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Surabaya, Indonesia

Yulia R.,University of Surabaya | Christyaningsih J.,Surabaya Health Polytechnic | Irmasari V.,University of Surabaya
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Soybean is known to be the best source of isoflavone and antioxidant. Black soybean var. Detam II is proven to decrease the lead level in lead intoxicated mice, so that the antioxidant of black soybean var. Detam II extract is held. Defatted black soybean was extracted with methanol, hydrolyzed with HCl, then extracted with diethylether. The diethylether in the extract was evaporated until constant weight, then flavonoid was identificated by TLC and the active substances was analysed by GC-MS. The TLC result showed three unidentified flavonoids and the result by GC-MS showed Hexadecanoic acid, methyl ester, and Hexadecanoic acid, ethyl ester which three act as antioxidant. Neither isoflavone genistein substance was detected in black soybean var. Detam II extract with obtained by diethylether. Source


Sasongkowati R.,Surabaya Health Polytechnic | Chitraningtyas D.,Public Health Laboratory of Surabaya | Suliati,Surabaya Health Polytechnic | Christyaningsih J.,Surabaya Health Polytechnic
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Urinary Tract Infection (UTI) is caused by bacteria entry into the urinary tract. Testing the species of bacteria in the urine has an important role in relations with the antibiotic selection for the patient. The aim of the research is to know the susceptibility of Enterococcus faecalis and Klebsiella ozaenae cause of UTIs for each type of antibiotic. This study was descriptive and carried out in the Public Health Laboratory of Surabaya from March to June 2013. Enterococcus faecalis that caused the UTIs in East Java, Indonesia, had a high susceptibility to Ampicillin, Penicillin, Vancomycin, Teicoplanin, Fosfomycin and high resistance to Erythromycin. Whereas Klebsiella ozaenae that caused the UTIs in the same area had a high susceptibility to Meropenem and Cefoperazone sulbactam and high resistance against Trimethoprim, Sulfamethoxazole and Ciprofloxacin. Source


Christyaningsih J.,Surabaya Health Polytechnic | Chitraningtyas D.,Public Health Laboratory of Surabaya | Sasongkowati R.,Surabaya Health Polytechnic
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Urinary Tract Infection (UTI) is an inflammatory reaction of the urothelium cells lining the urinary tract, as a form of defense of the body caused by bacteria entry into the urinary tract. Testing species of bacteria in the urine has an important role in relation with the antibiotic selection for the patient. People in Indonesia are often less orderly in taking antibiotics, so the antibiotic resistance pattern tends to change. The aim of the research is to know the pattern of antibiotic resistence to Escherichia coli causing urinary tract infections. This study was descriptive and carried out in Public Health Laboratory of Surabaya, from March to June 2013. The results show an antibiotic that has a pattern of resistance to Escherichia coli are trimethoprim sulfametoxazole (81.3%) and ciprofloxacin (76.5%), whereas Escherichia coli is sensitive to the antibiotic Fosfomycin, Meropenem (100%) and Amikacin (92.6%). Source


Christyaningsih J.,Surabaya Health Polytechnic
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Eradication effort of tuberculosis disease in Indonesia has been carried out by implementing the strategy of Directly Observed Treatment Short-Course (DOTS) free of charge. However, its prevention and eradication are still unsatisfactory and Vitamin D expected to be able to enhance intracellular immune response. An experimental research using randomized post-test control group design was selected in this study. Twenty four mice were selected and allocated randomly into two groups. Twelve mice in one group were given 100ng of vitamin D orally, while twelve mice in another group were not given vitamin D. Then each group was allocated randomly into two sub groups of six mice. Six mice in one sub group were infected with Mycobacterium tuberculosis, while six mice in another sub group were not infected with Mycobacterium tuberculosis. The results showed that Vitamin D plays a role in increasing the body's resistance to tuberculosis and inhibits lung tissue damage due to tuberculosis. Source


Lestari I.,Surabaya Health Polytechnic | Indra Pertiwi E.D.,Surabaya Health Polytechnic | Christyaningsih J.,Surabaya Health Polytechnic
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

The children' snacks in state elementary school tend to be sold at a low price, sometimes the food vendors do not seem to take into account the quality, hygiene and sanitation of the snacks. Electronic media often report about the food or the snacks that contain hazardous substances such as preservatives and dyes that are banned by the government. The survey was conducted in August and September 2014 in 74 state elementary schools scattered in the city of Surabaya with sample of 631 pieces, and the results show a Formalin content (0%) in children' snacks and the snacks content of Rhodamine B (2,32%) and Auramine (0%) that are sold in the state elementary schools in the city of Surabaya. Source

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