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Palo Alto, CA, United States

Patent
Symphony | Date: 2015-01-14

A method for controlling the parallelism of first and second surfaces that define an optically resonant cavity is disclosed. The surfaces are separated by a first separation that is based on a support that holds the first surface relative to the second surface. The support comprises a first material and includes one or more regions in which the material stress of the first material is heat tuned to locally induce a stress gradient that results in a localized deformation. By controlling the locations and amounts of one or more localized deformation regions, the orientation of the first surface relative to the second surface is controlled.


Patent
Symphony | Date: 2013-10-22

The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i.e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include spectrum selective kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.


The present invention provides methods of treating aneurysmal dilatation, blood vessel wall weakness, and specifically abdominal aortic aneurysm and thoracic aneurysm by inhibiting MMPs and ADAM-10. Such compounds are useful in the in vitro study of the role of MMPs and ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more MMPs or ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of aneurysmal dilatation or blood vessel wall weakness, for example abdominal aortic aneurysm and thoracic aneurysm. The invention also comprises methods of treating aneurysmal dilatation or blood vessel wall weakness, for example abdominal aortic aneurysm and thoracic aneurysm utilizing the compounds of the invention in conjunction with inhibitors of angiotensin II, including angiotensin II receptor blockers and angiotensin converting enzyme inhibitors, and cyclophilin inhibitors.


Patent
Symphony | Date: 2012-11-13

In an open environment, a consensus building means for maintaining dependability throughout the entire life cycle of a target system between stakeholders is provided, thereby appropriately operating the target system in accordance with the content of an agreement between the stakeholders. A consensus building support tool provides a support for consensus building through an argument regarding an ordinary operation state of a target system. History obtained in the process of the consensus building is recorded in a database layer as an agreement graph. A monitoring node tool detects deviation from the ordinary operation state of the target system based on an actual operation state of the target system and the agreement graph. A contract generating tool extracts information data regarding the consensus building from the agreement graph when the deviation from the ordinary operation state is detected in the target system.


Patent
Symphony | Date: 2011-06-23

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.

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