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Jung C.,Max Delbrück Center for Molecular Medicine | Jung C.,Surface Medical
Biochimica et Biophysica Acta - Proteins and Proteomics | Year: 2011

The cytochrome P450 protein-bound porphyrin complex with the iron-coordinated active oxygen atom is called Compound I, which is presumably the intermediate species which hydroxylates inert carbon-hydrogen bonds of substrates. In this mini-review, the milestones in discovering Compound I of cytochrome P450 are summarized. It will be discussed what was known and suggested in the years before 1984, the year when Klaus Ruckpaul's first book about cytochrome P450 appeared, and compared with recent approaches and studies to catch and characterize this intermediate oxygen species in the reaction cycle of cytochrome P450. Although many studies have been undertaken before and after 1984 to characterize Compound I, its electronic structure and physicochemical properties are still a mystery. The conclusion from this review is that the knowledge about Compound I has significantly increased; however, we still ask the same questions. There is a need for improved experimental approaches, detection techniques, and theoretical simulations for future studies of cytochrome P450 Compound I. This mini-review is dedicated to Klaus Ruckpaul on the occasion of his 80th birthday. © 2010 Elsevier B.V. All rights reserved.


Iyer G.,Surface Medical | Srinivasan B.,Surface Medical | Agarwal S.,Surface Medical | Rachapalle S.R.,Surface Medical
American Journal of Ophthalmology | Year: 2014

Purpose To analyze the cases of lamina resorption following the modified osteo-odonto-keratoprosthesis (MOOKP) procedure. Design Retrospective case series. Patients and Methods Case records of 18 eyes (20 laminae) of 17 patients who showed evidence of lamina resorption out of the 85 eyes (87 laminae) of 82 patients that underwent MOOKP procedure between March 2003 and March 2013 were analyzed. Results Of the 17 patients (20 laminae), 1 underwent MOOKP procedure following multiple graft failures, 6 (7 laminae) belonged to the chemical injury group, and 10 (12 laminae) to the Stevens-Johnson syndrome (SJS) group. Resorption was noted in 20 out of 87 laminae (22.98%). The need for removal of lamina/extrusion was noted in 3 out of the 7 laminae in the chemical injury group and 8 out of the 12 laminae in the SJS group. The mean duration to the first sign suggestive of resorption among patients of SJS was 36.7 months and among patients of chemical injury was 43 months. Vitritis was the presenting feature (7 of 20 laminae, 35%) indicative of early resorption, and the occurrence of the same in eyes with lamina resorption was noted to be statistically significant in comparison to controls (P <.001). Sixteen out of 20 laminae showed evidence of resorption superiorly. Conclusion Vitritis was the most common presenting feature of lamina resorption and could be an indicator of lamina resorption. Resorption of the laminae was noted to occur along the aspect with thinner bone support in all eyes. Incidence of severe resorption with extrusion of cylinder/requiring lamina removal was noted to be higher among patients with SJS. © 2014 by Elsevier Inc. All rights reserved.


A 36-year-old active duty male with migraine headaches presented for evaluation of poorly controlled hypertension. The workup included an endocrinological examination, which revealed a moderately elevated urine normetanephrine level, suggesting the possibility of a pheochromocytoma. The evaluation also included a sleep study for possible obstructive sleep apnea (OSA) because of a history of snoring, apneic episodes, and daytime somnolence. The sleep study confirmed the diagnosis of OSA. The patient was treated with continuous positive airway pressure therapy and a plasma normetanephrine level demonstrated improvement, but persistent elevation. The patient was noted to be taking amitriptyline for migraine headache prevention. With approval from Neurology, the medication was discontinued and a repeat urine normetanephrine level revealed normalization. This case demonstrates the well-documented medication-associated false-positive test result that can be seen in patients taking tricyclic antidepressants. Tricyclic antidepressants, along with phenoxybenzamine, account for 41 to 45% of all elevated metanephrine and normetanephrine levels in patients without pheochromocytoma. This case also shows that patients with OSA can develop hypertension through elevated sympathetic tone, mimicking a pheochromocytoma. Treatment with continuous positive airway pressure therapy is recommended to not only improve hypertension and catecholamine excess but also distinguish the condition from a pheochromocytoma. Reprint & Copyright © 2014 Association of Military Surgeons of the U.S.


