum β-lactamases (ESBLs), and presence of class 1 and 2 integrons in 150 clinical isolates of Klebsiella pneumoniae from northwest Iran by performing phenotypic confirmatory tests and polymerase chain reaction (PCR) analysis. Of the 150 isolates, 149 (99.3%) were multidrug resistant (MDR). Of the MDR isolates, 124 (83.2%) were ESBL positive. The results of the PCR analysis showed that 117 (78.5%) and 20 (13.4%) MDR K. pneumoniae isolates carried intI1 and intI2, respectively, and 16 (10.7%) MDR K. pneumoniae isolates contained the integrase genes of both class 1 and class 2. Resistance of the isolates to gentamicin, tetracycline, ceftazidime, cephalothin, chloramphenicol, and nalidixic acid was observed to be significantly associated with the presence of class 1 integrons; however, the resistance to tetracycline was observed to be associated with the presence of class 2 integrons alone. This study showed that integrons are widely prevalent in the clinical isolates of K. pneumoniae from northwest Iran, and that they may be playing an important role in attributing multidrug resistance to the clinical K. pneumoniae isolates. To the best of our knowledge, this is the first report showing the presence of class 1 and class 2 integrons in MDR K. pneumoniae isolates from clinical settings in northwest Iran.