Syft Technologies Ltd.

Christchurch, New Zealand

Syft Technologies Ltd.

Christchurch, New Zealand
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Storer M.K.,SYFT Technologies Ltd | Hibbard-Melles K.,Christchurch Polytechnic Institute of Technology | Davis B.,SYFT Technologies Ltd | Scotter J.,SYFT Technologies Ltd
Journal of Microbiological Methods | Year: 2011

Selected ion flow tube-mass spectrometry has been used to measure the volatile compounds occurring in the headspace of urine samples inoculated with common urinary tract infection (UTI)-causing microbes Escherichia coli, Proteus vulgaris, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, Enterococcus faecalis, or Candida albicans. This technique has the potential to offer rapid and simple diagnosis of the causative agent of UTIs. © 2011 Elsevier B.V.

Langford V.,Syft Technologies Ltd. | Gray J.,Syft Technologies Ltd. | Foulkes B.,Quintessence Developments Ltd. | Bray P.,Airborne | And 2 more authors.
Journal of Agricultural and Food Chemistry | Year: 2012

Honeys have a range of physicochemical and organoleptic properties, depending on the nectar source. Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) is an emerging technology that quantifies volatile organic compounds (VOCs) to low concentrations (usually parts-per-trillion (ppt) levels) and is here applied to monitor the aromas in the headspace of different New Zealand monofloral honeys. Honey aromas arise from VOCs in the honeys that differ according to the flower type from which they were derived. In this exploratory study, the headspaces of nine monofloral New Zealand honeys (beech honeydew, clover, kamahi, manuka, rata, rewarewa, tawari, thyme, and vipers bugloss) were analyzed using SIFT-MS without sample preparation. The purpose of the investigation was to identify the major volatiles in each of the honeys and to test the feasibility of using SIFT-MS to distinguish between New Zealand monofloral honeys. In the nine monofloral honeys sampled, a clear distinction was observed between them based on their aroma signatures. © 2012 American Chemical Society.

Langford V.S.,Syft Technologies Ltd | Graves I.,New Hill | McEwan M.J.,Syft Technologies Ltd | McEwan M.J.,University of Canterbury
Rapid Communications in Mass Spectrometry | Year: 2014

Rationale The gold standard for monitoring volatile organic compounds (VOCs) is gas chromatography/mass spectrometry (GC/MS). However, in many situations, when VOC concentrations are at the ppmv level, there are complicating factors for GC/MS. Selected ion flow tube mass spectrometry (SIFT-MS) is an emerging technique for monitoring VOCs in air. It is simpler to use and provides results in real time. Methods Three different experiments were used for the comparison. First SIFT-MS was applied to monitor the concentrations of 25 VOCs in a mixture at concentrations up to 1 ppmv using only a generic database for known kinetic data of three reagent ions (H3O +, NO+ and O2 +) with each VOC. In experiment 2, a side-by-side comparison was made of 17 VOCs at concentrations between 1 ppmv and 5 ppbv after small corrections had been made to the SIFT-MS kinetic data. In a third experiment, a side-by-side comparison examined two groups of samples received for commercial analysis. Results In experiment 1, 85% of the VOC concentrations were within 35% of their stated values without any calibration of the SIFT-MS instrument. In experiment 2, the two techniques yielded good correspondence between the measured VOC concentrations. In experiment 3, good correlation was found for VOCs from three of the samples. However, interferences from some product ions gave over-reported values in one sample from the SIFT-MS instrument. Conclusions These three experiments showed that GC/MS was better suited to monitoring samples containing large numbers of VOCs at high concentrations. In all other applications, SIFT-MS proved simpler to use, was linear with concentration over a much wider concentration range than GC/MS and provided faster Results. Copyright © 2013 John Wiley & Sons, Ltd. Copyright © 2013 John Wiley & Sons, Ltd.

Prince B.J.,Syft Technologies Ltd. | Milligan D.B.,Syft Technologies Ltd. | McEwan M.J.,Syft Technologies Ltd. | McEwan M.J.,University of Canterbury
Rapid Communications in Mass Spectrometry | Year: 2010

Data are presented for real-time atmospheric monitoring of volatile organic chemicals (VOCs) in air using selected ion flow tube mass spectrometry (SIFT-MS) technology. These measurements were made by one of the new generation of SIFT-MS instruments. Results are shown for five VOCs that were continually monitored from a stationary sampling point over a 4-day period: ethene, ethanol, 1,3-butadiene, benzene and toluene. All analytes except ethene in the study have at least two simultaneous and independent measures of concentration. These results demonstrate the great advances in SIFT-MS that have been made in recent years. 1,3-Butadiene is measured at a concentration of 9 pptv with a precision of 44%. For a 1-s integration time, a detection limit of 50 pptv is achieved. Instrument sensitivities are reported for all five analytes. © 2010 John Wiley & Sons, Ltd.

