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Daegu, South Korea

Choi S.-S.,Suseong College | Park E.K.,Kyungpook National University | Kwack M.H.,Kyungpook National University | Sung Y.K.,Kyungpook National University
Naunyn-Schmiedeberg's Archives of Pharmacology

Abstract Recent studies have showed that psychosocial stress causes elevated secretion of cortisol, the principal glucocorticoid (GC), and thus increases the extent of periodontal breakdown. In this study, we investigated whether stress-associated periodontal disturbance may be due to GC-induced changes in the periodontal ligament stem cells (PDLSCs), one of the most promising candidates for periodontal tissue regeneration. Our results in this study showed that dexamethasone (Dex) treatment causes the translocation of the glucocorticoid receptor (GR) into the nucleus and increases the expression of many genes, including dickkopf-1 (DKK-1) in PDLSCs. ELISA showed that DKK-1 is secreted from PDLSCs in response to Dex treatment. The GR antagonist RU486 attenuated the Dex-inducible DKK-1 messenger RNA (mRNA) expression. DKK-1 inhibited the growth of PDLSCs and suppressed Wnt-mediated activation of β-catenin signaling in PDLSCs. Our results strongly suggest that stress-associated periodontal disturbance may be due to GC-induced changes in the activity of PDLSCs via DKK-1 expression and might provide a possible explanation for the deteriorating effect of stress on periodontal breakdown. © 2015 Springer-Verlag Berlin Heidelberg. Source

Lee H.-I.,Sunchon National University | Yun K.W.,Sunchon National University | Seo K.-I.,Sunchon National University | Kim M.-J.,Suseong College | Lee M.-K.,Sunchon National University
Metabolism: Clinical and Experimental

Objective This study investigated the effects of scopoletin on alcohol-induced hepatic lipid accumulation in diet-induced obese mice and its mechanism. Material/Methods Alcohol (25% v/v, 5 g/kg body weight) was orally administered once a day for 6 weeks to mice fed with a high-fat diet (35%kcal) with or without scopoletin (0.05%, wt/wt). Results Scopoletin reduced plasma acetaldehyde, fatty acid, total cholesterol, triglyceride and insulin levels, hepatic lipid and droplets and fasting blood glucose levels that were increased by alcohol. Scopoletin significantly activated hepatic AMPK and inhibited ACC and SREBP-1c and the activities of lipogenic enzymes, such as FAS, PAP and G6PD compared to the alcohol control group. Moreover, scopoletin significantly inhibited hepatic CYP2E1 activity and protein levels but elevated the activities of SOD, CAT, GSH-Px and GST and the levels of GSH compared to the alcohol control group. The hepatic lipid peroxide level was significantly lowered by scopoletin supplementation in alcohol-administered obese mice. Conclusions Taken together, these results suggested that scopoletin can ameliorate alcohol-induced hepatic lipid accumulation by modulating AMPK-SREBP pathway-mediated lipogenesis in mice fed a high-fat diet. © 2014 Elsevier Inc. Source

Hong S.J.,Semyung University | Kim E.H.,Suseong College
International Journal of Bio-Science and Bio-Technology

To examine the effect of a program to encourage fluid intake in institutionalized elderly people. A non-equivalent control group pre- and post-time series design was used. Data were analyzed with the SPSS program by t-test, chi-square test, and repeated measures ANOVA. Elderly people in the experimental group showed significantly better outcomes in terms of body weight reduction, skin moisture levels, and fluid intake and output compared with elderly people in the control group. Elderly people in the experimental group also showed significantly better outcomes in comparison with elderly people in the control group in relation to urinalysis including odor, pH, specific gravity, osmolality, color, white blood cell count, and bacteriuria. A hydration management program could be one of the most effective nursing strategies to ultimately enhance the quality of life and health of institutionalized elderly people. © 2015 SERSC. Source

Kang B.-S.,Konkuk University | Song K.-M.,Konkuk University | Lee H.-K.,Suseong College
Journal of Nano- and Electronic Physics

The electronic property and the magnetism of AlGaMnP2 compound by 3.125 %, 6.25 %, and 9.375 % Mn concentrations were investigated using the first-principles calculations. The Mn-doped AlGaP2 chalcopyrite with or without defect of Al, Ga, or P atom yields a strong half-metallic ground state. The ferromagnetic state is the most energetically favorable one. The spin-polarization of Mn dopant is stable with a magnetic moment close to 4μB due to intra-atomic exchange coupling. The states of host Al, Ga, or P atoms at the Fermi level are mainly a P-3p character, which mediates a strong interaction between the Mn-3d and P-3p states. The ferromagnetic state with high magnetic moment is originated from the hybridized P(3p)-Mn(3d)- P(3p) interaction formed through the p-d coupling without the defects. It is noted that the ferromagnetism arises from two distinguishing characteristics by polarons and by holes-mediated exchange-coupling. © 2016 Sumy State University. Source

Seo K.-I.,Sunchon National University | Lee J.,Sunchon National University | Choi R.-Y.,Sunchon National University | Lee H.-I.,Sunchon National University | And 4 more authors.
Food and Function

This study investigated the mechanism of processed tomato vinegar beverage (TVB)-mediated anti-obesity and anti-insulin resistance effects in high-fat diet (HF)-induced obese mice. Oral administration of TVB (14 mL kg-1 body weight) to HF-fed mice for 6 weeks effectively reduced the body and visceral fat weight and significantly lowered plasma free fatty acid, triglyceride and hepatic triglyceride levels. TVB significantly increased fecal triglyceride excretion, both phosphorylated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) and peroxisome proliferator-activated receptor (PPAR)α protein levels in the liver, which were associated with increased fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice. TVB improved glucose tolerance, hyperinsulinemia and HOMA-IR levels in the HF + TVB group compared to the HF group. Additionally, TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, which enhanced glucose metabolism in obese mice. These results suggest that TVB prevents visceral obesity and insulin resistance via AMPK/PPARα-mediated fatty acid and glucose oxidation. This journal is © the Partner Organisations 2014. Source

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