Hanno, Japan
Hanno, Japan

Surugadai University is a private university in Hannō, Saitama, Japan, established in 1987. Aiming to produce able people who can contribute to today's internationalized, information-oriented society, the university places emphasis on thorough small-class teaching, foreign language education, acquisition of rich computer skills, and preparation for various certifying examinations. Wikipedia.

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Iwami T.,Kyoto University | Kitamura T.,Kyoto University | Kawamura T.,Kyoto University | Mitamura H.,Saiseikai Central Hospital | And 6 more authors.
Circulation | Year: 2012

BACKGROUND: It remains unclear which is more effective to increase survival after out-of-hospital cardiac arrest in those with public-access defibrillation, bystander-initiated chest compression-only cardiopulmonary resuscitation (CPR) or conventional CPR with rescue breathing. METHODS AND RESULTS: A nationwide, prospective, population-based observational study covering the whole population of Japan and involving consecutive out-of-hospital cardiac arrest patients with resuscitation attempts has been conducted since 2005. We enrolled all out-of-hospital cardiac arrests of presumed cardiac origin that were witnessed and received shocks with public-access automated external defibrillation (AEDs) by bystanders from January 1, 2005, to December 31, 2009. The main outcome measure was neurologically favorable 1-month survival. We compared outcomes by type of bystander-initiated CPR (chest compression-only CPR and conventional CPR with compressions and rescue breathing). Multivariable logistic regression was used to assess the relationship between the type of CPR and a better neurological outcome. During the 5 years, 1376 bystander-witnessed out-of-hospital cardiac arrests of cardiac origin in individuals who received CPR and shocks with public-access AEDs by bystanders were registered. Among them, 506 (36.8%) received chest compression-only CPR and 870 (63.2%) received conventional CPR. The chest compression-only CPR group (40.7%, 206 of 506) had a significantly higher rate of 1-month survival with favorable neurological outcome than the conventional CPR group (32.9%, 286 of 870; adjusted odds ratio, 1.33; 95% confidence interval, 1.03-1.70). CONCLUSIONS: Compression-only CPR is more effective than conventional CPR for patients in whom out-of-hospital cardiac arrest is witnessed and shocked with public-access defibrillation. Compression-only CPR is the most likely scenario in which lay rescuers can witness a sudden collapse and use public-access AEDs. © 2012 American Heart Association, Inc.

Kitamura T.,Kyoto University | Iwami T.,Kyoto University | Kawamura T.,Kyoto University | Nitta M.,Osaka Medical College | And 3 more authors.
Circulation | Year: 2012

BACKGROUND: Little is known about the nationwide trend in the survival of out-of-hospital cardiac arrest (OHCA) in Japan and the differences in incidence and survival by age group and origin of arrest. METHODS AND RESULTS: A nationwide, prospective, population-based observation covering the whole population of Japan and involving consecutive OHCA patients with resuscitation attempts was conducted from January 2005 to December 2009. The main outcome measure was 1-month survival with favorable neurological outcome. The nationwide trends in OHCA incidence and outcome by age and origin of arrest were assessed. Multiple logistic regression analysis for bystander-witnessed OHCA was used to adjust for factors that were potentially associated with favorable neurological outcome. During 5 years, 547 153 overall OHCAs and 169 360 bystander-witnessed OHCAs were enrolled. The annual incidence significantly increased among overall OHCAs and bystander-witnessed OHCAs. Neurologically favorable survival significantly increased from 1.6% (1676/102 737) in 2005 to 2.8% (3280/115 250) in 2009 (P<0.001), from 2.1% (638/30 556) to 4.3% (1558/36 361) (P<0.001), and from 9.8% (437/4461) to 20.6% (1215/5906) (P<0.001) among overall OHCA, bystander-witnessed OHCA, and bystander-witnessed ventricular fibrillation OHCA, respectively. Public-access automated external defibrillator use, either bystander-initiated chest compression-only cardiopulmonary resuscitation or conventional cardiopulmonary resuscitation, and earlier emergency medical services response time were associated with a better neurological outcome. Favorable neurological outcome among adult OHCA subjects significantly improved, but the outcome among younger children and very elderly subjects did not improve and was poor irrespective of origin of OHCA. CONCLUSIONS: Nationwide improvements of favorable neurological outcome from OHCA were observed in Japan and differed by age group and origin of OHCA. © 2012 American Heart Association, Inc.

