Palo Alto, CA, United States
Palo Alto, CA, United States

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Patent
Symphony | Date: 2012-07-03

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.


Patent
Symphony | Date: 2014-03-21

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.


Patent
Symphony | Date: 2015-09-04

The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include spectrum selective kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.


Patent
Symphony | Date: 2012-03-14

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.


Patent
Symphony | Date: 2015-01-14

A method for controlling the parallelism of first and second surfaces that define an optically resonant cavity is disclosed. The surfaces are separated by a first separation that is based on a support that holds the first surface relative to the second surface. The support comprises a first material and includes one or more regions in which the material stress of the first material is heat tuned to locally induce a stress gradient that results in a localized deformation. By controlling the locations and amounts of one or more localized deformation regions, the orientation of the first surface relative to the second surface is controlled.


The present invention provides a method and apparatus for separating rubber components and metal components of tread portions of road vehicle tyres. Each tread portion comprises a tread side and a back side, and the method comprising the steps: forming a chain of tread portions by connecting a plurality of tread portions in a longitudinal direction, said tread portions being connected such that the tread side of each tread portion faces in the same direction, such that the chain of tread portions comprises a tread side and a back side; causing the tread side of at least a part of the chain of tread portions to contact a curved surface; and directing at least one high-pressure jet against the back side of the part of the chain of tread portions contacting the curved surface, to cause separation of the rubber components from the metal components. In a preferred arrangement the at least one high-pressure jet is at least one ultra high-pressure water jet. An apparatus is provided to perform the method.


Patent
Symphony | Date: 2014-08-06

In an open environment, a consensus building means for maintaining dependability throughout the entire life cycle of a target system between stakeholders is provided, thereby appropriately operating the target system in accordance with the content of an agreement between the stakeholders. A consensus building support tool provides a support for consensus building through an argument regarding an ordinary operation state of a target system. History obtained in the process of the consensus building is recorded in a database layer as an agreement graph. A monitoring node tool detects deviation from the ordinary operation state of the target system based on an actual operation state of the target system and the agreement graph. A contract generating tool extracts information data regarding the consensus building from the agreement graph when the deviation from the ordinary operation state is detected in the target system.


Patent
Symphony | Date: 2013-10-22

The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include spectrum selective kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Innovation Voucher | Award Amount: 5.00K | Year: 2015

Supporting final design of a new British manufactured residential and commercial future proofed charging point that charges any electric vehicle whatever the type of cable used by the car manufacturer. Developed by SYMPHONY CARS LTD in Liverpool, it will complete a range of products by SYMPHONY that will enable the integrated delivery to businesses and the public of everything that the electric vehicle operator needs to get on the road and stay on the road.


To control cardiac arrhythmias such as atrial fibrillation post-operatively, a synthetic resorbable self-curing hydrogel material may be introduced as a non-ablative agent into one or more cardiac fat pads in proximity to the autonomic ganglia therein. Any desired technique may be used for introducing the agent, including injection. The sinoatrial nodal fat pad target site and the atrioventricular nodal fat pad target site are identified using a stimulator, which may have electrodes coupled thereto or which may be coupled to electrodes built into a delivery system.

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