Naik P.P.,Surat Municipal Institute of Medical Education and Research |
Mehta C.D.,Surat Municipal Institute of Medical Education and Research |
Srivastava S.K.,Surat Municipal Institute of Medical Education and Research
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2017
Background: Antibiotics are frequently prescribed medication. When drugs are dispensed in form of syrups or suspensions, appropriate volume should be dispensed in a bottle otherwise, it may result into wastage of drug, inadequate treatment, and resistance and also increased cost of treatment. Aims and Objective: The aim of our study was to analyze systemic antibacterial liquid formulations to ascertain the availability of adequate strength, volume dispensed for adequate treatment. Materials and Methods: The commonly available (IDR triple, Issue 2, 2016) oral liquid antibacterial formulations were analyzed. According to the weight of child (for 12 and 18 kg), amount of drug and requirement of number of bottles for 5 days were calculated. Results: Majority of manufacturers have dispensed inadequate volume of antibacterial drugs which was not sufficient for one course of therapy. For example, most of the formulations of cephalexin, cefixime, cefpodoxime, and amoxicillin + clavulanic acid were available in dispensing volume of 30 ml. This results into inadequate dose, wastage of drug (residual volume), resistance, and unnecessary social and financial burden to the patient. Hence, more number of bottles shall be required to complete a course of antibiotic. Conclusion: The dispensing volume of oral liquid dosage forms of most of the formulations were inadequate and thus, minimum amount dispensed should be 60 ml or as applicable for an antibiotic. © 2016 Payal P Naik et al.
Joshi G.,Surat Municipal Institute of Medical Education and Research |
Tada N.,Surat Municipal Institute of Medical Education and Research
Sri Lanka Journalof Child Health | Year: 2017
Objective: To find effect of noise intensity on heart rate, respiratory rate and oxygen saturation in late preterm and term newborns in a tertiary care hospital. Method: A controlled prospective study was carried out on 100 preterm and term newborns in the Surat Municipal Institute of Medical Education and Research during a 3 month period. Newborns were exposed to white noise of different intensities for 5 seconds and vital parameters were recorded. A statistical analysis was performed with SPSS 16.0. Results: Out of the 100 newborns, 65 were term and 35 were late preterm (34-36 weeks). Male to female ratio was 51:49. Heart rate increased significantly (p < 0.01) to all levels of noise exposure i.e. from 60- 70 dB and 80-90 dB in both groups. Oxygen saturation decreased as the noise intensity increased in both groups but only significantly (p < 0.05) in high noise intensity of 80-90 dB whereas, there was no effect on the respiratory rate and by gender. Conclusions: A 5 second white noise has a variable effect on the vital parameters of newborns; it accelerates heart rate and decreases oxygen saturation but has no effect on respiratory rate and gender.
Patel M.,Institute of Medical Technology |
Ramavataram D.V.S.S.,Surat Municipal Institute of Medical Education and Research
Indian Journal of Clinical Biochemistry | Year: 2012
Iron is an essential trace element and plays a number of vital roles in biological system. It also leads the chains of pathological actions if present in excess and/or present in free form. Major portion of iron in circulation is associated with transferrin, a classical iron transporter, which prevent the existence of free iron. The fraction of iron which is free of transferrin is known as non transferrin bound iron. Along with the incidence in iron over loaded patient non transferrin bound iron has been indicated in patients without iron overload. It has been suggested as cause as well as consequence in a number of pathological conditions. The major organs influenced by iron toxicity are heart, pancreas, kidney, organs involved in hematopoiesis etc. The most commonly suggested way for iron mediated pathogenesis is through increased oxidative stress and their secondary effects. Generation of free oxygen radicals by iron has been well documented in Fenton chemistry and Haber-Weiss reaction. Non transferrin bound iron has obvious chance to generate the free reactive radicals as it is not been shielded by the protective carrier protein apo transferrin. The nature of non transferrin bound iron is not clear at present time but it is definitely a group of heterogenous iron forms free from transferrin and ferritin. A variety of analytical approaches like colorimetry, chromatography, fluorimetry etc. have been experimented in different research laboratories for estimation of non transferrin bound iron. However the universally accepted gold standard method which can be operated in pathological laboratories is still to be developed. © 2012 Association of Clinical Biochemists of India.