Xu S.,U.S. National Institutes of Health | Xu S.,Sun Yat Sen University | Ogura S.,Surugadai University | Chen J.,Fudan University | And 3 more authors.
Cellular and Molecular Life Sciences | Year: 2013

Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved in endothelial dysfunction, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation, as well as plaque instability; all of these events are critical in the pathogenesis of atherosclerosis. These LOX-1-dependent biological processes contribute to plaque instability and the ultimate clinical sequelae of plaque rupture and life-threatening tissue ischemia. Administration of anti-LOX-1 antibodies inhibits atherosclerosis by decreasing these cellular events. Over the past decade, multiple drugs including naturally occurring antioxidants, statins, antiinflammatory agents, antihypertensive and antihyperglycemic drugs have been demonstrated to inhibit vascular LOX-1 expression and activity. Therefore, LOX-1 represents an attractive therapeutic target for the treatment of human atherosclerotic diseases. This review aims to integrate the current understanding of LOX-1 signaling, regulation of LOX-1 by vasculoprotective drugs, and the importance of LOX-1 in the pathogenesis of atherosclerosis. © 2012 Springer Basel.

Suzuki-Karasaki M.,Surugadai University | Ochiai T.,Surugadai University | Suzuki-Karasaki Y.,Nihon University
International Journal of Oncology | Year: 2014

We previously showed that membrane-depolarizing agents such as K + and ATP-sensitive potassium (KATP) channel inhibitors potentiate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human melanoma cells, but not in normal melanocytes. In this study, we investigated whether the tumor-selective effect of depolarization was observed among different tumor cell types and the mechanisms by which depolarization potentiates death pathways. We found that K+ and KATP channel inhibitors elicited similar apoptosis-potentiating effects in human tumor cells with different origins, including leukemia, melanoma and lung cancer cells. In contrast, minimal potentiation of apoptosis was observed in non-transformed lung cells. The potentiation was associated with increased mitochondrial and endoplasmic reticulum stress death pathways. Upregulation of surface TRAIL receptor-2 expression and modulation of the caspase-3 activation pathway seemed to play roles in the enhancement of death signaling. Moreover, the results showed that depolarization and mitochondria-derived reactive oxygen species (mROS) mutually regulated one another. Depolarization potentiated TRAIL-induced mROS accumulation. Conversely, scavenging of mROS by the antioxidant MnTBaP reduced depolarization, whereas mROS accumulation caused by metabolic inhibitors potentiated the depolarization. These findings suggest a positive loop between depolarization and mROS accumulation. This may provide a rationale for the tumor-selective cytotoxicity and/or potentiation of TRAIL cytotoxicity of a wide variety of ROS-producing substances in different types of tumor cells.

Hasegawa M.,Japan Forestry and Forest Products Research Institute | Ito M.T.,Surugadai University | Kaneko S.,Japan Forestry and Forest Products Research Institute | Kiyono Y.,Japan Forestry and Forest Products Research Institute | And 2 more authors.
Journal of Environmental Radioactivity | Year: 2013

We investigated the concentrations of radiocesium in epigeic earthworms, litter, and soil samples collected from forests in Fukushima Prefecture 6 months after the Fukushima Dai-ichi Nuclear Power Plant accident in 2011. Radiocesium concentrations in litter accumulated on the forest floor were higher than those in the soil (0-5cm depth). The highest average 134+137Cs concentrations in earthworms (approximately 19Bqg-1 of wet weight with gut contents and 108Bqg-1 of dry weight without gut contents) were recorded from a plot that experienced an air dose rate of 3.1μSvh-1, and earthworm concentrations were found to increase with litter and/or soil concentrations. Average 134Cs and 137Cs concentrations (with or without gut contents) were intermediate between accumulated litter and soil. Different species in the same ecological groups on the same plots had similar concentrations because of their use of the same habitats or their similar physiological characteristics. The contribution of global fallout 137Cs to earthworms with gut contents was calculated to be very low, and most 137Cs in earthworms was derived from the Fukushima accident. Transfer factors from accumulated litter to earthworms, based on their dry weights, ranged from 0.21 to 0.35, in agreement with previous field studies. © 2013 Elsevier Ltd.

Matsumoto N.,Surugadai University
BMJ case reports | Year: 2014

We present the case of coronary vasospasm during adenosine stress in a patient with a prior drug-eluting stent implantation. The patient had a stent implantation in the left anterior descending coronary artery 3 years ago. Recently, he developed a chest pain and underwent adenosine stress myocardial perfusion single photon emission CT (SPECT). During the adenosine stress, he felt severe chest pain and ST elevation on electrocardiogram. An invasive coronary angiography showed no in-stent restenosis. This phenomenon deemed to be adenosine-induced coronary vasospasm after stent implantation.

