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Fang Q.,Nanjing Southeast University | Ma C.,Nanjing Southeast University | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Nanohealth Biotech. Corporation Ltd
Integrated Ferroelectrics | Year: 2016

NanoSolve, which enables the production of transparent emulsions with particle sizes of approximately 100 nm, is a promising carrier system for various lipids or lipophilic actives. The purpose of this study was to prepare a trans-Resveratrol NanoSolve which can enhance the water solubility and physical stability. The particles of trans-Resveratrol NanoSolve showed spherical morphology under transmission electron microscope and the mean size was 122 ± 0.8 nm. The zeta potential was −41.7 ± 0.9 mV at dilution 200 folds. In-vitro permeation results showed that trans-Resveratrol NanoSolve presented good skin compatibility. Consequently, trans-Resveratrol NanoSolve has a very promising potential in cosmetic industry. © 2016, © Taylor & Francis Group, LLC.


Kong R.,Nanjing Southeast University | Kong R.,Suzhou University | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou University | And 3 more authors.
Advanced Materials Research | Year: 2011

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers were prepared by High Pressure Homogenization (HPH) technique. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of VAP-NLCs were studied in details. Preparation and physicochemical properties of VAP lipid nanoparticles were investigated using various analytical equipments such as TEM, photon correlation spectroscopy (PCS), laser diffractometry (LD) and ultraviolet spectrophotometer. The respective optimal HPH pressure and cycles were 70MPa and 5 cycles, so VAP-NLC dispersions under the optimized condition gave rise to the entrapment efficiency (EE) of 99.8%, PI of 0.234, mean diameter of 144±1.7 nm (2% VAP loading capacity). In addition, VAP lipid nanoparticle has a distinct spherical shape, its particle sizes were around 60-330 nm according to VAP contents and zeta potential values -18∼-23 mV. Furthermore, the pH of VAP-NLC dispersion was near to 7.0. This study showed that VAP-NLC could hopefully be applied for food products. © (2011) Trans Tech Publications.


Li Y.,Nanjing Southeast University | Li Y.,Suzhou Key Laboratory of Biomedical Materials and Technology | Huang Y.-Q.,Nanjing Southeast University | Huang Y.-Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 5 more authors.
Journal of Applied Polymer Science | Year: 2014

In this study, fragrance microcapsules were prepared by a spray-drying method, in which the osmanthus flower fragrance acted as the core material and gum arabic and maltodextrin acted as shell materials. Scanning electron microscopy images showed that the microcapsules were approximately spherical in shape with a concave surface. Fourier transform infrared spectroscopy was used to prove the formations of the microcapsules. The fragrance retention rate at high temperatures (80-120°C) after a short heating time (30 min) reached 85.20 ± 2.72% and the retention rate after a long heating time (a week) at 60°C reached 95.40 ± 2.88%. The retention rate after 100 days exceeded 90%, and the transdermal release experiments showed that on the surface of the skin, the fragrance in the microcapsules stayed longer than in the pure fragrance oil. These results indicate that the fragrance microcapsules had an excellent aroma-reserving ability. The results of the release test proved that the transport mechanism of the fragrance microcapsules conformed to the Weibull equation. © 2013 Wiley Periodicals, Inc.


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou University | Xia Q.,Suzhou Nanohealth Biotech Co. | Wu J.,Nanjing Southeast University | Wu J.,Suzhou University
Materials Science Forum | Year: 2011

The enhancement of stability of light sensitive CoQ10 was achieved by preparation of coenzyme Q10-loaded Nanostructured Lipid Carriers through High Pressure Homogenization (HPH). Well-dissolved lipids of CoQ10 were selected, optimized ratio of emusifiers and lipids were determined for the formulation. Obtained by photon correlation spectroscopy (PCS), the mean particle size of CoQ10-NLC was 112 ± 7 nm within 60 days after preparation. In terms of centrifugal stability, results of laser diffraction (LD) analysis eliminated the existence of aggregated particles with micrometers and showed almost no size growth before and after centrifugation. Zeta potential values were from -50 to -55 mV with pH in the range of 6.56-6.72. The concentration of CoQ10-NLC measured by UV-Vis spectroscopy was as high as 8.13 mg/mL.


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Suzhou Nanohealth Biotech Co. | Yao Y.,Nanjing Southeast University | Yao Y.,Suzhou Key Laboratory of Biomedical Materials and Technology
Materials Science Forum | Year: 2011

As the instability of vitamin C and vitamin E, double emulsion was chosen as a carrier system for dermal delivery of vitamins. The present work shows how to prepare and evaluate a double emulsion containing both vitamin C and vitamin E. The double emulsion was produced by two-step process. The concentration of vitamins were analyzed by UV, and the morphology of double emulsions were observed with optical microscopic. Vitamins could be protected well in one system, which was W/O/W double emulsion. The shape of double emulsion was also an evidence for the safety of vitamins. In the end, we obtained a stable double emulsion containing both vitamin C and vitamin E for cosmetics.


