Suresh Gyan Vihar University
Jaipur, India

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Mahendra P.,Suresh Gyan Vihar University | Bisht S.,Suresh Gyan Vihar University
Pharmacognosy Journal | Year: 2011

Coriandrum sativum Linn. has been credited with many medicinal properties. The green leaves of coriander are known as "asotu" in the Eastern Anatolian region or "cilantro" in the United States and are consumed as fresh herb. The essential oil obtained from its fruits at amounts ranging from approximately 0.5 to 2.5% is used both in flavours and in the manufacture of perfumes and soaps. The plant is grown widely all over the world for seed, as a spice, or for essential oil production. It is one of the earliest spices used by mankind. It has been used as a flavouring agent in food products, perfumes and cosmetics. It is used for various purposes such as for flavouring sweets, beverages, tobacco products and baked goods and as a basic ingredient for curry powder. It has been used as an analgesic, carminative, digestive, anti-rheumatic and antispasmodic agent.

Mahendra P.,Suresh Gyan Vihar University | Bisht S.,Suresh Gyan Vihar University
Indian Journal of Pharmacology | Year: 2011

Interest in alternative medicine and plant-derived medications that affect the "mind" is growing. The aim of present study was to explore the anti-anxiety activity of hydroalcoholic extract of Coriandrum sativum (Linn.) using different animal models (elevated plus maze, open field test, light and dark test and social interaction test) of anxiety in mice. Diazepam (0.5 mg/kg) was used as the standard and dose of hydroalcoholic extract of C. sativum fruit (50, 100 and 200 mg/kg) was selected as per OECD guidelines. Results suggested that extract of C. sativum at 100 and 200 mg/kg dose produced anti-anxiety effects almost similar to diazepam, and at 50 mg/kg dose did not produce anti-anxiety activity on any of the paradigm used. Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed central effects of the hydroalcoholic extract of C. sativum.

Sharma P.V.,Suresh Gyan Vihar University | Samanta K.C.,Suresh Gyan Vihar University
Journal of Applied Pharmaceutical Science | Year: 2011

This research aims to investigate the hypoglycemic activity of methanolic extract of Tectona grandis root in alloxan induced diabetic albino rats. A comparison was made between the action of Tectona grandis methanolic extract and a known antidiabetic drug glibenclamide (0.5mg/kg p.o).The methanolic extract of Tectona grandis linn. root was administered orally at different doses to normal rats. The methanolic extract at 500 mg/kg dose level exhibited significant (p<0.05) hypoglycemic activity.

Nisha K.,Suresh Gyan Vihar University | Deshwal R.K.,Suresh Gyan Vihar University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

In recent years many articles have been published on oxidative stress. Perhaps the knowledge about free radicals like reactive oxygen and nitrogen species metabolism; definition of markers for oxidative damage provide evidences linking chronic diseases and oxidative stress. Identification of flavonoids and other dietary polyphenol antioxidants present in plant foods and data supporting the idea that health benefits are associated with fruits, vegetables and red wine in the diet are probably linked to the polyphenol antioxidants they contain. Excessive reactive oxygen species may cause irreparable DNA damage, leading to mutagenesis and perhaps cancer. Investigation into the nature of DNA damage and repair have provided valuable insight into aging, human genetics and cancer.Now, there is deep interest in identifying free radical scavengers or antioxidants that inhibit oxidative DNA damage. In this review we discuss DNA damage due to oxidative stress, and the role of potent Antioxidants in its protection.

Rastogi H.,Suresh Gyan Vihar University | Jana S.,Laila Nutraceuticals Research and Development Center
European Journal of Drug Metabolism and Pharmacokinetics | Year: 2016

Phenolic compounds are common ingredients in many dietary supplements and functional foods. However, data concerning physicochemical properties and permeability of polyphenols on the intestinal epithelial cells are scarce. The aims of this study were to determine the experimental partition coefficient (Log P), and parallel artificial membrane permeability assay (PAMPA), to characterize the bi-directional transport of six phenolic compounds viz. caffeic acid, chrysin, gallic acid, quercetin, resveratrol and rutin in Caco-2 cells. The experimental Log P values of six polyphenols were correlated (R 2 = 0.92) well with the calculated Log P values. The apparent permeability (P app) range of all polyphenols in PAMPA for the apical (AP) to basolateral (BL) was 1.18 ± 0.05 × 10-6 to 5.90 ± 0.16 × 10-6 cm/s. The apparent Caco-2 permeability (P app) range for the AP-BL was 0.96 ± 0.03 × 10-6 to 3.80 ± 0.45 × 10-6 cm/s. The efflux ratio of P app (BL → AP) to P app (AP → BL) for all phenolics was <2, suggesting greater permeability in the absorptive direction. Six compounds exhibited strong correlations between Log P and PAMPA/Caco-2 cell monolayer permeation data. Dietary six polyphenols were poorly absorbed through PAMPA and Caco-2 cells, and their transepithelial transports were mainly by passive diffusion. © 2014 Springer International Publishing Switzerland.

