Suresh Gyan Vihar University

www.gyanvihar.org
Jaipur, India
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Rao N.,Suresh Gyan Vihar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Various herbal products are being tried to treat common ailments. Quercus infectoria has been found to possess antioxidant and antibacterial properties against some common oral pathogens. Also, the incidences of an assortment of diseases are becoming important with the augment in rate of population. The diseases chiefly comprise respiratory disorders, cardiovascular disorders, throat inflammation, skin infections etc. In the current study, broadly claimed crude drug Quercus infectoria, have been screened for their antiodxidant activity by radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and antibacterial activity against Shigella flexneri, Staphylococcus aureus, Salmonella typhi, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus vulgaris, Enterobacter aerogenes, Aspergillus niger, Candida albicans, Trichophyton rubrum. Also, Phytochemical screening of methanolic extracts of Quercus infectoria have been screened. Phytochemical screening recorded positive results for terpenoids, tannin and flavonoids. Further,the antioxidant activity shows moderate to potent antioxidant activity, with the ED50 value i.e. 0.254 μg/ml. When screening for antimicrobial activity, the results were expressed in terms of the diameter of the inhibition zone: The maximum efficacy of methanolic extract was showed against Proteus vulgaris (20 mm) of MIC & Aspergillus fumigates (12 mm).


Rastogi H.,Suresh Gyan Vihar University | Jana S.,Laila Research and Development Center
Phytotherapy Research | Year: 2014

When herbal drugs and conventional allopathic drugs are used together, they can interact in our body which can lead to the potential for herb-drug interactions. This work was conducted to evaluate the herb-drug interaction potential of caffeic acid and quercetin mediated by cytochrome P450 (CYP) inhibition. Human liver microsomes (HLMs) were added to each selective probe substrates of cytochrome P450 enzymes with or without of caffeic acid and quercetin. IC50, Ki values, and the types of inhibition were determined. Both caffeic acid and quercetin were potent competitive inhibitors of CYP1A2 (Ki= 1.16 and 0.93 μM, respectively) and CYP2C9 (Ki =0.95 and 1.67 μM, respectively). Caffeic acid was a potent competitive inhibitor of CYP2D6 (Ki=1.10 μM) and a weak inhibitor of CYP2C19 and CYP3A4 (IC50> 100 μM). Quercetin was a potent competitive inhibitor of CYP 2C19 and CYP3A4 (Ki=1.74 and 4.12 μM, respectively) and a moderate competitive inhibitor of CYP2D6 (Ki=18.72 μM). These findings might be helpful for safe and effective use of polyphenols in clinical practice. Our data indicated that it is necessary to study the in vivo interactions between drugs and pharmaceuticals with dietary polyphenols. Copyright © 2014 John Wiley & Sons, Ltd.


Soni H.,Suresh Gyan Vihar University | Singhai A.K.,P.A. College
International Journal of Applied Pharmaceutics | Year: 2013

Hydrogels, the swellable polymeric materials, have been widely investigated as the carrier for drug delivery systems. The hydrogel can be defined as a cross-linked polymeric network which has the capacity to hold water within its porous structure. The water holding capacity of the hydrogels arise mainly due to the presence of hydrophilic groups, viz. amino, carboxyl and hydroxyl groups in the polymer chains. Hydrogels are cross-linked polymeric networks and hence provide a 3-dimensional polymeric network structure. Rutin is the rhamnoglucoside of the flavonoid quercetin. It is quercetin 3-rutinoside and found in many plants and used for treatment of various vascular diseases. The goal of this work was to formulate and optimized hydrogel systems containing rutin 0.025% (w/w) which can improve the therapeutic efficacy of poor water soluble drugs (rutin). Hydrogels were prepared using Carbopol 934 and HPMC in different concentrations ratio 2:1, 1:1 & 2:1 along with methanolic (co-solvent) dispersion of rutin. Choice of optimal concentrations of polymers is based on rheological properties of hydrogels. Hydrogels were characterized by means of pH measurement, determination of % entrapment, pH, viscosity, Spreadability. In vitro release behaviour of rutin from hydrogels was determined using Franz diffusion cell. Release profile of the rutin was also fit into various kinetic models to find out the mechanism of drug release and formulations were showing the release by zero order system. On the basis of these parameters, the formula was optimized.


Mahendra P.,Suresh Gyan Vihar University | Bisht S.,Suresh Gyan Vihar University
Indian Journal of Pharmacology | Year: 2011

Interest in alternative medicine and plant-derived medications that affect the "mind" is growing. The aim of present study was to explore the anti-anxiety activity of hydroalcoholic extract of Coriandrum sativum (Linn.) using different animal models (elevated plus maze, open field test, light and dark test and social interaction test) of anxiety in mice. Diazepam (0.5 mg/kg) was used as the standard and dose of hydroalcoholic extract of C. sativum fruit (50, 100 and 200 mg/kg) was selected as per OECD guidelines. Results suggested that extract of C. sativum at 100 and 200 mg/kg dose produced anti-anxiety effects almost similar to diazepam, and at 50 mg/kg dose did not produce anti-anxiety activity on any of the paradigm used. Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed central effects of the hydroalcoholic extract of C. sativum.


Sharma P.V.,Suresh Gyan Vihar University | Samanta K.C.,Suresh Gyan Vihar University
Journal of Applied Pharmaceutical Science | Year: 2011

This research aims to investigate the hypoglycemic activity of methanolic extract of Tectona grandis root in alloxan induced diabetic albino rats. A comparison was made between the action of Tectona grandis methanolic extract and a known antidiabetic drug glibenclamide (0.5mg/kg p.o).The methanolic extract of Tectona grandis linn. root was administered orally at different doses to normal rats. The methanolic extract at 500 mg/kg dose level exhibited significant (p<0.05) hypoglycemic activity.


