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Qin W.-X.,Suzhou University
Nonlinearity | Year: 2010

In this paper we focus on the dynamics of the overdamped limit case of the Frenkel-Kontorova (F-K) model with irrational mean spacing. We extend the results of Baesens and MacKay on rational mean spacing case to irrational case: there exists a depinning force F d ≥ 0 such that the F-K model possesses an equilibrium with a given mean spacing if the constant driving force F ε [0, F d] or it admits a uniform sliding solution provided F > Fd . Moreover, the average velocity of the particles exists and is unique, and it is non-decreasing and continuous with respect to F ε [0, +∞). In particular, we prove that the average velocity depends continuously upon the mean spacing. © 2010 IOP Publishing Ltd & London Mathematical Society.


Background: To explore the value of minimally invasive surgery for the removal of calculus and preservation of the gallbladder with the combination of a hard gallbladder endoscope and a soft choledochoscope. Patients and Methods: A retrospective analysis was conducted of the clinical data of 42 patients with cholecystolithiasis who underwent minimally invasive surgery for the removal of calculus and preservation of the gallbladder from April 2009 to April 2011. Results: None of the 42 cases had bile flowing from the gallbladder neck tube to the gallbladder lumen after removal of stones in the gallbladder lumen by the hard gallbladder endoscope; all the 42 cases had residual stones in the gallbladder tube when probed by the soft choledochoscope. The numbers of stones range from one to three, while the diameters of the stones range from 0.5 cm to 1.0 cm. In 8 cases, there was one calculus embedded. In 39 cases, the calculi were taken out through the soft choledochoscope, and the gallbladders were preserved successfully; yet the other 3 cases failed to receive surgery to preserve the gallbladder because of calculi embedded in the gallbladder tube, which were finally treated by laparoscopic cholecystectomy. Conclusions: A hard gallbladder endoscope combined with a soft choledochoscope for removing calculi and preserving the gallbladder in laparoscopic microscopic trauma surgery can effectively find residual stones in the gallbladder tube and help to increase the rate of complete removal of calculi and preserving the gallbladder. © Mary Ann Liebert, Inc.


Wang C.,Suzhou University | Cheng L.,Suzhou University | Liu Z.,Suzhou University
Theranostics | Year: 2013

Photodynamic therapy (PDT) is a non-invasive treatment modality for a variety of diseases in-cluding cancer. PDT based on upconversion nanoparticles (UCNPs) has received much attention in recent years. Under near-infrared (NIR) light excitation, UCNPs are able to emit high-energy visible light, which can activate surrounding photosensitizer (PS) molecules to produce singlet oxygen and kill cancer cells. Owing to the high tissue penetration ability of NIR light, NIR-excited UCNPs can be used to activate PS molecules in much deeper tissues compared to traditional PDT induced by visible or ultraviolet (UV) light. In addition to the application of UCNPs as an energy donor in PDT, via similar mechanisms, they could also be used for the NIR light-triggered drug release or activation of 'caged' imaging or therapeutic molecules. In this review, we will summarize the latest progresses regarding the applications of UCNPs for photodynamic therapy, NIR trig-gered drug and gene delivery, as well as several other UCNP-based cancer therapeutic ap-proaches. The future prospects and challenges in this emerging field will be also discussed. © Ivyspring International Publisher.


Zhang L.,Suzhou University
Applied Surface Science | Year: 2013

A self-assembled protocol is introduced to provide effective platforms for the fabrication of ordered Ag nanosized monolayer film. The assembled Ag nanosized monolayer film was characterized using scanning electronic microscopy and surface-enhanced Raman scattering (SERS). The results show that the assembled SERS substrate own excellent Raman enhancement and reproducibility. The synthesized SERS-active substrate was further used to detect methyl-parathion, and the limitation of detection can reach 10-7 M. © 2013 Elsevier B.V.


The platelet protein disulfide isomerase called ERp57 mediates platelet aggregation, but its role in thrombus formation is unknown. To determine the specific role of platelet-derived ERp57 in hemostasis and thrombosis, we generated a megakaryocyte/platelet-specific knockout. Despite normal platelet counts and platelet glycoprotein expression, mice with ERp57-deficient platelets had prolonged tail-bleeding times and thrombus occlusion times with FeCl3-induced carotid artery injury. Using a mesenteric artery thrombosis model, we found decreased incorporation of ERp57-deficient platelets into a growing thrombus. Platelets lacking ERp57 have defective activation of the αIIbβ3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57, implicating surface ERp57 in platelet aggregation. Using mutants of ERp57, we demonstrate the second active site targets a platelet surface substrate to potentiate platelet aggregation. Binding of Alexa 488-labeled ERp57 to thrombin-activated and Mn(2+)-treated platelets lacking β3 was decreased substantially, suggesting a direct interaction of ERp57 with αIIbβ3. Surface expression of ERp57 protein and activity in human platelets increased with platelet activation, with protein expression occurring in a physiologically relevant time frame. In conclusion, platelet-derived ERp57 directly interacts with αIIbβ3 during activation of this receptor and is required for incorporation of platelets into a growing thrombus.


