Clarkson, NY, United States
Clarkson, NY, United States

SUNY Downstate Medical Center, located in central Brooklyn, New York, is the only academic medical center for health education, research, and patient care serving Brooklyn’s 2.5 million residents. As of Fall 2011, it had a total student body of 1,738 and approximately 8,000 faculty and staff.Downstate Medical Center comprises a College of Medicine, Colleges of Nursing and Health Related Professions, Schools of Graduate Studies and Public Health, and University Hospital of Brooklyn. It also includes a major research complex and biotechnology facilities.SUNY Downstate ranks eighth nationally in the number of alumni who are on the faculty of American medical schools. More physicians practicing in New York City graduated from Downstate than from any other medical school. With 1,040 residents , Downstate's residency program is the 16th largest in the country.SUNY Downstate Medical Center is the fourth largest employer in Brooklyn. Eighty-six percent of its employees are New York City residents; 68 percent live in Brooklyn. The medical center's total direct, indirect, and induced economic impact on New York State is in excess of $2 billion. SUNY Downstate Medical Center attracted close to $60 million in external research funding in 2011, which includes $26 million from federal sources. It ranks fourth among SUNY campuses in grant expenditures, and second among SUNY's academic health centers. Wikipedia.

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Martinez-Conde S.,SUNY Downstate Medical Center | Macknik S.L.,SUNY Downstate Medical Center
Philosophical Transactions of the Royal Society B: Biological Sciences | Year: 2017

Scientists have pondered the perceptual effects of ocular motion, and those of its counterpart, ocular stillness, for over 200 years. The unremitting ‘trembling of the eye’ that occurs even during gaze fixation was first noted by Jurin in 1738. In 1794, Erasmus Darwin documented that gaze fixation produces perceptual fading, a phenomenon rediscovered in 1804 by Ignaz Paul Vital Troxler. Studies in the twentieth century established that Jurin’s ‘eye trembling’ consisted of three main types of ‘fixational’ eye movements, now called microsaccades (or fixational saccades), drifts and tremor. Yet, owing to the constant and minute nature of these motions, the study of their perceptual and physiological consequences has met significant technological challenges. Studies starting in the 1950s and continuing in the present have attempted to study vision during retinal stabilization—a technique that consists on shifting any and all visual stimuli presented to the eye in such a way as to nullify all concurrent eye movements—providing a tantalizing glimpse of vision in the absence of change. No research to date has achieved perfect retinal stabilization, however, and so other work has devised substitute ways to counteract eye motion, such as by studying the perception of afterimages or of the entoptic images formed by retinal vessels, which are completely stable with respect to the eye. Yet other research has taken the alternative tack to control eye motion by behavioural instruction to fix one’s gaze or to keep one’s gaze still, during concurrent physiological and/or psychophysical measurements. Here, we review the existing data—from historical and contemporary studies that have aimed to nullify or minimize eye motion—on the perceptual and physiological consequences of perfect versus imperfect fixation. We also discuss the accuracy, quality and stability of ocular fixation, and the bottom–up and top–down influences that affect fixation behaviour. © 2017 The Author(s) Published by the Royal Society. All rights reserved.

The International Nurses Association is pleased to welcome Laila N. Sedhom, PhD, RN to their prestigious organization with her upcoming publication in the Worldwide Leaders in Healthcare. Laila is a Registered Nurse with more than four decades of experience in her field and an extensive expertise in all facets of nursing, especially pediatrics, oncology, education, and nurse research. She is currently working as Professor and Associate Dean within SUNY Downstate Medical Center, College of Nursing in Brooklyn, New York. Laila graduated with her Bachelor of Science Degree in Nursing and Master of Science Degree in Public Health Nursing with an emphasis on Maternal Child Health from the Higher Institute of Nursing in Alexandria, Egypt. Upon relocating to the United States, she obtained her PhD in Nursing Research and Theory Development from New York University. To keep up to date with the latest advances and developments in nursing, Laila maintains a professional membership with the New York State Nurses Association and the National Association of Clinical Nurse Specialists, appointed by the President of the organization. Learn more about Laila here: and and be sure to read her upcoming publication in the Worldwide Leaders in Healthcare.