Rastogi H.,Suresh Gyan Vihar University | Jana S.,Laila Nutraceuticals Research and Development Center
European Journal of Drug Metabolism and Pharmacokinetics | Year: 2016

Phenolic compounds are common ingredients in many dietary supplements and functional foods. However, data concerning physicochemical properties and permeability of polyphenols on the intestinal epithelial cells are scarce. The aims of this study were to determine the experimental partition coefficient (Log P), and parallel artificial membrane permeability assay (PAMPA), to characterize the bi-directional transport of six phenolic compounds viz. caffeic acid, chrysin, gallic acid, quercetin, resveratrol and rutin in Caco-2 cells. The experimental Log P values of six polyphenols were correlated (R 2 = 0.92) well with the calculated Log P values. The apparent permeability (P app) range of all polyphenols in PAMPA for the apical (AP) to basolateral (BL) was 1.18 ± 0.05 × 10-6 to 5.90 ± 0.16 × 10-6 cm/s. The apparent Caco-2 permeability (P app) range for the AP-BL was 0.96 ± 0.03 × 10-6 to 3.80 ± 0.45 × 10-6 cm/s. The efflux ratio of P app (BL → AP) to P app (AP → BL) for all phenolics was <2, suggesting greater permeability in the absorptive direction. Six compounds exhibited strong correlations between Log P and PAMPA/Caco-2 cell monolayer permeation data. Dietary six polyphenols were poorly absorbed through PAMPA and Caco-2 cells, and their transepithelial transports were mainly by passive diffusion. © 2014 Springer International Publishing Switzerland.


Soni H.,Suresh Gyan Vihar University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Nature has been a source of medicinal agents for thousands of year and an impressive number of modern drug have been isolated from natural sources, many based on their use in traditional medicine. Plants from the genus Coleus have been used in traditional medicine by many cultures. Flavonoids, glycosides, phenolic compounds and volatile constituents have been reported as the major phytoconstituents of the Coleus species. This review describes the morphology, traditional and folklore uses, phytoconstituents and pharmacological reports of the prominent species of the genus Coleus. Various virgin areas of research on the species of this genus have been highlighted with a view to explore, isolate and identify the medicinally important phyto-constituents which could be utilized to alleviate various diseases affecting the mankind.


Ribonucleotide reductase subunit R2 regulates catalytic action of the enzyme to provide DNA synthesis material via reduction. It has been continuously investigated as anticancer drug target for design and discovery of its inhibitors. Present studies aim to design novel heterocyclic/aryl substituted and adamantyl added thiosemicarbazones out fitted with improved cell permeability and effective RNR inhibition. Design strategy renders significant use of virtual screening and molecular docking studies to converge search of selective molecules for synthesis and further experimental studies. Selected candidates were synthesized and evaluated in vitro for their RNR inhibitory activity (IC50, uM) on MCF-7 cells, breast cancer cell lines. Molecular docking results (docking scores) and experimental results (IC50, uM) were found to be correlated and in agreement. Structure-based and ligandbased studies of results substantiate regulative role of water molecules at catalytic site (H2O: 2057) as well as at RNR inhibitor binding site (H2O: 2023, 2047, 2060 and 2070). Admantyl group has testified constant spatial position in docked poses and involved in steric interactions with Cys271, Asp272, Phe237, Gly234 and Val238. Heterocyclic/aryl substitutions equally offered H-bonds with water molecules (H2O: 2028, 2054, 2061 and 2073) along with amino acids Ser264, Asp272, Tyr324 and Asn346. Present efforts to design new inhibitors incur new characteristics in RNR Inhibition. © 2015 Bentham Science Publishers.


Mittal S.,Suresh Gyan Vihar University
International Journal of Pharma and Bio Sciences | Year: 2013

Medicinal plant contains matter that can be used for therapeutic reason or which are precursors for the production of useful drugs. Very few and periodic works are there in the literature regardingthe phytochemistry and TLC of Viola odorata L. TLC profiling of plant extract gives an idea about thepresence of various phytochemicals. Different Rf (Retention factor) value of various phytochemicals provide valuable clue regarding their polarity and selection of solvents for separation of phytochemicals. HPLC profile of petroleum ether extract of Viola odorata have characteristics peaks at retentiontime 2.885, 3.370, 3.487, 3.900, 4.067, 4.191, 5.207, 6.724 (Stigmasterol), 17.698 (Lupeol), 18.174 (β-Sitosterol), 23.118. These peaks showed that there are different compounds and characteristic fingerprints for each drug to judge in an herbal formulation.


Mahendra P.,Suresh Gyan Vihar University | Bisht S.,Suresh Gyan Vihar University
Pharmacognosy Reviews | Year: 2012

Ferula asafoetida is herbaceous plant of the umbelliferae family. It is oleo gum resin obtained from the rhizome and root of plant. This spice is used as a digestive aid, in food as a condiment and in pickles. It is used in modern herbalism in the treatment of hysteria, some nervous conditions, bronchitis, asthma and whooping cough. It was at one time employed in the treatment of infantile pneumonia and flatulent colic. The gum resin is antispasmodic, carminative, expectorant, laxative, and sedative. The volatile oil in the gum is eliminated through the lungs, making this an excellent treatment for asthma. The odor of asafoetida is imparted to the breath, secretions, flatus, and gastric eructations. Its properties are antispasmodic, expectorant, stimulant, emmenagogue and vermifuge. Asafoetida has also been used as a sedative. It also thins the blood and lowers blood pressure. It is widely used in India in food and as a medicine in Indian systems of medicine like ayurveda. Asafoetida has been held in great esteem among indigenous medicines, particularly in Unani system from the earliest times.

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