La Jolla, CA, United States
La Jolla, CA, United States

Synthetic Genomics is a company dedicated to using modified or synthetically produced microorganisms to produce the alternative fuels—ethanol and hydrogen. Synthetic Genomics was founded in part by J. Craig Venter. Venter's previous company, Celera Genomics, was a driving force in the race to sequence the Human Genome.The firm takes its name from the phrase synthetic genomics which is a scientific discipline of synthetic biology related to the generation of organisms artificially using genetic material. As of 2009, Synthetic Genomics is working to produce biofuels on an industrial-scale using recombinant algae and other microorganisms. They are receiving funding from companies like ExxonMobil for this venture.The company has purchased an 81 acre site in Southern California's Imperial valley where they intend to produce algae fuel. Wikipedia.


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Patent
Synthetic Genomics, Inc | Date: 2016-03-11

Recombinant microorganisms engineered for the production of polyunsaturated fatty acids (PUFAs) are provided. Also provided are biomass, microbial oils, and food products and ingredients produced by or comprising the microorganisms of the invention.


Patent
Synthetic Genomics, Inc | Date: 2016-02-23

Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.


Patent
Synthetic Genomics, Inc | Date: 2016-02-29

Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.


The present invention relates to methods of joining two or more double-stranded (ds) or single-stranded (ss) DNA molecules of interest in vitro, wherein the distal region of the first DNA molecule and the proximal region of the second DNA molecule of each pair share a region of sequence identity. The method allows the joining of a large number of DNA fragments, in a predetermined order and orientation, without the use of restriction enzymes. It can be used, e.g. to join synthetically produced sub-fragments of a gene or genome of interest. Kits for performing the method are also disclosed. The methods of joining DNA molecules may be used to generate combinatorial libraries useful to generate, for example, optimal protein expression through codon optimization, gene optimization, and pathway optimization.


Patent
Synthetic Genomics, Inc | Date: 2016-02-24

Methods and apparatus are disclosed herein for encoding human readable text conveying a non-genetic message into nucleic acid sequences with a substantially reduced probability of biological impact and decoding such text from nucleic acid sequences. In one embodiment, each symbol of a symbol set of human readable symbols uniquely maps to a respective codon identifier. Mapping may ensure that each symbol will not map to a codon identifier that generates an amino acid residue which has a single-letter abbreviation that is the equivalent to the respective symbol. Synthetic nucleic acid sequences comprising such human readable text, and recombinant or synthetic cells comprising such sequences are provided, as well as methods of identifying cells, organisms, or samples containing such sequences.


Patent
Synthetic Genomics, Inc | Date: 2016-02-29

The present disclosure generally relates to novel polynucleotide molecules for use in regulating gene expression in recombinant cells, such as labyrinthulomycetes cells. The disclosure further relates to nucleic acid constructs, such as vectors and expression cassettes, containing a regulatory element operably linked to a heterologous nucleotide sequence. The disclosure further relates to methods for stably transforming a host cell, such as a labyrinthulomycetes cell with transgenes. Stably transformed recombinant cells, progeny, biomaterials derived therefrom, and methods for preparing and using the same are also provided.


Patent
Synthetic Genomics, Inc | Date: 2016-01-25

Processes for extracting product molecules from an algae feed are provided. The algae feed represents an input stream, batch sample, or other algae portion suitable for use in product extraction. The product extraction is typically performed at pressures greater than ambient pressure. This allows for improved extraction, including the potential for use of extraction solvents at temperatures greater than the boiling point for the solvent.


Patent
Synthetic Genomics, Inc | Date: 2016-02-19

The present invention relates to the seminal discovery of a highly efficient method of transforming algal cells. Specifically, the invention relates to a novel method of delivering a plasmid containing a nucleic acid molecule to algal cells by bacterial conjugation wherein the plasmid remains episomal in the algal cell through multiple generations.


Patent
Synthetic Genomics, Inc | Date: 2016-04-15

Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutant strains have mutated chloroplastic SRP54 genes and exhibit increased productivity with respect to wild type strains. Also provided are mutant algal strains having mutated cytosolic SRP54 genes. Provided herein are methods of producing biomass and other products such as lipids using strains having mutations in an SRP54 gene. Also included are constructs and methods for attenuating or disrupting SRP54 genes.


Patent
Synthetic Genomics, Inc | Date: 2016-01-25

The present invention provides a protein material and food ingredient from a sustainable and stable source. The sustainable and stable source of the food or food ingredient is cellular biomass, for example an algal or microbial biomass. The invention discloses that the cellular biomass can be subjected to a series of steps to derive the protein material and food or food ingredient, which has high nutritional content and has pleasing organoleptic properties.

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