The State University of New York College at Old Westbury is a university college that is part of the State University of New York system. The college is in Old Westbury, New York, with portions in the neighboring town of Jericho, New York. With nearly 4,000 students, SUNY College at Old Westbury serves as the only public liberal arts college on Long Island. Wikipedia.
Gao R.,SUNY College at Old Westbury
Journal of Chemical Education | Year: 2015
In a typical chemistry instrumentation laboratory, students learn analytical techniques through a well-developed procedure. Such an approach, however, does not engage students in a creative endeavor. To foster the intrinsic motivation of students' desire to learn, improve their confidence in self-directed learning activities and enhance their problem-solving skills, students' self-designed, research-based analytical chemistry projects have been developed within the course of Advanced Chemical Methods for junior and senior undergraduates at SUNY College at Old Westbury. In addition to a series of manual-based laboratories held on a regular basis, students also do a literature search to formulate their own ideas that are tested using appropriate analytical instruments. By participating in self-designed projects, students independently go through the key components of analytical chemistry with greater engagement: from literature survey, problem identification, experimental design, sample preparation, measurements, results and discussion to conclusion, in a self-inquiry-based learning environment. The instructor's observation, assessment of written reports and students' self-evaluations indicate successful implementation of the projects and students' progress toward the goals mentioned above. This project provides students a research-based chemistry laboratory for self-inquiry-driven learning and independent thinking. © 2015 The American Chemical Society and Division of Chemical Education, Inc.
Miller-Struttmann N.E.,SUNY College at Old Westbury |
Miller-Struttmann N.E.,University of Missouri |
Geib J.C.,Appalachian State University |
Franklin J.D.,University of Missouri |
And 8 more authors.
Science | Year: 2015
Ecological partnerships, or mutualisms, are globally widespread, sustaining agriculture and biodiversity. Mutualisms evolve through the matching of functional traits between partners, such as tongue length of pollinators and flower tube depth of plants. Long-tongued pollinators specialize on flowers with deep corolla tubes, whereas shorter-tongued pollinators generalize across tube lengths. Losses of functional guilds because of shifts in global climate may disrupt mutualisms and threaten partner species. We found that in two alpine bumble bee species, decreases in tongue length have evolved over 40 years. Co-occurring flowers have not become shallower, nor are small-flowered plants more prolific. We argue that declining floral resources because of warmer summers have favored generalist foraging, leading to a mismatch between shorter-tongued bees and the longer-tubed plants they once pollinated.
Kim Y.,Yale University |
Kim Y.,SUNY College at Old Westbury |
Li Z.,Yale University |
Apetri M.,Yale University |
And 4 more authors.
Biochemistry | Year: 2012
Epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor tyrosine kinases (RTK). EGFR overexpression or mutation in many different forms of cancers has highlighted its role as an important therapeutic target. Gefitinib, the first small molecule inhibitor of EGFR kinase function to be approved for the treatment of nonsmall cell lung cancer (NSCLC) by the FDA, demonstrates clinical activity primarily in patients with tumors that harbor somatic kinase domain mutations in EGFR. Here, we compare wild-type EGFR autophosphorylation kinetics to the L834R (also called L858R) EGFR form, one of the most common mutations in lung cancer patients. Using rapid chemical quench, time-resolved electrospray mass spectrometry (ESI-MS), and Western blot analyses, we examined the order of autophosphorylation in wild-type (WT) and L834R EGFR and the effect of gefitinib (Iressa) on the phosphorylation of individual tyrosines. These studies establish that there is a temporal order of autophosphorylation of key tyrosines involved in downstream signaling for WT EGFR and a loss of order for the oncogenic L834R mutant. These studies also reveal unique signature patterns of drug sensitivity for inhibition of tyrosine autophosphorylation by gefitinib: distinct for WT and oncogenic L834R mutant forms of EGFR. Fluorescence studies show that for WT EGFR the binding affinity for gefitinib is weaker for the phosphorylated protein while for the oncogenic mutant, L834R EGFR, the binding affinity of gefitinib is substantially enhanced and likely contributes to the efficacy observed clinically. This mechanistic information is important in understanding the molecular details underpinning clinical observations as well as to aid in the design of more potent and selective EGFR inhibitors. © 2012 American Chemical Society.
Zhu J.,SUNY College at Old Westbury
Procedia Computer Science | Year: 2013
Point-of-Sales (POS) data can be helpful to improve demand forecast even your business is at the upstream of the supply chain. When your business is several steps away from the end-user, regression analysis using POS data as the predictors provides is an effective way to improve your demand forecast. In this article, we present a real case where the business is two steps away from the end-user and demonstrate how the business uses POS data to improve a business forecast. © 2013 The Authors. Published by Elsevier B.V.
Heller J.,SUNY College at Old Westbury
American Journal of Public Health | Year: 2015
The social context of the early HIV/AIDS epidemic in the United States provided fertile ground for rumors about transmission. Today, however, rumors about HIV/AIDS persist only within the African American public. Focus group and public discourse data reveal the content and distribution of HIV/AIDS origin and conspiracy rumors. Rumor and contemporary legend theory allows reinterpretation of rumors as a measure of trust between the African American public and health professionals, not as evidence of ignorance or of historical racial oppression. To improve public health results in the African American community, HIV/AIDS efforts must acknowledge the sources and meanings of rumors, include rumors as a measure of trust, and address the underlying distrust that the rumors signify.