Suseong, South Korea
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Choi S.-S.,Suseong College | Park E.K.,Kyungpook National University | Kwack M.H.,Kyungpook National University | Sung Y.K.,Kyungpook National University
Naunyn-Schmiedeberg's Archives of Pharmacology | Year: 2015

Abstract Recent studies have showed that psychosocial stress causes elevated secretion of cortisol, the principal glucocorticoid (GC), and thus increases the extent of periodontal breakdown. In this study, we investigated whether stress-associated periodontal disturbance may be due to GC-induced changes in the periodontal ligament stem cells (PDLSCs), one of the most promising candidates for periodontal tissue regeneration. Our results in this study showed that dexamethasone (Dex) treatment causes the translocation of the glucocorticoid receptor (GR) into the nucleus and increases the expression of many genes, including dickkopf-1 (DKK-1) in PDLSCs. ELISA showed that DKK-1 is secreted from PDLSCs in response to Dex treatment. The GR antagonist RU486 attenuated the Dex-inducible DKK-1 messenger RNA (mRNA) expression. DKK-1 inhibited the growth of PDLSCs and suppressed Wnt-mediated activation of β-catenin signaling in PDLSCs. Our results strongly suggest that stress-associated periodontal disturbance may be due to GC-induced changes in the activity of PDLSCs via DKK-1 expression and might provide a possible explanation for the deteriorating effect of stress on periodontal breakdown. © 2015 Springer-Verlag Berlin Heidelberg.

PubMed | Keimyung University and Suseong College
Type: Journal Article | Journal: Journal of Korean Academy of Nursing | Year: 2016

This study was conducted to develop a program to help emergency nurses overcome compassion fatigue, and to analyze the effects of the program.A nonequivalent control group pretest-posttest design was used. There were 14 participants in the experimental group and 18 subjects in the control group. The program was comprised of five, weekly 80-minute sessions including understanding and assessment of compassion fatigue, enhancing positive affect, balancing work-life, planning self care, training in relaxation techniques and cognitive restructuring, and getting social support. Research variables were ego-resiliency, compassion satisfaction and compassion fatigue of the ProQOL 5, and salivary cortisol. Data were analyzed using Chi-square test, independent t-test, and paired t-test.The first hypothesis, There will be a difference in scores for ego resiliency between the experimental group and the control group. was not supported. The second hypothesis, There will be a difference in scores for compassion satisfaction between the experimental group and the control group was supported (t=2.15, p=.046). The third hypothesis, There will be a difference in scores for compassion fatigue between the experimental group and the control group was not supported.The first program for emergency nurses to overcome compassion fatigue in Korea was effective in increasing emergency nurses compassion satisfaction and decreasing salivary cortisol level in the experimental group. Therefore, this program for overcoming compassion fatigue is useful to increase emergency nurses compassion satisfaction. However replication studies of short-term intensive program reflecting emergency nurses opinion are needed.

Seo K.-I.,Sunchon National University | Lee J.,Sunchon National University | Choi R.-Y.,Sunchon National University | Lee H.-I.,Sunchon National University | And 4 more authors.
Food and Function | Year: 2014

This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice. Oral administration of TVB (14 mL kg-1 body weight) to HF-fed mice for 6 weeks effectively reduced the body and visceral fat weight and significantly lowered plasma free fatty acid, triglyceride and hepatic triglyceride levels. TVB significantly increased fecal triglyceride excretion, both phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) and peroxisome proliferator-activated receptor (PPAR)α protein levels in the liver, which were associated with increased fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice. TVB improved glucose tolerance, hyperinsulinemia and HOMA-IR levels in the HF + TVB group compared to the HF group. Additionally, TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, which enhanced glucose metabolism in obese mice. These results suggest that TVB prevents visceral obesity and insulin resistance via AMPK/PPARα-mediated fatty acid and glucose oxidation. This journal is © the Partner Organisations 2014.

