Lyngby, Denmark
Lyngby, Denmark

Symphogen is a biotechnology company located in Copenhagen, Denmark that produces recombinant polyclonal antibody drugs for disease treatment and prevention. Their three main areas of therapeutic research are immunoglobulin replacement, cancer, and infectious diseases. The company was founded in 2000 and has patents on a drug discovery platform called Symplex and a drug manufacturing platform called Sympress. Currently, ten drugs are being developed with rozrolimupab being the lead product. Wikipedia.


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Patent
Symphogen | Date: 2017-04-19

The present invention is directed to improved therapeutics against receptors within the EGFR/ErbB/HER family that more broadly interfere with multiple members of the HER family (pan-HER inhibition). More particularly, the invention is directed to the use of antibody compositions for human cancer therapy. In vitro studies have shown that the antibody compositions of the invention targeting multiple HER family receptors are superior to antibody compositions targeting only one HER family receptor.


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Main Companies are Adaptimmune Therapeutics Plc, ADC Therapeutics Sar, Aduro BioTech Inc, Advaxis Inc, Advenchen Laboratories LLC , Almac Discovery Ltd, Amgen Inc , Aprea AB , ArQule Inc , Array BioPharma Inc , Aslan Pharmaceuticals Pte Ltd , ATLAB Pharma SAS , Bayer AG , BeiGene Ltd , Beta Pharma Inc , Boehringer Ingelheim GmbH , Bristol-Myers Squibb Company , CBT Pharmaceuticals Inc , Celgene Corp , Celldex Therapeutics Inc, Cellectar Biosciences Inc, CellSeed Inc , Clovis Oncology Inc , Cyclacel Pharmaceuticals Inc , Eli Lilly and Company , F. Hoffmann-La Roche Ltd , Genmab A/S , GlaxoSmithKline Plc, Glycotope GmbH , Hutchison China MediTech Ltd , Ignyta Inc , Immunocore Ltd, ImmunoFrontier Inc , Immunomedics Inc , Intezyne Technologies Inc , Jiangsu Hengrui Medicine Co Ltd , Johnson & Johnson , Komipharm International Co Ltd , Leap Therapeutics Inc , MaxiVAX SA , Mebiopharm Co Ltd , MedImmune LLC , Merck & Co Inc , Novartis AG , Omeros Corp , Oncolys BioPharma Inc , OncoMed Pharmaceuticals Inc , Ono Pharmaceutical Co Ltd , Puma Biotechnology Inc, Rhizen Pharmaceuticals SA , Shionogi & Co Ltd , Spectrum Pharmaceuticals Inc , Stelic Institute & Co Inc , Supratek Pharma Inc 63, Symphogen A/S 63, Taiho Pharmaceutical Co Ltd 64, Taiwan Liposome Company Ltd 64, Takara Bio Inc 65, Transgene Biotek Ltd 65, VioQuest Pharmaceuticals Inc 66, XuanZhu Pharma Co Ltd. Place Order to This Report at http://www.reportsnreports.com/purchase.aspx?name=992867. Esophageal cancer is cancer that occurs in the esophagus. 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Our database includes 500,000+ market research reports from over 95 leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the For more information, please visit http://www.reportsnreports.com/reports/992867-esophageal-cancer-pipeline-review-h1-2017.html


Patent
Symphogen | Date: 2016-11-28

The present invention is directed to improved therapeutics against receptors within the EGFR/ErbB/HER family that more broadly interfere with multiple members of the HER family (pan-HER inhibition). More particularly, the invention is directed to the use of antibody compositions for human cancer therapy. In vitro studies have shown that the antibody compositions of the invention targeting multiple HER family receptors are superior to antibody compositions targeting only one HER family receptor.


Tebbutt N.,Ludwig Oncology Unit | Pedersen M.W.,Symphogen | Johns T.G.,Monash Institute of Medical Research
Nature Reviews Cancer | Year: 2013

The ERBB family of receptor tyrosine kinases has a central role in the tumorigenesis of many types of solid tumour. Various therapeutics targeting these receptors have been approved for the treatment of several cancers. Considerable preclinical data have shown that the administration of two inhibitors against an individual ERBB family member-particularly epidermal growth factor receptor (EGFR) or ERBB2-leads to markedly higher antitumour activity than the administration of single agents. This Opinion article describes the preclinical and clinical performance of these dual-targeting approaches, discusses the key mechanisms that mediate their increased efficacy and highlights areas for ongoing investigation. © 2013 Macmillan Publishers Limited. All rights reserved.


The invention relates to a method for manufacturing an anti-RhD recombinant polyclonal antibody composition (anti-RhD rpAb). The method comprises obtaining a collection of cells transfected with a library of anti-RhD antibody expression vectors, wherein each cell in the collection is capable of expressing from a VH and VL comprising nucleic acid segment, one member of the library, which encodes a distinct member of anti-RhD recombinant polyclonal antibody composition and is located at the same site in the genome of individual cells in said collection. The cells are cultured under suitable conditions for expression of the recombinant polyclonal antibody, which is obtained from the cells or culture supernatant. Nucleic acid segments encoding the anti-RhD rpAb are introduced into the cells by transfection with a library of vectors for site-specific integration. The method is suitable for manufacturing anti-RhD rpAb, thereby making available a superior replacement of plasma-derived prophylactic and therapeutic immunoglobulin products.


Patent
Symphogen | Date: 2013-05-02

The invention relates to humanized recombinant antibodies targeting the EGFR family receptors EGFR, HER2 and HER3, compositions comprising at least one humanized anti-EGFR antibody, at least one humanized anti-HER2 antibody and at least one humanized anti-HER3 antibody, and use of the antibody compositions for treatment of cancer. The invention also relates to the use of antibodies targeting multiple EGFR-family receptors to treat cancer (e.g., pancreatic cancer) and cancer that has acquired resistance to previous therapies.

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