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Huang Y.Q.,Nanjing Southeast University | Huang Y.Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology
Advanced Materials Research | Year: 2014

The present work reports on complexation of hydroxypropyl-β-cyclodextrin (HP-β-CD) with salicylic acid (SA) by vacuum evaporation and inclusion behavior confirmed by FT-IR, OM and SEM. Complex stoichiometry, release mechanism and skin sensitivity were evaluated. The results showed that SA could be encapsulated into cyclodextrin at the ratio of 1:1. Negative values of Gibbs free energy, enthalpy and entropy changes indicated a feasible, spontaneous and exothermic process. Release studies evidenced a burst release in first 2 h, followed by a sustained release and the release rate was temperature-dependent. Furthermore, an improved water solubility and significant reduced irritation effect of SA could be obtained by HP-β-CD. © (2014) Trans Tech Publications, Switzerland.


Li Y.,Nanjing Southeast University | Li Y.,Suzhou Key Laboratory of Biomedical Materials and Technology | Huang Y.-Q.,Nanjing Southeast University | Huang Y.-Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 5 more authors.
Journal of Applied Polymer Science | Year: 2014

In this study, fragrance microcapsules were prepared by a spray-drying method, in which the osmanthus flower fragrance acted as the core material and gum arabic and maltodextrin acted as shell materials. Scanning electron microscopy images showed that the microcapsules were approximately spherical in shape with a concave surface. Fourier transform infrared spectroscopy was used to prove the formations of the microcapsules. The fragrance retention rate at high temperatures (80-120°C) after a short heating time (30 min) reached 85.20 ± 2.72% and the retention rate after a long heating time (a week) at 60°C reached 95.40 ± 2.88%. The retention rate after 100 days exceeded 90%, and the transdermal release experiments showed that on the surface of the skin, the fragrance in the microcapsules stayed longer than in the pure fragrance oil. These results indicate that the fragrance microcapsules had an excellent aroma-reserving ability. The results of the release test proved that the transport mechanism of the fragrance microcapsules conformed to the Weibull equation. © 2013 Wiley Periodicals, Inc.


Zhou H.,Nanjing Southeast University | Zhou H.,Suzhou Key Laboratory of Biomedical Materials and Technology | Tian F.,Shanghai Institute of Planned Parenthood Research | Xia Q.,Nanjing Southeast University | And 4 more authors.
Advanced Materials Research | Year: 2012

The objective is to study the stability of Nifeviroc-loaded microemulsions (Nifeviroc-MEs). The dilution stability of Nifeviroc-MEs with different loading capacity (0.1%, 0.2%, 0.3%) was tested by change of mean size, pH and appearance. The centrifugal stability was evaluated by comparing the mean size of Nifeviroc-MEs and dilutions before and after high-speed centrifugation for 30, 60, 120 min at 10000 rpm. The storage stability was evaluated by the change of appearance, the mean size, PDI and the retention rate of Nifeviroc in the ME. The pH, appearance, size analysis and retention rate results showed the Nifeviroc-MEs had good dilution, centrifugal stability and good storage stability without light. © (2012) Trans Tech Publications, Switzerland.


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Wang H.,Nanjing Southeast University | Wang H.,Suzhou Key Laboratory of Biomedical Materials and Technology
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy - Technical Proceedings of the 2010 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2010 | Year: 2010

Coenzyme Q10 (CoQ10) is practically insoluble and chemically labile in water and should be incorporated in some carriers such as NLC to improve its stability and realize the final application as a versatile anti-oxidant. CoQ10-NLC (Nanostructured Lipid Carrier) was prepared based on the phase behavior of a special hot transparent emulsion containing CoQ10. The good physical stability of particle was obtained by Photon Correlation Spectroscopy (PCS). UV measurements sho-wed that the loading capacity of CoQ10 could reach 5%. The 99.8% entrapment efficiency (UV analysis) was obtained for all formulations. Atomic Force Microscope studies revealed NLC of pellet-like shape.


Liu G.Y.,Nanjing Southeast University | Liu G.Y.,Suzhou Key Laboratory of Biomedical Materials and Technology | Wang J.M.,Nanjing Southeast University | Wang J.M.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 2 more authors.
European Food Research and Technology | Year: 2012

Nanostructured lipid carriers (NLC) could be used as suitable carriers of water-insoluble nutrients such as coenzyme Q10 (CoQ10) improve their bioavailability. The CoQ10-NLC was prepared by high-pressure homogenization method. The freshly prepared CoQ10-NLC showed ellipsoid morphology under atomic force microscope, and the average encapsulation efficiency was about 98. 4 ± 0. 3%. Good physical and chemical stability was observed by photon correlation spectrum and HPLC, respectively. In 3 months' storage, the concentration of CoQ10-NLC kept at 8. 5 ± 1. 5 mg/mL; the particle size was 190 ± 30 nm with polydispersity index (PDI) lower than 0. 1. Lyophilization was proved feasible for the storage of NLC dispersion. The formulation also showed the potent possibility of application on beverage. Particle size remained relatively steady in simulated beverage solution for 3 months. The oral bioavailability study was carried out using Wistar rats. The relative bioavailability of CoQ-NLC was about 200% compared with CoQ10 suspension. In conclusion, the NLC formulation showed good stability and improved bioavailability. It demonstrated a promising perspective for daily consuming and industrial production. © 2011 Springer-Verlag.