News Article | May 5, 2017

BROOKLYN, NY, May 05, 2017-- Christopher Stephen Lange is a celebrated Marquis Who's Who biographee. As in all Marquis Who's Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in a field are all taken into account during the selection process.Marquis Who's Who, the world's premier publisher of biographical profiles, is proud to name Dr. Lange a Lifetime Achiever. An accomplished listee, Dr. Lange celebrates many years' experience in his professional network, and has been noted for achievements, leadership qualities, and the credentials and successes he has accrued in his field.A lauded and long-standing figure in his industry, Dr. Lange currently serves as Professor of Radiation Oncology, Associate Director of the Radiation Oncology Residency program, Professor of Molecular and Cell Biology, and Director of Radiation Research at the SUNY Downstate Medical Center.In addition to his status as Lifetime Achiever, Dr. Lange received the Presidential Certificate of Gratitude from the University of Hirosaki, the Lifetime Honorary Consultant Award from the Swietokrzyskie Centrum Onkologii, and the Research Career Development Award from the National Institutes of Health. Furthermore, Dr. Lange has been a grantee of the National Science Foundation, Mather's Foundation, the Royal Society of London, the U.S. Atomic Energy Commission, ERDA, U.S. Department of Energy, and the National Cancer Institute. An honoree decorated with the Knight's Cross of The Order of Merit of the Republic of Poland, Dr. Lange has been a featured listee in Who's Who in the World, Who's Who in America, Who's Who in American Education, and Who's Who in Science and Engineering.About Marquis Who's Who :Since 1899, when A. N. Marquis printed the First Edition of Who's Who in America , Marquis Who's Who has chronicled the lives of the most accomplished individuals and innovators from every significant field of endeavor, including politics, business, medicine, law, education, art, religion and entertainment. Today, Who's Who in America remains an essential biographical source for thousands of researchers, journalists, librarians and executive search firms around the world. Marquis publications may be visited at the official Marquis Who's Who website at

Meister L.,SUNY Downstate Medical Center
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | Year: 2013

Emergency physicians often encounter females presenting with symptoms suggestive of urinary tract infections (UTIs). The diagnostic accuracy of history, physical examination, and bedside laboratory tests for female UTIs in emergency departments (EDs) have not been quantitatively described. This was a systematic review to determine the utility of history and physical examination (H&P) and urinalysis in diagnosing uncomplicated female UTI in the ED. The medical literature was searched from January 1965 through October 2012 in PUBMED and EMBASE using the following criteria: Patients were females greater than 18 years of age in the ED suspected of having UTIs. Interventions were H&P and urinalysis used to diagnose a UTI. The comparator was UTI confirmed by a positive urine culture. The outcome was operating characteristics of the interventions in diagnosing a UTI. Study quality was assessed using Quality Assessment Tool for Diagnostic Accuracy Studies (QUADAS-2). Sensitivity, specificity, and likelihood ratios (LRs) were calculated using Meta-DiSc. Four studies (pooled n = 948) were included with UTI prevalence ranging from 40% to 60%. H&P variables all had positive LRs (+LR, range = 0.8 to 2.2) and negative LRs (-LR, range = 0.7 to 1.0) that are insufficient to significantly alter pretest probability of UTI. Only a positive nitrite reaction (+LR = 7.5 to 24.5) was useful to rule in a UTI. To rule out UTI, only a negative leukocyte esterase (LE; -LR = 0.2) or blood reaction on urine dipstick (-LR = 0.2) were significantly accurate. Increasing pyuria directly correlated with +LR, and moderate pyuria (urine white blood cells [uWBC] > 50 colony-forming units [CFUs]/ml) and moderate bacteruria were good predictors of UTI (+LR = 6.4 and 15.0, respectively). No single H&P finding can accurately rule in or rule out UTI in symptomatic women. Urinalysis with a positive nitrite or moderate pyuria and/or bacteruria are accurate predictors of a UTI. If the pretest probability of UTI is sufficiently low, a negative urinalysis can accurately rule out the diagnosis. © 2013 by the Society for Academic Emergency Medicine.

