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Rong F.,Nanjing Southeast University | Rong F.,Suzhou Key Laboratory of Environment and Biosafety | Li P.,Beihang University
Advanced Materials Research | Year: 2012

Molecularly imprinted polymers (MIPs) of L-phenylalanine ethyl ester were synthesized in this study. Then, the prepared MIPs were packed in a stainless column and evaluated as the chiral stationary phases of high performance liquid chromatography (HPLC). The MIPs exhibited a considerable capability of chiral separation between template molecule and its enantiomer with the separation factor of 1.69. Furthermore, the weakest interaction model was introduced to study the chiral recognition mechanism of MIPs. The results suggested that the weakest interaction between the template molecule and the imprinted cavity played crucial role in chiral separation, and the molecular tension should be taken into consideration during the separation procedure. The separation factor of 2.07 was calculated by the theoretical model, which was very close to the value obtained from chromatographic experiment. Source

Rong F.,Nanjing Southeast University | Rong F.,Suzhou Key Laboratory of Environment and Biosafety | Li P.,Beihang University
High Performance Polymers | Year: 2011

The interactions between template and functional monomers of molecularly imprinted polymers (MIPs) were studied by ultraviolet and infrared spectral analysis and computer simulation, with S-naproxen as template molecule and methacrylic acid (MAA), acrylamide (AM) and 4-vinyl pyridine (4-VP) as functional monomers, respectively. Then, the S-naproxen imprinted polymers made from three functional monomers were prepared, respectively, and the binding parameters and chiral separation performance of the synthesized MIPs were investigated by Scatchard analysis and thin layer chromatography using MIPs as chiral stationary phase. The results showed that the MIP based on 4-VP possessed the highest imprinting effect while the MIP based on MAA was the lowest, which correlated positively with the interaction strength between template molecule and three monomers. The results of theoretical and experimental studies of S-naproxen imprinted polymers suggested that using spectral analysis and computer aided prediction could promote the synthetic strategy for researching more efficient MIPs. © SAGE Publications 2011. Source

Yin T.,Nanjing Southeast University | Lin Z.,Nanjing Southeast University | Su L.,Nanjing Southeast University | Yuan C.,Nanjing Southeast University | And 2 more authors.
ACS Applied Materials and Interfaces | Year: 2015

A unique vertically oriented TiO2 nanosheets (TiO2-NSs) layer was synthesized in situ on the surface of a carbon paper (CP) electrode via hydrothermal synthesis upon addition of a suitable amount of activated carbon powders in a reactor. Field emission scanning electron microscopy images showed that the nanosheets were about 2 μM in length, 200-600 nm in width and 15 nm in thickness. X-ray diffraction and Raman patterns verified TiO2-NSs crystallized in the anatase phase. The electrochemical activities of CP and TiO2-NSs/CP electrode have been investigated by cyclic voltammetry and electrochemical impedance spectroscopy. The maximum power output density of a mixed consortia inoculated microbial fuel cell was increased by 63% upon using TiO2-NSs/CP as a bioanode compared with that using bare CP as a bioanode. The performance improvement could be ascribed to unique 3D open porous interface made of vertically oriented TiO2-NSs, which provides good biocompatibility, favorable mass transport process, large surface areas for adhension of bacteria and direct pathways for electron movement to the electrode. © 2014 American Chemical Society. Source

Zhao Y.,Nanjing Southeast University | Zhao X.,Nanjing Southeast University | Tang B.,Nanjing Southeast University | Xu W.,Nanjing Southeast University | And 2 more authors.
Langmuir | Year: 2010

We present a new method to prepare inverse opaline photonic beads with good spherical shape and superior optical performance by simply introducing an interfacial tension system into a template replication method. When the scaffolds of these beads were composed of poly(ethylene glycol) diacrylate hydrogel, they could provide a homogeneous water surrounding, which remedied many shortcomings of biomolecular microcarriers introduced by the presence of the solid surface of them. The suspension array, which used these macroporous hydrogel photonic beads as coding elements, showed obvious advantages in multiplexed capability, rapid biomolecular screening (within 12 min), and highly sensitive detection (with limit of detection of ∼10-12 M). © 2010 American Chemical Society. Source

Xu S.,Nanjing Southeast University | Xu Q.,Nanjing Southeast University | Xu Q.,Suzhou Key Laboratory of Environment and Biosafety | Zhou J.,Nanjing Southeast University | And 3 more authors.
Journal of Nanoscience and Nanotechnology | Year: 2013

For the purpose of achieving targeted chemotherapy of pancreatic cancer, we prepared core-shell nanoparticles by coaxial electrospray technology, with folate-chitosan as the polymeric coating material and gemcitabine as the encapsulated drug. The effects of various solution properties and processing parameters on nanoparticles formation were investigated. By optimizing the electrospray parameters, the diameter of the core-shell nanoparticles was in the range of 200∼300 nm with drug loading and encapsulation efficiency of 3.91±0.12% and 85.37±4.9%. The drug release kinetics revealed a controlled initial burst release followed by a sustained release over a period of 72 h at pH 7.4 and pH 5.0, and at pH 5.0 the drug released more quickly. Moreover, the cellular uptake experiment confirmed that the folate conjugated core-shell nanoparticles had high pancreatic cancer (BXPC3) cells uptake efficiency. And the cell cytotoxicity test displayed that they had remarkable cytotoxicity towards BXPC3 cells. This study indicates that coaxial electrospray is a facile technique in producing core-shell nanoparticles encapsulating hydrophilic small molecule drugs, and clearly infers that the folate conjugated core-shell nanoparticles is very much effective to use as a pancreatic tumor-targeted delivery carrier for anticancer drugs. Copyright © 2013 American Scientific Publishers All rights reserved. Source

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