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Yao W.-J.,Nanjing University | Ouyang B.-S.,Suzhou Hospital of Traditional Chinese Medicine
Journal of Acupuncture and Tuina Science | Year: 2014

Objective: To observe the effect of relaxing needling plus rehabilitation training on post-stroke upper limb dysfunction. Methods: Sixty-eight eligible subjects with post-stoke upper limb dysfunction were randomized into 2 groups by the random number table, 34 in each group, to respectively receive relaxing needling method or ordinary needling method in addition to rehabilitation training for 2 months. Fugl-Meyer assessment of upper limb motor function, neurological defect score, and clinical efficacies were observed and compared. Results: The two groups both showed effects. The total effective rate in the relaxing needling group was 93.8% versus 84.9% in the ordinary needling group, and the difference was statistically significant (P<0.05). The relaxing needling group was better than the ordinary needling group in improving the motor function of upper limb and neurological defect (P<0.05). Conclusion: Relaxing needling plus rehabilitation training can significantly improve the post-stroke motor dysfunction of upper limb, better than ordinary needling plus rehabilitation training. © 2014 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg. Source

Hu W.,Nanjing University of Traditional Chinese Medicine | Qian X.,Jiangsu Province Hospital of Traditional Chinese Medicine | Guo F.,Jiangsu Province Hospital of Traditional Chinese Medicine | Zhang M.J.,Jiangsu Province Hospital | And 4 more authors.
Chinese Medical Journal | Year: 2014

Background: Traditional Chinese medical treatment of primary Sjögren's syndrome has advantages over Western medicine in terms of fewer side effects and improved patient conditions. This study was a multicenter, randomized, doubleblind, placebo-controlled clinical trial of the efficacy and safety of ShengJinRunZaoYangXue granules for the treatment of primary Sjögren's syndrome, including the symptoms of dry mouth and dry eye. Methods: We undertook a 6-week, double-blind, randomized trial involving 240 patients with primary Sjögren's syndrome at five centers in East China. A computer-generated randomization schedule assigned patients at a 2:1 ratio to receive either ShengJinRunZaoYangXue granules or placebo once daily. Patients and investigators were blinded to treatment allocation. The primary endpoints were the salivary flow rate, Schirmer test results, and sugar test results. Intention-to-treat and per-protocol analyses were performed. Results: All 240 patients were randomly allocated to either the treatment group (n=160, ShengJinRunZaoYangXue granules) or placebo group (n=80) and were included in the intention-to-treat analysis. After program violation and loss to follow-up, a total of 199 patients were included in the per-protocol analysis. At six week, intention-to-treat and per-protocol analyses of the left-eye Schirmer I test results showed an improved difference of 1.36 mm/5 min (95% CI: 0.03 to 2.69 mm/5 min) and 1.35 mm/5 min (95% CI: 0.04 to 2.73 mm/5 min), respectively, and those of the right-eye Schirmer I test results showed an improved difference of 1.12 mm/5 min (95% CI: 0.02 to 2.22 mm/5 min) and 1.12 mm/5 min (95% CI: -0.02 to 2.27 mm/5 min), respectively. There was no significant difference between the two groups before treatment. After treatment, the between-group and within-group before-and-after paired comparison results were statistically significant (P <0.05). Intention-to-treat and per-protocol analyses showed an improved salivary flow rate by 0.04 ml/15 min (95% CI: -0.49 to 0.58 ml/15 min) and 0.04 ml/15 min (95% CI: -0.52 to 0.60 ml/15 min), respectively, but the differences were not significant. Intention-to-treat and per-protocol analyses showed that the sugar test results were improved by 1.77 minutes (95% CI: 0.11 to 3.44 minutes) and 1.84 minutes (95% CI: 0.12 to 3.55 minutes), respectively, but the differences were not significant. For the secondary endpoint, intention-to-treat and per-protocol analyses showed significant improvement in the integrated evaluation of treated patients with dry eye and dry mouth after six weeks of treatment. The incidence of adverse events was 15.6% in the treatment group and 10.0% in the placebo group. Most (94%) adverse events were mild to moderate in the two groups, and only two cases of serious adverse events occurred in the treatment group; both were caused by autoimmune liver disease. Conclusions: Six-week treatment with ShengJinRun ZaoYangXue granules for primary Sjögren's syndrome in this large-scale study improved the symptoms of dry mouth, dry eyes, and low tear flow rate with minimal adverse events. Source

Lai H.-J.,Suzhou Hospital of Traditional Chinese Medicine | Huang K.-C.,Suzhou Hospital of Traditional Chinese Medicine
Chinese Journal of Medical Imaging Technology | Year: 2012

