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The paper presents and defines the processes of pollutant transport in subsoil. The landfill's vertical barrier and assumption of numerical model of groundwater flow and pollutant transport are also discussed, based on example of the old sanitary landfill Łubna localized near Warsaw. The water monitoring results of landfill areas, which includes water chemical analyses from the period before and after the vertical barrier was built, is also analyzed in this paper. Source

Agency: Cordis | Branch: FP7 | Program: MC-ERG | Phase: FP7-PEOPLE-2009-RG | Award Amount: 30.00K | Year: 2012

Genital herpes is the main cause of genital ulcers worldwide. Ulcerations resulting from recurrent HSV-2 infection consists one of the most common factors influencing integrity and functioning of genital mucosa and heighten the risk of HIV transmission. There are several types of cell death, of which apoptosis is a physiological process necessary for vaginal epithelium turnover during an oestrous cycle. Cell death receptors, such as Fas receptor together with its natural ligand, FasL, have been shown to participate in vaginal regression by inducing apoptosis. The Fas/FasL system plays an important role in skin and epithelial homeostasis, carcinogenesis and inflammatory skin diseases. Considering the fact that HSV-2 infection heightens the risk of other STDs, such as HIV and may involve exacerbation of apoptosis and inflammatory mechanisms, the idea of this project is to further explore the role of Fas/FasL system in regulation of the inflammatory and immune response and infection resolution during HSV-2 genital infection. The project will use the mouse model of genital herpes in the mice lacking Fas and FasL genes to compare inflammatory cytokines/chemokines production, local early immune response and efficiency of genital infection with the HSV-2 infection in wild-type mice. Further, the project will use the knowledge gained in an animal model to test how HSV-2 facilitates mucosal HIV-1 infection by eliciting inflammatory states in the in vitro human epithelial model. The will use up-to day techniques such as flow cytometry, DNA microarray assays, confocal microscope visualisation system and RNA intereference technology. The knowledge and expertise gained through this training project should help to designate and develop a new treatment methods (microbicides) in sexually transmitted diseases as well as to help a fellow to develop further independence as researcher.

Agency: Cordis | Branch: H2020 | Program: CSA | Phase: ISIB-02-2015 | Award Amount: 2.00M | Year: 2016

EuroDairy will foster development and dissemination of practice-based innovations in dairy farming on key sustainability issues for the post-quota era. Work Package 1 (Project co-ordination) oversees formation of the Thematic Network, ensures interconnectivity in generation, capture and demonstration of innovation and best practice, and reports project outputs including recommendations for further innovation-driven research. WP 2 (Network of innovating pilot farmers and Knowledge Transfer Centres) establishes a community of innovating dairy farmers which through experience and practice on their own farms, bring good ideas and implementable solutions to EuroDairy. The farms participate in regional multi-actor operational groups, and connect as a network to share knowledge across borders. WPs 3-6 focus on four key topics - Resource efficiency, Biodiversity, Animal care, and Socio-economic resilience. These WPs provide leadership, direction and technical expertise for the exchange of innovative thinking, tools, technologies and best practice across the thematic network (pilot farmers, Knowledge Transfer Centres, and regional operational groups). WP 7 (Synergies in scientific and practice-based knowledge) draws from WPs 3-6 to capture new insights from combining science with practice-based knowledge, including benefits and trade-offs in solutions identified. WP 8 (Production and communication of end-user materials) implements a mix of novel and tried-and-tested approaches to internal and external communications. A diverse range of end-user outputs will be produced, made widely accessible to farmers. EuroDairy supports H2020 objectives to increase productivity, improve competitiveness and impact less on the environment. Involvement of dairy levy bodies, farmers organisations and cooperatives in an interactive, bottom-up approach will ensure practical relevance, and multiply benefits across Europe. Direct links to Hennovation and AgriSPIN, will add value to the project.

Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-01b-2014 | Award Amount: 10.52M | Year: 2015

SAPHIR aims to develop vaccine strategies effective against endemic pathogens responsible for high economic losses in livestock in order to strengthen the profitability of food animal systems, improve animal welfare and reduce xenobiotic usage in farming with a One Health perspective. SAPHIR will bring novel vaccine strategies to the market i) at short term, with several promising vaccines brought to demonstration (RTL6), ii) at long term, with cutting edge strategies brought at proof of concept (RTL3) and iii) in line with socio-economic requirements. SAPHIR has selected two representative pathogens of pigs (Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma hyopneumoniae), chickens (Eimeria and Clostridium perfringens) and cattle (Bovine Respiratory Syncytial Virus, Mycoplasma bovis) to develop generic vaccine approaches applicable to other pathogens. SAPHIR will issue i) knowledge of immune mechanisms of protection, ii) affordable, safe and multivalent vaccines with DIVA properties, iii) efficient adjuvants targeting dendritic cells, optimal formulations, new mucosal and skin delivery systems, a new generation of DNA vectors and viral replicon platforms for fostering an earlier and longer duration of immunity including the perinatal period, and iv) basal biomarkers of individual immuno-competence for future breeding strategies. The SAPHIR dissemination and training programme includes creation of an integrated health management website, launch of a Global Alliance for Veterinary Vaccines and organization of workshops directed at food animal system stakeholders. This will ensure optimal research translation of SAPHIR outputs to market and field applications. SAPHIR brings together interdisciplinary expertise from fourteen academic institutes including a Chinese partner, five SMEs and two pharmaceutical companies.

Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-03 | Award Amount: 12.00M | Year: 2013

Production diseases compromise health and welfare, generating inefficiencies which impact adversely on profitability, environmental footprint, antibiotic use and product quality. The PROHEALTH project will develop understanding of the multi-factorial dimension of animal pa-thologies linked to the intensification of production and use this to develop, evaluate and disseminate ef-fective control strategies to reduce impact. It will address production diseases of pigs and poultry raised in a wide range of EU intensive systems, using both epidemiological and experimental approaches to consider the extent of, and the risk factors associated with diseases, the influence of genotype and its modification by early life experience, and the dynamic influences of the environment on disease. The mechanisms underlying differences in disease susceptibility will be explored at different levels. Improvement strategies for diseases including neo-natal mortality, gut and respiratory disorders, leg and metabolic disorders will be evaluated in farm scale tests, and data from diverse systems used to model whole-chain socioeconomic implications of disease states and their alleviation. The consortium has expertise in veterinary science and epidemiology, physiology and immunology, ge-netics, nutrition, socioeconomics, welfare and production science of pigs and poultry. The 10 academic, 1 association 4 industry and 7 SME partners cover the full European geographic range to derive meaningful epidemiological data and test interventions across diverse production circumstances. Dissemination activities will encompass all stakeholders in the food chain and establish new e-learning tools. PROHEALTH will deliver novel diagnostics for the propensity to develop production diseases and their occurrence, and multifactorial improvement strategies that can be applied to produce better quality products in a welfare friendly manner and improve competitiveness and sustainability of EU pig & poultry systems

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