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Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Suzhou Nanohealth Biotech Co. | Yao Y.,Nanjing Southeast University | Yao Y.,Suzhou Key Laboratory of Biomedical Materials and Technology
Materials Science Forum | Year: 2011

As the instability of vitamin C and vitamin E, double emulsion was chosen as a carrier system for dermal delivery of vitamins. The present work shows how to prepare and evaluate a double emulsion containing both vitamin C and vitamin E. The double emulsion was produced by two-step process. The concentration of vitamins were analyzed by UV, and the morphology of double emulsions were observed with optical microscopic. Vitamins could be protected well in one system, which was W/O/W double emulsion. The shape of double emulsion was also an evidence for the safety of vitamins. In the end, we obtained a stable double emulsion containing both vitamin C and vitamin E for cosmetics. Source


Zhou H.,Nanjing Southeast University | Zhou H.,Suzhou Key Laboratory of Biomedical Materials and Technology | Tian F.,Shanghai Institute of Planned Parenthood Research | Xia Q.,Nanjing Southeast University | And 4 more authors.
Advanced Materials Research | Year: 2012

The objective is to study the stability of Nifeviroc-loaded microemulsions (Nifeviroc-MEs). The dilution stability of Nifeviroc-MEs with different loading capacity (0.1%, 0.2%, 0.3%) was tested by change of mean size, pH and appearance. The centrifugal stability was evaluated by comparing the mean size of Nifeviroc-MEs and dilutions before and after high-speed centrifugation for 30, 60, 120 min at 10000 rpm. The storage stability was evaluated by the change of appearance, the mean size, PDI and the retention rate of Nifeviroc in the ME. The pH, appearance, size analysis and retention rate results showed the Nifeviroc-MEs had good dilution, centrifugal stability and good storage stability without light. © (2012) Trans Tech Publications, Switzerland. Source


Huang Y.Q.,Nanjing Southeast University | Huang Y.Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology
Advanced Materials Research | Year: 2014

The present work reports on complexation of hydroxypropyl-β-cyclodextrin (HP-β-CD) with salicylic acid (SA) by vacuum evaporation and inclusion behavior confirmed by FT-IR, OM and SEM. Complex stoichiometry, release mechanism and skin sensitivity were evaluated. The results showed that SA could be encapsulated into cyclodextrin at the ratio of 1:1. Negative values of Gibbs free energy, enthalpy and entropy changes indicated a feasible, spontaneous and exothermic process. Release studies evidenced a burst release in first 2 h, followed by a sustained release and the release rate was temperature-dependent. Furthermore, an improved water solubility and significant reduced irritation effect of SA could be obtained by HP-β-CD. © (2014) Trans Tech Publications, Switzerland. Source


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Wang H.,Nanjing Southeast University | Wang H.,Suzhou Key Laboratory of Biomedical Materials and Technology
Integrated Ferroelectrics | Year: 2011

Coenzyme Q10 (CoQ10) is practically insoluble and chemically labile in water, Nanostructured Lipid Carriers loading CoQ10 can solve the problems of poor stability and low bioavilability of CoQ10. Good physical stability of particle was obtained through monitoring the change of particle size while the condition of storage changed. During exposed to day light for 15 days, retention rate of CoQ10-absolute ethanol solution decreased by about 80.0% which was much higher than that of CoQ10 Nanostructured Lipid Carrier. Also, the decreasing speed of CoQ10 unloaded in NLC was faster than CoQ10-NLC's by protecting from light for 6 months. Copyright © Taylor & Francis Group, LLC. Source


Liang H.,Nanjing Southeast University | Liang H.,Suzhou Key Laboratory of Biomedical Materials and Technology | Liu M.,Nanjing Medical University | Gu N.,Nanjing Southeast University | And 2 more authors.
Dongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Southeast University (Natural Science Edition) | Year: 2010

The toughening and strengthening effects of different contents of nano-zirconia on diatomite ceramics are investigated. Zirconia nanoparticles are added to the diatomite ceramic matrix materials(w(ZrO2)= 0 to 30%). After balling, drying, grinding and riddling, the composite ceramics are pressed by a bead machine, and then the obtained greenwares are sintered under atmospheric pressure at 1100°C. After milling and polishing, the mechanical properties of the sintered samples are tested using the three-point method and the indentation method. The phases and microstructures of the composite ceramics are studied by X-ray diffraction and scanning electron microscope, respectively. The experimental results indicate that when w(ZrO2)= 20%, the toughening effect of diatomite ceramic is obvious. Correspondingly, the flexural strength and the fracture toughness increase 130% and 30% respectively, while the hardness increases a little. The nano-zirconia toughened diatomite ceramic meets the basic requirements of dental machinable ceramics. Source

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