Szkola Glowna Gospodarstwa Wiejskiego and Instytut Technologii Materialow Elektronicznych | Date: 2015-02-05
The present invention relates to a water suspension of graphene oxide nanoflakes decorated by nanoparticles of metallic platinum, characterised in that it comprises: 100 g/ml to 500 g/ml of graphene oxide nanoflakes, 5 g/ml to 50 g/ml of nanoparticles of metallic platinum (Pt), deposited on the surface of graphene oxide nanoflakes. The invention also relates to a method of preparing such suspension and its use as an antitumor agent.
Agency: Cordis | Branch: H2020 | Program: BBI-RIA | Phase: BBI.VC2.R5-2015 | Award Amount: 5.26M | Year: 2016
The project focuses on increasing access to wood resources through more efficient silviculture and a better understanding of the business models governing the procurement of forest operations services. The project further considers increasing efficiency in forest harvesting and collection, and the reduction of soil impact from forest operations, and puts forward ways of making this a measurable and integrated part of operational efficiency. TECH4EFFECT offers the potential to revolutionize forest operations with a state-of-the-art knowledge-based efficiency development system, providing easily accessible decision support exploiting the large amount of data available in modern industrial forest management. The ambition of TECH4EFFECT is to implement such as management tool, enhanced through 4 years of intensive R&D in close cooperation with the end-users of the Efficiency Portal in 5 participating countries. It is the projects hope that implementation will result in such obvious benefits amongst the industrial partners that its application will become widespread within the European forest sector.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-07b-2015 | Award Amount: 9.01M | Year: 2016
This aim of IMAGE is to enhance the use of genetic collections and to upgrade animal gene bank management. IMAGE will better exploit DNA information and develop methodologies, biotechnologies, and bioinformatics for rationalising animal genetic resources. It will demonstrate the benefits brought by gene banks to the development of sustainable livestock systems by: enhancing the usefulness of genetic collections to allow the livestock sector to respond to environment and market changes; using latest DNA technology and reproductive physiology for collecting, storing and distributing biological resources; Minimising genetic accidents such as abnormalities or genetic variability tipping points; Developing synergies between ex-situ and in-situ conservation to maximise resources for the future. To this end, the project will involve stakeholders, SME, and academic partners to achieve the following objectives. At the scientific level, the project will: Assess the diversity available in genetic collections; Search for adaptive traits through landscape genetics in local populations; Contribute to elucidate local populations and major genes history; Identify detrimental variants that can contribute to inbreeding depression; Predict cryobank samples reproductive performance; Facilitate the use of collections for genome-assisted breeding. At the technological level, it will develop: Procedures for harmonising gene bank operations and rationalising collections; Conservation and reproductive biotechnologies; A central information system to connect available data on germplasm and genomic collections. At the applied level, it will develop methods and tools for stakeholders to: Restore genetic diversity in livestock populations; Create or reconstruct breeds fitting new environmental constraints and consumer demands; Facilitate cryobanking for local breeds; Define and track breed-based product brands; Implement access and benefit sharing regulations.
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: ISIB-02-2015 | Award Amount: 2.00M | Year: 2016
EuroDairy will foster development and dissemination of practice-based innovations in dairy farming on key sustainability issues for the post-quota era. Work Package 1 (Project co-ordination) oversees formation of the Thematic Network, ensures interconnectivity in generation, capture and demonstration of innovation and best practice, and reports project outputs including recommendations for further innovation-driven research. WP 2 (Network of innovating pilot farmers and Knowledge Transfer Centres) establishes a community of innovating dairy farmers which through experience and practice on their own farms, bring good ideas and implementable solutions to EuroDairy. The farms participate in regional multi-actor operational groups, and connect as a network to share knowledge across borders. WPs 3-6 focus on four key topics - Resource efficiency, Biodiversity, Animal care, and Socio-economic resilience. These WPs provide leadership, direction and technical expertise for the exchange of innovative thinking, tools, technologies and best practice across the thematic network (pilot farmers, Knowledge Transfer Centres, and regional operational groups). WP 7 (Synergies in scientific and practice-based knowledge) draws from WPs 3-6 to capture new insights from combining science with practice-based knowledge, including benefits and trade-offs in solutions identified. WP 8 (Production and communication of end-user materials) implements a mix of novel and tried-and-tested approaches to internal and external communications. A diverse range of end-user outputs will be produced, made widely accessible to farmers. EuroDairy supports H2020 objectives to increase productivity, improve competitiveness and impact less on the environment. Involvement of dairy levy bodies, farmers organisations and cooperatives in an interactive, bottom-up approach will ensure practical relevance, and multiply benefits across Europe. Direct links to Hennovation and AgriSPIN, will add value to the project.
