Surflay Nanotec GmbH

Berlin, Germany

Surflay Nanotec GmbH

Berlin, Germany
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Patzelt A.,Charité - Medical University of Berlin | Richter H.,Charité - Medical University of Berlin | Knorr F.,Charité - Medical University of Berlin | Schafer U.,Saarland University | And 4 more authors.
Journal of Controlled Release | Year: 2011

Hair follicles represent interesting target sites for topically applied substances such as topical vaccinations or agents used in the field of regenerative medicine. In recent years, it could be shown that particles penetrate very effectively into the hair follicles. In the present study, the influence of particle size on the follicular penetration depths was examined. The penetration depths of two different types of particles sized 122 to 1000 nm were determined in vitro on porcine skin. The results revealed that the particles of medium size (643 and 646 nm, respectively) penetrated deeper into the porcine hair follicles than smaller or larger particles. It was concluded that by varying the particle size, different sites within the porcine hair follicle can be targeted selectively. For the human terminal hair follicle, the situation can be expected to be similar due to a similar size ratio of the hair follicles. © 2010 Elsevier B.V.

Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: NMP.2011.1.2-3 | Award Amount: 4.96M | Year: 2012

The shortage of drinking water in many regions on the planet constitutes a real problem and hazard. The use of seawater, brackish water and wastewater for human consumption is not a new concept. In spite of the success of membrane technology in water reclamation, membrane separation systems suffer from a serious problem: membrane fouling. The main downside is an inevitabe increase in operation and maintenance costs as well as an adverse effect on the lifespan of the membrane (harsh cleaning treatment). LbLBRANE is an ambitious project ensuring competent input right from the membrane concept down to lab-scale production and optimisation before scaling-up in pilot plants for end users. LbLBRANE applies novel nanotechnology tools, namely the layer-by-layer (LbL) technology to develop a versatile and generic procedure for the fast fabrication of low-cost, stable, chemical-resistant polyelectrolyte membranes. The LbL technology is the way to go for a bottom-up nano-engineered membrane whereby the modification is performed stepwise in a controlled manner - the thickness can be finely tuned by the number of layers deposited, the architecture of the film can be compartmentalised by incorporating functional species (polyelectrolyte as well as nanoparticles with specific functions, such as antibacterial properties) and the morphology of the film can be modulated via the pH, charge density and type of polyelectrolyte pairs to create pore size (hence permeability) tailored according to the specific need of the membranes. Our concern is focused towards high performance, regenerable membranes which could be cleaned in-situ and hybrid membranes with extremely high flux with high permselectivity and mechanical robustness. The ultimate aim is towards implementation of LbL on large industrial scale, from module design and construction to end user, especially for water reuse and metal/acid recovery.

Surflay Nanotec Gmbh and Severus Patent Ag | Date: 2012-02-17

The invention relates to a smokeless cigarette, cigar, or pipe having at least one depot (10) for storing and for defined release due to external heat input of nicotine and/or compound comprising nicotine to an airflow to be guided through the depot (10). According to the invention the depot (10) comprises at least one heat transfer segment (16) for targeted heat input for defined release of the nicotine and/or nicotine compound to the airflow.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.65M | Year: 2015

Photonics will play a major, enabling role in the future of ICT and healthcare. However, to fulfill its potential and deliver on its promises, photonics will heavily rely on novel and more performing materials, that can be manufactured cheaply for the specific requirements of photonic applications. To lead this photonics revolution and rip the societal benefits of being at the leading-edge of novel technological and scientific developments, the EC needs a highly-skilled scientific and technical workforce that can effectively implement the transition to a truly knowledge-based society. SYNCHRONICS mission is to synergistically address both needs by training a pool of future science-leaders in the synthesis, characterisation and application to photonics of supramolecularly-engineered functional materials within state-of the-art photonic nanostructures fabricated thanks to the top-quality facilities and unique expertise available within the network. This kind of research requires an inter-multidisciplinary, intersectorial approach by specialized and skilled scientists from different disciplines, each one bringing a particular expertise: organic and supramolecular synthesis (UNI-OX,UNI-W, SURFLAY), theory (UNI-GE, IBM, UNI-GE), surface studies (UdS, UCL), photophysics (IIT, IBM, UCL, UNI-GE,UNI-CY, UNI-MO), device fabrication and characterisation (IBM, AMO, SURFLAY, UCL, IIT, UNI-PI, UNI-GE). The SYNCHRONIX Network, through the trans-national and trans-disciplinary coordination and integration of these 12, highly specialised and internationally-leading teams, consolidates the European training efforts in the emerging area of both supramolecular nanoscience and nanophotonics. SYNCHRONICS will deliver 540 person-months of unparalleled multidisciplinary and intersectorial training that is carefully and intensively structured through local, network wide, and extra-network training in both scientific/technical topics, as well as complementary and managerial skills.

Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP-2009-4.0-3 | Award Amount: 8.13M | Year: 2010

In vivo multimodality imaging is a fast growing field in medical research and, although the achievements at clinical level of this diagnostic method are recent, it is already one of the most promising approaches in the diagnosis of diseases in many research addressed medical centres. At present in this area, the USA plays the protagonist role as a result of the amount of resources engaged in the arena in the last decade. Both government and private companies agree, when considering the potential of this approach, that it is one of the foremost medical advancements as it will lead to early diagnosis of diseases with high impact on the societies of western countries. Multimodality imaging is currently viewed as a simple and powerful integration of two or more imaging methods (e.g. PET-CT). 3MICRON is an ambitious project which gathers some of the most advanced European medical and technical institutions together to address the design of new strategies in diagnostics, and to push the potential of medical imaging beyond the state-of-the-art. The multimodality approaches are supported by a class of next-generation micro/nanodevices called microballoons. These subsystems are able to implement the function of an ultrasound contrast agent with other imaging methods (SPECT, MRI). In the future, they may act as a minimally invasive drug delivery method and hyperthermia device. In 3MICRON, this multi-functional device will be tested in vitro and in vivo in order to assess bioclearance and cytoxicity effects toward high impact diseases, e.g. cardiovascular and inflammation pathologies. Finally, selected types of microballoons will undergo pre-clinical screening for a consolidated assessment of the bench-to-bed pathway for these new microdevices.

Bischler R.,NanoBioAnalytics | Bischler R.,Surflay Nanotec GmbH | Olszyna M.,Surflay Nanotec GmbH | Himmelhaus M.,NanoBioAnalytics | Dahne L.,Surflay Nanotec GmbH
European Physical Journal: Special Topics | Year: 2014

During the past decade, whispering gallery modes (WGMs) have been proven to enable highly sensitive microscopic optical sensors capable of in-vitro label-free bio-detection under physiological conditions. While the basic aspects of this quite novel and promising approach have been explored, it still lacks implementation at a level that would effectively rival well-established state-of-the-art biosensor systems, such as Surface Plasmon Resonance sensors and Quartz Crystal Microbalance. In this work, we present a fully automated in-vitro diagnostics system based on low-Q whispering gallery modes designed to accept this challenge. Starting from the principles of low-Q WGM sensing, various aspects and intricacies of implementing a fully fletched in-vitro diagnostics system are discussed with special foci on WGM analysis and numerical evaluation, sensor conditioning, fluid handling, and control of the overall device. First results of the performance of the system are presented and interpreted in view of the method’s potential. © EDP Sciences, Springer-Verlag 2014.

Kang J.,Surflay Nanotec GmbH | Loew M.,Humboldt University of Berlin | Arbuzova A.,Humboldt University of Berlin | Andreou L.,Qiagen | Dahne L.,Surflay Nanotec GmbH
Advanced Materials | Year: 2010

An advanced system based on layer-bylayer (LbL) technology and fluorescence resonance energy transfer (FRET) for the detection of small amounts of DNA has been developed. Several advantages over conventional particle systems due to nanoroughness, flexibility and specific surface properties of LbL films were determined, making LbL-oligonucleotide particles a first choice for homogeneous diagnostic assays. (Figure Presented) © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Agency: European Commission | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2013-IAPP | Award Amount: 1.15M | Year: 2013