Chen Q.,Suzhou University | Liang C.,Suzhou University | Wang C.,Suzhou University | Zhuang L.,Suzhou University
Advanced Materials | Year: 2015

A study was conducted to demonstrate an imagable and photothermal 'abraxane-like' nanodrug for combination cancer therapy to treat subcutaneous and metastatic breast tumors. It was reported that the new 'abraxane' was composed by HSA, PTX, and indocyanine green (ICG), the latter of which was a FDA-approved NIR dye. It was found that HSA, PTX, and ICG would self-assemble into stable nanoparticles in the aqueous solution by simple mixing. HAS was a biocompatible carrier platform in this system and PTX was an effective antitumor drug, while ICG can serve as a fluorescence imaging probe and a photothermal agent. The obtained HSA-ICG?PTX nanoparticles showed enhanced stability and prolonged blood circulation time as compared with HSA?ICG complex.


Patent
Suzhou University | Date: 2011-09-23

A method for inputting text using the keys of 0-9 of a numeric keypad. The code length of digital encoding may be from 4 to 5 bits. For Chinese-characters, the total number of strokes expressed by two figures may correspond to the first two bits, the first three stroke codes may correspond to the third to the fifth bits, respectively, and inputting the termination code when the total code length is less than 5 bits. For letters, figures, and symbols, two bits express the serial number, the third bit is an identification code, and the fourth bit is the termination code, Chinese-characters and other characters may be inputted with the same input method without switching the input state. The probability of repeated codes is low. The methods can be used by various kinds of input devices with numeric keys.


Patent
Suzhou University and SVG Optronics Co. | Date: 2010-12-16

The present invention discloses a color filter includes a substrate layer and a medium grating layer, wherein the medium grating layer, arranged on the substrate layer, has a grating structure of periodic arrangement. The color filter is characterized in that: the medium grating layer is provided with a metal profiling film, which covers the ridge portion of the grating structure, one or two sides of the lateral portion of the grating structure, and a part of the groove portion of the grating structure, with the area of the groove portion of the grating structure covered by the metal profiling film occupying 30%-95% of the total area of the lateral portion and the groove portion. By providing the metal profiling film, this invention can break the condition of the original metal surface plasmon resonance, and reduce influence of the incident angle of light on the resonance condition, thus achieving the filtering effect within a relatively wide range of angle.


Patent
Suzhou University and SVG OPTRONICS Co. | Date: 2011-05-31

A reflective color filter comprises a medium grating layer (220), a metal layer (230), and a first medium layer (240). The metal layer is provided on the ridge portion, at least one side portion, and a part of the groove portion of the medium grating layer. The first medium layer reflecting outside light is provided on the medium grating layer and the metal layer. Because a part of the medium grating layer is exposed through an opening of the metal layer on the groove portion, the angular sensitivity of the resonance output is reduced, and the influence of the incident angle on the resonance condition is diminished. Therefore, a reflection filtering can be realized in a wide angular area.


Zhou J.,Fudan University | Liu Z.,Suzhou University | Li F.,Fudan University
Chemical Society Reviews | Year: 2012

Rare-earth upconversion nanophosphors (UCNPs), when excited by continuous-wave near-infrared light, exhibit a unique narrow photoluminescence with higher energy. Such special upconversion luminescence makes UCNPs promising as bioimaging probes with attractive features, such as no auto-fluorescence from biological samples and a large penetration depth. As a result, UCNPs have emerged as novel imaging agents for small animals. In this critical review, recent reports regarding the synthesis of water-soluble UCNPs and their surface modification and bioconjugation chemistry are summarized. The applications of UCNPs for small-animal imaging, including tumor-targeted imaging, lymphatic imaging, vascular imaging and cell tracking are reviewed in detail. The exploration of UCNPs as multifunctional nanoscale carriers for integrated imaging and therapy is also presented. The biodistribution and toxicology of UCNPs are further described. Finally, we discuss the challenges and opportunities in the development of UCNP-based nanoplatforms for small-animal imaging (276 references). © 2012 The Royal Society of Chemistry.

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