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: RUR-10-2016-2017 | Award Amount: 2.00M | Year: 2016
The European Union (EU) is the worlds second biggest producer of pigmeat and is the markets largest exporter. In order to maintain an economically viable and sustainable pig industry, innovation is a key factor. EU PiG specifically aims to more effectively connect producers with the latest science, husbandry techniques and technologies from within their industry via fellow producers, academics and advisors connected through thematic and regional platforms. A unique consortium of 19 organisations has been brought together, representing 13 Member States that together account for 92% of the EUs pig meat production and 89% of the EUs pig herd in 2014. The EU PiG consortium represents a wide range of actors, including national and regional pig producer groups, researchers, rural development boards, innovation practitioners and SMEs. EU PiG will provide a platform for dialogue for the actors, facilitating the exchange of knowledge and sharing of innovative best practice.
Agency: Cordis | Branch: FP7 | Program: CP-TP | Phase: KBBE.2013.1.3-03 | Award Amount: 12.00M | Year: 2013
Production diseases compromise health and welfare, generating inefficiencies which impact adversely on profitability, environmental footprint, antibiotic use and product quality. The PROHEALTH project will develop understanding of the multi-factorial dimension of animal pa-thologies linked to the intensification of production and use this to develop, evaluate and disseminate ef-fective control strategies to reduce impact. It will address production diseases of pigs and poultry raised in a wide range of EU intensive systems, using both epidemiological and experimental approaches to consider the extent of, and the risk factors associated with diseases, the influence of genotype and its modification by early life experience, and the dynamic influences of the environment on disease. The mechanisms underlying differences in disease susceptibility will be explored at different levels. Improvement strategies for diseases including neo-natal mortality, gut and respiratory disorders, leg and metabolic disorders will be evaluated in farm scale tests, and data from diverse systems used to model whole-chain socioeconomic implications of disease states and their alleviation. The consortium has expertise in veterinary science and epidemiology, physiology and immunology, ge-netics, nutrition, socioeconomics, welfare and production science of pigs and poultry. The 10 academic, 1 association 4 industry and 7 SME partners cover the full European geographic range to derive meaningful epidemiological data and test interventions across diverse production circumstances. Dissemination activities will encompass all stakeholders in the food chain and establish new e-learning tools. PROHEALTH will deliver novel diagnostics for the propensity to develop production diseases and their occurrence, and multifactorial improvement strategies that can be applied to produce better quality products in a welfare friendly manner and improve competitiveness and sustainability of EU pig & poultry systems
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-01b-2014 | Award Amount: 10.52M | Year: 2015
SAPHIR aims to develop vaccine strategies effective against endemic pathogens responsible for high economic losses in livestock in order to strengthen the profitability of food animal systems, improve animal welfare and reduce xenobiotic usage in farming with a One Health perspective. SAPHIR will bring novel vaccine strategies to the market i) at short term, with several promising vaccines brought to demonstration (RTL6), ii) at long term, with cutting edge strategies brought at proof of concept (RTL3) and iii) in line with socio-economic requirements. SAPHIR has selected two representative pathogens of pigs (Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma hyopneumoniae), chickens (Eimeria and Clostridium perfringens) and cattle (Bovine Respiratory Syncytial Virus, Mycoplasma bovis) to develop generic vaccine approaches applicable to other pathogens. SAPHIR will issue i) knowledge of immune mechanisms of protection, ii) affordable, safe and multivalent vaccines with DIVA properties, iii) efficient adjuvants targeting dendritic cells, optimal formulations, new mucosal and skin delivery systems, a new generation of DNA vectors and viral replicon platforms for fostering an earlier and longer duration of immunity including the perinatal period, and iv) basal biomarkers of individual immuno-competence for future breeding strategies. The SAPHIR dissemination and training programme includes creation of an integrated health management website, launch of a Global Alliance for Veterinary Vaccines and organization of workshops directed at food animal system stakeholders. This will ensure optimal research translation of SAPHIR outputs to market and field applications. SAPHIR brings together interdisciplinary expertise from fourteen academic institutes including a Chinese partner, five SMEs and two pharmaceutical companies.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SFS-20-2015 | Award Amount: 6.91M | Year: 2016