Sturney S.C.,Christchurch Hospital | Storer M.K.,Syft Technologies Ltd | Shaw G.M.,Christchurch Hospital | Shaw D.E.,Nottingham City Hospital | Epton M.J.,Christchurch Hospital
Journal of Breath Research | Year: 2013

Analysis of breath acetone could be useful in the Intensive Care Unit (ICU) setting to monitor evidence of starvation and metabolic stress. The aims of this study were to examine the relationship between acetone concentrations in breath and blood in critical illness, to explore any changes in breath acetone concentration over time and correlate these with clinical features. Consecutive patients, ventilated on controlled modes in a mixed ICU, with stress hyperglycaemia requiring insulin therapy and/or new pulmonary infiltrates on chest radiograph were recruited. Once daily, triplicate end-tidal breath samples were collected and analysed off-line by selected ion flow tube mass spectrometry (SIFT-MS). Thirty-two patients were recruited (20 males), median age 61.5 years (range 26-85 years). The median breath acetone concentration of all samples was 853 ppb (range 162-11 375 ppb) collected over a median of 3 days (range 1-8). There was a trend towards a reduction in breath acetone concentration over time. Relationships were seen between breath acetone and arterial acetone (rs = 0.64, p < 0.0001) and arterial beta-hydroxybutyrate (rs = 0.52, p < 0.0001) concentrations. Changes in breath acetone concentration over time corresponded to changes in arterial acetone concentration. Some patients remained ketotic despite insulin therapy and normal arterial glucose concentrations. This is the first study to look at breath acetone concentration in ICU patients for up to 8 days. Breath acetone concentration may be used as a surrogate for arterial acetone concentration, which may in future have a role in the modulation of insulin and feeding in critical illness. © 2013 IOP Publishing Ltd.

Dummer J.,Christchurch Hospital | Storer M.,Syft Technologies Ltd | Sturney S.,Christchurch Hospital | Scott-Thomas A.,University of Otago | And 3 more authors.
Journal of Breath Research | Year: 2013

Hydrogen cyanide (HCN) in exhaled breath has been proposed as a biomarker for airway inflammation, and also a marker of the presence in the airways of specific organisms, especially Pseudomonas aeruginosa. However the production of HCN by salivary peroxidase in the oral cavity increases orally exhaled concentrations, and may not reflect the condition of the lower airways. Using SIFT-MS we aimed to determine an appropriate single-exhalation breathing maneuver which avoids the interference of HCN produced in the oral cavity. We have established that the SIFT-MS Voice200™ is suitable for the online measurement of HCN in exhaled breath. In healthy volunteers a significantly higher end exhaled HCN concentration was measured in oral exhalations compared to nasal exhalations (mean ± SD) 4.5 ± 0.6 ppb versus 2.4 ± 0.3 ppb, p < 0.01. For the accurate and reproducible quantification of end exhaled HCN in breath a nasal inhalation to full vital capacity and nasal exhalation at controlled flow is recommended. This technique was subsequently used to measure exhaled HCN in a group of patients with chronic suppurative lung disease (CSLD) and known microbiological colonization status to determine utility of HCN measurement to detect P. aeruginosa. Median nasal end exhaled HCN concentrations were higher in patients with CSLD (3.7 ppb) than normal subjects (2.0 ppb). However no differences between exhaled HCN concentrations of subjects colonized with P. aeruginosa and other organisms were identified, indicating that breath HCN is not a suitable biomarker of P. aeruginosa colonization. © 2013 IOP Publishing Ltd.

Langford V.S.,Syft Technologies Ltd. | Gray J.D.C.,Syft Technologies Ltd. | McEwan M.J.,Syft Technologies Ltd. | McEwan M.J.,University of Canterbury
Rapid Communications in Mass Spectrometry | Year: 2013

