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Budapest, Hungary

Julow J.,Szent Janos Hospital
Ideggyogyaszati Szemle | Year: 2010

The paper is the summary of mostly published works of the clinical results of intracavitary Yttrium-90 colloid irradiation of recurrent cystic craniopharyngiomas, and Iodine-125 interstitial irradiation of gliomas, pinealomas, brainstem tumors, recurrent meningeomas, solid craniopharyngiomas and metastases. It concisely demonstrates the usefulness of image fusion in the verification of isotope seeds and catheters, the comparison of 125 Iodine stereotactic brachytherapy and LINAC radiosurgery modalities on physical dose distribution and radiobiological efficacy, and the analysis of volumetric changes after interstitial irradiation of gliomas. Results of the immunohistochemical study deal with the role of microglia/macrophage system in the tissue response to I-125 interstitial brachytherapy of cerebral gliomas. Due to financial reasons, gamma knife and Linac are not available to many countries and neurosurgical institutes. In the absence of the above mentioned radiosurgical methods, we have shown brachytherapy as an alternative solution in the treatment of different types of inoperable or recurrent brain tumors. The observed results may be noticable at LINAC and gamma knife irradiation too. Source


Pethes A.,Szent Janos Hospital | Kiss R.M.,Budapest University of Technology and Economics | Szendroi M.,Semmelweis University
International Orthopaedics | Year: 2014

Purpose: The purpose of this study was to work out an objective and sensitive method for the early postoperative period following total knee arthroplasty (TKA) in which analysis of the gait parameters is possible and also to investigate the influence of different surgical approaches for TKA on the gait during stepping in the first three months of the postoperative period. Methods: Three groups of patients: age-matched healthy elderly patients as a control group, patients operated upon by the conventional technique and finally by the minimally invasive technique combined with computer-assisted navigation. All three groups included ten patients. The motions of knee, shoulder and pelvis were measured by ZEBRIS ultrasound-based system preoperatively plus six and 12 weeks postoperatively. From the joint motion, the variability of cadence, and the variability of knee joint motion and that of pelvis and shoulder girdle was determined. Results: Osteoarthritis (OA) of the knee joint and TKA using both operation techniques significantly influenced the variability of stepping parameters compared to the controls. In the early postoperative period a significant difference was detected between the two groups of the operated patients in all parameters. Conclusion: Our data prove that our method seems appropriate to provide objective measurement of the gait in the early postoperative period. The variability of motion of the patient groups approaches that of the healthy control group steadily, but does not reach them. © 2013 Springer-Verlag Berlin Heidelberg. Source


Reinisch W.,McMaster University | Reinisch W.,Medical University of Vienna | Panes J.,CIBER ISCIII | Khurana S.,Premier Medical Group | And 10 more authors.
Gut | Year: 2015

Objective Interleukin 13 (IL-13) is thought to play a key role as an effector cytokine in UC. Anrukinzumab, a humanised antibody that inhibits human IL-13, was evaluated for the treatment of UC. Design In a multicentre, randomised, double-blind, placebo-controlled study, patients with active UC (Mayo score ≥4 and <10) were randomised to anrukinzumab 200, 400 or 600 mg or placebo. Patients received five intravenous administrations over 14 weeks. The primary endpoint was fold change from baseline in faecal calprotectin (FC) at Week 14. Secondary endpoints included safety, pharmacokinetics and IL-13 levels. Results The modified intention-to-treat population included 84 patients (21 patients/arm). Fold change of FC from baseline at Week 14 was not significantly different for any treatment groups compared with the placebo. The study had a high dropout rate, in part, related to lack of efficacy. The exploratory comparisons of each dose were not significantly different from placebo in terms of change from baseline in total Mayo score, clinical response, clinical remission and proportion of subjects with mucosal healing. An increase in serum total IL-13 (free and bound to anrukinzumab) was observed for all anrukinzumab groups but not with placebo. This suggests significant binding of anrukinzumab to IL-13. The safety profile was not different between the anrukinzumab and placebo groups. Conclusions A statistically significant therapeutic effect of anrukinzumab could not be demonstrated in patients with active UC in spite of binding of anrukinzumab to IL-13. © 2015 BMJ Publishing Group Ltd & British Society of Gastroenterology. Source


