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Li J.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Liu W.,First peoples Hospital of Suqian | Lu H.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Zheng J.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group
Chinese Journal of Evidence-Based Medicine | Year: 2014

Objective To systematically review the efficacy between key hole approach versus large trauma craniotomy for patients with hypertensive intracerebral hemorrhage. Methods Such databases as The Cochrane Library (Issue 3, 2013), PubMed, EMbase, WangFang Data, CNKI and VIP was searched to identify randomized controlled trials (RCTs) on key hole approach versus large trauma craniotomy for patients with hypertensive intracerebral hemorrhage from January 2005 to June 2013. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of included studies. Then meta-analysis was performed using RevMan 5.2. Results A total of 13 studies involving 1 324 patients was included. The results of metaanalysis showed that, key hole approach was superior to large trauma craniotomy with significant differences in the fatality rate (OR=0.29, 95%CI 0.19 to 0.45, P<0.000 01), incidence of postoperative complications (OR=0.35, 95%CI 0.21 to 0.57, P<0.000 1), recovery time of consciousness (MD=-4.52, 95%CI-5.84 to-3.20, P<0.000 01), neurologic impairment score after 1-month treatment (MD=-12.63, 95%CI­16.36 to­8.90, P<0.000 01), total effectiveness (OR=3.79, 95%CI 2.54 to 5.66, P<0.000 01), and postoperative living ability (ADL Grade I, II). Conclusion Key hole approach is better than large trauma craniotomy for patients with hypertensive intracerebral hemorrhage. Due to limited quality and quantity of the included studies, the abovementioned conclusion still needs to be verified by conducting more high quality studies, especially conducting multicenter blinding RCTs with large sample-size. © 2014 Editorial Board of Chin J Evid-based Med. Source


Hui B.-J.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Zhang Q.-Q.,Xuzhou Medical College | Chen D.-M.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Ling B.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | And 3 more authors.
Chinese Journal of Interventional Imaging and Therapy | Year: 2012

Objective: To evaluate the effect of TACE combined with partial splenic embolization (PSE) in the treatment of primary hepatocellular carcinoma (PHC) associated with hypersplenism. Methods: Twenty-six PHC patients associated with hypersplenism underwent TACE and PSE. Following up was performed with liver ultrasound, CT scan, liver function, peripheral blood routine test and alfa fetoprotein. Results: Sixty-three times of TACE and 27 times of PSE procedures were performed on 26 patients. All the interventional procedures were successful without serious complications. Twenty-six patients were followed up for 2 months after TACE and PSE, and all survived. Twenty-three patients were followed up for 6 months and 17 cases survived. Thirteen patients were followed up for 1 year and 9 cases survived. Eight patients were followed up for 2 years and 5 cases survived. Conclusion: TACE combined with PSE is an effective method in treatment of PHC associated with hypersplenism. © 2012 by the Press of Chinese Journal of Medical Imaging Technology. Source


Wen L.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Wang R.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Lu X.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | You C.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group
Oncology Letters | Year: 2015

The aim of the present study was to investigate the prognostic value of vascular endothelial growth factor (VEGF) and its receptor, fms‑related tyrosine kinase‑1 (FLT‑1), in patients with colorectal cancer. An immunohistochemical approach was used to detect the protein expression of VEGF and FLT‑1 in 90 patients with colorectal cancer. The impact of VEGF and FLT‑1 tumor cell expression, in addition to other factors, on overall survival (OS) was retrospectively assessed in 90 patients. Multivariate analysis was performed in order to determine the prognostic significance of the factors. The positive expression rate of VEGF in the colorectal cancer tissues was 62.2% (56/90). The positive expression rate of FLT‑1 in colorectal cancer tissues was 48.9% (44/90). The results of the log‑rank test revealed that improved OS rates were significantly associated with the absence of VEGF expression (P<0.0001). By contrast, FLT‑1 expression had no significant impact on OS (P=0.289). Upon multivariate analysis, VEGF expression (P=0.038) and clinical stage (P=0.021) maintained significance. VEGF expression proved to be an independent negative predictor of OS in patients with colorectal cancer. Conversely, FLT‑1 expression demonstrated no impact on OS. © 2015, Spandidos Publications. All rights reserved. Source


Guan X.-Q.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Wu J.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Gu S.-C.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | Zhang X.-X.,Suqian Peoples Hospital Of Nanjing Drum Tower Hospital Group | And 3 more authors.
World Chinese Journal of Digestology | Year: 2016

AIM: To investigate the diagnosis and treatment of massive duodenal gastrointestinal stromal tumors. METHODS: We retrospectively analyzed the diagnosis, treatment and follow-up data for 12 patients with massive duodenal gastrointestinal stromal tumors treated at our hospital since January 2000. RESULTS: Among the 12 patients, 6 without any adjuvant therapy died of tumor recurrence and metastasis, whose survival time was 23 to 36 mo. One patient died of liver and abdominal metastases and intestinal obstruction at 13 mo, who developed intraoperative tumor rupture and refused reoperation and other therapies. The rest five patients are still alive, all of whom had received Gleevec treatment for 1-3 years; liver metastasis occurred in 3 cases and was controlled with Gleevec, and 1 case survived for 61 mo, who is still on Gleevec targeted therapy. CONCLUSION: Massive tumor and nuclear division phase > 5/50 at high magnification are main risk factors for postoperative recurrence and metastasis in duodenal gastrointestinal stromal tumors. Complete resection, even combined with resection of other organs, is the only means to cure massive duodenal gastrointestinal stromal tumors, because it can achieve R0 resection and avoid intraoperative tumor rupture. Gleevec targeted therapy of patients with risk factors for recurrence is an effective method of prevention and treatment of recurrence and metastasis. © 2016 Baishideng Publishing Group Inc. All rights reserved. Source

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