Lexington, MA, United States
Lexington, MA, United States

Time filter

Source Type

Patent
T2 Biosystems | Date: 2015-04-27

The invention features a diagnostic platform utilizing T2 magnetic resonance to directly measure integrated reactions in whole blood samples such as clotting, clot contraction, and fibrinolysis to provide a comprehensive assessment of hemostatic parameters on a single instrument in minutes. The methods of the invention can be performed with less than 1 mL of blood and minimal sample handling.


Patent
T2 Biosystems | Date: 2014-09-08

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.


Patent
T2 Biosystems | Date: 2015-09-01

The invention relates to detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of samples. More particularly the invention relates to methods and apparatus for monitoring coagulation and/or obtaining a coagulation time of a sample using NMR-based detectors.


Patent
T2 Biosystems | Date: 2013-01-04

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.


Patent
T2 Biosystems | Date: 2015-07-20

The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.


Nuclear magnetic resonance systems and methods of use thereof are provided. The systems employ implantable radiofrequency coils (105) and optionally implantable magnets (101). The systems can employ weak permanent magnets and/or permanent magnets that provide magnetic fields that are much less homogeneous than in conventional systems. This allows, for example, for inexpensive and simple probeheads for nuclear magnetic resonance relaxometry with suitable biosensors. The methods of the present invention allow in vivo magnetic resonance measurements and, in particular, monitoring of analytes and determination of medical diagnostic information, for example, based on determined magnetic resonance parameters.


Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.


Patent
T2 Biosystems | Date: 2013-10-17

This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.


Patent
T2 Biosystems | Date: 2013-02-21

The present invention relates to devices including a heating element with an opening, which can control condensation of liquid samples during thermal incubation. The opening of the heating element can provide direct access to the samples in a process that may be automated. The invention also provides methods for heating containers.


Patent
T2 Biosystems | Date: 2016-02-17

This invention features magnetic sensor based systems and methods for the detection of analytes, such as nucleic acids and pathogens. In particular systems employing an RF pulse in combination with a bias magnetic field methods are featured. Magnetic particles used have a mean particle diameter between 700 and 950 nm, leading to an increased sensitivity as a consequence of increased size aggregates with an increased T2 relaxivity. A removable cartridge for insertion and removal from the system is also described.

Loading T2 Biosystems collaborators
Loading T2 Biosystems collaborators