Swami Ramanand Teerth Marathwada University

Nanded, India

Swami Ramanand Teerth Marathwada University was established in 1994. Named after Swami Ramanand Teerth, it is located at Nanded in Maharashtra, India. The university is intended to serve primarily the southern part of Marathwada, specifically the districts of Nanded, Latur, Parbhani, and Hingoli. The main university campus, which is about 10 km south of Nanded township, occupies approximately 525 acres , and there is a 22-acre sub-campus at Latur. Wikipedia.

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Deosarkar S.D.,Swami Ramanand Teerth Marathwada University
Russian Journal of Physical Chemistry A | Year: 2012

The density, viscosity and ultrasonic velocity of some substituted pyrazoles viz. 5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4-benzoylpyrazol, 5-(2-hydroxyphenyl)-3-(3-nitrophenyl)-4-(3-pyridinoyl)-pyrazol, 5-(2-hydroxyphenyl)-3-(3-nitrophenyl)-4-benzoylpyrazol and 5-(2-hydroxyphenyl)- 3-phenyl-4-(3-pyridinoyl)-pyrazole have been measured in 70: 30 (vol/vol) acetone-water mixture at 298, 303, 308, and 313 K for 0.01 mol dm -3 concentration of pyrazoles. The acoustical parameters such as adiabatic compressibility (β s), relative association (R A), specific acoustic impedance (Z), apparent molar volume (φ v), apparent molar adiabatic compressibility (φ K), and intermolecular free length (L f) were calculated from the experimental densities and velocities. The changes in acoustical properties have been used to interpret the molecular interactions in solutions. The activation energies of viscous flow of pyrazole solutions were determined from the data of viscosity at different temperature. © 2012 Pleiades Publishing, Ltd.

Deosarkar S.D.,Swami Ramanand Teerth Marathwada University | Kalyankar T.M.,Swami Ramanand Teerth Marathwada University
Russian Journal of Physical Chemistry A | Year: 2013

Density, viscosity and refractive index of aqueous solutions of metoprolol succinate of different concentrations (0.005-0.05 mol dm-3) were measured at 38 C. Apparent molar volume of resultant solutions were calculated and fitted to the Masson's equation and apparent molar volume at infinite dilution was determined graphically. Viscosity data of solutions has been fitted to the Jone-Dole equation and viscosity A- and B-coefficients were determined graphically. Physicochemical data obtained were discussed in terms of molecular interactions. © 2013 Pleiades Publishing, Ltd.

Chaudhari A.,Swami Ramanand Teerth Marathwada University
International Journal of Quantum Chemistry | Year: 2010

This work reports an interaction of 1,4-dioxane with one, two, and three water molecules using the density functional theory method at B3LYP/6- 311++G * level. Different conformers were studied and the most stable conformer of 1,4-dioxane-(water)n (n = 1-3) complex has total energies -384.1964038, -460.6570694, and -537.1032381 hartrees with one, two, and three water molecules, respectively. Corresponding binding energy (BE) for these three most stable structures is 6.23, 16.73, and 18.11 kcal/mol. The hydrogen bonding results in red shift in O-O stretching and C-C stretching modes of 1,4-dioxane for the most stable conformer of 1,4-dioxane with one, two, and three water molecules whereas there was a blue shift in C-O symmetric stretching and C-O asymmetric stretching modes of 1,4-dioxane. The hydrogen bonding results in large red shift in bending mode of water and large blue shift in symmetric stretching and asymmetric stretching mode of water. © 2009 Wiley Periodicals, Inc.

Gacche R.N.,Swami Ramanand Teerth Marathwada University
Oncogenesis | Year: 2015

Since the establishment of tumor angiogenesis as a therapeutic target, an excitement in developing the anti-angiogenic agents was resulted in tailoring a humanized monoclonal antibody (Bevacizumab) against vascular endothelial growth factor (VEGF): a key factor in recruiting angiogenesis. The past three decades' research in the area of angiogenesis also invented a series of novel and effective anti-angiogenic agents targeting the VEGF signaling axis. Despite the demonstrable clinical benefits of anti-angiogenic therapy, the preclinical and clinical data of the current therapeutic settings clearly indicate the transient efficacy, restoration of tumor progression and aggressive recurrence of tumor invasion after the withdrawal of anti-angiogenic therapy. Therefore, the impact of this therapeutic regime on improving overall survival of patients has been disappointing in clinic. The recent advances in pathophysiology of tumor angiogenesis and related molecular and cellular underpinnings attributed the conspiracy of compensatory angiogenic pathways in conferring evasive and intrinsic tumor resistance to anti-angiogenic agents. The understandings of how these pathways functionally cross-talk for sustaining tumor angiogenesis during VEGF blockade is essential and perhaps may act as a basic prerequisite for designing novel therapeutic strategies to combat the growing arrogance of tumors toward anti-angiogenic agents. The present review offers a discourse on major compensatory angiogenic pathways operating at cellular and molecular levels and their attributes with resistance to anti-angiogenic agents along with strategic opinions on future setting in targeting tumor angiogenesis.