Iyer G.,Medical Research Foundation | Iyer G.,Surface Medical | Srinivasan B.,Medical Research Foundation | Agarwal S.,Medical Research Foundation | And 2 more authors.
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2014

Background: Stevens Johnson Syndrome (SJS) can lead to end stage corneal blindness. This study describes the comprehensive treatment measures and their outcomes in the management of ocular sequelae and complications of SJS. Methods: Four hundred sixty-four eyes of 232 patients of SJS who underwent surgical intervention (punctal cautery, mucus membrane grafting for lid margin keratinisation, fornix reconstructive procedures, tectonic procedures, keratoplasty and keratoprosthesis) were studied. It was a non-comparative, retrospective, interventional case series. The primary outcome was the change in the best corrected visual acuity (BCVA). Secondary outcome measures included an improvement in the ocular surface status as indicated by corneal epithelial fluorescein staining and Schirmer's I strip wetting. Results: The BCVA and the ocular surface status improved and/or stabilized in > 70% of eyes following punctal cautery (n = 160) and > 80% of eyes following lid margin mucus membrane grafting (n = 238). BCVA improved in 50% of eyes following fornix reconstructive procedures (n = 24) with COMET (n = 6), in 63.9% eyes with the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) lens (n = 36), in 81.8% of eyes after cataract surgery (n = 22). A BCVA of ≥20/200 was achieved in 72.34% of eyes following keratoprostheses procedures (n = 47). The mean duration of follow up was 53.3±15.2 months. Conclusion: The ocular sequelae of Stevens Johnson Syndrome can be blinding. They need to be identified and addressed early to retard the continued deterioration of the ocular surface. Our study aims to highlight the problem as well as the importance of comprehensive measures in the management of this potentially blinding disorder. © Springer-Verlag Berlin 2014.


Trademark
Surface Medical | Date: 2013-06-13

Patches to repair tears, rips or cracks on vinyl, leather and plastic surfaces.


Trademark
Surface Medical | Date: 2012-04-01

Fitted plastic films known as skins featuring a polymer germ shield additive coating for use covering and protecting electronic devices, namely, MP3 players, mobile telephones, smart telephones, digital cameras, global positioning systems and personal digital assistants.


Patent
Surface Medical | Date: 2012-03-05

The disclosure provides, in part, adhesive patches for repairing damaged surfaces of health care devices. In one of its aspects the disclosure provides a method of repairing the surface of health care device by applying an adhesive patch over a damaged portion of the surface, the patch comprising a film layer and an adhesive layer. In another one of its aspects, the disclosure provides an adhesive patch for repairing the surface of a health care device comprising a film layer and an adhesive layer.


Patent
Surface Medical | Date: 2015-09-28

The present disclosure provides for a repair device useful in the repair of surfaces, particularly in a healthcare environment. An exemplary form of the present comprises a repair patch, a pre-mask and release liner; the repair patch interposed between the pre-mask and release liner; the removable adhesive interposed between the pre-mask and repair patch; and the permanent adhesive interposed between the repair patch and the release liner; wherein the adhesion value of the removable adhesive is lower than that of the permanent adhesive.


The present invention relates to a cross-linked PEG polymer coating that is hydrophilic, lubricious, and resistant to adsorption of biological matters including proteins and cells. The coating is created using plasma glow discharge polymerization of organic compounds with a formula R(OCH_(2)CH_(2))_(n)OH, where R is an alkane group with 1-4 carbon atoms and n=1-6.


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