Lang E.K.,SUNY Downstate Medical Center
Journal of endourology / Endourological Society | Year: 2013

We present our experience with the use of metallic stents (Wallstents®) in the management of malignant ureteral obstruction to maintain renal function, thereby permitting the use of chemotherapeutic agents to treat the underlying malignancy. We retrospectively reviewed the records of 24 patients with ureteral obstruction secondary to advanced cervical carcinoma, stage T3b (n=10) and T4 (n=14), that was relieved by Wallstents. Nineteen patients needed bilateral and 5 needed unilateral Wallstents to relieve the obstruction. Fifty-six additional endourologic interventions were necessary to assure continued patency. Holmium laser ablation was used 14 times to manage tumor proliferation and ingrowth at the distal end of the stent. Thirty-two endostents, 4 extension, and 6 replacement stents were used to maintain patency of the ureter. Nineteen of our 24 patients received between one and five chemotherapeutic cycles over 18 to 140 months. In five patients, placement of Wallstents did not achieve adequate decrease of the creatinine levels to allow treatment with chemotherapy. Thirteen of 24 Wallstents remained patent over 18 months, yielding a primary patency rate of 54%. Technical success rate of Wallstent placement was 100%. The overall mean primary and secondary patency rates of the stent were 16.5 and 52 months, respectively. For T3b and T4 patients, the mean primary patency rates were 20.6 and 13.6 months, respectively. Secondary patency for T3b patients was 73.9 months vs 36.4 months for T4 patients. There were no serious complications associated with Wallstent placement. Wallstents offer a salutary solution to the problem of maintaining prolonged patency of ureters compromised by encasing neoplasms.

Bodis-Wollner I.,SUNY Downstate Medical Center
Parkinsonism and Related Disorders | Year: 2013

Purpose: The article aims to review foveal involvement in Parkinson's disease. Scope: Clinical observations as well as electrophysiological and anatomical studies in animal models provide evidence that Parkinson's disease (PD) affects vision. The retina is the most distal locus of visual dysfunction in PD as shown by electroretinographic (ERG) and optical coherence tomographic (OCT) studies. Thinning of the retinal nerve fibre layer (RNFL) and the fovea has been reported in PD. This review summarises retinal physiology and foveal visual dysfunction in PD and quantification of retinal thinning as reported in different studies and using different instruments. At this point due to methodological diversity and relatively low number of subjects studied, a meta-analysis is not yet possible. Results obtained on one equipment are not yet transferable to another. The author also briefly alludes to some links of visual processing deficits beyond visual detection, such as visual discrimination, visual categorisation and visuospatial orientation in PD. Conclusions: There are some promising results suggesting the potential applicability of ST-Oct as a biomarker in PD. Furthermore, these data raise some interesting neurobiological questions. However, there are identifiable pitfalls before OCT quantification may be used as a biomarker in PD. Analysis standardisation is needed on a larger than existing healthy and patient population. Furthermore, longitudinal studies are needed. The exact relationship between retinal foveal deficits and visuo-cognitive impairment in PD remains a challenging research question. © 2012 Elsevier Ltd.

Smith S.S.,SUNY Downstate Medical Center
Frontiers in Neural Circuits | Year: 2013

The onset of puberty is associated with alterations in mood as well as changes in cognitive function, which can be more pronounced in females. Puberty onset in female mice is associated with increased expression of α4βδ γ-amino-butyric acid-A (GABAA) receptors (GABARs) in CA1 hippocampus. These receptors, which normally have low expression in this central nervous system (CNS) site, emerge along the apical dendrites as well as on the dendritic spines of pyramidal neurons, adjacent to excitatory synapses where they underlie a tonic inhibition that shunts excitatory current and impairs activation of N-methyl-D-aspartate (NMDA) receptors, the trigger for synaptic plasticity. As would be expected, α4βδ expression at puberty also prevents long-term potentiation (LTP), an in vitro model of learning which is a function of network activity, induced by theta burst stimulation of the Schaffer collaterals to the CA1 hippocampus. The expression of these receptors also impairs spatial learning in a hippocampal-dependent task. These impairments are not seen in δ knock-out (-/-) mice, implicating α4βδ GABARs. α4βδ GABARs are also a sensitive target for steroids such as THP ([allo]pregnanolone or 3α-OH-5α[β]-pregnan-20-one), which are dependent upon the polarity of GABAergic current. It is well-known that THP can increase depolarizing current gated by α4βδ GABARs, but more recent data suggest that THP can reduce hyperpolarizing current by accelerating receptor desensitization. At puberty, THP reduces the hyperpolarizing GABAergic current, which removes the shunting inhibition that impairs synaptic plasticity and learning at this time. However, THP, a stress steroid, also increases anxiety, via its action at α4βδ GABARs because it is not seen in δ-/- mice. These findings will be discussed as well as their relevance to changes in mood and cognition at puberty, which can be a critical period for certain types of learning and when anxiety disorders and mood swings can emerge. © 2013 Smith.