Patocs B.,Semmelweis University | Nemeth K.,Semmelweis University | Garami M.,Semmelweis University | Arato G.,Szent Janos Hospital | And 3 more authors.
Cellular Oncology | Year: 2013

Purpose: The Ewing sarcoma family of tumors (EFT) is characterized by fusions of the EWSR1 gene on chromosome 22q12 with either one of the genes encoding members of the ETS family of transcription factors, in the majority of cases FLI1 or ERG. Many alternative EWSR1-ETS gene fusions have been encountered, due to variations in the locations of the EWSR1 and ETS genomic breakpoints. The resulting heterogeneity in EWSR1-ETS fusion transcripts may further be increased by the occurrence of multiple splice variants within the same tumor. Here we present a retrospective study designed to detect all of the EWSR1-FLI1 and EWSR1-ERG fusion transcripts in a series of 23 fresh frozen EFT tissues. Methods: RT-PCR and nested fluorescent multiplex PCR were used to amplify EWSR1-FLI1 and EWSR1-ERG transcripts from EFT tissues. Fusion transcripts were identified by laser-induced fluorescent capillary electrophoresis and confirmed by sequence analysis. Results: Nine different EWSR1-FLI1 fusion transcripts and one EWSR1-ERG fusion transcript were identified in 21 out of 23 fresh frozen EFT tissue samples. In five cases multiple fusion transcripts were found to coexist in the same tumor sample. We additionally reviewed previous reports on twelve cases with multiple EWSR1-ETS fusion transcripts. Conclusions: Alternative splicing may frequently affect the process of EFT-associated fusion gene transcription and, as such, may significantly contribute to the pathogenic role of EFT-associated chromosome translocations. In a considerable number of cases this may result in multiple splice variants within the same tumor. © 2013 International Society for Cellular Oncology. Source


Holnapy G.,Semmelweis University | Illyes A.,Szent Janos Hospital | Kiss R.M.,Budapest University of Technology and Economics
Journal of Electromyography and Kinesiology | Year: 2013

Introduction, objective: Gait analysis has provided important information about the variability of gait for patients prior to and after total hip arthroplasty (THA). The objective of this research was to clarify how the method of exposure in total hip arthroplasty affects the variability of gait. Materials and method: Gait analysis was performed at 0.8. m/s, 1.0. m/s, and 1.2. m/s on 25 patients with direct-lateral exposure (DL), 22 with antero-lateral exposure (AL) and 25 with posterior exposure (P) during total hip arthroplasty. The control group was represented by 45 healthy subjects of identical age. Gait analysis was performed pre-operatively and 3 and 6. months after the surgery. Gait parameter variability was characterized by the coefficient of variance (CV) of spatial-temporal parameters and by the mean coefficient of variance (MeanCV) of angular parameters. Results: The variability of gait tends to reach control values during the first 6. months of the postoperative period in all three patient groups. Six months after THA, in patients operated with DL and AL exposure the variability of gait differs significantly from control values; however, in patients operated with P exposure, the variability of spatial-temporal and angular parameters - except the rotation of pelvis - was similar to that of controls. Discussion, conclusion: The type of surgical technique significantly influences the variability of gait. Difference in the variability of angular parameters predicts gait instability and increased risk of falling after THA without the joint capsule preserved. Joint capsule preservation ensures a recovery of gait variability. It should be taken into account when compiling rehabilitation protocols. Differences related to the method of exposure should be considered when abandoning therapeutic aids. © 2013 Elsevier Ltd. Source

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