Prakash S.,SSG Hospital |
Mehta N.C.,Medical College |
Dabhi A.S.,Medical College |
Lakhani O.,Medical College |
And 2 more authors.
Journal of Headache and Pain | Year: 2010
According to recent observations, there is worldwide vitamin D insufficiency (VDI) in various populations. A number of observations suggest a link between low serum levels of vitamin D and higher incidence of chronic pain. A few case reports have shown a beneficial effect of vitamin D therapy in patients with headache disorders. Serum vitamin D level shows a strong correlation with the latitude. Here, we review the literature to delineate a relation of prevalence rate of headaches with the latitude. We noted a significant relation between the prevalence of both tension-type headache and migraine with the latitude. There was a tendency for headache prevalence to increase with increasing latitude. The relation was more obvious for the lifetime prevalence for both migraine and tension-type headache. One year prevalence for migraine was also higher at higher latitude. There were limited studies on the seasonal variation of headache disorders. However, available data indicate increased frequency of headache attacks in autumn-winter and least attacks in summer. This profile of headache matches with the seasonal variations of serum vitamin D levels. The presence of vitamin D receptor, 1α-hydroxylase and vitamin D-binding protein in the hypothalamus further suggest a role of vitamin D deficiency in the generation of head pain. © Springer-Verlag 2010.
Prajapati P.,Surat Municipal Institute of Medical Education and Research
Journal of Indian Academy of Forensic Medicine | Year: 2012
Uterus is the most unique reproductive organ in humans. Rupture uterus is a hazardous complication of pregnancy and labour, and carries high risk both to the mother and the foetus. Uterine rupture during third trimester of pregnancy is a rare complication but if there is rupture and not suspect with in time may have fatal out come for the mother, foetus or both. In this modern medical era, prenatal check-up, advanced non invasive diagnostic facilities and subsequent treatment does not produce such life threatening complication. Rupture uterus cases are observed due to either carelessness of the patient or negligence of the doctor. Three cases of rupture uterus are discussed in this paper of full term pregnancy, had complete antenatal visits with all investigations including ultrasonography and attended the hospital well in time before death. Most cases of rupture uterus are preventable with good ante-natal and intra-partum care, and proper identification of high-risk cases.
Prajapati P.,Surat Municipal Institute of Medical Education and Research |
Kaushik V.K.,Surat Municipal Institute of Medical Education and Research
Medico-Legal Update | Year: 2016
Every year a substantial proportion of deaths in India occur due to burn injuries. Burn deaths are a major public health problem in our country. This prospective study was carried out in Forensic Medicine & Toxicology department of SMIMER, Surat in the year of 2014. The 21 to 30 years age group accounted for 35% of the burn cases and male: female ratio was 1:2. The commonest cause of death in these cases was burns shock with toxaemia while the most common complication of burn cases was septicaemia. 75 to 100% of the total body surface area (TBSA) was involved in 46% of burn cases. The objective of the study was to understand various demographic aspects of deaths due to burns as to suggest some remedial measures. © 2016, World Informations Syndicate. All rights reserved.
Bosamiya S.,Surat Municipal Institute of Medical Education and Research
Indian Journal of Dermatology | Year: 2011
A paradoxical clinical worsening of a known condition or the appearance of a new condition after initiating antiretroviral therapy in HIV-infected patients is defined as immune reconstitution inflammatory syndrome (IRIS). Because of wide variation in clinical presentation and the still increasing spectrum of symptoms and etiologies reported, diagnosis remains problematic. Furthermore, no test is currently available to establish an IRIS diagnosis. Until a greater understanding of the syndrome is achieved in different regions of the world, clinicians need to remain vigilant when initiating ART and individualize therapy according to known treatment options for the specific infectious agent.