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou University | Xia Q.,Suzhou Nanohealth Biotech Co. | Kong R.,Nanjing Southeast University | Kong R.,Suzhou University
Materials Science Forum | Year: 2011

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers (VAP-NLC) were prepared by High Pressure Homogenization (HPH) technique. Trehalose, glucose, mannitol, a-lactin, D-sorbitol, D-maltose monohydrate and sucrose were chosen as the cryoprotectants. Also, the centrifugal stability of VAP-NLC dispersions after diluting different times and the effects of cryoprotectants on the diameter during the freeze-drying process were investigated extensively. Glucose and a-lactin proved to be the most effective in preventing particles aggregation during the VAP-NLC freeze-drying process. The most suitable concentrations were proved to be 5 wt% and 5 wt%, respectively when the dilution times of VAP-NLC dispersions reached 7 or more before freeze-drying. In conclusion, the NLC formulation demonstrated a promising perspective for oral delivery of poorly water-soluble actives in food industry.


Tang J.-G.,Nanjing Southeast University | Tang J.-G.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 3 more authors.
Guocheng Gongcheng Xuebao/The Chinese Journal of Process Engineering | Year: 2010

Alpha-lipoic acid-loaded lipid nanoparticles (ALA-LNs) were prepared by high pressure homogenization method. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of ALA-LNs were studied in details. The stability was evaluated by particle size and polydispersity index, morphology of ALA-LNs, and capacity of ALA loading. The dilution and pH stability of ALA-LNs suspensions were also studied. After three months storage, the mean size of ALA-LNs at 4 and 40 °C was increased by 2.68% and 3.62% compared with the original size, respectively. ALA-LNs stored at 40 °C had ellipsoid shape and the mean size was about 152 nm (SD=23.6). The loading capacity of ALA at 40 °C was much higher than those stored at other two temperatures. The good dilution and pH stability were also demonstrated. The sample had good fluidity even at 4 °C.


Wu J.Y.,Nanjing Southeast University | Wu J.Y.,Suzhou University | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou University | Xia Q.,Suzhou Nanohealth Biotech Co.
Advanced Materials Research | Year: 2011

To function lipophilic drug Azithromycin (AZM) as ophthalmic preparation, Azithromycin-loaded Nanostructured Lipid Carriers (AZM-NLC) were prepared by High Pressure Homogenization (HPH), and its stability was analyzed afterwards. Well-dissolved lipids of Azithromycin were selected, how the ratio of surfactants to lipids influenced the preparation of AZM-NLC was studied, and mature surfactant system was chosen. The optimized ratio of lipid carriers to emulsifiers [ polyoxyethylene (40) stearate - Poloxamer188 (7:3)] in this study was 1:6, and the final drug-capacity rate was 0.5%. Obtained by photon correlation spectroscopy, the mean particle size of AZM-NLC was 76±2 nm. The results showed that AZM-NLC had kept stable for 15 days, and mean particle size increased to 83 nm after four months. © (2011) Trans Tech Publications.


Zhao G.D.,Nanjing Southeast University | Zhao G.D.,Suzhou Key Laboratory of Biomedical Materials and Technology | Sun R.,Nanjing Southeast University | Sun R.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 5 more authors.
Journal of Microencapsulation | Year: 2015

This article describes the physicochemical properties of chitosan-coated liposomes containing skin-protecting agents, coenzyme Q10 and alpha-lipoic acid (CCAL). CCAL had a spherical shell-core structure and liposomes inverted the surface charge from negative to positive after coating with chitosan. Compared with the uncoated liposome, CCAL had higher zeta potential, larger droplet size and long-term stability. Fourier transform infrared spectroscopy (FTIR) study showed that the driving force for chitosan coating the liposomes was enhanced via hydrogen bonding and ionic bond force between the chitosan and the alpha-lipoic acid. While the encapsulation efficiency (EE) of alpha-lipoic acid also increased by interacting with the chitosan shell. In vitro antioxidant activity study showed an excellent hydroxyl radical scavenging activity of CCAL. In vitro release study displayed a sustained drug release, and in vitro penetration studies promoted the accumulation of drugs in rabbit skin. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.


PubMed | Suzhou Nanohealth Biotech Co. and Nanjing Southeast University
Type: | Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V | Year: 2016

This work aimed at developing a large-scale modular production line, which referred to coenzyme Q

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