Suzuki-Karasaki Y.,Nihon University | Suzuki-Karasaki M.,Surugadai University | Uchida M.,Surugadai University | Ochiai T.,Surugadai University
Frontiers in Oncology | Year: 2014

Conventional genotoxic anti-cancer drugs target the proliferative advantage of tumor cells over normal cells. This kind of approach lacks the selectivity of treatment to cancer cells, because most of the targeted pathways are essential for the survival of normal cells. As a result, traditional cancer treatments are often limited by undesirable damage to normal cells (side-effects). Ideal anti-cancer drugs are expected to be highly effective against malignant tumor cells with minimal cytotoxicity toward normal cells. Such selective killing can be achieved by targeting pathways essential for the survival of cancer cells, but not normal cells. As cancer cells are characterized by their resistance to apoptosis, selective apoptosis induction is a promising approach for selective killing of cancer cells. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising tumor-selective anti-cancer drug. However, the congenital and acquired resistance of some cancer cell types, including malignant melanoma cells, currently impedes effective TRAIL therapy, and an innovative approach that can override TRAIL resistance is urgently required. Apoptosis is characterized by cell shrinkage caused by disruption of the maintenance of the normal physiological concentrations of K+ and Na+ and intracellular ion homeostasis. The disrupted ion homeostasis leads to depolarization and apoptosis. Recent evidence suggests that depolarization is an early and prerequisite event during TRAIL-induced apoptosis. Moreover, diverse natural products and synthetic chemicals capable of depolarizing the cell membrane exhibit tumor-selective killing and TRAIL-sensitizing effects. Here, we discuss the role of depolarization in selective killing of cancer cells in connection with the emerging concept that oxidative stress is a critical mediator of mitochondrial and endoplasmic reticulum dysfunctions and serves as a tumor-selective target in cancer treatment. © 2014 Suzuki-Karasaki, Suzuki-Karasaki, Uchida and Ochiai.

Sugie N.,Surugadai University
Proceedings of the ASIST Annual Meeting | Year: 2014

This study explores patterns of information-seeking behavior of public library users through statistical analysis of quantitative data. A behavioral investigation using radio frequency identification (RFID) and a questionnaire survey were conducted at Chiyoda Public Library in Japan in 2012. Data was obtained on the time spent in the library, travel distance, traveling path, time spent browsing in each zone and time spent browsing books by subject. Probability density for visiting points in the library was estimated from users' positional data gathered in the behavioral investigation in 2012. The results of the questionnaire survey were used to identify behavioral differences between two groups. As a result, it was found that users' visiting points concentrated on the general book zone, users who borrowed materials walk around mainly in the general book zone, and users who did not borrow materials visited fewer points. Copyright © 2014 Noriko Sugie.

Oberg A.,Surugadai University | Daniels P.,Kochi University of Technology
Computer Assisted Language Learning | Year: 2013

In this study a self-paced instructional method based on the use of Apple's iPod Touch personal mobile devices to deliver content was compared with a group-oriented instructional method of content delivery in terms of learner acquisition of course material. One hundred and twenty-two first-year Japanese university students in four classes were used in the study. The subjects were placed in two experimental groups and two control groups, and each researcher taught one control and one experimental group. An independent samples t-test performed on the groups' placement scores on the university's English entrance examination showed no significant difference between the two groups in terms of general English ability at the outset of the experiment. During the treatment sessions the control groups studied in a group-oriented classroom environment while the experimental groups studied the same course material but did so with a self-paced method that used Apple's iPod Touch personal mobile devices. As such, the subjects in the experimental group were allowed to study at a rate they chose rather than having the timing of the language input controlled by the teacher. The curriculum for both the control and experimental groups was based on the course textbook (Science English: Communication skills for scientists and engineers, Daniels, 2007, Tokyo: Thomson). The same standardized tests were given to all students involved in the study and the scores of the control and experimental groups were analysed using independent samples t-tests supported by Mann-Whitney tests. The post-treatment data showed a significant difference emerge between the groups, while the experimental group scored consistently higher than the control group. Results of a post-treatment survey given to the experimental group also indicated very positive learner attitudes towards the self-study iPod Touch-based instructional method. © 2013 Copyright Taylor and Francis Group, LLC.

Sugie N.,Surugadai University
Library and Information Science Research | Year: 2013

Radio frequency identification (RFID) technology has application to research on information-seeking behavior of library users. A user study was conducted to track traveling paths using the RFID system. Three undergraduate students carried a reader/writer and explored information sources in a library to complete a given set of tasks. Data regarding the traveling paths and information sources used were collected. The information offers insight into participants' information-seeking patterns. For example, all participants started in the online public access catalog zone; they used secondary sources for fact-based tasks more than for topic-based tasks. In addition, they spent the most time exploring the general book zone. A small percentage of tag recordings had to be removed or created because of errors in transmission readings; however, the procedure and results of the experiment were not affected. The results suggest that RFID technology provides data accurate enough to explain library users' information-seeking behavior, and can be applied to future studies. © 2012 Elsevier Inc.

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