Objective: To explore the general hemodynamic changes in patients of primary open angle glaucoma (POAG) through observing the finger artery hemodynamics. Methods: The right and left ring finger artery of 41 cases diagnosed with POAG (POAG group) and 88 health adults (normal control group) were scanned, and the hemodynamic parameters were obtained and compared according to sex, side and age (≤30, 31-40, 41-50, 51-60 and >60 years). Results: The resistance index (RI) in POAG group was higher than that in normal control group, while the peak velocity was lower. Conclusion: POAG refers to the existence of hemodynamic disorders showing in the lower artery flow and higher RI, suggesting that the patients have systemic vascular disease, therefore hemodynamics should be improved at the same time of local treatment. © 2012 by the Press of Chinese Journal of Medical Imaging Technology. Source

Xue Y.-L.,Shandong University of Traditional Chinese Medicine | Meng X.-Q.,Suzhou Hospital of Traditional Chinese Medicine | Ma L.-J.,Peoples Hospital of Yangxin | Yuan Z.,Shandong Provincial Qianfoshan Hospital
Oncology Letters | Year: 2016

Plumbagin, a naphthoquinone constituent of Plumbago zeylanica L. (Plumbaginaceae) is widely used in traditional Chinese medicine as an antifungal, antibacterial and anti‑inflammatory agent. Plumbagin is known to exhibit proapoptotic, antiangiogenic and antimetastatic effects in cancer cells. The transcriptional co‑factor four and a half LIM domains 2 (FHL2) is a multifunctional adaptor protein that is involved in the regulation of gene expression, signal transduction and cell proliferation and differentiation, and also acts as a tumor suppressor or oncoprotein depending on the tissue microenvironment. The present study investigated the effect of plumbagin on FHL2 expression, Wnt/β‑catenin signalling and its anti‑proliferative activity in various human osteosarcoma cell lines, including SaOS2, MG63, HOS and U2OS. The cells were exposed to plumbagin and the expression of FHL2 was evaluated using western blot analysis. Furthermore, the anti‑proliferative effect of plumbagin was evaluated using a 3‑(4,5 dimethyl‑thiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay. In addition, since FHL2 is involved in Wnt/β‑catenin signaling, the effect of plumbagin on β‑catenin and its primary target genes, including v‑myc avian myelocytomatosis viral oncogene homolog (c‑Myc) and WNT1 inducible signaling pathway protein‑1 (WISP‑1), was evaluated using western blot analysis. It was observed that plumbagin suppressed the expression of FHL2 and exhibited significant anti‑proliferative activity in osteosarcoma cells. It also attenuated Wnt/β‑catenin signalling by downregulating β‑catenin and its target genes, including c‑Myc and WISP‑1. In conclusion, plumbagin demonstrated anti‑proliferative activity in osteosarcoma cells by downregulating FHL2 and interfering with Wnt/β‑catenin signalling. © 2016, Spandidos Publications. All rights reserved. Source

Chen J.,Suzhou Hospital of Traditional Chinese Medicine | Zhu B.,Jiangsu Hospital of Traditional Chinese Medicine | Li Y.,Suzhou Hospital of Traditional Chinese Medicine
DNA and Cell Biology | Year: 2013

The tumor suppressor P53 and its negative regulator mouse double minute 2 (MDM2) play crucial roles in carcinogenesis. Previous case-control studies also revealed that P53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of common cancers. However, the relationship between these two functional polymorphisms and adult acute lymphoblastic leukemia (ALL) susceptibility has not been explored. In this study, we performed a case-control study to explore the association between MDM2 and P53 gene polymorphisms and ALL risk in a Chinese population. We found an increased adult ALL risk associated with the MDM2 GG (odds ratio [OR]=2.79, 95% confidence interval [95% CI]=1.67-4.68) and TG (OR=1.49, 95% CI=0.95-2.53) genotypes. An increased risk associated with the P53 Pro/Pro genotype (OR=2.22, 95% CI=1.30-3.79) compared with the Arg/Arg genotype was also observed. Furthermore, the gene-gene interaction of MDM2 and P53 polymorphisms increased the adult ALL risk in a super-multiplicative manner (OR for the presence of both MDM2 GG and P53 Pro/Pro genotypes=8.05, 95% CI=2.53-25.58). These findings suggest that polymorphisms of MDM2 and P53 genes may be genetic modifiers for developing adult ALL. © 2013 Mary Ann Liebert, Inc. Source

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