Ryu W.-S.,Seoul National University |
Kang B.,Centers for Disease Control and Prevention |
Hong J.,Centers for Disease Control and Prevention |
Hwang S.,Centers for Disease Control and Prevention |
And 3 more authors.
Emerging Infectious Diseases | Year: 2010
We assessed neurologic sequelae associated with an enterovirus 71 (EV71) outbreak in South Korea during 2009. Four of 94 patients had high signal intensities at brainstem or cerebellum on magnetic resonance imaging. Two patients died of cardiopulmonary collapse; 2 had severe neurologic sequelae. Severity and case-fatality rates may differ by EV71 genotype or subgenotype.
Ryu W.-S.,National Institute of Health |
Ryu W.-S.,Seoul National University |
Kang B.,National Institute of Health |
Hong J.,National Institute of Health |
And 3 more authors.
Journal of Clinical Microbiology | Year: 2010
Human enterovirus 71 (EV 71) has caused large-scale outbreaks of hand-foot-and-mouth disease (HFMD), particularly in the Asian-Pacific region. In this study, we report a major outbreak of EV 71 infection in Korea and describe the clinical differences between EV 71 and non-EV 71 enterovirus infections. We prospectively enrolled patients with suspected viral infections during a recent 2-year period through a nationwide surveillance system. We identified 719 patients with suspected HFMD or herpangina using real-time PCR and genotyping based on VP1 sequence analysis. The major pathogen causing HFMD changed substantially from 2008 to 2009, with EV 71 becoming the most common cause of HFMD in Korea in 2009. We successfully identified the enteroviral genotypes for 218 of the 719 patients. Patients with EV 71 infections tended to be younger than those with non-EV 71 enteroviral infections and presented with HFMD and meningoencephalitis. In addition, the occurrence of fever, headache, and neck stiffness was significantly higher in patients with EV 71 infections. Multivariable analysis showed that for patients presenting with HFMD, fever, or a sore throat, each covariate was independently associated with EV 71 infection; the adjusted odds ratios (with 95% confidence intervals in parentheses) for these variables were 31.86 (10.04 to 101.09), 4.76 (1.71 to 13.25), and 0.18 (0.04 to 0.77), respectively. Our results indicate that EV 71 was a major cause of HFMD in Korea during the study period. In addition, we found that clinical symptoms may be helpful in the early identification of patients with EV 71 infections. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Chun Y.-M.,Suwon Catholic University |
Cho S.-M.,The Korean Alcohol Research Foundation |
Shin S.-M.,Handong Global University
Psychology of Addictive Behaviors | Year: 2010
The Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) is an instrument used to measure the level of motivation in regards to changing drinking and other addictive behaviors. While some initial factor analysis studies on the SOCRATES described a three-factor orthogonal structure of the scale, some other studies found a two-factor correlated structure. Therefore, the primary objective of the present study was to test the validity of the Korean language version of the instrument using a Korean population. The study examined the factor structure of the Korean version of the SOCRATES with clinical samples consisting of 219 inpatients and 271 outpatients with alcohol dependency. An exploratory factor analysis with an alpha factoring method revealed a three-factor correlated structure (i.e., Taking Steps, Recognition, and Ambivalence). The factorial structure of the SOCRATES Korean version corresponded almost exactly to that of its original French version as well as the German version. Moreover, confirmatory factor analyses showed that a three-factor correlated structure provided the best fit for the data. © 2010 American Psychological Association.
Ko J.M.,Suwon Catholic University |
Park H.J.,Suwon Catholic University |
Kim C.H.,Suwon Catholic University
AJR. American journal of roentgenology | Year: 2015
MATERIALS AND METHODS: A total of 126 adults with active tuberculosis who underwent CT were enrolled. A retrospective investigation of CT images focused on the presence of perilymphatic micronodules, as well as other CT features of active tuberculosis. We selected two groups of patients with micronodules according to distribution (perilymphatic vs centrilobular). We compared clinical and CT findings between the two groups.RESULTS: Fifteen patients were excluded because of coexisting pulmonary disease. Among 111 patients, the prevalence of perilymphatic micronodules, galaxy or cluster signs, and interlobular septal thickening was 64 (58%), 18 (16%), and 30 (27%), respectively. Of 106 patients with micronodules, 37 and 40 were classified into the perilymphatic and centrilobular groups, respectively. Compared with the centrilobular group, the perilymphatic group had statistically significantly lower frequencies of positive acid-fast bacilli smears (32% vs 70%), consolidation (70% vs 98%), and cavitation (30% vs 60%). However, frequencies of interlobular septal thickening (41% vs 18%), galaxy or cluster signs (30% vs 0%), and pleural effusion (43% vs 20%) were statistically significantly higher in the perilymphatic group.CONCLUSION: CT findings representing pulmonary perilymphatic involvement are relatively common in adults with tuberculosis. These findings may represent lymphatic spread of tuberculosis and provide an explanation for the unusual CT features of pulmonary tuberculosis mimicking sarcoidosis and the low detection of Mycobacterium tuberculosis in patients with micronodules.OBJECTIVE: The purpose of this study is to evaluate the prevalence and clinicoradiologic characteristics of pulmonary tuberculosis with lymphatic involvement.