Baird A.E.,SUNY Downstate Medical Center
Journal of the American College of Cardiology | Year: 2010

Evidence for a genetic basis for stroke comes from twin and family studies and from the occurrence of a number of uncommon monogenic disorders, but the contribution of genetic factors identified for stroke so far is small. Advances in genetics and genomics may permit new insights. In recent genome-wide association studies, a number of single-nucleotide polymorphisms have been associated with specific stroke subtypes and major stroke risk factors such as diabetes and atrial fibrillation. These await replication. Studies of messenger ribonucleic acid expression have also shown promise for the development of genomic signatures for stroke classification. Stroke and coronary heart disease share some features of pathophysiology, risk, and treatment, and their genetic and genomic bases also appear to overlap. © 2010 American College of Cardiology Foundation.

Quadros E.V.,SUNY Downstate Medical Center
British Journal of Haematology | Year: 2010

The haematological and neurological consequences of cobalamin deficiency define the essential role of this vitamin in key metabolic reactions. The identification of cubilin-amnionless as the receptors for intestinal absorption of intrinsic factor-bound cobalamin and the plasma membrane receptor for cellular uptake of transcobalamin bound cobalamin have provided a clearer understanding of the absorption and cellular uptake of this vitamin. As the genes involved in the intracellular processing of cobalamins and genetic defects of these pathways are identified, the metabolic disposition of cobalamins and the proteins involved are being recognized. The synthesis of methylcobalamin and 5′-deoxyadenosylcobalamin, their utilization in conjunction with methionine synthase and methylmalonylCoA mutase, respectively, and the metabolic consequences of defects in these pathways could provide insights into the clinical presentation of cobalamin deficiency. © 2009 Blackwell Publishing Ltd.

Agency: Department of Health and Human Services | Branch: | Program: STTR | Phase: Phase I | Award Amount: 619.66K | Year: 2012

DESCRIPTION (provided by applicant): Most preterm infants have episodes of apnea (cessation of breathing), bradycardia (low heart rate), and desaturations (low levels of oxygen in the blood) or what is collectively called as ABD events. The resolution of such ABD episodes depends to a large extent on the maturation of the central nervous system (CNS).The electroencephalogram (EEG) is the only reliable and noninvasive tool required for recording from the CNS, and determining electrographic markers that couldpredict recurrence or resolution of ABD episodes. Despite such obvious need, standard EEG is not constantly available in most Neonatal Intensive Care Units (NICUs). The main obstacles to its routine availability in NICUs include high cost of standard EEGmachines, inability of most standard machines to operate in electrically-noisy environments such as the NICU, and more importantly the absence of full-time coverage neurologists for prompt EEG interpretation. There is an obvious unmet need for routine EEGavailability in the NICU, not only for identification of maturation of brain electrical activity in infants with ABD events, but also for identification of seizures, evaluation of treatment response, and prognosticating high-risk neonates in the choice ofearly neuroprotective treatments. Allowing for routine EEG availability in the NICU requires the innovation of a product capable of overcoming the aforementioned impediments, particularly allowing for immediate EEG assessment by remote neurologists, without compromising the quality of EEG's generated in that setting. We propose, first, to determine the feasibility of obtaining an artifact-free EEG in the NICU with accurate detection of background rhythm abnormalities. For this purpose we will leverage the performance of our existing digital wireless telemetry unit, the microEEG for the NICU, particularly in prolonged recordings. Secondly, we propose to finalize the development of an inexpensive system to record an artifact free EEG in the NICU, and develop a case management system for obtaining a centralized network of EEG interpretation from off-site neurologists. Finally, we will examine the level of agreement between the various EEG interpretations provided by the neurologists, and therefore set up consensus guidelines for low agreement EEG interpretations. PUBLIC HEALTH RELEVANCE: Most infants born prematurely have episodes in which they stop breathing (apnea), have low heart rate (bradycardia) and low levels of oxygen in the blood (desaturations). We propose to study the maturation of brain electrical activity in these infants using microEEG , a wireless, non-invasive device with numerous advantages over current technology. This investigation will allow us to better understand the etiologyand treatment of ABD events, while investigating the feasibility and reliability of centralized EEG interpretation.

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