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Boddupalli B.M.,Osmania University | Anisetti R.N.,Osmania University | Ramani R.,Osmania University | Malothu N.,Swami Ramananda Tirtha Institute of Pharmaceutical science
Asian Pacific Journal of Tropical Disease

Objective: To investigate the formulation of gastroretentive microspheres of omeprazole along with piperine and estimate the pharmacokinetic parameters in comparison with omeprazole alone. Methods: In our present investigation, gastroretentive microspheres of omeprazole were prepared with the inclusion of piperine. Pharmacokinetic parameters like Cmax, Tmax and area under curve were estimated by administering the prepared microspheres to rabbits and the results were compared with omeprazole alone. Results: There was a significant increase in area under curve from 3.441±1.093 mg·h/mL to 14.422±0.708 mg·h/mL along with an increase in Cmax. Conclusions: This clearly shows the increased absorption and decreased metabolism of omeprazole when administered along with piperine as gastroretentive microspheres. © 2014 Asian Pacific Tropical Medicine Press. Source

Kantilal P.V.,Alembic Pharmaceuticals Ltd | Shabbeer S.,Swami Ramananda Tirtha Institute of Pharmaceutical science
International Journal of Pharmacy and Technology

Indomethacin, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1 H -indole-3-acetic acid is a non-steroidal antiinflammatory drug used in the treatment of rheumatoid arthritics, ankolysing spondylitis, oesteo arthritis and acute gout and it is poorly soluble in water and aqueous fluids and its absorption is dissolution rate limited. Further indomethacin has a side effect like dizziness, rash, nausea, abdominal pain etc. The prolonged contact of indomethacin with the gastric mucosa causes severe gastric ulceration and bleeding. Hence the aim of present work to prepare and evaluation of sustained release microcapsules to release drug for prolong time to maintain a constant plasma concentration and reduce gastric irritation in stomach. The solvent-evaporation method was used first for its simplicity. This method had been developed for lipophilic drug. Encapsulation of hydrophilic drugs also possible if the method of preparation is slightly adapted to reduce the diffusion of the drug in the continuous phase. In solvent evaporation technique first preparation of solid dispersions by common solvent, these micronised the drug at molecule and adhere to the surface of hydrophilic drug carriers. This method enhances the solubility and bioavailability of indomethacin. Once a solid dispersion was prepared it coated with ethylcellulose for sustained release in small intestine. The half-life of indomethacin is also short (4.5 hrs) which makes it suitable candidate for sustained release formulation, moreover it reducing side effects, decreasing dosing frequency and improve patient compliance. In the present work has been made to prepare indomethacin microcapsules by emulsion solvent evaporation technique by using PVP, MCC, pectin and ethylcellulose and were evaluated by using various evaluation studies. Digital photography was used for morphological observation. The micromeritics data showed that there was showed good flow ability in term of angle of repose, bulk density and porosity. Size distribution by sieve analysis and microscopic method showed not much significant difference in formulations F 1, F 2, F 3 and F 4, while formulations F 5 having small particle size than remaining formulation. The compatibility studies were done by FT IR spectroscopy and DSC analysis. Both the studies imply that there was no interaction between drug and polymers and they are compatible with each other. In vitro studies showed that F 1, F 2, F 3 and F 5 were able to release the drug up to 18 hrs, but only formulation F 4 followed the release up to 24 hrs, and follows the first order release kinetics. Furthermore the result of formulation F 6, F 7 shows the release rate up to 6 hours only witch was prepared by solid dispersion method, that the microencapsulation by Emulsion solvent evaporation technique was superior to simple solid dispersion method. Source

Ramani R.,Swami Ramananda Tirtha Institute of Pharmaceutical science | Boddupalli B.M.,Swami Ramananda Tirtha Institute of Pharmaceutical science | Miryala R.,Swami Ramananda Tirtha Institute of Pharmaceutical science | Anisetti R.N.,Osmania University | And 2 more authors.
International Journal of Phytomedicine

Leucas aspera (LA) is a plant that has been used in folk medicine to treat asthma, fever, skin diseases and has several pharmacological activities. The antiepileptic property of LA was not yet been studied. Aim: The present study was aimed to investigate the antiepileptic activity of ethanolic extract obtained from leaves of LA on pentylenetetrazol (PTZ) kindling seizures in mice. Method: The ethanolic extract 200mg/kg and 400mg/kg were evaluated for the antiepileptic activity against PTZ (40mg/kg IP) induced seizure method. Diazepam was used as the standard drug. Antiepileptic activity was evaluated by observing seizure intensity, motor coordination, depression and oxidative stress by malondialdehyde (MDA) content. Results: Treatment with extract was found to be in dose dependant manner with significant prolonged onset time, decreased duration and intensity of seizure when compared with vehicle treated group. Extract has even protected the animal from loss of motor coordination and depression. Conclusion: From the results of present study it can be concluded that, the ethanolic extract of leaves of LA protected the animals from seizure effect induced by PTZ and attenuated the oxidative stress induced by PTZ without producing loss of motor coordination and depression. © 2014, Advanced Research Journals. All rights reserved. Source

Hari Prasad P.,Swami Ramananda Tirtha Institute of Pharmaceutical science | Patel P.M.,Swami Ramananda Tirtha Institute of Pharmaceutical science | Vijaysree D.,Swami Ramananda Tirtha Institute of Pharmaceutical science | Suresh Reddy Y.,Swami Ramananda Tirtha Institute of Pharmaceutical science | Ranjith kumar B.,Swami Ramananda Tirtha Institute of Pharmaceutical science
Der Pharma Chemica

A simple, rapid and accurate reverse phase-high performance liquid chromatographic method for the simultaneous determination of Metoprolol Tartrate and Chlorthalidone in tablet dosage form is developed and validated. The chromatographic analysis was performed on a C 18column grace smart RP18 (250×4.6 mm, 5 μm) in isocratic mode, the mobile phase consisted of methanol, acetonitrile and 0.05 M phosphate buffer (adjusted topH 4.5 with ortho-phosphoric acid) at a ratio of 60:20:20 v/v/v, and a flow rate of 1.0 mL/min and ASPD detector is used. The eluents were monitored at 254 nm. The retention time of lamivudine and stavudine were found to be 2.50 min and 4.25 min, respectively. The linear ranges were found to be 10-602 2 μg/mL (r =0.9992) for lamivudine and 10-60 μg/mL (r =0.999) for stavudine. The proposed method is also found to be accurate, precise androbust. The method could be applied to routine quality control of pharmaceutical formulations containing Metoprolol Tartrate and Chlorthalidone. Source

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