RATIONALE People are using increasing amounts of siloxanes that ultimately end up in landfills and then in landfill gas and biogas digesters. Their presence poses difficulties for industries seeking to utilize the energy content of landfill and biogas, as the combustion process oxidises silicon to silicon dioxide that in turn damages engine parts. Rapid, efficient and accurate methods are needed to quantify their presence. METHODS Selected ion flow tube mass spectrometry (SIFTMS) is an emerging real-time technique that has found application for monitoring trace volatiles in air. Samples containing the trace volatiles are simply drawn into the flow tube and convected in a stream of helium. Chemical ionization reactions from mass-selected reagent ions with the volatiles ensue. To quantify the volatiles in the sample, the ion chemistry of the reagent ion with each volatile must be known. RESULTS Rate coefficients and product ion branching ratios were found for the compounds dodecamethylpentasiloxane, decamethylcyclopentasiloxane, decamethyltetrasiloxane, octamethylcyclotetrasiloxane, triethylsilanol, tetramethylsilane and hexamethyldisilazane. CONCLUSIONS The ion-molecule reactions of the seven silicon-containing compounds examined here were fast, occurring at or near the collision rate, thus allowing for detection at low levels. The very simple reaction chemistry found of proton transfer, electron transfer and methyl loss will enable easy quantitation of the siloxanes in landfill gas and biogas using the SIFTMS technique. Copyright © 2013 John Wiley & Sons, Ltd.

Storer M.K.,Syft Technologies Ltd. | Dummer J.D.,University of Otago | Dummer J.D.,Christchurch Hospital | Cook J.,Christchurch Hospital | And 2 more authors.
Journal of Breath Research | Year: 2011

The haloamines, including the chloramines (H2NCl, HNCl 2) and bromamine (H2NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath. Although haloamines are quite reactive, it is possible to measure these compounds in humid samples using SIFT-MS. Until recently the quantification of haloamines in breath suffered from interference from other common breath compounds. This was overcome by heating the flow tube which removed major water cluster product ions. Despite the improvements to the method, previous attempts to measure the haloamines in breath samples from normal volunteers had found no evidence to support their presence. Since it is proposed that the haloamines may be present in higher concentrations during airways inflammation we have attempted to detect the compounds in the exhaled breath of patients with airways inflammatory conditions. On-line and off-line breath samples were analyzed; however, there was no discernable change to any of product ions when compared to ambient air or normal subjects. This suggests that despite sensitivity in the mid part per trillion range haloamines are not significantly raised in airways inflammation. © 2011 IOP Publishing Ltd.

Dummer J.,Christchurch Hospital | Dummer J.,University of Otago | Storer M.,Syft Technologies Ltd | Swanney M.,Christchurch Hospital | And 6 more authors.
TrAC - Trends in Analytical Chemistry | Year: 2011

The analysis of volatile biomarkers of disease in breath is attractive because breath analysis is non-invasive and quick, and allows for repeated sampling. Challenges faced in the development of breath analysis include developing techniques that can measure analytes at very low concentrations, gaining an understanding of the exhalation physiology of individual volatiles, and determining the relationship between the proposed biomarker and the underlying condition. A small number of breath tests are used in clinical practice, but there is great potential for the development and wider application of clinical breath analysis in infection, inflammation, cancer and metabolic disease. © 2011 Elsevier Ltd.

Endre Z.H.,University of Otago | Endre Z.H.,Canterbury District Health Board | Pickering J.W.,University of Otago | Storer M.K.,Syft Technologies Ltd. | And 6 more authors.
Physiological Measurement | Year: 2011

Non-invasive monitoring of breath ammonia and trimethylamine using Selected-ion-flow-tube mass spectroscopy (SIFT-MS) could provide a real-time alternative to current invasive techniques. Breath ammonia and trimethylamine were monitored by SIFT-MS before, during and after haemodialysis in 20 patients. In 15 patients (41 sessions), breath was collected hourly into Tedlar bags and analysed immediately (group A). During multiple dialyses over 8 days, five patients breathed directly into the SIFT-MS analyser every 30 min (group B). Pre-and post-dialysis direct breath concentrations were compared with urea reduction, Kt/V and creatinine concentrations. Dialysis decreased breath ammonia, but a transient increase occurred mid treatment in some patients. Trimethylamine decreased more rapidly than reported previously. Pre-dialysis breath ammonia correlated with pre-dialysis urea in group B (r2 = 0.71) and with change in urea (group A, r2 = 0.24; group B, r 2 = 0.74). In group B, ammonia correlated with change in creatinine (r2 = 0.35), weight (r2 = 0.52) and Kt/V (r2 = 0.30). The ammonia reduction ratio correlated with the urea reduction ratio (URR) (r2 = 0.42) and Kt/V (r2 = 0.38). Pre-dialysis trimethylamine correlated with Kt/V (r2 = 0.21), and the trimethylamine reduction ratio with URR (r2 = 0.49) and Kt/V (r 2 = 0.36). Real-time breath analysis revealed previously unmeasurable differences in clearance kinetics of ammonia and trimethylamine. Breath ammonia is potentially useful in assessment of dialysis efficacy. © 2011 Institute of Physics and Engineering in Medicine Printed in the UK.

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