Viroma project aims to fabricate multiplexed bead-based arrays as sensing devices on the basis of virus capsid and virosome Layer by Layer-assisted assembly on colloidal carriers. The virosome based platform technology will be suitable for the detection of several analytes ranging from comparatively small molecules, of the size of dioxins to larger biomolecules such as small proteins. Such systems are fast and sensitive, and require due to multiplexing and single particle based fluorometric read-outs only a very small amount of sample for analysis and is, suitable for high throughput analysis. The uniqueness of the approach developed in VIROMA is that the virus particles will retain their specific recognition properties provided by the virus capsides and transfer this specificity to the colloidal carrier. Moreover, the possibility of assembling different virus nanoparticles and virosomes on top of the colloids will result in particles with multiple recognition capabilities, going a step ahead nature. Depending on the analytes size two different detection mechanisms will be employed. If the analyte is a larger peptide or protein, a sandwich immunoassay can be employed with the capture antibody integrated into the virosome and transferred to the bead by means of virosome-membrane fusion. The fluorescence will be recorded with a flowcytometry using a colloidal dispersion of the beads or a laser scanning microscope if the beads are immobilized on a chip. As an example, we will assemble beads capable of detecting troponin, a standard marker for myocardial infarction. For small molecule s specific receptor molecules will be designed for a competitive assay. The project involves a synergic collaboration between two academic institutions: CIC biomaGUNE and the University of Leipzig with the company SURFLAY.

Kang J.,Surflay Nanotec GmbH | Dahne L.,Surflay Nanotec GmbH
Langmuir | Year: 2011

The influence of common cationic surfactants on the physical properties of differently composed polyelectrolyte films prepared by the layer-by-layer (LbL) technology was investigated. Free-standing polyelectrolyte films as microcapsules showed a fast, strong response to the addition of less than 1 mM cationic surfactant cetyltrimethylammonium bromide (CeTAB). As a function of the polyelectrolyte composition, the behavior of the capsules varied from negligible changes to complete disintegration via strong swelling. The response of microcapsules consisting of (poly(allylamine hydrochloride)(PAH)/poly(styrene sulfonate)(PSS))4 was associated with a 5-fold volume increase, a fast switch of permeability, and in the case of fluorescently labeled films a 4-fold increase in fluorescence intensity. The kinetics and strengths of the interaction process were investigated by confocal laser scanning microscopy (CLSM) and fluorescence spectroscopy. Also, the relative stabilities of the polycation/polyanion and surfactant/polyanion complexes were determined. A mechanism was suggested to explain the interactions between the cationic surfactants and polyelectrolyte capsules. The strong response can be exploited in potential applications such as the triggered release of drugs or other encapsulated materials, the fluorescence-based detection of cationic detergents, and a switchable stopper in microchannels. However, the high sensitivity of LbL films to traces of cationic surfactants can also limit their applicability to the encapsulation of drugs or other materials because pharmaceutical or technical formulations often contain cationic surfactants as preservatives such as benzalkonium salts (BAC). It was demonstrated that undesired capsule opening can be effectively prevented by cross-linking the polyelectrolyte multilayers. © 2011 American Chemical Society.

Agency: European Commission | Branch: FP7 | Program: MC-IIF | Phase: FP7-PEOPLE-IIF-2008 | Award Amount: 170.42K | Year: 2009

The project at hand aims at the development of new improved magnetic nano particles for diagnostics. These magnetic nano particles will then be incorporated in layer-by-layer capsules, which allow for a better detection of tiny amounts of analyte material in blood, urine and other body fluids. This innovative technology will significantly improve the reliability of the analysis of small amounts of bioorganic material and thereby facilitate medical diagnosis. If nowadays samples have to be sent to diagnostic laboratories for analysis, with the new technology every practitioner will be able to conduct diagnostic tests himself. Surflay, the Berlin-based host company for this project, is specialised in layer-by-layer technology and its application in diagnostics. However the necessary knowledge about the preparation of magnetic nanoparticles is missing. Therefore, Surflay plans to host Dr. Huang from Sichuan University, China for two years. Dr. Huang has achieved unique results on the preparation of magnetic nanoparticles. This project is meant to be the foundation of a long-term cooperation between Sichuan University and Surflay as well as other European network partner of Surflay.

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