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Suzhou Nanohealth Biotech Co. | Yao Y.,Nanjing Southeast University | Yao Y.,Suzhou Key Laboratory of Biomedical Materials and Technology
Materials Science Forum | Year: 2011

As the instability of vitamin C and vitamin E, double emulsion was chosen as a carrier system for dermal delivery of vitamins. The present work shows how to prepare and evaluate a double emulsion containing both vitamin C and vitamin E. The double emulsion was produced by two-step process. The concentration of vitamins were analyzed by UV, and the morphology of double emulsions were observed with optical microscopic. Vitamins could be protected well in one system, which was W/O/W double emulsion. The shape of double emulsion was also an evidence for the safety of vitamins. In the end, we obtained a stable double emulsion containing both vitamin C and vitamin E for cosmetics.


Tang J.-G.,Nanjing Southeast University | Tang J.-G.,Suzhou Key Laboratory of Biomedical Materials and Technology | Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 3 more authors.
Guocheng Gongcheng Xuebao/The Chinese Journal of Process Engineering | Year: 2010

Alpha-lipoic acid-loaded lipid nanoparticles (ALA-LNs) were prepared by high pressure homogenization method. The influences of storage conditions such as time and temperature on the physical and chemical storage stability of ALA-LNs were studied in details. The stability was evaluated by particle size and polydispersity index, morphology of ALA-LNs, and capacity of ALA loading. The dilution and pH stability of ALA-LNs suspensions were also studied. After three months storage, the mean size of ALA-LNs at 4 and 40 °C was increased by 2.68% and 3.62% compared with the original size, respectively. ALA-LNs stored at 40 °C had ellipsoid shape and the mean size was about 152 nm (SD=23.6). The loading capacity of ALA at 40 °C was much higher than those stored at other two temperatures. The good dilution and pH stability were also demonstrated. The sample had good fluidity even at 4 °C.


Zhao G.,Nanjing Southeast University | Zhao G.,Suzhou Key Laboratory of Biomedical Materials and Technology | Hu C.,Nanjing Southeast University | Hu C.,Suzhou Key Laboratory of Biomedical Materials and Technology | And 6 more authors.
Journal of Food Process Engineering | Year: 2015

A novel drug delivery system called multiple lipid particles containing both coenzyme Q10 and tea polyphenols were proposed for the stabilization of water-in-oil-in-water emulsions. The effects of the type and concentration of lipophilic and hydrophilic emulsifier, and drug concentration on multiple lipid particles were investigated. The experimental results revealed that it is possible to stabilize the primary emulsions of multiple lipid particles with mixtures of lecithin, polyglycerol polyricinoleate and PEG 30 dipolyhydroxystearate. Polyglyceryl-10 laurate as proper hydrophilic emulsifier exhibited terrific compatibility with polyglycerol polyricinoleate. In vitro release study displayed a sustained drug release and the obtained outcomes also suggested that multiple lipid particles could enhance loading capacity of both lipophilic and hydrophilic drugs with high level of encapsulation efficiency and long-term stability. Practical Applications: Multiple emulsions are a complex system that could incorporate both lipophilic and hydrophilic drugs. However, the destabilization of multiple emulsions with time limits their application. To obtain a stable formulation for encapsulation of both lipophilic and hydrophilic drugs, a novel drug delivery system, called multiple lipid particles, was proposed, which combines the advantages of multiple emulsions and solid lipid nanoparticles. This study investigated the emulsification process of multiple lipid particles to obtain stable formulation. The results revealed that multiple lipid particles could encapsulate both lipophilic and hydrophilic drugs with high loading capacity and encapsulation efficiency. The solid state of multiple lipid particles is more stable than that of multiple emulsions. Thus, multiple lipid particles have potential application in food, cosmetics and pharmaceutical industries. © 2014 Wiley Periodicals, Inc.


Liang H.,Nanjing Southeast University | Liang H.,Suzhou Key Laboratory of Biomedical Materials and Technology | Liu M.,Nanjing Medical University | Gu N.,Nanjing Southeast University | And 2 more authors.
Dongnan Daxue Xuebao (Ziran Kexue Ban)/Journal of Southeast University (Natural Science Edition) | Year: 2010

The toughening and strengthening effects of different contents of nano-zirconia on diatomite ceramics are investigated. Zirconia nanoparticles are added to the diatomite ceramic matrix materials(w(ZrO2)= 0 to 30%). After balling, drying, grinding and riddling, the composite ceramics are pressed by a bead machine, and then the obtained greenwares are sintered under atmospheric pressure at 1100°C. After milling and polishing, the mechanical properties of the sintered samples are tested using the three-point method and the indentation method. The phases and microstructures of the composite ceramics are studied by X-ray diffraction and scanning electron microscope, respectively. The experimental results indicate that when w(ZrO2)= 20%, the toughening effect of diatomite ceramic is obvious. Correspondingly, the flexural strength and the fracture toughness increase 130% and 30% respectively, while the hardness increases a little. The nano-zirconia toughened diatomite ceramic meets the basic requirements of dental machinable ceramics.


Xia Q.,Nanjing Southeast University | Xia Q.,Suzhou Key Laboratory of Biomedical Materials and Technology | Wang H.,Nanjing Southeast University | Wang H.,Suzhou Key Laboratory of Biomedical Materials and Technology
Integrated Ferroelectrics | Year: 2011

Coenzyme Q10 (CoQ10) is practically insoluble and chemically labile in water, Nanostructured Lipid Carriers loading CoQ10 can solve the problems of poor stability and low bioavilability of CoQ10. Good physical stability of particle was obtained through monitoring the change of particle size while the condition of storage changed. During exposed to day light for 15 days, retention rate of CoQ10-absolute ethanol solution decreased by about 80.0% which was much higher than that of CoQ10 Nanostructured Lipid Carrier. Also, the decreasing speed of CoQ10 unloaded in NLC was faster than CoQ10-NLC's by protecting from light for 6 months. Copyright © Taylor & Francis Group, LLC.

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