Soni H.,Suresh Gyan Vihar University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Nature has been a source of medicinal agents for thousands of year and an impressive number of modern drug have been isolated from natural sources, many based on their use in traditional medicine. Plants from the genus Coleus have been used in traditional medicine by many cultures. Flavonoids, glycosides, phenolic compounds and volatile constituents have been reported as the major phytoconstituents of the Coleus species. This review describes the morphology, traditional and folklore uses, phytoconstituents and pharmacological reports of the prominent species of the genus Coleus. Various virgin areas of research on the species of this genus have been highlighted with a view to explore, isolate and identify the medicinally important phyto-constituents which could be utilized to alleviate various diseases affecting the mankind.

Mohapatra A.G.,Suresh Gyan Vihar University | Lenka S.K.,University of Rajasthan
Procedia Computer Science | Year: 2016

Watering system in agricultural lands plays a major activity in water and soil conservations. The future expectation of soil moisture content (MC) utilizing online soil and ecological parameters may give an effective stage to agriculture land watering system prerequisites. This article focuses on two optimization strategies, for example, Scaled Conjugate Gradient and BFGS Quasi-Newton based neural network algorithms utilized to predict hourly requirement of soil MC. The prediction performance of these two optimization techniques are also studied by calculating MSE (Mean Square Error), RMSE (Root Mean Square Error), and R-squared error. The calculations are tried for the forecast of soil MC in every one hour advance by considering eleven distinctive soil and environmental parameters. The best technique is used for the final prediction, and the predicted soil MC is utilized for generating appropriate notifications using fuzzy logic based weather model. The proposed system is hybrid system utilized to solve a single problem that is the generation of best irrigation suggestions for the farmers. © 2016 The Authors.

Ribonucleotide reductase subunit R2 regulates catalytic action of the enzyme to provide DNA synthesis material via reduction. It has been continuously investigated as anticancer drug target for design and discovery of its inhibitors. Present studies aim to design novel heterocyclic/aryl substituted and adamantyl added thiosemicarbazones out fitted with improved cell permeability and effective RNR inhibition. Design strategy renders significant use of virtual screening and molecular docking studies to converge search of selective molecules for synthesis and further experimental studies. Selected candidates were synthesized and evaluated in vitro for their RNR inhibitory activity (IC50, uM) on MCF-7 cells, breast cancer cell lines. Molecular docking results (docking scores) and experimental results (IC50, uM) were found to be correlated and in agreement. Structure-based and ligandbased studies of results substantiate regulative role of water molecules at catalytic site (H2O: 2057) as well as at RNR inhibitor binding site (H2O: 2023, 2047, 2060 and 2070). Admantyl group has testified constant spatial position in docked poses and involved in steric interactions with Cys271, Asp272, Phe237, Gly234 and Val238. Heterocyclic/aryl substitutions equally offered H-bonds with water molecules (H2O: 2028, 2054, 2061 and 2073) along with amino acids Ser264, Asp272, Tyr324 and Asn346. Present efforts to design new inhibitors incur new characteristics in RNR Inhibition. © 2015 Bentham Science Publishers.

Mittal S.,Suresh Gyan Vihar University
International Journal of Pharma and Bio Sciences | Year: 2013

Medicinal plant contains matter that can be used for therapeutic reason or which are precursors for the production of useful drugs. Very few and periodic works are there in the literature regardingthe phytochemistry and TLC of Viola odorata L. TLC profiling of plant extract gives an idea about thepresence of various phytochemicals. Different Rf (Retention factor) value of various phytochemicals provide valuable clue regarding their polarity and selection of solvents for separation of phytochemicals. HPLC profile of petroleum ether extract of Viola odorata have characteristics peaks at retentiontime 2.885, 3.370, 3.487, 3.900, 4.067, 4.191, 5.207, 6.724 (Stigmasterol), 17.698 (Lupeol), 18.174 (β-Sitosterol), 23.118. These peaks showed that there are different compounds and characteristic fingerprints for each drug to judge in an herbal formulation.

Mahendra P.,Suresh Gyan Vihar University | Bisht S.,Suresh Gyan Vihar University
Pharmacognosy Reviews | Year: 2012

Ferula asafoetida is herbaceous plant of the umbelliferae family. It is oleo gum resin obtained from the rhizome and root of plant. This spice is used as a digestive aid, in food as a condiment and in pickles. It is used in modern herbalism in the treatment of hysteria, some nervous conditions, bronchitis, asthma and whooping cough. It was at one time employed in the treatment of infantile pneumonia and flatulent colic. The gum resin is antispasmodic, carminative, expectorant, laxative, and sedative. The volatile oil in the gum is eliminated through the lungs, making this an excellent treatment for asthma. The odor of asafoetida is imparted to the breath, secretions, flatus, and gastric eructations. Its properties are antispasmodic, expectorant, stimulant, emmenagogue and vermifuge. Asafoetida has also been used as a sedative. It also thins the blood and lowers blood pressure. It is widely used in India in food and as a medicine in Indian systems of medicine like ayurveda. Asafoetida has been held in great esteem among indigenous medicines, particularly in Unani system from the earliest times.

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