Gacche R.N.,Swami Ramanand Teerth Marathwada University | Dhole N.A.,Swami Ramanand Teerth Marathwada University
Food and Chemical Toxicology | Year: 2011

Phytotherapy has played an important role in the management of diabetes and related complications. In the present study different fractions of Catharanthus roseus L. (Apocynaceae), Ocimum sanctum L. (Labiatae), Tinospora cordifolia Willd. (Menispermaceae), Aegle marmelos L. (Rutaceae), Ficus golmerata L. (Moraceae), Psoralea corlifolia L. (Fabaceae), Tribulus terrestris L. (Zygophyllaceae), and Morinda cetrifolia L. (Rubiaceae) were evaluated as possible inhibitors of aldose reductase (AR: a key enzyme implicated in cataractogenesis) and antioxidant agents. Anti-cataract activity of the selected plants was demonstrated using 'sugar induced lens opacity model' and the cytotoxicity studies were carried out using MTT assay. Among the tested plants, water extract of M. cetrifolia (IC50 0.132. mg/ml) exhibited maximum AR inhibitory activity as compared to other phytofractions which showed the activity in an IC50 range of 0.176-0.0.82. mg/ml. All the plant fractions showed considerable antioxidant potential. Sugar induced lens opacity studies revealed that, M. cetrifolia possess significant anti-cataract potential to maintain lens opacity as compared to glucose induced lens opacity in bovine lens model. The extract of the selected plants showed moderate cytotoxicity against HeLa cell line. Results of the present studies may find useful in converting botanicals into therapeutic modalities. © 2011 Elsevier Ltd.

Joshi Y.S.,Lal Bahadur Shastri Mahavidyalaya | Kumbharkhane A.C.,Swami Ramanand Teerth Marathwada University
Fluid Phase Equilibria | Year: 2012

The complex permittivity of 2-butoxyethanol (BE)-water mixtures over entire concentrations has been measured as a function of frequency from 10MHz to 30GHz. All spectra were fitted using Cole-Davidson (CD) relaxation spectral function which gives an asymmetric distribution of relaxation times. As composition of butoxyethanol in water increases the width of distribution function broadens. By using least squares fit method the dielectric parameters such as static dielectric constant (e{open} 0), dielectric constant at high frequency (e{open} ∞), relaxation time (τ) and relaxation distribution parameter (β) were extracted from complex permittivity spectra at temperature range from 25°C to 0°C. The heterogeneous interaction in unlike molecules and intramolecular interaction in same molecules has been discussed using the excess dielectric properties, Kirkwood correlation factor, thermodynamic properties and Bruggeman factor. © 2012 Elsevier B.V.

Gacche R.N.,Swami Ramanand Teerth Marathwada University | Meshram R.J.,Swami Ramanand Teerth Marathwada University
Biochimica et Biophysica Acta - Reviews on Cancer | Year: 2014

Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic prerequisite for sustainable growth and proliferation of tumor. Several growth factors, cytokines, small peptides and enzymes support tumor growth either independently or in synergy. Decoding the crucial mechanisms of angiogenesis in physiological and pathological state has remained a subject of intense interest during the past three decades. Currently, the most widely preferred approach for arresting tumor angiogenesis is the blockade of vascular endothelial growth factor (VEGF) pathway; however, the clinical usage of this modality is still limited by several factors such as adverse effects, toxicity, acquired drug resistance, and non-availability of valid biomarkers. Nevertheless, angiogenesis, being a normal physiological process imposes limitations in maneuvering it as therapeutic target for tumor angiogenesis. The present review offers an updated relevant literature describing the role of well-characterized angiogenic factors, such as VEGF, basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), placenta growth factor (PLGF), hepatocyte growth factor/scatter factor (HGF/SF) and angiopoetins (ANGs) in regulating tumor angiogenesis. We have also attempted to discuss tumor angiogenesis with a perspective of 'an attractive target with emerging challenges', along with the limitations and present status of anti-angiogenic therapy in the current state-of-the-art. © 2014 Elsevier B.V.