Shin I.H.,Kyung Hee University |
Park D.C.,Suwon Catholic University |
Kwon C.,Kyung Hee University |
Yeo S.G.,Kyung Hee University
Archives of Otolaryngology - Head and Neck Surgery | Year: 2011
Objective: To evaluate changes in taste threshold in patients with chronic otitis media with effusion (COME) and their relationship with body mass index. A relationship has been suggested between pediatric obesity and COME, and we hypothesized that changes in taste function may occur in children with COME and that such changes may be associated with changes in body weight. Design: A prospective, nonrandomized, case-control study. Setting: A university tertiary care center. Subjects: The experimental group comprised 42 children with COME who underwent tympanostomy tube insertion, and the control group, 42 children without otitis media with effusion. Patients were enrolled between September 2007 and August 2009. Main Outcome Measure: Taste threshold was measured by electrogustometry, and 4 standard taste solutions (sucrose, sodium chloride, citric acid, and quinine hydrochloride) were used in chemical taste tests. Results: Body mass index was significantly higher in the COME than in the control group (P=.02). Electrogustometry showed that the anterior part of the tongue had a significantly higher taste threshold in the COME than in the control group (anterior right, P=.03; anterior left, P=.04), and chemical taste test results showed that sweet and salty tastes were significantly lower in the COME group (sweet, P=.02; salty, P=.04). Conclusion: These results showed that COME can cause changes in taste and that these changes may be related to pediatric obesity. ©2011 American Medical Association. All rights reserved.
Kang S.U.,Ajou University |
Cho J.-H.,Suwon Catholic University |
Chang J.W.,Ajou University |
Shin Y.S.,Ajou University |
And 7 more authors.
Cell Death and Disease | Year: 2014
Nonthermal plasma (NTP) is generated by ionization of neutral gas molecules, which results in a mixture of energy particles including electrons and ions. Recent progress in the understanding of NTP has led to its application in the treatment of various diseases, including cancer. However, the molecular mechanisms of NTP-induced cell death are unclear. The purpose of this study was to evaluate the molecular mechanism of NTP in the induction of apoptosis of head and neck cancer (HNC) cells. The effects of NTP on apoptosis were investigated using MTT, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling, Annexin V assays, and western blot analysis. The cells were examined for production of reactive oxygen species (ROS) using DCFCA or MitoSOX staining, intracellular signaling, and an animal model. NTP reduced HNC cell viability in a dosedependent manner and induced apoptosis. NTP resulted in alteration of mitochondrial membrane potential and accumulation of intracellular ROS generated from the mitochondria in HNC cells. Blockade of ROS production by N-acetyl-L-cysteine inhibited NTP-induced apoptosis. NTP led to the phosphorylation of c-JUN N-terminal kinase (JNK) and p38, but not extracellularregulated kinase. Treatment with JNK and p38 inhibitors alleviated NTP-induced apoptosis via ROS generation. Taken together, these results show that NTP induced apoptosis of HNC cells by a mechanism involving MAPK-dependent mitochondrial ROS. NTP inhibited the growth of pre-established FaDu tumors in a nude mouse xenograft model and resulted in accumulation of intracellular ROS. In conclusion, NTP induced apoptosis in HNC cells through a novel mechanism involving MAPK-mediated mitochondrial ROS. These findings show the therapeutic potential of NTP in HNC. © 2014 Macmillan Publishers Limited.
Lee S.W.,Suwon Catholic University |
Jo H.H.,Suwon Catholic University |
Kim M.R.,Suwon Catholic University |
You Y.O.,Suwon Catholic University |
Kim J.H.,Suwon Catholic University
Gynecological Endocrinology | Year: 2012
Background: Osteocalcin, a marker of bone formation, is also known as a regulator of glucose and fat mass. The purpose of this study was to determine the association between obesity, metabolic risks and serum osteocalcin in postmenopausal women. Methods: We selected 214 postmenopausal women and determined serum osteocalcin, fasting plasma glucose (FPG), fasting insulin, high-sensitivity C-reactive protein (hs-CRP), the homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and anthropometric values (body mass index [BMI], waist-to-hip ratio [WHR], body fat, and visceral fat area [VFA]). Results: After adjustment for age and years since menopause, WHR and VFA were negatively correlated with serum osteocalcin, but BMI did not show a significant correlation. Serum osteocalcin was negatively correlated with fasting insulin and HOMA-IR, but FPG, lipid profile, and blood pressure did not show a significant correlation. Based on multiple regression analysis, age and HOMA-IR were the most important predictors of osteocalcin. Conclusion: Our study showed that serum osteocalcin has some significance as an indicator of metabolic risk, including abdominal obesity and insulin resistance. Bone as well as adipose tissue may be an active organ that regulates energy metabolism. A larger study will be needed to clarify the potential of osteocalcin as an indicator of cardiovascular disease. © 2012 Informa UK, Ltd.
