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Al-Kahraman Y.M.S.A.,University of Balochistan | Madkour H.M.F.,University of Balochistan | Madkour H.M.F.,Synthetic Organic Chemistry Laboratory | Ali D.,University of Balochistan | Yasinzai M.,University of Balochistan
Molecules | Year: 2010

A series of eighteen azomethines has been synthesized by the reaction of appropriate primary aromatic amines with aryl and/or heteroaryl carboxaldehydes. The synthesized azomethines have been evaluated for their in vitro antileishmanial, antibacterial and antifungal activities. The results revealed some antifungal activity of most of the synthesized compounds, whereas the antileishmaniasis activity results highlighted that all synthesized azomethines inhibited parasite growth and most of them showed highly potent action towards Leishmania major promastigotes. No remarkable bactericidal activities were observed. © 2010 by the authors.


Vece V.,Synthetic Organic Chemistry Laboratory | Vuocolo G.,Synthetic Organic Chemistry Laboratory
Tetrahedron | Year: 2015

Three novel coelenterazine derivatives substituted at the C-3 position were synthesized through a multicomponent strategy based on Groebke-Blackburn-Bienaymé reaction without using protecting groups. An efficient one-pot tert-butyl group cleavage from an aminoimidazopirazine and the first example of direct diazoimidazole derivative hydrogen abstraction in acidified water (traditional Sandmeyer hydroxylation conditions) were described. © 2015 Elsevier Ltd.


Mahmoud M.R.,Synthetic Organic Chemistry Laboratory | El-Ziaty A.K.,Synthetic Organic Chemistry Laboratory | Hussein A.M.,Synthetic Organic Chemistry Laboratory
Synthetic Communications | Year: 2013

Novel thiazolo [3,2-a]pyridine and thiazolo[3,2-a]pyrimidine derivatives, pyrazolo[3,4-b]pyrano[2,3-d]thiazole, and coumarin derivatives were synthesized from readily obtainable starting materials such as (Z)-2-ethoxycarbonyl methyl-5-(4-chlorobenzylidene)-2-thiazolidin-4(H)one 3 and (Z)-4-(4- hydroxybenzylidene)-2-imino-2-thiazolidin-4(H)one 11. © 2013 Copyright Taylor and Francis Group, LLC.

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