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Ann Arbor, MI, United States

Erba H.P.,University of Michigan | Othus M.,Statistical Center | Walter R.B.,SWOG Headquarters | Walter R.B.,Fred Hutchinson Cancer Research Center | And 13 more authors.
Leukemia Research | Year: 2014

We report on 348 patients. ≥. 70 years (median age 78 years) with acute myeloid leukemia (>50% with secondary AML) randomized to receive either 600. mg or 300. mg of tipifarnib orally twice daily on days 1-21 or days 1-7 and 15-21, repeated every 28 days (4 treatment regimens). Responses were seen in all regimens, with overall response rate (CR. +. CRi. +. PR) highest (20%) among patients receiving tipifarnib 300. mg twice daily on days 1-21. Toxicities were acceptable. Unless predictors of response to tipifarnib are identified, further study as a single agent in this population is unwarranted. © 2013 Elsevier Ltd. Source

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