Joshi G.,Surat Municipal Institute of Medical Education and Research |
Gamit D.,Surat Municipal Institute of Medical Education and Research
Sri Lanka Journalof Child Health | Year: 2016
Introduction: Few studies are available as regards status of platelets in malaria in paediatric patients. Objectives: To correlate factors such as age, type of malaria species and degree of parasitaemia with the degree of thrombocytopenia and to correlate the mean platelet volume and platelet distribution width with the malaria species. Method: A prospective observational study was conducted on patients 1 to 17 years of age admitted to the department of paediatrics of a tertiary level hospital from January 2014 to November 2014 with a history of acute fever (less than 5 days) and peripheral blood smear positive for malarial parasites with the rapid diagnostic test. A detailed history and examination of the patients along with the demographic profile was entered in the predesigned proforma. Automated Coulter haematology analyser (Abacus) was used for investigations. The data was analysed by SPSS 16 statistical analysis. Comparison among three groups of continuous data was done using a One-way ANOVA, whereas data not conforming to normal distribution were compared by a Kruskal-Wallis Test. Categorical data were compared using Pearson Chi-Square Test. Results: There were 105 patients who met the inclusion criteria. Of them, 60% had vivax malaria, 33% had falciparum malaria and the rest had mixed malaria. Thrombocytopenia was present in 85%, severe thrombocytopenia (< 50,000/cu mm) being present in 36%. The platelet count significantly correlated with the type of malaria and the degree of parasitaemia. The platelet count decreased as the age increased in moderate to severe thrombocytopenia. There was also correlation between the mean platelet volume but not the platelet distribution width and the malaria species. Conclusion: Thrombocytopenia was present in 85% of patients, the degree of thrombocytopenia correlating significantly with the degree of parasitaemia and the type of malaria. The MPV but not the PDW correlated significantly with the type of malaria species.
Kanadhia K.C.,Surat Municipal Institute of Medical Education and Research |
Ramavataram D.V.S.S.,Surat Municipal Institute of Medical Education and Research |
Nilakhe S.P.D.,Surat Municipal Institute of Medical Education and Research |
Patel S.,Surat Municipal Institute of Medical Education and Research
Magnesium Research | Year: 2014
Background: Various sources of drinking water, with varying levels of total hardness, and calcium and magnesium concentrations, are used by populations in different regions. The use of water purifiers can compound the problem of maintaining the desired levels of hardness. An inverse relationship between various conditions, including cardiovascular disease, and hard water has been reported. Until this study, investigation of the hardness of drinking water from different sources, and serum magnesium and calcium in normal subjects from the Surat district, had not been undertaken. Objectives: This study was performed to assess the concentrations of calcium and magnesium, and total hardness in filtered and non-filtered water and the relationship with serum magnesium and calcium levels in normal subjects consuming such water. Methodology: Three water samples were collected, at 15-day intervals, from 12 urban and rural areas of Surat; and also 10 different brands of bottled water. Samples were analyzed for total hardness and calcium by complexometric and EDTA methods respectively. Magnesium concentrations were obtained by subtraction of the calcium concentration from total hardness. Serum samples from healthy individuals were analyzed for magnesium and calcium using calmagite and arsenazo methods respectively. The independent t-test was used to establish significance at a level of 95%. A p-value <0.05 was considered significant. Results: Mean total hardness, and calcium and magnesium concentrations in non-filtered, rural tube-well water were much higher than in filtered water from the same area, and the magnesium concentrations were significantly higher (p = 0.038). Filtered urban municipal had lower hardness and concentrations of calcium and magnesium (p = 0.01) compared to corresponding non-filtered water. Significantly lower levels were observed in bottled water compared to rural and urban sources of water. Serum magnesium was significantly lower in the population who were consuming filtered water compared to those drinking non-filtered water (p<0.05). No such difference was observed for serum calcium. Conclusion: Hypomagnesemia correlates with lower magnesium concentrations in drinking water (both rural tube-well and urban municipal waters), which can be attributed to the use of water purifiers. Assuming that a person consumes two liters of drinking water per day, it is estimated that there is an average loss of 160 mg (79%) of magnesium from total waterborne magnesium levels as a result of the filtration of both rural and urban water supplies. Bottled water is too hardness as in calcium and magnesium concentrations. © 2014, John Libbey Eurotext. All rights reserved.
Vaishnani J.B.,Surat Municipal Institute of Medical Education and Research
Indian Journal of Dermatology, Venereology and Leprology | Year: 2011
Malaria is an infectious disease caused by protozoa of the genus Plasmodium. Cutaneous lesions in malaria are rarely reported and include urticaria, angioedema, petechiae, purpura, and disseminated intravascular coagulation (DIC). Here, five malaria cases associated with cutaneous lesions have been described. Out of the five cases of malaria, two were associated with urticaria and angioedema, one case was associated with urticaria, and other two were associated with reticulated blotchy erythema with petechiae. Most of the cutaneous lesions in malaria were nonspecific and reflected the different immunopathological mechanism in malarial infection.