Lee H.-I.,Sunchon National University | Yun K.W.,Sunchon National University | Seo K.-I.,Sunchon National University | Kim M.-J.,Suseong College | Lee M.-K.,Sunchon National University
Metabolism: Clinical and Experimental | Year: 2014

Objective This study investigated the effects of scopoletin on alcohol-induced hepatic lipid accumulation in diet-induced obese mice and its mechanism. Material/Methods Alcohol (25% v/v, 5 g/kg body weight) was orally administered once a day for 6 weeks to mice fed with a high-fat diet (35%kcal) with or without scopoletin (0.05%, wt/wt). Results Scopoletin reduced plasma acetaldehyde, fatty acid, total cholesterol, triglyceride and insulin levels, hepatic lipid and droplets and fasting blood glucose levels that were increased by alcohol. Scopoletin significantly activated hepatic AMPK and inhibited ACC and SREBP-1c and the activities of lipogenic enzymes, such as FAS, PAP and G6PD compared to the alcohol control group. Moreover, scopoletin significantly inhibited hepatic CYP2E1 activity and protein levels but elevated the activities of SOD, CAT, GSH-Px and GST and the levels of GSH compared to the alcohol control group. The hepatic lipid peroxide level was significantly lowered by scopoletin supplementation in alcohol-administered obese mice. Conclusions Taken together, these results suggested that scopoletin can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet. © 2014 Elsevier Inc.

Lee J.,Sunchon National University | Lee H.-I.,Sunchon National University | Seo K.-I.,Sunchon National University | Cho H.W.,Sunchon National University | And 3 more authors.
Indian Journal of Experimental Biology | Year: 2014

Ursolic acid (UA) is a pentacyclic triterpenoid compound that naturally occurs in fruits, leaves and flowers of medicinal herbs. This study investigated the dose-response efficacy of UA (0.01 and 0.05%) on glucose metabolism, the polyol pathway and dyslipidemia in streptozotocin/nicotinamide-induced diabetic mice. Supplement with both UA doses reduced fasting blood glucose and plasma triglyceride levels in non-obese type 2 diabetic mice. High-dose UA significantly lowered plasma free fatty acid, total cholesterol and VLDL-cholesterol levels compared with the diabetic control mice, while LDLcholesterol levels were reduced with both doses. UA supplement effectively decreased hepatic glucose-6-phosphatase activity and increased glucokinase activity, the glucokinase/glucose-6-phosphatase ratio, GLUT2 mRNA levels and glycogen content compared with the diabetic control mice. UA supplement attenuated hyperglycemia-induced renal hypertrophy and histological changes. Renal aldose reductase activity was higher, whereas sorbitol dehydrogenase activity was lower in the diabetic control group than in the non-diabetic group. However, UA supplement reversed the biochemical changes in polyol pathway to normal values. These results demonstrated that low-dose UA had preventive potency for diabetic renal complications, which could be mediated by changes in hepatic glucose metabolism and the renal polyol pathway. High-dose UA was more effective anti-dyslipidemia therapy in non-obese type 2 diabetic mice.

Kim M.-J.,Suseong College | Sim M.-O.,Jeollanamdo Development Institute of Korean Traditional Medicine | Lee H.-I.,Sunchon National University | Ham J.R.,Sunchon National University | And 2 more authors.
Alcohol | Year: 2014

This study investigated the effects of umbelliferone (UF) on alcoholic fatty liver and its underlying mechanism. Rats were fed a Lieber-DeCarli liquid diet with 36% of calories as alcohol with or without UF (0.05g/L) for 8 weeks. Pair-fed rats received an isocaloric carbohydrate liquid diet. UF significantly reduced the severity of alcohol-induced body weight loss, hepatic lipid accumulation and droplet formation, and dyslipidemia. UF decreased plasma AST, ALT, and γGTP activity. UF significantly reduced hepatic cytochrome P450 2E1 activities and increased alcohol dehydrogenase and aldehyde dehydrogenase 2 activities compared to the alcohol control group, which resulted in a lower plasma acetaldehyde level in the rats that received UF. Chronic alcohol exposure inhibited hepatic AMPK activation compared to the pair-fed rats, which was reversed by UF supplementation. UF also significantly suppressed the lipogenic gene expression (SREBP-1c, SREBP-2, FAS, CIDEA, and PPARγ) and elevated the fatty acid oxidation gene expression (PPARα, Acsl1, CPT, Acox, and Acaa1a) compared to the alcohol control group, which could lead to inhibition of FAS activity and stimulation of CPT and fatty acid β-oxidation activities in the liver of chronic alcohol-fed rats. These results indicated that UF attenuated alcoholic steatosis through down-regulation of SREBP-1c-mediated lipogenesis and up-regulation of PPARα-mediated fatty acid oxidation. Therefore, UF may provide a promising natural therapeutic strategy against alcoholic fatty liver. © 2014 Elsevier Inc.

