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Borgaonkar V.V.,Organic Synthesis Research Laboratory | Patil B.R.,Sharda Mahavidyalaya
Der Pharma Chemica

A series of novel bis-ketimines were synthesized by the reaction of substituted hydroxypropiophenones and ethylene diamine by classical and solvent free microwave irradiation method. All the synthesized compounds were characterized by IR, 1HNMR, Mass data. The spectral data confirmed the structures of the synthesized compounds. All the synthesized products are screened for their in vitro antibacterial activity. The results signified that synthesized compounds have moderate to potent activities with respect to their appropriate reference standards and emerges as a potent antibacterial agents. Source

Mohammat M.F.,Organic Synthesis Research Laboratory | Najim N.,Institute of Science | Mansor N.S.,Organic Synthesis Research Laboratory | Sarman S.,Institute of Science | And 3 more authors.

2-Aryl-4,5-dioxopyrrolidine-3-carboxylate and 5-aryl-2,4-dioxopyrrolidine- 3-carboxylate derivatives were successfully synthesized via carbonyl-based multiple component reaction and Dieckmann cyclization, respectively. Successive functional group transformations which include decarboxylation and hydrazonation afforded 2-oxo-5-aryl-3-hydrazone and 2-oxo-5-aryl-4-hydrazone derivatives. Compound 3d exhibited activity against human histiocytic lymphoma (U937) and neuroblastoma (SH-SY5Y) cell lines while compound 6 showed neuroprotective ability from oxidative stress medium induced with H2O2. Source

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