Strength2Food is a 5-year, 6.9 million project to improve the effectiveness of EU food quality schemes (FQS), public sector food procurement (PSFP) and to stimulate Short Food Supply Chains (SFSC) through research, innovation and demonstration activities. Our 30-partner consortium representing 11 EU and 4 non-EU countries combines leading academic, communication, SME and stakeholder organisations to ensure a multi-actor approach. It will undertake case study-based quantitative research to measure economic, environmental and social impacts of FQS, PSFP and SFSC. The impact of PSFP policies on balanced nutrition in schools will also be assessed. Primary research will be complemented by advanced econometric analysis of existing datasets to determine impacts of FQS and SFSC participation on farm performance and survival, as well as understand price transmission and trade patterns. Consumer knowledge, confidence in, valuation and use of FQS labels and products will be assessed via cross-national survey, ethnographic and virtual supermarket-based research. Lessons from the research will be applied and verified in 6 pilot initiatives, focusing on less-developed and transition regions. These initiatives bring together academic and non-academic stakeholder partners in action research. The six pilot actions are: a school meals initiative to improve the nutritional outcomes and economic benefits for local agri-food producers; in-store trials (undertaken with a grocery retailer) to upscale sales of local produce; a scheme to stimulate a sustainable SFSC that adds value to the fishing community; and pilot actions to expand regional food labelling; increase sales of FQS products in non-traditional markers; and improve returns to local producers at food fairs and farmers markets (via a smartphone app). Project impact will be maximised through a knowledge exchange platform, hybrid forums, school educational resources, a Massive Open Online Course and practitioner recommendations.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EeB-06-2015 | Award Amount: 4.31M | Year: 2015
There is a compelling need of encouraging energy efficiency in buildings, enhance green technologies and promote advance thermal energy storage solutions. TESSe2b will enable the optimal use of renewable energy and provide one of the most advantageous solutions for correcting the mismatch that often occurs between the supply and demand of energy in residential buildings. The target of TESSe2b is to design, develop, validate and demonstrate a modular and low cost thermal storage technology based on solar collectors and highly efficient heat pumps for heating, cooling and domestic hot water (DHW) production. The idea is to develop advanced compact integrated PCM TES tanks exploiting RES (solar and geothermal) in an efficient manner coupled with enhanced PCM borehole heat exchangers (BHEs) that will take advantage of the increased underground thermal storage and maximize the efficiency of the ground coupled heat pumps (GCHP). The two TES tanks developed within TESSe2b project will be integrated with different PCM materials; (i) enhanced paraffin PCM, (ii) salt-hydrates PCM, while in both of them a highly efficient heat exchanger will be included. Even if the concept of phase change thermal stores has been demonstrated, TESSe2b project discriminates itself through incorporating; (i) PCM materials innovation, (ii) advanced energy management through self-learning model-based control system, (iii) enhanced PCM BHEs (v) compact modular design of thermal storage tank. Since the lifetime of TESSe2b solution is among the most critical factors determining its acceptability, reliability and success the on the long run, special emphasis will be given in the life-expectancy of the involved components.
Agency: Cordis | Branch: H2020 | Program: ERC-STG | Phase: ERC-2016-STG | Award Amount: 1.41M | Year: 2017
The proposed project seeks to open a new research front within the field of drug delivery to the solid tumours. Unsatisfactory response of tumours to chemotherapy is mainly related to impaired diffusion of the anticancer drug because of decreased drug uptake due to poor vasculature. Moreover, the drug is not able to penetrate the most hypoxic sites. Cells from these untreated sites are responsible for relapse and metastasis. However, these avascular regions attract macrophages that migrate even to areas far away from blood vessels. Therefore, they might constitute a unique delivery system of drug containing particles to these parts of the tumour mass. A promising example of such particles that could be used are ferritins, whose caged architecture allows for efficient drug encapsulation and whose uptake from macrophage cells has been well demonstrated. My recent ground breaking finding was that macrophages are also able to specifically and actively transfer these taken up ferritins (loaded with the compound of choice) to cancer cells. Thus, these preliminary results indicate the possibility to use macrophages to deliver ferritin encapsulated compounds directly to the tumour cells even in its hypoxic areas. Then, the use of hypoxia-activated prodrugs (HAP) which are selectively activated only in hypoxic regions will be exploited in order to make cancer therapy safer. However, the molecular mechanism of ferritin uptake by macrophages, their storage, and transport to the cancer cells represent key issues to be investigated and pave the way to the experimental design of the present project. In the present project, we will develop and characterize a completely new and modern approach to anticancer therapy and drug delivery. As such we expect to be able to precisely administer drugs to the tumour site (even to the hypoxic regions) where it is activated by tumour-specific conditions, avoiding side effects of anticancer therapy.