Ige P.P.,Rc Patel Institute Of Pharmaceutical Education And Research | Baria R.K.,Rc Patel Institute Of Pharmaceutical Education And Research | Gattani S.G.,Swami Ramanand Teerth Marathwada University
Colloids and Surfaces B: Biointerfaces | Year: 2013

Fenofibrate (FBT) is lipophillic drug used in hypercholesterolemia and hypertriglyceridemia having log. P 5.375, low solubility (practically insoluble in water) and low oral bioavailability (36%). The purpose of work was to develop FBT nanocrystals for the enhancement of solubility and oral bioavailability. Fenofibrate nanosuspension was prepared using probe sonicator and transformed into dry powder using freeze drying and characterized by DSC, FTIR, XRPD, SEM, particle size, polydispersity index (PDI), zeta potential, solubility, in vitro dissolution, in vivo bioavailability and stability studies. Formulation FNS3 and pure drug exhibited the in vitro dissolution about 73.89% and 8.53% in 1% sodium lauryl sulfate (SLS) media, respectively. When the particle size reduced from 80,000. ±. 923. nm to 460. ±. 20. nm, saturation solubility was significantly increased. The saturation solubility of formulation FNS3 in 0.5% and 1% of SLS media found to be 67.51. ±. 1.5. μg/mL and 107. ±. 1.9. μg/mL, respectively. While, the saturation solubility of pure drug in 0.5% and 1% of SLS was found to be 6.02. ±. 1.51. μg/ml and 23.54. ±. 1.54. μg/ml, respectively. The pharmacokinetic study of optimized nanocrystals (FNS3) conducted in New Zealand white rabbits showed 4.73-fold increase in relative bioavailability than that of pure drug. Long term stability studies showed that there was no significant change in the mean particle size and PDI at 5. °C. ±. 3. °C after 180 days. This enhanced dissolution and bioavailability of fenofibrate nanocrystals could be the promising approach for oral delivery. © 2013 Elsevier B.V.

Deosarkar S.D.,Swami Ramanand Teerth Marathwada University
Russian Journal of Physical Chemistry A | Year: 2013

Densities and refractive indices of KOH solutions of three different concentrations in solutions of ethanol in water with different concentrations were measured at 303.15 K. From densities and refractive indices the specific refractions and molar refractions were estimated and interpreted in terms of molecular interactions. Concentration dependence of (n D 2 - 1)/(n D 2 + 2) has been studied. © 2013 Pleiades Publishing, Ltd.

Gacche R.N.,Swami Ramanand Teerth Marathwada University | Meshram R.J.,Swami Ramanand Teerth Marathwada University
Progress in Biophysics and Molecular Biology | Year: 2013

Angiogenesis: a process of generation of new blood vessels has been proved to be necessary for sustained tumor growth and cancer progression. Inhibiting angiogenesis pathway has long been remained a significant hope for the development of novel, effective and target orientated antitumor agents arresting the tumor proliferation and metastasis. The process of neoangiogenesis as a biological process is regulated by several pro- and anti-angiogenic factors, especially vascular endothelial growth factor, fibroblast growth factor, epidermal growth factor, hypoxia inducible factor 1 and transforming growth factor. Every endothelial cell destined for vessel formation is equipped with receptors for these angiogenic peptides. Moreover, numerous other angiogenic cytokines such as platelet derived growth factor (PGDF), placenta growth factor (PGF), nerve growth factor (NGF), stem-cell factor (SCF), and interleukins-2, 4, 6 etc. These molecular players performs critical role in regulating the angiogenic switch. Couple of decade's research in molecular aspects of tumor biology has unraveled numerous structural and functional mysteries of these angiogenic peptides. In present article, a detailed update on the functional and structural peculiarities of the various angiogenic peptides is described focusing on structural opportunities made available that has potential to be used to modulate function of these angiogenic peptides in developing therapeutic agents targeting neoplastic angiogenesis. The data may be useful in the mainstream of developing novel anticancer agents targeting tumor angiogenesis. We also discuss major therapeutic agents that are currently used in angiogenesis associated therapies as well as those are subject of active research or are in clinical trials. © 2013 Elsevier Ltd.

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