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Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou University | Xia Q.,Suzhou Nanohealth Biotech Co. | Wu J.,Nanjing Southeast University | Wu J.,Suzhou University
Materials Science Forum | Year: 2011

The enhancement of stability of light sensitive CoQ10 was achieved by preparation of coenzyme Q10-loaded Nanostructured Lipid Carriers through High Pressure Homogenization (HPH). Well-dissolved lipids of CoQ10 were selected, optimized ratio of emusifiers and lipids were determined for the formulation. Obtained by photon correlation spectroscopy (PCS), the mean particle size of CoQ10-NLC was 112 ± 7 nm within 60 days after preparation. In terms of centrifugal stability, results of laser diffraction (LD) analysis eliminated the existence of aggregated particles with micrometers and showed almost no size growth before and after centrifugation. Zeta potential values were from -50 to -55 mV with pH in the range of 6.56-6.72. The concentration of CoQ10-NLC measured by UV-Vis spectroscopy was as high as 8.13 mg/mL. Source


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou University | Xia Q.,Suzhou Nanohealth Biotech Co. | Kong R.,Nanjing Southeast University | Kong R.,Suzhou University
Materials Science Forum | Year: 2011

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers (VAP-NLC) were prepared by High Pressure Homogenization (HPH) technique. Trehalose, glucose, mannitol, a-lactin, D-sorbitol, D-maltose monohydrate and sucrose were chosen as the cryoprotectants. Also, the centrifugal stability of VAP-NLC dispersions after diluting different times and the effects of cryoprotectants on the diameter during the freeze-drying process were investigated extensively. Glucose and a-lactin proved to be the most effective in preventing particles aggregation during the VAP-NLC freeze-drying process. The most suitable concentrations were proved to be 5 wt% and 5 wt%, respectively when the dilution times of VAP-NLC dispersions reached 7 or more before freeze-drying. In conclusion, the NLC formulation demonstrated a promising perspective for oral delivery of poorly water-soluble actives in food industry. Source


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Suzhou Nanohealth Biotech Co. | Yao Y.,Nanjing Southeast University | Yao Y.,Suzhou Key Laboratory of Biomedical Materials and Technology
Materials Science Forum | Year: 2011

As the instability of vitamin C and vitamin E, double emulsion was chosen as a carrier system for dermal delivery of vitamins. The present work shows how to prepare and evaluate a double emulsion containing both vitamin C and vitamin E. The double emulsion was produced by two-step process. The concentration of vitamins were analyzed by UV, and the morphology of double emulsions were observed with optical microscopic. Vitamins could be protected well in one system, which was W/O/W double emulsion. The shape of double emulsion was also an evidence for the safety of vitamins. In the end, we obtained a stable double emulsion containing both vitamin C and vitamin E for cosmetics. Source


Li Y.,Nanjing Southeast University | Li Y.,Suzhou Key Laboratory of Biomedical Materials and Technology | Huang Y.-Q.,Nanjing Southeast University | Huang Y.-Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 5 more authors.
Journal of Applied Polymer Science | Year: 2014

In this study, fragrance microcapsules were prepared by a spray-drying method, in which the osmanthus flower fragrance acted as the core material and gum arabic and maltodextrin acted as shell materials. Scanning electron microscopy images showed that the microcapsules were approximately spherical in shape with a concave surface. Fourier transform infrared spectroscopy was used to prove the formations of the microcapsules. The fragrance retention rate at high temperatures (80-120°C) after a short heating time (30 min) reached 85.20 ± 2.72% and the retention rate after a long heating time (a week) at 60°C reached 95.40 ± 2.88%. The retention rate after 100 days exceeded 90%, and the transdermal release experiments showed that on the surface of the skin, the fragrance in the microcapsules stayed longer than in the pure fragrance oil. These results indicate that the fragrance microcapsules had an excellent aroma-reserving ability. The results of the release test proved that the transport mechanism of the fragrance microcapsules conformed to the Weibull equation. © 2013 Wiley Periodicals, Inc. Source


Kong R.,Nanjing Southeast University | Kong R.,Suzhou University | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou University | And 3 more authors.
Advanced Materials Research | Year: 2011

Vitamin A Palmitate-loaded Nanostructured Lipid Carriers were prepared by High Pressure Homogenization (HPH) technique. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of VAP-NLCs were studied in details. Preparation and physicochemical properties of VAP lipid nanoparticles were investigated using various analytical equipments such as TEM, photon correlation spectroscopy (PCS), laser diffractometry (LD) and ultraviolet spectrophotometer. The respective optimal HPH pressure and cycles were 70MPa and 5 cycles, so VAP-NLC dispersions under the optimized condition gave rise to the entrapment efficiency (EE) of 99.8%, PI of 0.234, mean diameter of 144±1.7 nm (2% VAP loading capacity). In addition, VAP lipid nanoparticle has a distinct spherical shape, its particle sizes were around 60-330 nm according to VAP contents and zeta potential values -18∼-23 mV. Furthermore, the pH of VAP-NLC dispersion was near to 7.0. This study showed that VAP-NLC could hopefully be applied for food products. © (2011) Trans Tech Publications. Source

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