Shim H.J.,Eulji University |
Jung H.,Kyung Hee University |
Park D.C.,Suwon Catholic University |
Lee J.H.,Kyung Hee University |
Yeo S.G.,Kyung Hee University
Acta Oto-Laryngologica | Year: 2011
Conclusions: Ramsay Hunt syndrome (RHS) with multiple involvement of cranial nerves is more severe and intractable than RHS without such involvement. Objectives: Typically, RHS involves VII and VIII nerves and unilaterally, and RHS accompanied by multiple cranial neuropathy is very rare. We describe 11 patients who developed RHS with multicranial nerve involvement and we analyzed their clinical characteristics and compared them with those of patients with RHS not accompanied by multiple cranial neuropathy. Methods: During the period 19952009, we treated 339 patients with RHS; of these, 11 patients had concurrent multiple cranial neuropathy. We assessed the clinical characteristics of RHS patients with and without multiple cranial neuropathy. Results: The mean age of the 11 patients with multiple cranial neuropathy (6 men, 5 women) was 49.2 ± 19.4 years, although 7 were aged 50 years or older. Eight patients had right-sided and three had left-sided facial paralysis. The initial degree of facial paralysis was House-Brackmann (HB) grade IV in four patients (36.4%) and HB grade V in seven (63.6%). Six patients showed improvement in symptoms, whereas five (45.6%) showed no improvement. The recovery rates from facial paralysis in patients with and without multiple cranial neuropathy were 54.5% and 82.9%, respectively, and the complete recovery rates were 27.3% and 67.7%, respectively. © 2011 Informa Healthcare.
Jo K.-W.,Catholic University of Korea |
Park I.-S.,Catholic University of Korea |
Hong J.T.,Suwon Catholic University
Journal of Clinical Neuroscience | Year: 2011
The treatment of C1 Jefferson fractures is controversial. Non-surgical treatment with halo fixation always bears the risk of insufficient healing with further instability and increasing neck pain. However, a C1-2 fusion can markedly decrease the rotatory motion of the neck. The aim of this report is to describe a new treatment for C1 Jefferson fractures. We used open reduction and C1 fixation using a bilateral C1 lateral mass screw construct. The screws were connected with a rod and nuts to reduce lateral spread of the lateral masses. This mehod is an alternative surgical option for C1 Jefferson fractures in select patients and can maintain important C1-2 joint motion. © 2010 Elsevier Ltd. All rights reserved.
Moon H.,Catholic University of Korea |
Chon J.,Catholic University of Korea |
Joo J.,Suwon Catholic University |
Kim D.,Suwon Catholic University |
And 4 more authors.
Diabetes/Metabolism Research and Reviews | Year: 2013
Background: FTY720, an analogue of sphingosine-1-phosphate, has shown potential in the treatment of several autoimmune diseases, such as multiple sclerosis, type 1 diabetes and systemic lupus erythematosus. It prevents development or cure of autoimmune diabetes in animal models. Recently, we reported that FTY720 also prevents development of diabetes in db/db mice by β-cell regeneration in vivo. This study investigated the effect of FTY720 on apoptosis in β-cells in db/db mice treated with FTY720 16weeks. Methods: Six week old female db/db mice were divided into control and FTY720 groups. FTY720 (10mg/kg) was orally administrated daily. Body weights and fasting glucose levels were measured once a week after overnight fasting. After 16weeks of treatment, oral glucose and insulin tolerance tests were performed, serum insulin levels and insulin contents in pancreas were determined, and then all mice were subjected to physiological and histological analyses. Results: FTY720-treated mice showed normal fasting glucose levels, improved glucose tolerance with normal insulin sensitivity and restored β-cell function to produce and secret insulin. Pancreas histology revealed that FTY720 prevented islet damage and preserved β-cell mass by inhibiting apoptosis and increasing β-cell survival in pancreatic islets. Conclusions: We concluded that early intervention with FTY720 in db/db mice can prevent development of diabetes through preserving β-cell mass by inhibiting apoptosis and increasing survival of islet β-cells. © 2012 John Wiley & Sons, Ltd.