Lee K.-J.,Eulji University | Lee J.-Y.,Suseong College | Lee S.H.,Lumieye Genetics Co. | Choi T.H.,Nune Eye Hospital
BMB Reports | Year: 2013

To understand the corneal regeneration induced by bevacizumab, we investigated the structure changes of stroma and basement membrane regeneration. A Stick soaked in 0.5 N NaOH onto the mouse cornea and 2.5 mg/ml of bevacizumab was delivered into an alkali-burned cornea (2 μl) by subconjunctival injections at 1 hour and 4 days after injury. At 7 days after injury, basement membrane regeneration was observed by transmission electron microscope. Uneven and thin epithelial basement membrane, light density of hemidesmosomes, and edematous collagen fibril bundles are shown in the alkali-burned cornea. Injured epithelial basement membrane and hemidesmosomes and edematous collagen fibril bundles resulting from alkali-burned mouse cornea was repaired by bevacizumab treatment. This study demonstrates that bevacizumab can play an important role in wound healing in the cornea by accelerating the reestablishment of basement membrane integrity that leads to barriers for scar formation. © 2013 by the The Korean Society for Biochemistry and Molecular Biology.

Kang B.-S.,Konkuk University | Song K.-M.,Konkuk University | Lee H.-K.,Suseong College
Journal of Nano- and Electronic Physics | Year: 2016

The electronic property and the magnetism of AlGaMnP2 compound by 3.125 %, 6.25 %, and 9.375 % Mn concentrations were investigated using the first-principles calculations. The Mn-doped AlGaP2 chalcopyrite with or without defect of Al, Ga, or P atom yields a strong half-metallic ground state. The ferromagnetic state is the most energetically favorable one. The spin-polarization of Mn dopant is stable with a magnetic moment close to 4μB due to intra-atomic exchange coupling. The states of host Al, Ga, or P atoms at the Fermi level are mainly a P-3p character, which mediates a strong interaction between the Mn-3d and P-3p states. The ferromagnetic state with high magnetic moment is originated from the hybridized P(3p)-Mn(3d)- P(3p) interaction formed through the p-d coupling without the defects. It is noted that the ferromagnetism arises from two distinguishing characteristics by polarons and by holes-mediated exchange-coupling. © 2016 Sumy State University.

Hong S.J.,Semyung University | Kim E.H.,Suseong College
International Journal of Bio-Science and Bio-Technology | Year: 2015

To examine the effect of a program to encourage fluid intake in institutionalized elderly people. A non-equivalent control group pre- and post-time series design was used. Data were analyzed with the SPSS program by t-test, chi-square test, and repeated measures ANOVA. Elderly people in the experimental group showed significantly better outcomes in terms of body weight reduction, skin moisture levels, and fluid intake and output compared with elderly people in the control group. Elderly people in the experimental group also showed significantly better outcomes in comparison with elderly people in the control group in relation to urinalysis including odor, pH, specific gravity, osmolality, color, white blood cell count, and bacteriuria. A hydration management program could be one of the most effective nursing strategies to ultimately enhance the quality of life and health of institutionalized elderly people. © 2015 SERSC.

Kang B.-S.,Konkuk University | Chae K.-P.,Konkuk University | Lee H.-K.,Suseong College
Advances in Condensed Matter Physics | Year: 2015

We studied the electronic and magnetic properties of (Al1-yMny)GaP2 (Ga-rich) and Al(Ga1-yMny)P2 (Al-rich) with y = 0.03125, 0.0625, 0.09375, and 0.125 by using the first-principles calculations. The ferromagnetic Mn-doped AlGaP2 chalcopyrite is the most energetically favorable one. The spin polarized Al(GaMn)P2 state (Al-rich system) is more stable than spin polarized (AlMn)GaP2 state (Ga-rich) with the magnetic moment of 3.8 B /Mn. The Mn-doped AlGaP2 yields strong half-metallic ground states. The states of host Al, Ga, or P atoms at the Fermi level are mainly a P-3p character, which mediates a strong interaction between the Mn-3d and P-3p states. © 2015 Byung-Sub Kang et al.

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